• Korean Journal of Biological Psychiatry
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• v.7 no.1
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• pp.64-73
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• 2000

There are several candidate genes in genetic study of alcoholism. Among them, allelic associations have been reported between MAOA CA repeat polymorphism and alcohol dependence, recently. And also, several studies have been investigated genotype-phenotype relationships between MAOA CA repeat polymorphism and clinical manifestations. The authors tried to identify differences in allelic frequency of MAOA CA repeat polymorphism between alcohol dependence and controls, and in behavioral trait and clinical characteristics according to MAOA CA repeat polymorphism. We also tried to investigate genotype-phenotype relationships between MAOA CA repeat polymorphism and behavioral trait such as aggression. We examined 49 male patients with alcohol dependence(DSM-IV) who had been admitted in Yong-In Mental Hospital from June 1st 1998 to October 31th 1998. We performed semistructured interview for demographic and clinical characteristics. Self-report questionnaire for BDHI(Buss-Durkey Hostility Inventory) was given to all subject at least 4weeks later after admission. Using polymerase chain reaction and polyacrylamide gel electrophoresis, MAOA CA repeat polymorphism were observed in 52 male controls and 49 male patients with alcohol dependence. We devided alcoholic patients into two groups according to allelic length of MAOA CA repeat polymorphism ; alcoholics with short alleles(${\leq}$119bp, N=20) and alcoholics with long alleles(${\geq}$123bp, N=29). T-test, ${\chi}^2$-test and Fisher exact probability test were used for statistical analysis. There were no significant differences in frequency of each allele and short and long alleles of MAOA CA repeat polymorphism between alcoholics and controls. But there were significant differences in clinical symptoms and behavioral trait between alcoholics with short and long alleles. In clinical symptoms, alcoholics with long alleles used alcohol more frequently during one month before admission, had much more maximum amount of beer drinking and reported withdrawal seizure more frequently than with short alleles. In contrary, alcoholics with short alleles expressed depressed mood and guilty feeling more frequently and wanted complete abstinence as a treatment goal more frequently than with long alleles. In behavioral trait, alcoholics with long alleles had higher total aggression score and showed much more self-assertive attitude(subscale of expression of aggression) than with short alleles. Allelic length of MAOA CA repeat polymorphism was correlated with self-assertive attitude and accounted for 9% of the variance of self-assertive attitude. And also, predictable variables of allelic length of MAOA CA repeat polymorphism were drinking frequency and self-assertive attitude. Our findings suggest that MAOA CA repeat polymorphism may provide some behavior modifying role especially in self-assertive attitude and indirect symptom modifying role in Korean male alcoholics.

• Journal of The Korean Society of Grassland and Forage Science
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• v.37 no.1
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• pp.68-79
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• 2017

The objective of study was to find the relationship in hilly pasture landscape expectancy and tourist's satisfaction on grassland facility. It was followed by literature reviews and visitors' survey in Daegwallyeong Yangtte Farm on 31, July, 2014. 367 respondents were analyzed by F-test, t-test, Chi-square and Fisher's Exact Test at 0.05 level after data screening process. Computing factors were sex, marital status, age, academic career and occupation. The results was as followed; First, major respondents group of survey were in oder of woman, forty years old group, married office worker, and university graduate. Second, the expectancy for grassland was significant difference in age, but pasture color expectancy was not significant difference in gender, age, educational background, marital status, and there was significant difference in favorite grassland type with age, marital status. Third, favorite fence type was not significant difference along with all group of participants. However, color and material of fence was significant difference in marital status. Fourth, preferred ranch road was significant difference with occupation and marital status. There was significant difference in favorite grassland type near ranch road along with age and occupation type. Fifth, the mean satisfaction was 3.6 point in 5.0. Therefore, all respondents were generally satisfaction in visited. Tourists were more interested in ranch landscape than experience or contacts to animal.

• Tuberculosis and Respiratory Diseases
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• v.49 no.6
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• pp.684-690
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• 2000

Background : The most common cause of treatment failure of pulmonary tuberculosis is early stoppage of treatment or irregular medication. The most important aspect of a retreatment is regular medication provided over a long period. Inadequate treatment may cause drug resistance and prolong the duration of chemotherapy. This study analyzed the risk factors of pulmonary tuberculosis patients, who failed in retreatment, and to use the results as basic data in the management of intractable tuberculosis patients with improving the rate of retreatment success. Methods : We performed a retroactive study of 62 pulmonary tuberculosis patients in retreatment at National Mokpo Tuberculosis Hospital from Jan. 1994 to Dec. 1995. The patients were separated into two groups: group I was retreatment failure and group II was retreatrnent success. For the analysis of risk factors in retreatment failure, we compared the difference between the two groups and tested the confidence limit about results of the results by independent t-test, ${\chi}^2$ test and Fisher's exact test. Results : The treatment failure rate of retreatment patients was 13(21%), and treatment success 49(79%). No significant difference (p>0.05)in age, sex, number of treatment, irregular rate of treatment, extent of the disease & cavitary lesion on the chest X-ray, number of resistance drugs, number of used drugs to medication, number of sensitive bactericidal drugs to medication, rate of sensitive drugs to medication and resisiance to INH & RFP had not significant difference. was found. However, the number of treatment was $2.4{\pm}0.8$ in group I and $1.6{\pm}0.9$ in group II, and had showing a significant difference(p<0.05) between the two groups. Conclusion : The risk factor of retreatment failure was more irregular previous treatment the irregularity of the previous treatment. For reducing the retreatment failure of pulmonary tuberculosis, greater efforts are needed more need to be done to prevent failure of first treatment.

• Journal of Korean Dental Hygiene Science
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• v.6 no.2
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• pp.151-160
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• 2023

Background: This study analyzed the differences in practice satisfaction, major, and willingness to work abroad among dental hygiene department students at K University in Gangwon-do based on their participation in international practicums. Methods: A survey was conducted on a total of 215 students through convenience sampling of dental hygiene students, and the final 214 responses were analyzed. General characteristics were examined. Major satisfaction and grades were measured on a 5-point Likert scale. And satisfaction with practice, intention to participate in international practicums, and employment were investigated by papers. Descriptive statistical analysis was performed on general characteristics using SPSS software (version 26.0). Due to the convenience sample, nonparametric analysis was used to determine satisfaction with practice and major according to general characteristics using the Mann-whitney U and Kruskal-wallis test. An independent samples t-test was conducted to determine the difference between practice satisfaction and major satisfaction depending on participation in international practicums, and Fisher's exact test was conducted to determine practice satisfaction, willingness to participate in overseas internships, and employment. Results: Concerning future participation in international clinical practicums, 66.7% of students who had previously participated in overseas training expressed willingness to engage again. 40.9% of those who had not participated showed no intention of participating, and there was a significant difference (p<0.05). Additionally, 76.2% of the participants expressed interest in overseas employment, with this difference also being statistically significant (p<0.05). Conclusion: It was confirmed that students' satisfaction with practice and major increased through participation in international practicums, and that they had a positive intention to work abroad and participate in overseas internship programs in the future.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.6 s.52
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• pp.93-102
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• 2006

Control input's saturation of active control devices for large structures under large external disturbances are often occurred. It is more difficult to obtain the exact values of mass and stiffness as structures are higher. The modelling errors between mathematical models and real structures must be also included as parameter uncertainties. Therefore, in active vibration control of civil engineering structures like buildings and bridges, the robust saturation controller design method considering both control input's saturation and parameter uncertainties of system is needed. In this paper, stabilities of linear optimal controller LQR, modified bang-bang controller, saturated sliding mode controller, and robust saturation controller among various controllers which have been studied and applied to active vibration control of buildings are investigated. Especially, unstable phenomena of the LQR, the modified bang-bang controller and the saturated sliding mode controller when the control input is saturated or parameter uncertainties exist are presented to show the necessity of the robust saturation controller. The robust stability of the robust saturation controller are shown through a numerical example of a 2DOF linear vibrating system and an experimental test of the two-story structure with an active mass damper (AMD).

• Journal of KIISE:Software and Applications
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• v.33 no.12
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• pp.1073-1089
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• 2006

The goal of Natural Language Processing(NLP) is to make a computer understand a natural language and to deliver the meanings of natural language to humans. Word sense Disambiguation(WSD is a very important technology to achieve the goal of NLP. In this paper, we describe a technology for automatic homonyms disambiguation using both Mutual Information(MI) and a Sense-Tagged Compound Noun Dictionary. Previous research work using word definitions in dictionary suffered from the problem of data sparseness because of the use of exact word matching. Our work overcomes this problem by using MI which is an association measure between words. To reflect language features, the rate of word-pairs with MI values, sense frequency and site of word definitions are used as weights in our system. We constructed a Sense-Tagged Compound Noun Dictionary for high frequency compound nouns and used it to resolve homonym sense disambiguation. Experimental data for testing and evaluating our system is constructed from QA(Question Answering) test data which consisted of about 200 query sentences and answer paragraphs. We performed 4 types of experiments. In case of being used only MI, the result of experiment showed a precision of 65.06%. When we used the weighted values, we achieved a precision of 85.35% and when we used the Sense-Tagged Compound Noun Dictionary, we achieved a precision of 88.82%, respectively.

• Journal of Korean society of Dental Hygiene
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• v.10 no.4
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• pp.765-775
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• 2010

Objectives : 노인 환자들이 제공받고 있는 치과 의료서비스 만족도를 평가하여 노인 환자에게 양질의 구강보건진료 서비스를 제공하고 노인의 구강보건향상에 기여하기 위하여 실시하였다. 이와 같은 연구목적을 달성하기 위하여 노인관련 일반적 특성을 알아보고, 치과 병 의원을 이용하는 노인 환자의 만족도에 미치는 요인 및 병 의원 선택이유를 조사하였다. Methods : 서울특별시와 경기도, 경상도, 전라도 일부지역의 치과병원 및 치과의원을 이용하는 노인 환자 300명을 편의추출 하였으며, 2009년 4월 1일부터 5월 8일까지 면접 및 자기기입법으로 설문조사를 실시하였다. 설문지는 4개영역으로 구분하여 치과 의료서비스 만족도 22문항, 치과위생사의 의료서비스 만족도 14문항, 재이용 권유의사 4문항 및 일반적 특성과 치과이용에 관한 8문항으로 구성하였다. 노인환자의 일반적인 특성에 따른 치과 의료서비스 만족도, 연구대상자의 병원인지경로, 치과선택이유에 따른 치과의료서비스 만족도는 일원배치분산분석(One-way ANOVA)을 실시하였다. 치과의료서비스 만족도 영향인자, 만족도에 미치는 치과위생사 요인 등은 다중회귀분석을 실시하였다. 연구대상자의 성별과 병원내원기간에 따른 치과선택이유는 카이제곱 (${\chi}^2$) 분포를 따르는 정확검정(exact test)을 실시하였다. Results : 1. 노인환자들이 병원을 선택할 때 가족, 친척으로부터 추천을 받는 경우가 가장 많으며 이 경우 다른 인지경로에 비하여 치과에 대한 만족도가 가장 높았다. 2. 치과선택 이유에 따른 만족도를 비교하였을 때 첫째, 의사의 높은 진료수준, 둘째, 친절한 서비스에 만족도가 높았다. 또한 치과선택이유가 의사의 높은 진료수준과 친절함을 포함한 의사요인이 가장 중요한 것으로 나타났다. 3. 치과위생사의 높은 진료수준과 친절도는 치과의료서비스 만족도에 유의한 차이를 나타내었다. 노인환자들의 만족도를 높이기 위해 노인에 대한 치위생교육이 필요하고 노인에 대한 지식뿐만 아니라 태도에 대한 교육도 실시되어야 한다. 4. 동일한 치과를 계속적으로 다니는 이유는 첫 번째 의사의 높은 진료수준, 두 번째 친절도로 의사요인과 관련이 가장 높은 것으로 나타났다. 또한 3-4년 이상의 장기내원환자는 의사의 높은 진료수준 다음으로 친절도를 중요한 이유로 선택하였다. Conclusions : 이상의 결과로 노인 환자가 만족하는 치과는 치과의사와 치과위생사의 진료수준이 높아야 하겠고, 다음으로 친절한 서비스가 중요함을 알 수 있었다. 또한 노인환자들의 만족도를 높이기 위해 노인에 대한 치위생교육이 필요하고 노인에 대한 지식뿐만 아니라 태도에 대한 교육도 실시되어야 한다.

• Toxicological Research
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• v.32 no.3
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• pp.195-205
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• 2016

This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals. Genotyping analysis of the final 192 SNPs selected was performed on 1,483 subjects using the VeraCode Goldengate assay. Allele frequencies differences and genetic differentiations between the Korean population and Chinese (CHB), Japanese (JPT), Caucasian (CEU), and African (YIR) populations were tested by Fisher's exact test and fixation index ($F_{ST}$), respectively. The Korean population was genetically similar to the CHB and JPT populations ($F_{ST}$ < 0.05, for all SNPs in both populations). However, a significant difference in the allele frequencies between the Korean and CEU and YIR populations were observed in 99 SNPs (60.7%) and 120 SNPs (73.6%), respectively. Ten (6.1%) and 26 (16.0%) SNPs had genetic differentiation ($F_{ST}$ > 0.05) among the Korean-CEU and Korean-YIR comparisons, respectively. The SNP with the largest $F_{ST}$ value between the Korean and African populations was cystathionine-${\beta}$-synthase rs234709 ($F_{ST}$: KOR-YIR, 0.309; KOR-CEU, 0.064). Our study suggests that interethnic differences exist in SNPs associated with heavy metals of Koreans, and it should be considered in future studies that address ethnic differences in heavy-metal concentrations in the body and genetic susceptibility to the body burden of heavy metals.

• Journal of dental hygiene science
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• v.11 no.3
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• pp.205-211
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• 2011

The present study seeks to find the effect of oral health status that parents recognized, oral health habit and food intake on existence of decalcified teeth and decayed teeth. Participants were 293 infants aged 18-24 months who visited C dental clinic in Kyungki province between January and December 2010. Questionnaires and oral exam results were used and statistically analyzed by the SPSS program. Fisher's Exact and chi-square test were used to analyze the data. The 18-20 month-old age group had the highest rate of decalcified teeth with 36.4% while the 23-24 month-old age group had the highest rate of decayed teeth with 37.0%. Bottle feeding showed correlation with decalcified teeth, and decayed teeth. Parents were able to recognize decayed teeth and decalcified teeth. Group 2 food(soda/soft drinks/sugared fruit juice) was related to decalcified teeth and decayed teeth(p<.001). Group 4 food (cake/cookies/doughnut/dried fruit/banana) and group 5food(caramel/candy/chocolate bar) were both related to decalcified teeth(p<.001). As the result of dental examination, dental treatment was highly needed for the 21-22 month-old age group(89.3%), and preventive treatment and plaque control were highly needed for the 18-20 month-old age group(94.5%). The results concluded that 18-24 months was the critical period for children's oral health, therefore organized oral health education for parents is necessary.

• Journal of IKEEE
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• v.15 no.1
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• pp.76-85
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• 2011

In this paper, we analysed RSS characteristics by external factors and presented an efficient algorithm for real-time location tracking and its hardware system. The proposed algorithm enhanced the ranging accuracy using Kalman Filter based on the RSS DB. The location tracking system that consists of the tag, AP(Access Point), a data collector(Data Receiver) with IEEE 802.15.4(ZigBee) network environment, and location tracking application that reveal locations of each tag is implemented for the test environment. The location tracking system presented in this paper is implemented with MSP430 microprocessor manufactured by TI(Texas Instrument), CC2420 RF chipset and the location tracking application. With the results of the experiment, the proposed algorithm and the system can achieve the efficiency and the accuracy of location tracking with the average error of 19.12cm, and its standard deviation of 5.31cm in outdoor circumstance. Also, the experimental result shows that exact tracking of position in indoor circumstance cannot achieve because of vulnerable RSS with external circumstance.