• Title/Summary/Keyword: End-to-end evaluation

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Screening of Herbal Medicines from China and Vietnam with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (IV) (중국, 베트남산 약용식물의 최종당화산물 생성저해활성 검색 (IV))

  • Kim, Jong-Min;Kim, Young-Sook;Kim, Joo-Hwan;Yoo, Jeong-Lim;Kim, Jin-Sook
    • Korean Journal of Pharmacognosy
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    • v.40 no.4
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    • pp.388-393
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    • 2009
  • Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 64 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, eight herbal medicines ($IC_{50}$<50 ${\mu}g$/ml) were found to have strong AGEs inhibitory activity compared with aminoguanidine (14 days, $IC_{50}$=75.98 ${\mu}g$/ml; 28 days, $IC_{50}$=88.27 ${\mu}g$/ml). Particularly, four herbal medicines, Buddleja officinalis (whole plant), Syzygium cuminii (leaf), Eugenia caryophyllate (seed), and Paeonia suffruticosa (root) showed more potent inhibitory activity (approximately 5-6 fold) than the positive control aminoguanidine.

Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (II) (한국약용식물의 최종당화산물 생성저해활성 검색 (II))

  • Lee, Yun-Mi;Kim, Young-Sook;Kim, Jong-Min;Jang, Dae-Sik;Kim, Joo-Hwan;Yoo, Jeong-Lim;Kim, Jin-Sook
    • Korean Journal of Pharmacognosy
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    • v.39 no.3
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    • pp.223-227
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    • 2008
  • Advanced glycation end products (AGEs) contribute to the progression of micro and macrovsacular complication of diabetes and therefore present a promising target for therapeutic agents. In this study, 40 Korean herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 21 herbal medicines $(IC_{50}<50{\mu}g/ml)$ exhibited an inhibitory activity against AGEs formation compared with anminoguanidine $(IC_{50}=72.12{\mu}g/ml)$. Particularly, 7 herbal medicines, Actinidia arguta (root and stem), Crataegus pinnatifida (twig), Camellia japonica (whole), Kalopanax pictus (bark), Lagerstroemia indica (leaf-stem), Reynoutria sachalinensis (root) showed more potent inhibitory activity (approximately 3-10 fold) than the positive control aminoguanidine.

A Study on the Performance Evaluation of End Mill Tool Fabricated by Ultra-Fine WC (초미립 WC 소재 엔드밀 공구의 성능 평가에 관한 연구)

  • Kim, Do-Hyoung;Woo, Yong-Won;Lee, Hyun-Ho;Kim, Jeong-Suk
    • Transactions of the Korean Society of Machine Tool Engineers
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    • v.16 no.6
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    • pp.1-8
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    • 2007
  • The ultra-fine tungsten carbide(WC) powders have been actively used in the cemented carbides industry, because they have excellent mechanical properties such as high hardness, strength, and toughness. In this study, ultra-fine WC-Co alloys powders have been fabricated by thermochemical and thermomechanical process such as spray conversion process or high energy ball milling. The non-coated end-mill which is made of ultra-fine tungsten carbide is investigated by measuring cutting force, tool wear, tool life, and surface roughness profile according to cutting length. The machining test was conducted with high hardened workpiece and their performances are investigated in high speed cutting conditions. Also, the relationship between the machining characteristics and the Co contents are investigated under various high speed cutting conditions.

Design and Performance Evaluation of MPLS-DiffServ using MPLS Network Simulator (MPLS 네트워크 시뮬레이터를 이용한 MPLS-DiffServ 설계 및 성능평가)

  • 김지은;이귀상
    • Proceedings of the IEEK Conference
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    • 2000.11a
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    • pp.25-28
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    • 2000
  • As Internet users and network traffics are explosively increased, many researches have been done to provide fast and guaranteed Internet services. The results of these efforts are Multiprotocol Lab el Switching(MPLS) and differentiated service(Diff serv) emerging as a next generation backbone net work. In this paper, we make a research on gearing (or interworking) two technology needed to support end-to-end QoS and explain sequential procedure. And we simulate the L-LSP/E-LSP proposed by Working Group of IETF to be deployed to the DiffServ module which is implemented based on the MPLS network simulator and analyze the performance of the simulation result.

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Bond Strength Evaluation of Epoxy-Coated Reinforcement using Nonlinear Finite Element Analysis (비선형 유한요소법에 의한 에폭시 피막된 철근의 부착에 관한 연구)

  • 최완철
    • Proceedings of the Korea Concrete Institute Conference
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    • 1991.04a
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    • pp.65-68
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    • 1991
  • Finite element analysis is used to study the role of interfacial properties on the bond strength of reinforcing steel to concrete. Specifically, the role played by epoxy coatings on the failure of standard beam-end specimens is explored. Experimental results show that epoxy coatings reduce bond strength, but that the effect is dependent on the bar size and the deformation pattern. The finite element model for the beam-end specimen includes representations for the deformed steel bar, the concrete, and the interfacial material. The interface elements can be varied to match the stiffness and friction properties of the interfacial material. Cracking within the concrete is represented using Hillerborg's ficticious crack model. The model is used to study important aspects or behavior observed in the tests and to provide an explanation for the effect of the various test parameters.

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CRASHWORTHY DESIGN AND EVALUATION ON THE FRONT-END STRUCTURE OF KOREAN HIGH SPEED TRAIN

  • Koo, J.S.;Youn, Y.H.
    • International Journal of Automotive Technology
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    • v.5 no.3
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    • pp.173-180
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    • 2004
  • An intensive study was conducted for the crash worthy structural design of the recently developed Korean High Speed Train (KHST). Two main design concepts were set up to protect both crews and passengers from serious injury in heavy collision accidents, and to reduce damage to the train itself in light collision accidents. A collision against a movable 15-ton rigid obstacle at 110 kph was selected from train accident investigations as the accident scenario for the heavy collisions. A train-to-train collision at the relative velocity of 16 kph was used for the light collision. The crashworthiness behaviors of KHST were numerically evaluated using FEM. Analysis results using 1-D collision dynamics model of the full rake consist and 3-D shell element model of the front end structure showed good crashworthy responses in a viewpoint of structural design. Occupant analyses and sled tests demonstrated that KHST performed well enough to protect occupants under the considered accident scenarios. Finally our numerical approaches were evaluated by a real scale collision test.

Novel Approach to Analytical Jitter Modeling

  • Huremovic, Adnan;Hadzialic, Mesud
    • Journal of Communications and Networks
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    • v.17 no.5
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    • pp.534-540
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    • 2015
  • In this paper we propose an analytical model for jitter, wherein we implement the interrupted Poisson process (IPP) for incoming traffic. First, we obtain an analytical model for the jitter on one node with respect to the phase probabilities, traffic load, and tagged traffic share in the aggregate traffic flow. Then, we analyze N-node cases, and propose a model for end-to-end jitter. Our analysis leads to some fast-to-compute approximations that can be used for future network design or admission control. Finally, we validate our analytical results by comparing them with previous results for limit cases, as well as with event-driven simulations. We propose the use of our results as guidelines for jitter evaluation of real IP traffic.

Analytical and Experimental Study of an Unstiffened Extended End-Plate Connection (반복하중을 받는 비보강 확장 단부판 접합부의 해석 및 실험적 연구)

  • Kim, Hee Dong;Yang, Jae Guen;Pae, Da Sol
    • Journal of Korean Society of Steel Construction
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    • v.28 no.6
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    • pp.439-448
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    • 2016
  • Extended end-plate connections(EEPC) are a type of connection applied in Pre-Engineered Building structures comprising beam-column connections of steel structures or tapered members. Extended end-plate connections(EEPC) show different behavioral characteristics owing to the influence of plate thickness, gauge distance of high strength bolt, diameter of high strength bolt frame, and the number of high strength bolts. In the USA and Europe, extended end-plate connections(EEPC) are applied in beam-column connections of steel structures in various forms; however, these are not widely applied in structures in Korea.This can be attributed to the fact that the proposal of design strength types for extended end-plate connections(EEPC), proposal of connection specifications, evaluation of seismic performance, and are not being performed appropriately. Therefore, the purpose of this study is to provide basic data for the domestic application of Unstiffened extended endplate connections. To realize this, nonlinear finite element analysis was conducted on a 12-mm thick Unstiffened extended endplate connections.

The Influence of Consumer's Shopping Values on the Evaluations of Fashion Product Attributes and Brand Re-purchase Intention - Focused on the Moderating Role of Price Level - (소비자의 쇼핑가치가 패션제품 속성평가 및 브랜드 재구매의도에 미치는 영향 - 가격수준에 따른 조절효과를 중심으로 -)

  • Park, Hyun-Hee;Ku, Yang-Suk;Koo, Dong-Mo
    • Journal of the Korean Society of Clothing and Textiles
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    • v.31 no.2 s.161
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    • pp.236-246
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    • 2007
  • The purpose of the current study is to investigate the underlying reasons of fashion brand repurchase intention formation based on means-end chain theory and to identify whether the price level moderates the relationships between attribute evaluation and re-purchase intention. Questionnaire data from 291 consumers who had purchase experience of casual wear during the last 6 month period through off-line retail shops were analyzed. The results showed that hedonic shopping value had a positive impact on aesthetic attribute and utilitarian shopping value also had a positive impact on physical attribute of fashion product. While aesthetic attribute had a positive influence on brand repurchase intention, physical attribute had no effect on brand repurchase intention. In addition, there was no moderating effect of price level between the links from shopping value to fashion product attribute evaluation. When casual wear companies have to devise price related strategies, they need to pay attention to diverse promotion factors except for product attributes to realize price-based differentiation.

Stress Analysis and Life Evaluation of Rotor and Retaining Ring of Generator for fossil power plant (화력용 발전기 회전자 및 리테인 링의 응력해석 및 수명평가)

  • Lee, Ji-Moon
    • Proceedings of the KSME Conference
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    • 2004.11a
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    • pp.148-153
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    • 2004
  • This paper represents that parts of a large generator operating in 1000 MW are affected by centrifugal forces due to high-speed rotation in 3600 rpm and 3D FEM Analyses are required to obtained the structural reliability of the generator. From these results, one would know the weakest locations and the stress distributions. The fatigue life is calculated in order to grasp the remaining life of generator. 2D and 3D analyses are performed to calculate stresses of the generator rotor and the retaining ring. From 2D results, we find the SCF at the slot and sub-slot of the rotor. 3D analysis is applied at the end part of generator rotor, which represents complex geometry, and rotor and retaining ring shrink thermally. With these results, designers of rotor and retaining ring can compare with the results of design code and verify the stress distributions of generator rotor and retaining ring, and then calculate the remaining life from the low-cycle fatigue data.

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