• 한국농공학회논문집
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• 제60권1호
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• pp.37-45
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• 2018

This study is aims to voluntary participation in rural development projects, voluntary participation by analyzing the individual competence factors, how the what and how much influence affect the continued involvement and participation as a concept of strengthening community capacity the plan for it to present. The results of survey, through factor analysis and reliability analysis for extracting the components of individual competence areas and life satisfaction, self acting capacity, was extracted with recognized competence, was the factor analysis and reliability analysis for ongoing involvement and participation. Personal competence was a multiple regression analysis, the participation of three elements as independent variables as dependent variables to evaluate the impact of continuing involvement, and the resulting Regional and life satisfaction (${\beta}=0.301$) have the greatest impact It showed. In addition, regional analysis and life satisfaction (${\beta}=0.247$) on the impact of enlargement on the individual capabilities showed the highest participation. The elements of local life satisfaction and personal competencies exerts the greatest influence on the continued involvement and participation in the study was obtained. It based on the results in rural development for the voluntary participation and participation of the population should be considered with a plan to enhance the regional and life satisfaction, "the software business, which is carried out in rural areas developed for them by local residents the measures to increase life satisfaction will be provided.

• IMMUNE NETWORK
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• 제11권6호
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• pp.368-375
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• 2011

Background: Recent clinical observation reported that there was a significant correlation between change in circulating vascular endothelial growth factor (VEGF) levels and the occurrence of severe acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the action mechanisms of VEGF in GVHD have not been demonstrated. Methods: This study investigated whether or not blockade of VEGF has an effect on acute GVHD in a lethally irradiated murine allo-HSCT model of $B6\;(H-2^b)\;{\rightarrow}B6D2F1\;(H-2^{b/d})$. Syngeneic or allogeneic recipient mice were injected subcutaneously with anti-VEGF peptides, dRK6 ($50{\mu}g/dose$) or control diluent every other day for 2 weeks (total 7 doses). Results: Administration of the dRK6 peptide after allo-HSCT significantly reduced survival with greaterclinical GVHD scores and body weight loss. Allogeneic recipients injected with the dRK6 peptide exhibited significantly increased circulating levels of VEGF and expansion of donor $CD3^+$ T cells on day +7 compared to control treated animals. The donor $CD4^+$ and $CD8^+$ T-cell subsets have differential expansion caused by the dRK6 injection. The circulating VEGF levels were reduced on day +14 regardless of blockade of VEGF. Conclusion: Together these findings demonstrate that the allo-reactive responses after allo-HSCT are exaggerated by the blockade of VEGF. VEGF seems to be consumed during the progression of acute GVHD in this murine allo-HSCT model.

• 대한건축학회논문집:구조계
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• 제34권5호
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• pp.19-26
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• 2018

A civil-military facility sharing project is a part of mutual cooperative efforts, which enables the military to use any civilian (local government or company) or a civilian to use any military facility. Such facility sharing project may reduce or clear possible conflicts with the local residents in the surrounding area of a military facility while being available to save budgets for new construction or maintenance of a defense or military facility. Various measures have been proposed for institutional resolutions on conflicts with the local residents in the surrounding area of a military facility. This study collects and organizes previous cases of the civilian-military facility sharing projects, and analyzes the characteristics of such cases based on the project types. In addition, by organizing and proposing the project characteristics, plans (ideas) and determination criteria to expand and vitalize are presented regarding the project types having restrictions. AHP technique is employed to research on the matrix for the project feasibility determination. Also, the opinions organized through the cause analysis are categorized and presented as a project for the expansion and vitalization of future project. According to the rearch result, Type I, II and III are determined to be projects that can be implemented without difficulties. Type IV, on the other hands, is determined as not illegal, yet inadequate so that some legal and institutional complements are required to expand and vitaliza this facility sharing project.

• Asia Marketing Journal
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• 제15권2호
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• pp.29-47
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• 2013

Distribution channel decisions involve long-term commitments with other firms that are very difficult to change or replace. In particular, marketing channel decisions in emerging markets are much more complicated due to unfamiliar conditions and problems such as lack of market data and distribution systems. Therefore, when a company considers changing or introducing a marketing channel in an area, it is much more difficult to judge its effectiveness in an emerging market than in a developed market. In this study, we investigate the development process of a new direct marketing channel of Hongfu Fertilizer Company (hereafter Hongfu), a medium-sized Chinese fertilizer manufacturer, and propose an approach to test the feasibility of this new marketing channel in the Chinese rural market. We measure the effectiveness of Hongfu's new marketing channel from two perspectives: i) from customers' perspective through direct responses of farmers, which showed that a new channel can increase the convenience and lower the purchasing costs for the farmers, and ii) from the company's perspective, by calculating the incremental profit of the company using the expansion factor (T/Q) method, which suggested that the execution of Hongfu's strategy to expand a new marketing channel will result in an increase in profits. The results of this study contribute to the development of a methodology to test the feasibility of a new direct marketing channel in the emerging markets such as the Chinese rural market. Traditional and indirect distribution channels in emerging markets are generally not very efficient and difficult to change. Especially, in emerging markets, like the Chinese rural market, the methods of testing channel feasibility must be different from that of developed markets. Considering market situations, market experiments can be more effective then systematic market surveys in testing channel feasibility in emerging markets. This study implies that managers must learn to cope with a transition from the traditional marketing channels in emerging markets. With the development in farmers' understanding of marketing concept, the transition from traditional marketing channel is unavoidable for all firms. Farmers in China are generally very conservative, however, their buying behaviors are changing. Therefore, fertilizer companies should try to adjust in accordance with farmers' demand characteristics that the efforts to meet the economic needs of farmers with new marketing channels as well as trust building are critical in the near future.

• 대한치과교정학회지
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• 제30권3호
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• pp.317-333
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• 2000

급속 구개확장은 정중구개봉합을 이개하기 위하여 강한 힘을 치아에 가하게 된다. 확장후 정중구개봉합부에 존재하는 골모세포와 섬유모세포의 증식 활성도를 측정하여 정중구개확장이 생리적으로 진행되는지를 확인하고, 이때 개개 치아의 치주조직에서 나타나는 변화를 조사하기 위하여 약 10개월된 유성견 10마리를 대상으로 상악 제2소구치와 제1대구치에 Hyrak screw를 장착하였다. 실험동물은 대조군 1마리, 1주 확장한 군 3마리, 2주 확장한 군 3마리, 2주 확장후 2주 보정한 군 3마리로 구분하여, Screw를 1일 1/4회전시켜 확장하였고, 제2소구치, 제3소구치, 그리고 제 1대구치 부위의 정중구개봉합부와 치주조직을 절취하여 Soft X-ray로 관찰하고, 형태학적 및 면역조직화학적 변화를 광학현미경으로, 그리고 골개조를 편광현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. 편광현미경 소견에서는 대조군에 비하여 1주 확장군의 봉합부에서 골 형성과 흡수가 크게 증가되었으며, 2주 확장군에서 약간 감소를 보이다가, 보정군에서는 석회화가 크게 진행되었다. 2. 면역조직화학적 연구에서는 대조군에 비하여 1주 확장군의 봉합부에서 골모세포가 PCNA(Proliferating Cell Nuclear Antigen)에, 미분화 섬유모세포가 EGF(Epidermal Growth Factor)에 약간 증가된 양성 반응을 보였으며 EGF에 대한 골모세포의 반응은 낮았다. 2주 확장군에서는 섬유아세포와 골모세포에서 PCNA와 EGF에 대한 양성반응이 증가되었다. 보정군에서는 이들 PCNA와 EGF에 양성반응을 나타내는 세포들이 구개돌기 골단 주변에 집중되었다. 3. 확장기간 중 봉합부 주변에서 광범위한 골 흡수와 골형성을 동반한 골개조가 일어났으며, 보정군에서는 다소 감소하였다. 2주 확장군과 보정군의 제3소구치 와 제1대구치의 치근단에서 백악질 형성과 흡수가 나타났으며, 제1대구치의 협측 치경부에서 광범위한 초자양 변성대가 나타났다. 4. Soft X-ray소견에서 1주 확장군은 대조군에 비교하여 봉합부위의 여러부분에서 미세 파절과 저석회화된 결손부위를 보였다. 대조군과 보정군 사이 에는 정중구개봉합부의 석회화 정도에 별 차이 가 없었다. 2주 확장군과 보정군에서 제3소구치와 제1대구치는 협측으로 경사되는 경향을 보였다.

• Biomolecules & Therapeutics
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• 제23권2호
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• pp.110-118
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• 2015

According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide (LSP)-stimulated BV2 microglial cells. Shikonin dose-dependently inhibits the expression of the proinflammatory mediators, nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and tumor necrosis factor-${\kappa}B$ (TNF-${\alpha}$) as well as their main regulatory genes and products such as inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-${\alpha}$ in LPS-stimulated BV2 microglial cells. Additionally, shikonin suppressed the LPS-induced DNA-binding activity of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) to regulate the key regulatory genes of the proinflammatory mediators, such as iNOS, COX-2, and TNF-${\alpha}$, accompanied with downregulation of reactive oxygen species (ROS) generation. The results indicate that shikonin may downregulate the expression of proinflammatory genes involved in the synthesis of NO, $PGE_2$, and TNF-${\alpha}$ in LPS-treated BV2 microglial cells by suppressing ROS and NF-${\kappa}B$. Taken together, our results revealed that shikonin exerts downregulation of proinflammatory mediators by interference the ROS and NF-${\kappa}B$ signaling pathway.

• 소성∙가공
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• 제19권8호
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• pp.494-501
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• 2010

The main objective of this study is to examine the sensitivity of calibration curves of FEA of ring compression test to frictional shear factor. Ring compression test has been investigated by measuring dimensional changes at different positions of ring specimen and they include the changes in internal diameter at the middle and top section of the specimen, outer diameter at the middle and top section, surface expansion at the top surface, respectively. Initial ring geometries employed in analysis maintain a fixed ratio of 6 : 3 : 2, i.e. outer diameter : inner diameter : thickness of the ring specimen, which is generally known as 'standard' specimen. A rigid plastic material for different work-hardening characteristics has been modeled for simulations using rigid-plastic finite element code. Analyses have been performed within a definite range of friction as well as over whole range of friction to show different sensitivities to the interfacial friction for different ranges of friction. The results of investigation in this study have been summarized in terms of a dimensionless gradient. It has been known from the results that the dimensional changes at different positions of ring specimen show different linearity and sensitivity to the frictional condition on the contact surface.

• 한국전산구조공학회논문집
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• 제17권1호
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• pp.59-65
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• 2004

응력확대계수는 균열진전경로의 수치해석적 연구에서 널리 사용되고 있다. 그러나 많은 경우에서 균열선단주위 응력의 급수전개식 중 이어지는 항은 정량적으로 중요하다. 따라서 본 연구에서는 이의 항을 계산하기 위하여 등매개 2차특이요소를 이용한 유한요소해석을 수행하였다. 일례로 단축하중을 받는 무한 직방성체 내 경사균열에 대하여 균열요소크기와 균열경사각을 달리 주어 가며 해석을 수행하였으며, 수치해석결과는 이론해와 비교하여 잘 일치하고 있다.

• 품질경영학회지
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• 제45권1호
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• pp.93-116
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• 2017

Purpose: The purpose of this study is to suggest a key quality factor affecting user satisfaction based on quality attribute of weather information system and additionally, a managerial implication for activating weather information service market by analyzing causal relevance between weather information system and business performance. Methods: As its method, a causal relevance of quality factor of weather information system affecting satisfaction and business performance was analyzed by using structural equation model. An enterprise utilized in analysis sample performed a survey by targeting 186 distribution/logistics and general manufacturing company. Results: It was revealed that information, service quality of weather information system exerted a significant influence on user satisfaction and it did not take a significant influence on business performance in terms of quality of information, system and service. A significant relevance between user satisfaction and business performance was strong supported. Finally, it was revealed that utilization level of weather information system had a moderating effect on business performance. Conclusion: Domestic weather information system mainly focused on information utilization based weather information system and additional service level utilizing weather information is very low in practical terms. Therefore, in order to expand domestic weather related service market, systematic market expansion strategy of providing corporate customized service and case enlargement would be required.

• International Journal of Aeronautical and Space Sciences
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• 제15권1호
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• pp.102-111
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• 2014

An analytical model was developed to understand the physics and predict the functional performance of a pin puller. The formulated model is based on one-dimensional gas dynamics for an ideal gas. Resistive forces against pin shaft movement were measured in quasi-static mechanical tests, the results of which were incorporated into the model. The expansion chamber pressure and the pin shaft displacement were measured from an actual firing test and compared to the model prediction. The gas generation rate was adjusted by a correction factor, and the heat transfer rate was obtained through parametric analysis. The validity of the model is assessed for additional firing tests with different amounts of pyrotechnic charge. This model can provide knowledge on how the pin puller functions, and on which design parameters contribute the most to the actuation of the pin puller. Using this model, we estimate the functional safety factor by comparing the energy generated by the pyrotechnic charge to the energy required to accomplish the function.