• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6357-6362
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• 2013

Background: The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) has been associated with acute lymphoblastic leukemia (ALL). However, results were conflicting. The aim of this study was to quantitatively summarize the evidence for the MTHFRC677T polymorphism and ALL risk. Methods: Electronic searches of PubMed and the Chinese Biomedicine database were conducted to select case-control studies containing available genotype frequencies of C677T and the odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of any association. Results: Case-control studies including 6,371 cases and 10,850 controls were identified. The meta-analysis stratified by ethnicity showed that individuals with the homozygous TT genotype had decreased risk of ALL (OR= 0.776, 95% CI: 0.687~0.877, p< 0.001) in Caucasians (OR= 0.715, 95% CI: 0.655~0.781, p= 0.000). However, results among Asians (OR=0.711, 95% CI: 0.591~1.005, p= 0.055) and others (OR=0.913, 95% CI: 0.656~1.271, p= 0. 590) did not suggest an association. A symmetric funnel plot, the Egger's test (P=0.093), and the Begg- test (P=0.072) were all suggestive of the lack of publication bias. Conclusion: This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between the MTHFRC677T polymorphism and ALL.

• 한방재활의학과학회지
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• 제27권4호
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• pp.67-74
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• 2017

Objectives This study is aimed to identify and evaluate the already developed clinical practice guidelines (CPGs) of temporomandibular disorders (TMD) and contribute to making decisions in developing Korean medicine CPG of TMD. Methods We searched electronic database and selected CPGs of TMD according to the inclusion and exclusion criteria. Then, we made appraisal of selected CPGs by using AGREE II (Appraisal of Guidelines for Research & Evaluation II). Results Four CPGs are included and appraised with AGREE II. Among 6 domains of AGREE II, all CPGs failed to score over 60% in four domains. Only one CPG mentioned acupuncture as an adjunctive treatment for myofascial TMD. Conclusions It is difficult to indicate that included CPGs are with sufficient quality to recommend and it appears not to be appropriate to apply these already developed CPGs in Korean medicine clinical fields. Therefore, developing a new Korean medicine clinical practice guideline of TMD is required.

• 한국실내디자인학회논문집
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• 제21권4호
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• pp.146-154
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• 2012

As Damyang has preserved both beautiful natural environment and tradition very well, it needs colors which can coexist with Damyang while preserving it as it is rather than colorful and refined colors. However, the present Damyang deteriorates the quality of beautiful natural scenes by chaotic uses of colors. Therefore, colors which can represent symbolism based on the present colors of Damyang should be used so that everyone can be pleased with them. Finally, the basic colors decided were classified into main, supplement and highlight colors in consideration of characteristics of each scene and they were effectively arranged based on the colors decided. If such colors and color schemes are properly applied according to characteristics of scenes, ecological, historical, cultural and traditional scenes of Damyang can be preserved consistently. Academic literature uses the abstract to succinctly communicate complex research. An abstract may act as a stand-alone entity instead of a full paper. As such, an abstract is used by many organizations as the basis for selecting research that is proposed for presentation in the form of a poster, platform/oral presentation or workshop presentation at an academic conference. Most literature database search engines index only abstracts rather than providing the entire text of the paper. Full texts of scientific papers must often be purchased because of copyright and/or publisher fees and therefore the abstract is a significant selling point for the reprint or electronic version of the full-text. Abstracts are protected under copyright law just as any other form of written speech is protected. However, publishers of scientific articles invariably make abstracts publicly available, even when the article itself is protected by a toll barrier. For example, articles in the biomedical literature are available publicly from medline which is accessible through design. It is a common misconception that the abstracts in medline provide sufficient information for medical practitioners, students, scholars and patients. The abstract can convey the main results and conclusions of a scientific article but the full text article must be consulted for details of the methodology.

• 대한한의학회지
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• 제33권1호
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• pp.24-41
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• 2012

Objectives: This study reviewed research trends concerning the prevalence of complementary and alternative medicine (CAM) use and to suggest future research directions appropriate to medical circumstances in Korea. Methods: We searched for surveys of CAM use in 8 databases including 6 Korean databases, Ovid MEDLINE, and the CINAHL electronic database. Three independent reviewers working in pairs screened titles and abstracts of articles for eligibility. Full text was retrieved in case of disagreement on the eligibility. The main analysis targets included survey researcher's affiliation, terminology used in the title, study subject, definition of CAM, classifications of CAM modalities, and the area assortment of CAM and traditional Korean medicine (TKM). Results: 92 articles were included for analysis. The major constituent of affiliation was doctors (53%). According to years, study subjects were diversified to a large range of diseases. Since 2003, terminology is absorbed to use CAM. But actually, the most commonly used definition in the research was comprehensive such as "not generally considered part of major medicine" (55.4%) and the most used classification of CAM was self-criteria (61.9%). As for area assortment of CAM and TKM, many therapies exist in a gray zone between CAM and TKM. Conclusions: Standardized definition and classification criteria about CAM fit to the Korean healthcare system have not yet developed. For traditional Korean medicine academia, more concern should be paid to establishing appropriate development of definitions and classification criteria.

• 정보관리학회지
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• 제33권3호
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• pp.177-193
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• 2016

본 논문은 임상의사가 환자치료 시 발생하는 문제를 해결하기 위해 온라인상에서 정보검색하는 과정을 연구하였다. 이를 위해 국내 대학병원 내과 전문의 10명을 대상으로 관찰조사와 심층면담을 수행하였다. Wilson의 문제 해결 모형을 기반으로 임상의사가 임상질문 해결을 위해 온라인상에서 검색하는 단계별 특성과 정보검색의 효용성에 대해 분석하였다. 그 결과, 임상의사는 사전 배경지식을 바탕으로 즉각적인 임상질문을 구성하지만, 실제 검색에서는 대부분 기본 검색전략만 사용하였으며, 본인에게 익숙한 특정 정보원만을 선호하였다. 하지만, 온라인 정보검색 평균 만족도는 7점 리커트 스케일 기준 5.7로 높게 나타났으며, 정보검색 후에 문제해결지수가 상승하였다. 임상의사는 잘 정리된 근거 중심의 신뢰성 높은 정보를 빠르고 쉽게 이용하기를 원하기 때문에 환자 진료시스템에서 바로 치료에 필요한 정보를 보여줄 수 있는 검색시스템의 연계가 필요함을 알 수 있다. 또한, 구글이나 PubMed 외에 다른 온라인 정보원에 대한 인지도는 현격히 낮게 나타나 다른 정보원에 대한 적극적인 홍보와 정보활용교육의 활성화도 필요함을 알 수 있다.

• 동서간호학연구지
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• 제26권1호
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• pp.1-16
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• 2020

Purpose: The purpose of this study was to evaluate the effectiveness of non-pharmacologic interventions for chronic nonspecific low back pain (CLBP) in adults aged 18-64 years. Methods: We searched for potentially relevant randomized controlled trials and non-randomized controlled trials through five Korean electronic databases (i.e., Korean Studies Information Service System, Research Information Sharing Service, Korean Medical Database, KoreaMed, and National Assembly Library) published from January 2010 to May 2019. Two investigators independently selected the studies based on the criteria and assessed risk of bias in the included studies. We estimated the effect size of interventions using Comprehensive Meta Analysis 3.3. Results: Of 10,151 studies, 26 studies met the inclusion criteria and 15 studies were included in the meta-analysis. Exercise reduced low back pain (Hedges's g=-1.53, 95% CI: -2.22 to -0.85) and pain-related disabilities (Hedges's g=-0.92, 95% CI: -1.40 to -0.45). We found that taping was effective in decreasing low back pain (Hedges's g=-1.12, 95% CI: -1.51 to -0.73) and pain-related disabilities (Hedges's g=-0.50, 95% CI: -0.93 to -0.07). Manual therapy yielded a marginally significant reduction in low back pain (Hedges's g=-2.32, 95% CI: -4.64 to 0.00), the therapy was not effective in decreasing pain-related disabilities. Conclusion: Although there was little evidence for the effectiveness of manual therapy in adults with CLBP, exercise and taping were effective to relieve pain and pain-related disabilities. Based on these findings, we suggest the development of non-pharmacologic interventions or a nursing intervention protocol for the CLBP management. Also, nurses should consider implementation of effective non-pharmacologic interventions for CLBP.

• 대한한방내과학회지
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• 제40권6호
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• pp.1035-1042
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• 2019

Background: Herbal medication is widely used in the Korean Medicine Hospital, and drug-induced liver injury (DILI) in Korea has increased proportionally. Herb-induced liver injury now accounts for approximately 40% of cases of hepatotoxicity in Korea, according to research data. Currently, however, the component responsible for the toxicity is usually unknown or can only be suspected. Objective: To study the hepatotoxicity of Cheongsimyeonja-tang in DILI. Methods: A retrospective review was conducted of 82 inpatients between April 2010 and March 2017 with suspected drug-induced liver injury (n=5). The standard criteria (RUCAM scale) for drug-induced liver injury (DILI) were applied. The electronic medical records (EMRs) were retrospectively reviewed to identify the relevant database. Aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (T. Bili) were analyzed in blood samples before and after the administration of Cheongsimyeonja-tang. Results: Five cases out of 82 patients had a criterion-referenced probable (RUCAM) score ranging from 6 to 8 points DILI. However, statistical analysis of the liver function parameters results of the 82 patients did not show a statistically meaningful elevation after taking Cheongsimyeonja-tang. Conclusions: These data suggest a relationship between Cheongsimyeonja-tang and DILI. More studies are needed to validate these observations and to explore their implications.

• 한국지능시스템학회논문지
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• 제23권4호
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• pp.292-297
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• 2013

본 논문에서는 불응기(Refractory Period)에 기반한 부정맥 심전도 신호의 특이 파형 검출 알고리즘을 제안한다. 부정맥 심전도 신호는 대부분 평균 10% 정도의 특이 파형을 갖는다. 따라서 장시간 심전도 신호를 관찰 및 분석해야 하는 의료진에게 심전도 신호 샘플의 90%이상이 축소된 특이 파형만을 제공함으로써 시간과 비용 측면에서 매우 큰 효과를 볼 수 있다. 제안 알고리즘은 R-파의 특징과 가변 불응기를 이용하여 R-peak를 검출한다. 검출된 R-peak에 대해 특이 파형에 포함되지 않은 R-peak들의 전위 및 첨도의 평균과 표준편차를 이용하여 특이 파형을 검출한다. 제안한 알고리즘을 MIT-BIH 부정맥 데이터베이스의 모든 레코드에 적용한 결과 평균 90% 이상의 압축률을 보였다.

• 대한의용생체공학회:의공학회지
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• 제24권3호
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• pp.151-158
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• 2003

심장혈관 신호에 있어서 단기간의 beat-to-beat 변이(variability)에 대한 여러 연구에서 선형 분석기법들이 사용되었다. 그러나 단기간 beat-to-beat 변이에 대해 선형기법 사용의 타당성에 대한 연구나 선형과 비선형 특성을 비교한 연구는 수행되지 않았다. 본 논문의 목적은 단기간 beat-to-beat 변이의 비선형성 특성을 조사함으로써 선형기법 사용의 적절함을 증명하고자 한다. 이를 위해 선형 ARMA와 비선형 신경망(NN) 모델을 사용하여 예측을 수행하였는데, 과거의 순시 심박(HR)과 평균 혈압(BP)으로부터 현재의 심박과 혈압 예측을 상호 비교하였다. 이러한 예측모델을 평가하기 위해 MIMIC 데이터베이스로부터 HR와 BP 시계열을 사용하였다. 실험결과에 의하면 신경망에 의한 비선형성은 단기간 beat-to-beat 변이를 생성하는 시스템 동특성을 나타내는데 의미있는 역할을 하지 못하였으며, 이 사실은 ARMA 선형 분석기법이 이러한 시스템 동특성을 나타내는데 적절함을 보여주고 있다

• 대한한의학회지
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• 제33권3호
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• pp.200-230
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• 2012

Objectives: Ginseng, Panax ginseng C. A., white ginseng, has been used for thousands of years in Traditional Korean Medicine. Red ginseng can be made by a steaming process of white ginseng changing a variety of ginsenosides and ingredients such as dencichine. This article reviews red ginseng for mechanisms for pharmacodynamics and toxicity based on the content of ginseng's active ingredients, ginsenoside changed by steaming. Methods: The following electronic databases were searched: PubMed, Science Direct and Chinese Scientific Journals full text database (CQVIP), and KSI (Korean Studies Information) from their respective inceptions to June 2012. Results: Compared with unsteamed ginseng, the content of ginsenosides Rg2, Rg3, Rg5, Rh1, Rh2 and Rk1 called red ginseng-specific ginsenosides increased after the steaming process. Different ginsenosides have shown a wide variety of effects such as lowering or raising blood sugar and blood pressure or stimulating or sedating the nervous system. Especially, the levels of Rg2, Rg3, Rg5, Rh1, Rh2 and Rk1 were increased by the steaming process, showing a variety of pharmacodynamics in biological systems. Also, various processing methods such as puffing and fermentation have been developed in processing crude ginseng or red ginseng, affecting the content of ginseng's ingredients. The safety issue could be the most critical, specifically, on changed ginseng's ingredients such as dencichine. The level of dencichine was significantly reduced in red ginseng by the steaming process. In addition, the possible toxicity for red ginseng was affected by cytochrome P450, a herbal-drug interaction. Conclusions: The variety of pharmacological and toxicological properties should be changed by steaming process of Panax ginseng C. A., white ginseng. Even if it is not sure whether the steaming process of white ginseng would be better pharmacologically, it is sure that steaming reduces the level of dencichine causing a lower toxicity to the nervous system.