한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology)

  • 제30권1호
  • /
  • Pages.74-86
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  • 2017
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  • 1738-6640(pISSN)
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  • 2234-4020(eISSN)
대한한방안이비인후피부과학회 (The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology)
권호 표지
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황련해독탕이 비염 개선에 미치는 효과: 기초실험 연구 문헌 분석

Therapeutic effect of the traditional herbal formula, Hwanglyeonhaedok-tang, on rhinitis: A Review of the experimental study

  • 손미주 (한국한의학연구원 임상연구부) ;
  • 정의민 (한국한의학연구원 임상연구부) ;
  • 김윤희 (한국한의학연구원 한의약융합연구부) ;
  • 이동효 (우석대학교 한의과대학 안이비인후피부과학 교실) ;
  • 김성하 (한국한의학연구원 임상연구부)
  • Son, Mi-Ju (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Jerng, Ui-Min (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Yun-Hee (KM Convergence Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Dong-Hyo (Dept. of Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Woo-Suk University) ;
  • Kim, Sung-Ha (Clinical Research Division, Korea Institute of Oriental Medicine)
  • 투고 : 2017.01.06
  • 심사 : 2017.02.14
  • 발행 : 2017.02.25
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초록

Objectives : This study aimed to assess the scientific evidence for the use of Hwanglyeonhaedok-tang, a traditional herbal formula, in the treatment of rhinitis, and prepare the basis for the investigational new drug application by analyzing the experimental studies. Methods : Ten electronic databases were searched up to December, 2016 without language limitation. Experimental studies on the anti-inflammatory and anti-allergic effects of Hwanglyeonhaedok-tang against rhinitis were included. We extracted data about study design, characteristics of intervention, outcomes, and pharmacological effects from the included studies and summarized them. Results : Eight hundred and thirty-three potentially relevant studies were identified, of which 18 experimental studies met our inclusion criteria. Of 18 included studies, 5 had conducted cell viability test, and all studies had reported that Hwanglyeonhaedok-tang was non-cytotoxic. Hwanglyeonhaedok-tang exhibits anti-inflammatory effect by regulating the inflammation-related cytokines including nitric oxide(NO), prostaglandin $E_2(PGE_2)$, interleukin-6(IL-6), and tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ in vitro and in vivo. Hwanglyeonhaedok-tang exhibits anti-allergic effect by suppressing eosinophil, and histamine levels. Hwanglyeonhaedok-tang helps in the recovery of nasal mucous membrane by supressing goblet cells, heat shock protein 70, and substance P. Conclusions : This study suggests that Hwanglyeonhaedok-tang has the potential to be developed as therapeutic agent for rhinitis. Further experimental and clinical studies needed to be performed to prove the safety and efficacy.

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