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http://dx.doi.org/10.7845/kjm.2012.029

Antimicrobial Effect of Ursolic Acid and Oleanolic Acid against Methicillin-Resistant Staphylococcus aureus  

Kim, Saeng-Gon (Department of Human Biology, School of Dentistry, Chosun University)
Kim, Min-Jung (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University)
Jin, Dong-Chun (Department of Veterinary Medicine, College of Agriculture, Yanbian University)
Park, Soon-Nang (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University)
Cho, Eu-Gene (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University)
Freire, Marcelo Oliveira (Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard University)
Jang, Sook-Jin (Department of Laboratory Medicine, Chosun University Medical School)
Park, Young-Jin (Department of Laboratory Medicine, Chosun University Medical School)
Kook, Joong-Ki (Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University)
Publication Information
Korean Journal of Microbiology / v.48, no.3, 2012 , pp. 212-215 More about this Journal
Abstract
The antimicrobial activity of ursolic acid (UA) and oleanolic acid (OA), both triterpenoid compounds, against methicillin-resistant Staphylococcus aureus (MRSA) is controversial. We examined the antimicrobial effects of UA and OA against 19 strains of MRSA isolated from Koreans by determining minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC). The data showed that the methicillin-sensitive strain S. aureus KCTC $1621^T$ was more resistant to UA and OA than that of the MRSA strains. The MBC values of UA and OA against MRSA had broad ranges; 4 to 32 ${\mu}g/ml$ and 16 to >256 ${\mu}g/ml$, respectively. It was difficult to understand the different antimicrobial activities of UA and OA among the MRSA strains, because UA and OA antimicrobial mechanisms are unknown. These results indicate that the antimicrobial effects of UA and OA against MRSA are dependent on resistance to UA and OA in each strain.
Keywords
antimicrobial effect; methicillin-resistant Staphylococcus aureus; oleanolic acid; ursolic acid;
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Times Cited By KSCI : 2  (Citation Analysis)
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