• 약학회지
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• 제40권6호
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• pp.646-652
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• 1996

Epidermal Growth Factor (EGF), discovered by Stanley Cohen in 1960, has a potential healing effect for wounds and bums. Considering wound care, in order to avoid physical stress at the wound surface and efficiently apply EGF, the need for viscous spraying solutions was essential. Viscous spraying solutions containing EGF were prepared by utilizing viscosity-building polymer, poloxamer 407, and by introducing liposome systems. On the other hand, EGF is purified on reverse HPLC gradient program with the mobile solvent of acetonitrile. It is necessary to observe liposomal EGF changes as the acetonitrile contents varied in order to introduce liposome systems at the step of EGF solution (at the time of EGF purifying). By evaluating the size distribution and entrapment efficiency of EGF liposome, it was possible to detemine the limit contents of acetonitrile and establish the optimal conditions for solution formulations. It has been revealed that, as the acetonitrile content increases, mean diameter of EGF liposomes increased and the width of size distribution tends to decrease. The limit contents of acetonitrile were 10%, since there was little difference to the acetonitrile free liposomes.

• 한국물환경학회지
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• 제26권1호
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• pp.44-51
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• 2010

A lab-scale apparatus for turbid water transport control was tested and examined. The channel had a dimension of $100cm{\times}30cm{\times}15cm$ (length${\times}$hight${\times}$width). And the turbidity water was prepared using two types of particles, bentonite and loess. The channel equipped with filamentous mat was operated under various shock load conditions. In the control channel, instantly, turbid water mixed with the clean water inside the channel and turbidity prevails the entire channel. While in the mat-equipped channel, it increases only at the bottom. Overall, the filamentous mat gave capture efficiency of 70~90% compared with the control group. The capture efficiency of turbid particles decreased with increased input turbidity flux. The result of experimental run on how turbid particles are separated in the mat channel shows that settling, filtration and attachment are the main processes. Meanwhile, turbidity was diffused from the channel bottom due to turbidity gradient before and after mat zone. The particle size before mat zone was lightly coarser than that after mat zone.

• Nuclear Engineering and Technology
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• 제52권11호
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• pp.2422-2430
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• 2020

In order to improve calculational efficiency of the CAPP code in the analysis of the hexagonal reactor core, we have tried to implement a refined AFEN method with transverse gradient basis functions and interface flux moments in the hexagonal geometry. The numerical scheme for the refined AFEN method adopted here is the response matrix method that uses the interface partial currents as nodal unknowns instead of the interface fluxes used in the original AFEN method. Since the response matrix method is single-node based, it has good properties such as good calculational efficiency and parallel computing affinity. Because a refined AFEN method equivalent nonlinear FDM response matrix method tried first could not provide a numerically stable solution, a direct formulation of the refined AFEN response matrix were developed. To show the numerical performance of this response matrix method against the original AFEN method, the numerical error analyses were performed for several benchmark problems including the VVER-440 LWR benchmark problem and the MHTGR-350 HTGR benchmark problem. The results showed a more than three times speedup in computing time for the LWR and HTGR benchmark problems due to good convergence and excellent calculational efficiency of the refined AFEN response matrix method.

• 한국산업융합학회 논문집
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• 제23권3호
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• pp.433-444
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• 2020

This study proposes a method to improve the sleep stage and efficiency estimation of sleep apnea patients using a UWB (Ultra-Wideband) radar. Motion and respiration extracted from the radar signal were used. Respiratory signal disturbances by motion artifacts and irregular respiration patterns of sleep apnea patients are compensated for in the preprocessing stage. Preprocessing calculates the standard deviation of the respiration signal for a shift window of 15 seconds to estimate thresholds for compensation and applies it to the breathing signal. The method for estimating the sleep stage is based on the difference in amplitude of two kinds of smoothed respirations signals. In smoothing, the window size is set to 10 seconds and 34 seconds, respectively. The estimated feature was processed by the k-nearest neighbor classifier and the feature filtering model to discriminate between the sleep periods of the rapid eye movement (REM) and non-rapid eye movement (NREM). The feature filtering model reflects the characteristics of the REM sleep that occur continuously and the characteristics that mainly occur in the latter part of this stage. The sleep efficiency is estimated by using the sleep onset time and motion events. Sleep onset time uses estimated features from the gradient changes of the breathing signal. A motion event was applied based on the estimated energy change in the UWB signal. Sleep efficiency and sleep stage accuracy were assessed with polysomnography. The average sleep efficiency and sleep stage accuracy were estimated respectively to be about 96.3% and 88.8% in 18 sleep apnea subjects.

• 멤브레인
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• 제31권4호
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• pp.253-261
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• 2021

물 오염, 지구 온난화, 기후 변화를 해결하기 위한 해결책이 시급한 상황에서, 담수의 수요를 충당하고 친환경 에너지를 생산하기 위한 방법으로 염도차를 이용한 압력지연삼투공정이 제시되고 있다. 압력지연삼투공정에 대한 꾸준한 연구에도 불구하고 최근 기술의 부족과 비싼 멤브레인의 가격 등의 한계로 인해 상용화가 되지 않고 있다. 한편 멤브레인은 압력지연삼투공정과 염도차 발전 기술에 가장 중요한 구성품이다. 염도차 발전 기술에 사용되는 산화그래핀 멤브레인과 나노복합체 멤브레인의 기술 발전 연구가 지속되고 있다. 특히 낮은 온도의 폐기물 온도에서도 높은 에너지 효율 발전이 가능하도록 효율이 높은 멤브레인과 용매 및 용질에 대한 연구가 활발하다. 높은 투과도와 분리도를 가진 멤브레인, 특히 산화그래핀 멤브레인을 사용함으로써 농도 분극을 줄이고 전력 밀도를 높이는 연구들도 진행 중이다. 본 총설에서는 압력지연삼투 멤브레인과 이를 통한 이론적 모델링, 그 외 기술을 통해 공정의 효율을 발전시키는 방법에 대해 논의한다.

• 한국터널지하공간학회 논문집
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• 제26권1호
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• pp.39-58
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• 2024

TBM (Tunnel boring machine)은 터널 굴착 과정에서 여러 디스크 커터를 이용하여 암석을 절삭한다. 디스크 커터는 암석과의 지속적인 접촉과 마찰로 인해 마모된다. 디스크 커터의 표면이 마모되면 절삭 능력이 감소하고 굴착 효율이 떨어진다. 암석의 마모성은 디스크 커터 마모에 큰 영향을 미친다. 높은 마모도를 가진 암석은 커터에 더 큰 마모를 일으키며, 이는 디스크 커터의 수명을 단축시킨다. 세르샤 마모지수(Cerchar abrasivity index, CAI)는 암석의 마모성을 평가하는데 널리 사용되는 지표로 CAI는 암석의 마모특성을 나타내며, 디스크 커터의 수명과 성능 예측에 필수적인 요소로 인식되고 있다. 본 연구의 목적은 암석의 강도, 암석학적 특성과 선형회귀, 머신러닝 기법을 이용하여 CAI를 효과적으로 추정하는 새로운 방법을 개발하는 것이다. 문헌 조사를 통해 CAI, 일축압축강도, 압열인장강도, 등가석영함량이 포함된 데이터베이스를 구축하고 파생변수를 추가하였다. 통계적 유의성과 다중공선성을 고려하여 다중선형회귀분석을 위한 입력변수를 선정하였고, 머신러닝 모델의 입력변수는 변수중요도 분석을 통해 선정하였다. 머신러닝 예측모델 중 Gradient Boosting 모델의 예측 성능이 가장 높게 나타나 최적의 CAI 예측 모델로 선정되었다. 마지막으로 본 연구에서 도출한 다중선형회귀분석과 Gradient Boosting 모델의 예측 성능을 선행연구들의 CAI 예측모델과 비교하여 연구 결과의 타당성을 확인하였다.

• 한국위성정보통신학회논문지
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• 제11권2호
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• pp.55-59
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• 2016

기존 무선에너지 하비스팅시스템에서 유저는 하나의 Hybirid-AP (H-AP)로부터 에너지와 정보를 동시에 받았다. 하지만 무선에너지 하비스팅은 거리가 멀수록 감쇄가 심하기 때문에 H-AP에서 거리가 먼 유저들은 낮은 하비스팅 효율 가진다 (이중 근거리/원거리 문제). 이러한 문제를 해결하기 위해서 본 논문은 Power beacon (PB)을 통해 유저에게 별도의 파워를 공급하는 비결합 무선에너지 하비스팅 네트워크를 시스템 모델로 사용하였다. 이 논문의 주된 목적은 다양한 제약 조건과 Quality of service (QoS), 그리고 Quality of harvested power (QoP)를 만족하면서 목적 함수인 Energy efficiency (EE)를 최대화 하는 것이다. 제안된 시스템은 라그랑지안 쌍대 분해법 이론을 기반으로 EE 최대화를 위한 최적의 시간 스케줄링 알고리즘을 제안한다. 이 알고리즘을 통해 프레임 분해 요소, H-AP의 송신파워, 그리고 PB의 송신파워의 최적 값과 EE의 최대값을 구할 수 있다. 모의 실험 결과는 제안된 알고리즘으로 파라미터가 최적 값으로 빠르게 수렴하고 제안된 모델의 성능이 기존의 시스템 모델보다 우수하다는 것을 증명한다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제9권1호
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• pp.47-53
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• 2004

본 연구에서는 동전기-펜턴 공정을 이용한 phenanthrene 오염토양 정화의 타당성을 확인하기 위해서, 토양 시스템 내에서 전기삼투흐름에 의한 과산화수소의 이동과 펜턴유사 반응에 의한 phenanthrene의 산화분해 양상을 살펴보았다. 10 mA와 5 mA의 두 가지 전류 조건 중에서, 10 mA일 때 더 높은 전압경사와 전기삼투유량이 관찰되었다. 높은 전기삼투유량은 토양 내로 많은 양의 과산화수소가 이동한 것을 의미하므로, phenanthrene 제거효율이 전기삼투유량이 증가함에 따라 증가한 것으로 판단된다. 동전기 정화기술만을 이용한 토양 세척에 의해 7일간의 가동기간 동안 8.5%의 phenanthrene이 제거되었다. Phenanthrene을 직접 산화분해하기 위하여 양극 전극조를 통하여 과산화수소 용액을 토양에 공급한 경우에는 14일 동안 최고 95.6%의 제거효율을 얻을 수 있었다. 실험 종료 후 95.6%의 제거효율을 나타낸 토양시료를 분석한 결과 phenanthrene의 중간산물이 거의 관찰되지 않음으로써, 과산화수소의 연속적인 주입을 통하여 가동기간 중간에 생성된 중간산물들이 저분자 물질로 산화분해 되었거나 물과 이산화탄소로 분해된 것으로 추정된다.

• Journal of Electrochemical Science and Technology
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• 제10권1호
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• pp.14-21
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• 2019

Supported liquid membrane process usually is used for recovering or enrichment of valuable metals in the industrial wastewater. But, even if the metals in the wastewater was separated with high chemical selectivity, it cannot be enough concentrated since separation performance of supported liquid membrane (SLM) process is limited by concentration gradient between feed solution and stripping solution. If metal concentration in the stripping solution to be enough low, transport of metal through membrane can be accomplishment constantly. Therefore, Electrodialysis (ED) has been placed after SLM process and the stripping solution of SLM was used as the feed solution for the ED process. Transport of ions in the solutions is successfully performed by ED process. Thus, the metal concentration in the stripping solution does not rise as to stop ion transport. Besides, valuable metals easily are concentrated by ED process for re-use. In this study, effects of operation parameters like initial Cd(II) concentration, HCl concentration in the feed solution of SLM and applied voltage are investigated on separation efficiency, flux and permeability of the both processes. As the feed solution concentration increased, all performance values has increased. When initial concentration of 100 mg/L is used, separation performances (SP) are 55% and 70%, for SLM and consecutive process, respectively. The best HCl concentration in the feed solution of SLM has determined as 2 M, in this conditions SP are 64% and 72%, for SLM and consecutive process, respectively. With increased of applied voltage on ED process, SP of the consecutive process has been raised from 72% to 83%. According to the obtained experimental data, consecutive process has better separation performance than SLM. When the separation performances of both processes were compared for the same operating conditions, it was determined higher the separation efficiency, permeability and flux values of the consecutive process, 8%, 9% and %10.6, respectively. Consequently, the use of the consecutive process increases the performance efficiency of both processes. The consecutive process studied has quite a good chemical separation efficiency, and enrichment capability. Moreover, this process requires few water and energy.

• 한국연안방재학회지
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• 제5권4호
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• pp.173-182
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• 2018

As the research about increasing the efficiency of dredging soil transport, the technology, which reduce the friction between pipe wall and fluid in the pipe and disturbed generating pipe blockage, has been developed. So for the purpose of applying this technology to real construction site, main test has been tried at the real scale test in field. As a test result, this paper will show 30% flow efficiency increasing by permitted electro magnetic force to the pipe. And test result was evaluated as a ultra sonic velocity profiler. To propose the design technique and the execution manual of the high efficiency dredging material transport technic, this research have confirmed flow status changing depending on a soil material kind under electro-magnetic field and analyze the effect of electro-magnetic field which affects to each dredged soil material transportation. For achieving this research, EMF(Electro-Magnetic Field) generator is installed on the dredger(20,000HP) and through monitored flow status, dredging soil flow rate and sampled material specification is confirmed. Also dredger operating condition is measured and dredger power for soil transportation, hydraulic gradient and flow rate are compared, as transportation efficiency is calculated by this parameter, it is possible to check transportation efficiency improvement depending on each dredged soil material under electro-magnetic field. To verify the technique of dredged soil transfer using electromagnetic field, which is the core technique of the high efficiency dredged soil transfer, and the technique of expert system for pipeline transfer and the flow state. This could lead to a verification of transfer efficiency according to the characteristics of the dredged soil (sand, clay, silt) and the transfer distance (5km, 10km, 15km), which is planned to be used for a technology development of pump power reduction and long-distance transfer applying the high efficiency dredged soil transfer technology.