Browse > Article

Effects on EDC-like farming chemicals in aquatic Organism  

Kim, Hyun-Woo (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Park, Kun-Ho (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Park, Jin-Hong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Jin, Hua (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Kim, Joon-Seong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Eu, Gook-Jong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Cho, Hyun-Sun (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Kang, Ga-Mi (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Lee, Myung-Sung (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Song, Byung-Hoon (Pesticide Safety Division, Department of Crop Protection, National Institute of Agricultural Science & Technology)
Shin, Jin-Sup (Pesticide Safety Division, Department of Crop Protection, National Institute of Agricultural Science & Technology)
Cho, Maing-Haing (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Publication Information
The Korean Journal of Pesticide Science / v.7, no.3, 2003 , pp. 188-197 More about this Journal
Abstract
Endocrine disrupting chemicals (EDCs) can alter hormone regulation that control reproductive system in animals. The effects of endosulfan, molinate, and alachlor that suspected to have examined disruption EDCs effect on a fish species of interest, Xiphophorus helleri (swordtail fish), were studied using vitellogenin (Vtg) and aromatase as diagnostic biomarkers. Induction of Vtg proteins was detected by RT-PCR in male fish treated with alachlor, and mixture of endosulfan and molinate in dose response manner. Also, induction of aromatase was detected by RT-PCR in male fish treated with alachlor, endosulfan, and mixture of endosulfan and molinate in sinlilar manner. In this study, swordtail fish exposed to endosulfan or molinate individually did not show any adverse effects. However, Vtg and aromatase expressions and apoptosis were detected in swordtail. fish exposed to the mixture of endosulfan and molinate. These results suggested that low concentrations of mixture of molinate and endosulfan individually do not affect swordtail fish, but may influence genital system, and induce apoptosis.
Keywords
endocrine disrupting chemicals (EDCs); swordtail fish; vitellogenin; aromatase; apoptosis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Jobling, S, D. Sheahan, J. A. Osborne, P. Mauhiessen and J. P. Sumpter (1996) Inhibition of testicular growth in rainbow trout(Onchohynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ Toxicol Chem 15: 194-202   DOI
2 Kwak, H. I, M. O. Bae, M. H. Lee, Y. S. Lee, B. J. Lee, K. S. Kang, C. H Chae, H. J. Sung, J. S. Shin, J. H. Kim, W. C. Mar, Y. Y. Sheen and M. H. Cho (2001) Effects of nonylphenol, bisphenol A, and their mixture on the viviparous swordtail fish (Xiphophorus Helleri). Environ Toxicol Chem 20(4): 787-795   DOI
3 Miles-Richardson, S. R. (1999) effects of waterborne exposure to 4-nonylphenol and nonylphenol ethoxylate on secondary sex characteristics and gonads of fathead minnows (pimephales promelas). Environ Res 80: S122-S137
4 Monteverdi, G. H. and R. T. Di Giulio (1999) An enzyme-linked immunosorbent assay for estrogenicity using primary hepatocyte cultures from the channel catfish (Ictalurus punctatus). Arch Environ Contam Toxicol 37: 62-69   DOI
5 Nicolas, J. M. (1999) Vitellogenesis in fish and the effects of polycyclic aromatic hydrocarbon contaminants. Auat Toxicol 45: 77-90
6 Schulz, R. (2001) Rainfall-induced sediment and pesticide input from orchards into the Laurens River, Western Cape, South Africa : Importance of a single event 8: 1869-1876
7 Hontela A. (1997) Endocrine and physiological responses of fish to xenobiotics: Role of glucocorticosteroid hormones. Rev Toxicol 1:1-46
8 Formoli, T. A. and H. R. Fong (1995) Estimation of exposure of persons in California to pesticide products that contain molinate HS. pp.1543. Worker Health and Safety Branch, Department of Pesticide Regulation, California Environmental Protection Agency, U.S.A
9 Jonsson, C. J., B. O. Lund, B. Brunstrom and I. Brandt (1994) Toxicity and irreversible binding of two DDT metabolites-3-methylsulfonyl-DDE and o,p'-DDD-in adrenal interrenal cells in birds. Environ Toxicol Chem 13: 1303-1310   DOI
10 Finlayson, B. J. and G. A. Faggella (1986) Comparison of laboratory and field observations of fish exposed to the herbicides molinate and thiobencarb. Trans Am Fish Soc 12: 212-215
11 Orlando, E. F. and N. D. Denslow Jr. (1999) A comparison of the reproductive physiology of largemouth bass, Micropterus salmoides, collected from the Escambia and Blackwater Rivers in Florida. Environ health Perspect 107: 199-204   DOI
12 Gronen, S, N. Denslow, S. Manning, S. Barenes, D. Barnes and M. Brower (1999) Serum vitellogenin production levels and reproductive impairment of male Japanese medaka (Oryzias latipes) exposed to 4-tertoctylphenol. Environ Health Perspect 107: 385-390   DOI
13 Mellanen, P, M. Soimasuo, B. Holmbom, A. Oikari and R. Santti (1999) Expression of the vitellogenin gene in the liver of juvenile whitefish (Coregonus lavaretus) exposed to effluents from pulp and paper mills. Ecotoxicol Environ Saf 43:133-137   DOI   ScienceOn
14 Gendron, A. D., C. A. Bishop, R. Fortin and A. Hontela (1997) In vivo testing of the functiional integrity of the corticosterone-producing axis in mudpuppy (Am- phibia) exposed to chlorinated hydrocarbons in the wild. Environ Toxicol Chem 16: 1694-1706   DOI
15 Harris, M. L., C. A. Bishop, J. Struger, M. R. Van Den Heuvel, G. J. Van Der Kraak, D. G. Dixon, B. Ripley and J. P. Bogart (1998) The functional integrity of northern leopard frog (Rana pipiens) and green frog (Rana clarnitans) populations in orchard wetlands. I. Genetics, physiology, and biochemistry of breeding adults and young-of-the-year. Env Toxicol Chem 17: 1338-1350   DOI
16 Kime, D. E., J. P. Nash and A. P. Scott (1999) Vitellogenesis as a biomarker of reproductive disruption by xeno- biotics. Aquaculture 177: 345-352   DOI   ScienceOn