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Antimicrobial Effect of Ursolic Acid and Oleanolic Acid against Methicillin-Resistant Staphylococcus aureus (Ursolic Acid와 Oleanolic Acid의 메티실린 저항성 Staphylococcus aureus에 대한 항균작용)

  • Kim, Saeng-Gon;Kim, Min-Jung;Jin, Dong-Chun;Park, Soon-Nang;Cho, Eu-Gene;Freire, Marcelo Oliveira;Jang, Sook-Jin;Park, Young-Jin;Kook, Joong-Ki
    • Korean Journal of Microbiology
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    • v.48 no.3
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    • pp.212-215
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    • 2012
  • The antimicrobial activity of ursolic acid (UA) and oleanolic acid (OA), both triterpenoid compounds, against methicillin-resistant Staphylococcus aureus (MRSA) is controversial. We examined the antimicrobial effects of UA and OA against 19 strains of MRSA isolated from Koreans by determining minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC). The data showed that the methicillin-sensitive strain S. aureus KCTC $1621^T$ was more resistant to UA and OA than that of the MRSA strains. The MBC values of UA and OA against MRSA had broad ranges; 4 to 32 ${\mu}g/ml$ and 16 to >256 ${\mu}g/ml$, respectively. It was difficult to understand the different antimicrobial activities of UA and OA among the MRSA strains, because UA and OA antimicrobial mechanisms are unknown. These results indicate that the antimicrobial effects of UA and OA against MRSA are dependent on resistance to UA and OA in each strain.

A Thought on the Right to Be Forgotten Articulated in the European Commission's Proposal for General Data Protection Regulation (유럽연합(EU) 정보보호법(General Data Protection Regulation)개정안상의 잊혀질 권리와 현행 우리 법의 규율 체계 및 앞으로의 입법방향에 관한 소고)

  • Hah, Jung Chul
    • Journal of Digital Convergence
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    • v.10 no.11
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    • pp.87-92
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    • 2012
  • In the early 2012, European Union proposed new legal framework, including the right to be forgotten, for the protection of personal data. The new Proposal articulates kind of sweeping new privacy right and there has been debates on its potential threat to free speech in the digital age. While the situation is similar in Korea, I want to introduce the right to be forgotten in the Proposal. Then, I will analyze current legal system in Korea regarding the new privacy right and suggest some guidelines in searching direction for the coming legislation with respect to the right to be forgotten. The right to be forgotten should not have been promulgated without considering fully its effect on the free speech, especially in the society where the voice toward direct democracy or movement toward participation of the citizen, mainly through cyber space or Social Network Services, has risen much higher in Korea. Especially, the new right seems not to cover the control of data subject on a third party where the third party expressing his opinion by posting himself other's personal data on his blog or others.

Sapflow of Two Poplars under Swine wastewater Irrigation (양돈폐수 처리할 때 포플러의 수액이동)

  • Lee, Eu Ddeum;Woo, Su Young;Yeo, Jin Kie;Koo, Yeong Bon
    • Journal of Korean Society of Forest Science
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    • v.98 no.3
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    • pp.242-246
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    • 2009
  • We examined sapflow of two populus tree species (Populus alba ${\times}$ Populus glandulosa and Populus euramericana) grown under Swine wastewater treatment, and measured relationship between sapflow and climate facters. Sapflow of P. euramericana was 1.5 times greater than that of P. alba ${\times}$ P. glandulosa from September to late December 2007. However, sapflow of P. euramericana and P. alba ${\times}$ P. glandulosa was similar after late January. The relationship between the mean temperature and sapflow was relatively high. There was a decrease in sapflow tendency of the two poplar species during the late October when the mean temperature was low. Trends on relationship between the relative humidity and sapflow showed low relationship. However, data showed weak relationship between sapflow and precipitation. During the period of less precipitation, sapflow of P. alba ${\times}$ P. glandulosa has no relationship. Sapflow of two populus species was still active during non-growing season. P. euramericana was considered as a better species than P. alba ${\times}$ P. glandulosa, in terms of phytoremediation.

Blood Vessel Regeneration using Human Umbilical Cord-derived Endothelial Progenitor Cells in Cyclophosphamide-treated Immune-deficient Mice

  • Kwon, Soon-Keun;Ko, Yu-Jin;Cho, Tae-Jun;Park, Eu-Gene;Kang, Byung-Chul;Lee, Gene;Cho, Jae-Jin
    • International Journal of Oral Biology
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    • v.36 no.3
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    • pp.117-122
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    • 2011
  • Endothelial cells are a vital constituent of most mammalian organs and are required to maintain the integrity of these tissues. These cells also play a major role in angiogenesis, inflammatory reactions, and in the regulation of thrombosis. Angiogenesis facilitates pulp formation and produces the vessels which are essential for the maintenance of tooth homeostasis. These vessels can also be used in bone and tissue regeneration, and in surgical procedures to place implants or to remove cancerous tissue. Furthermore, endothelial cell regeneration is the most critical component of the tooth generation process. The aim of the present study was to stimulate endothelial regeneration at a site of acute cyclophosphamide (CP)-induced endothelial injury by treatment with human umbilical cord-derived endothelial/mesenchymal stem cells (hEPCs). We randomly assigned 16 to 20-week-old female NOD/SCID mice into three separate groups, a hEPC ($1{\times}10^5$ cells) transplanted, 300mg/kg CP treated and saline (control) group. The mice were sacrificed on days 5 and 10 and blood was collected via the abdominal aorta for analysis. The alanine transaminase (ALT), aspartate aminotransferase (AST), serum alkaline phosphatase (s-ALP), and albumin (ALB) levels were then evaluated. Tissue sections from the livers and kidneys were stained with hematoxylin and eosin (HE) for microscopic analysis and were subjected to immunohistochemistry to evaluate any changes in the endothelial layer. CP treatment caused a weight reduction after one day. The kidney/body weight ratio increased in the hEPC treated animals compared with the CP only group at 10 days. Moreover, hEPC treatment resulted in reduced s-ALP, AST, ALT levels compared with the CP only group at 10 days. The CP only animals further showed endothelial injuries at five days which were recovered by hEPC treatment at 10 days. The number of CD31-positive cells was increased by hEPC treatment at both 5 and 10 days. In conclusion, the CP-induced disruption of endothelial cells is recovered by hEPC treatment, indicating that hEPC transplantation has potential benefits in the treatment of endothelial damage.

A Study on the Implications and Trends of Logistics Security Assurance Programs for International Trade Facilitation (국제물류보안 인증제도 동향 및 시사점에 관한 연구)

  • Ko, Hyun-Jeung
    • Journal of Korea Port Economic Association
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    • v.27 no.2
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    • pp.333-354
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    • 2011
  • After the terrorist attack of 9/11 on the USA, the security concern to global trade has been raised. In particular, the USA has actively promoted a series of initiatives and rules such as CSI, 24 hour rule, C-TPAT, and so on in the area of logistics activities, which aimed to better protect the country against the potential terrorist threats. While implementing such schemes called as a multi-layed logistics security strategy, a large number of countries trading with USA are facing with the issues of additional time and costs for inspecting cargos in their logistics facilities. As a result, most countries all over the world have sought a way to minimize the impacts from such strategy. The Korea also is preparing the several security programs operated by various ministries, which are aiming to not only improve the efficiency of trade flows but also to ensure supply chain security. However, many companies are expressing the inefficiency of operating such programs. Thus, this paper analyzed several global supply chain security programs currently adopted by international organizations(ISO, WCO, and IMO) and major countries(USA, EU, and Singapore) and suggested a guideline for developing the national logistics security system.

The Strategy for the Position and Development of the Land Logistics System of the Korean Peninsula (한반도의 동북아 육상물류체계 위상과 발전 전략에 관한 연구)

  • Kim, Hong-Seop
    • Journal of Korea Port Economic Association
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    • v.32 no.2
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    • pp.1-24
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    • 2016
  • Northeast Asia is changing rapidly, including becoming an increasingly important part of the world economy. Various logistical systems and networks are being established in this area, including South and North Korea, China, Japan, Russia, and Mongolia. Thus, a new systematic logistical network and development strategy is required. The division of the Korean peninsula has for a long time made the region ineffective in terms of land logistics. South Korea's connection to Eurasia is blocked by North Korea, which means it is essentially treated as an island. Furthermore, South Korea does not have an efficient logistics system or effective vision and strategy. Northeast Asia has the potential to be one of the largest economic communities in the world, similar to the EU and North America. Thus, a united Korea can play an important role as the land bridge of Northeast Asia and the logistical hub of the region. This study reviews the logistical position, tasks, and problems of the Korean peninsula and suggests a desirable development strategy and vision. Specifically, after examining the conditions for a land logistical system, focusing on railways, this study proposes several future-oriented development strategies and tactics that will position the peninsula as a logistical hub in Northeast Asia. We anticipate that this study will serve as the basis for future research that will investigate the topics presented here in more detail.

A Study on Construction of Barge Transportaion System between Incheon and Gaesung (인천-개성 항로 바지 수송시스템 구축에 관한 기초적 연구)

  • Kim, Sang-Hyun;Lee, Seung-Hee;Lee, Young-Gill;Yu, Jin-Won
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.14 no.3
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    • pp.227-233
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    • 2008
  • Recently, the transport quantity of goods between South and North Korea is rising rapidly by increasing of economical exchange between South and North Korea and growth of Gaeseoung industrial complex. In addition to a land transportation route, it is necessary to secure various logistics and transportation route for freight transportation between Incheon and Gaesung. In this paper, we investigated a construction of barge transportaion system between Incheon and Gaesung. The barge transportation system which has many merits such as a little initial investment and convenience of harbor loading/ unloading has been also used to transport freight widely in the EU and USA. Firstly, we investigated barge transport route, marine freight and barge fleet which consists of barge and pusher between Incheon and Gaesung. And next, we designed hull form and general arrangement of a barge and pusher based on shipping service condition, barge fleet, etc. Finally, a construction plans of barge transport system such as a operation of shipping service, berthing facilities, logistics center, intermodal transport are investigated.

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Effects on EDC-like farming chemicals in aquatic Organism (환경생물에 대한 내분비교란물질 의심 농약의 영향)

  • Kim, Hyun-Woo;Park, Kun-Ho;Park, Jin-Hong;Jin, Hua;Kim, Joon-Seong;Eu, Gook-Jong;Cho, Hyun-Sun;Kang, Ga-Mi;Lee, Myung-Sung;Song, Byung-Hoon;Shin, Jin-Sup;Cho, Maing-Haing
    • The Korean Journal of Pesticide Science
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    • v.7 no.3
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    • pp.188-197
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    • 2003
  • Endocrine disrupting chemicals (EDCs) can alter hormone regulation that control reproductive system in animals. The effects of endosulfan, molinate, and alachlor that suspected to have examined disruption EDCs effect on a fish species of interest, Xiphophorus helleri (swordtail fish), were studied using vitellogenin (Vtg) and aromatase as diagnostic biomarkers. Induction of Vtg proteins was detected by RT-PCR in male fish treated with alachlor, and mixture of endosulfan and molinate in dose response manner. Also, induction of aromatase was detected by RT-PCR in male fish treated with alachlor, endosulfan, and mixture of endosulfan and molinate in sinlilar manner. In this study, swordtail fish exposed to endosulfan or molinate individually did not show any adverse effects. However, Vtg and aromatase expressions and apoptosis were detected in swordtail. fish exposed to the mixture of endosulfan and molinate. These results suggested that low concentrations of mixture of molinate and endosulfan individually do not affect swordtail fish, but may influence genital system, and induce apoptosis.

Design and Performance Analysis of EU Directory Service (ENUM 디렉터리 서비스 설계 및 성능 평가)

  • 이혜원;윤미연;신용태;신성우;송관우
    • Journal of KIISE:Information Networking
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    • v.30 no.4
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    • pp.559-571
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    • 2003
  • ENUM(tElephon NUmbering Mapping) is protocol that brings convergence between PSTN Networks and IP Networks using a unique worldwide E.164 telephone number as an identifier between different communication infrastructure. The mechanism provides a bridge between two completely different environments with E.164 number; IP based application services used in PSTN networks, and PSTN based application services used in IP networks. We propose a new way to organize and handle ENUM Tier 2 name servers to improve performance at the name resolution process in ENUM based application service. We build an ENUM based network model when NAPTR(Naming Authority PoinTeR) resource record is registered and managed by area code at the initial registration step. ENUM promises convenience and flexibility to both PSTN and IP users, yet there is no evidence how much patience is required when users decide to use ENUM instead of non-ENUM based applications. We have estimated ENUM response time, and proved how to improve performance up to 3 times when resources are managed by the proposed mechanism. The proposition of this thesis favorably influences users and helps to establish the policy for Tier 2 name server management.

Comparing Validity of Body Mass Index, Waist to Hip Ratio, and Waist Circumference to Cardiovascular Disease Risk Factors in Korean Elderly (한국노인에서 심장혈관계 질환 위험인자에 대한 비만지표인 체질량지수, 허리-엉덩이둘레비, 및 허리둘레의 타당도 비교)

  • Moon Hyun-Kyung;Kim Eu-Gene
    • Journal of Nutrition and Health
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    • v.38 no.6
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    • pp.445-454
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    • 2005
  • The purpose of this study was to compare the validity of obese index among body mass index (BMI), waist to hip ratio (WHR), and waist circumference (WC) and to determine which is the best in relation to cardiovascular disease (CVD) risk in Korean elderly more than 65 ages. Data from the 1998 Korean Health and Nutrition Survey were used (n=1017). Anthropometric indices and CVD risk factors were measured, and chi-square test, analysis of variance following duncan's multiple range test, partial correlation analysis, and Receiver Operator Characteristic (ROC) curves were used in the analysis. Anthropometric values were decreased in both male and female when ages were goes up. In female elderly, it specially showed the characteristics of upper body fat and systolic blood pressure risk (p<0.05). Among life style factors the current smokers were prevalent in obese male (p<0.05), but not prevalent in female having obese or upper body fat. Also, person with upper body obesity have more exercise than that of normal group (p<0.01). Mean BMI values of the current smoker was lower than that of normal group in both sexes (p<0.01). Mean BMI value of person with other risk factors were higher than that of normal groups (p<0.05). Among 7 CVD risk factors in partial correlation analysis, WC had the highest correlation coefficient in 5 in male, whereas BMI in 4 in female. In ROC analyses of 12 risk factors and health conditions, the largest area under curve of obese indices for risk factors were WC>WHR>BMI in male and BMI>WHR>WC in female. The optimal cutoff values of each index (BMI : WHR : WC) for one or more risk factors were 19.02 : 0.84 : 71.3 in male and 19.04 : 0.88 : 85.6 in female. In conclusion, Most Korean elderly showed non-obese and abdominal obesity likewise other Asians. Also CVD risk factors were prevalent in Korean elderly within normal limits of obese indices. Therefore the upper body fat indices reflected in the aged whose muscle mass is replaced by fat must be used as an indicator of CVD risk together with BMI. Although WHR was the worst index based on partial correlation analysis and so located between BMI and WC in ROC curve analysis in both sexes, it need to be use with WC to screen the cardiovascular risk group.