• Biomolecules & Therapeutics
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• 제30권4호
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• pp.320-327
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• 2022

Neurodevelopmental disorders are complex conditions that pose difficulty in the modulation of proper motor, sensory and cognitive function due to dysregulated neuronal development. Previous studies have reported that an imbalance in the excitation/inhibition (E/I) in the brain regulated by glutamatergic and/or GABAergic neurotransmission can cause neurodevelopmental and neuropsychiatric behavioral deficits such as autism spectrum disorder (ASD). NMDA acts as an agonist at the NMDA receptor and imitates the action of the glutamate on that receptor. NMDA however, unlike glutamate, only binds to and regulates the NMDA receptor subtypes and not the other glutamate receptors. This study seeks to determine whether NMDA administration in mice i.e., over-activation of the NMDA system would result in long-lasting behavioral deficits in the adolescent mice. Both gender mice were treated with NMDA or saline at early postnatal developmental period with significant synaptogenesis and synaptic maturation. On postnatal day 28, various behavioral experiments were conducted to assess and identify behavioral characteristics. NMDA-treated mice show social deficits, and repetitive behavior in both gender mice at adolescent periods. However, only the male mice but not female mice showed increased locomotor activity. This study implies that neonatal exposure to NMDA may illicit behavioral features similar to ASD. This study also confirms the validity of the E/I imbalance theory of ASD and that NMDA injection can be used as a pharmacologic model for ASD. Future studies may explore the mechanism behind the gender difference in locomotor activity as well as the human relevance and therapeutic significance of the present findings.

• Archives of Pharmacal Research
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• 제27권1호
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• pp.111-117
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• 2004

Hepatic microcirculatory failure is a major component of reperfusion injury in the liver. Recent data provided some evidence that endothelium-derived vasoconstrictors and vasodilators may be functionally important to the control of the total hepatic blood flow under these conditions of circulatory failure. Since Kupffer cells provide signals that regulate the hepatic response in ischemia/reperfusion (I/R), the aim of this study was to investigate the role of Kupffer cells in the I/R-induced imbalance of vasoregulatory gene expression. Rats were subjected to 60 min hepatic ischemia, followed by 5 h of reperfusion. The Kupffer cells were inactivated by gadolinium chloride ($GdCl_3$, 7.5 mg/kg body weight, intravenously) 1 day prior to ischemia. Liver samples were obtained 5 hrs after reperfusion for RT-PCR analysis of the mRNA for genes of interest: endothelin-1 (ET-1), its receptors $ET_A and ET_B$, endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1). ET-1 mRNA expression was increased by I/R. mRNA levels for $ET_A$ receptors showed no change, whereas $ET_B$ receptor transcripts increased in the I/R group. The increases in ET-1 and $ET_B$ mRNA were not prevented by the $GdCI_3$ pretreatment. The mRNA levels for iNOS and eNOS significantly increased within the I/R group with no significant difference between the I/R group and the $GdCl_3$-treated I/R group. HO-1 mRNA expression significantly increased in the I/R group and this increase was attenuated by $GdCI_3$. In conclusion, we have demonstrated that an imbalance in hepatic vasoregulatory gene expression occurs during I/R. Our findings suggest that the activation of Kupffer cells is not required for I/R-induced hepatic microvascular dysfunction.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권2호
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• pp.263-283
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• 2024

Users' comments after online shopping are critical to product reputation and business improvement. These comments, sometimes known as e-commerce reviews, influence other customers' purchasing decisions. To confront large amounts of e-commerce reviews, automatic analysis based on machine learning and deep learning draws more and more attention. A core task therein is sentiment analysis. However, the e-commerce reviews exhibit the following characteristics: (1) inconsistency between comment content and the star rating; (2) a large number of unlabeled data, i.e., comments without a star rating, and (3) the data imbalance caused by the sparse negative comments. This paper employs Bidirectional Encoder Representation from Transformers (BERT), one of the best natural language processing models, as the base model. According to the above data characteristics, we propose the F_MixBERT framework, to more effectively use inconsistently low-quality and unlabeled data and resolve the problem of data imbalance. In the framework, the proposed MixBERT incorporates the MixMatch approach into BERT's high-dimensional vectors to train the unlabeled and low-quality data with generated pseudo labels. Meanwhile, data imbalance is resolved by Focal loss, which penalizes the contribution of large-scale data and easily-identifiable data to total loss. Comparative experiments demonstrate that the proposed framework outperforms BERT and MixBERT for sentiment analysis of e-commerce comments.

• 무역상무연구
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• 제70권
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• pp.135-157
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• 2016

Globalization of consumption, expansion of cross border e-trade, increase use of internet and mobile have led to rapid growth of world e-commerce particularly in Asia and emerging markets. Impacted by Korean wave, online export is continuously increasing, yet Korea is experiencing severe e-commerce trade imbalance. Export growth rate and ratio of Korean small companies are relatively low from OECD member countries. Therefore, Korean government is currently emphasizing on vitalization of online export to China to resolve trade imbalance and to increase export of small companies. To propose detail measures to vitalize online export to China, this study is focused on export customs clearance procedure of Korea and import customs clearance procedure of China in view of online export company. Also suggested countermeasure plan and analysis for the new tax revision plan related to e-commerce which implemented on April 8th 2016. This study have grouped countermeasure plan by short term plan of firms and long term plan of the government. As for the short-term countermeasure plan for firms, first, comparison analysis of tax rate on products is need to decide type of e-commerce strategy; second, if planning to start e-commerce business to China, sales possibility and certification check is necessary; third, through preparation of customs clearance document is needed; last in order to obtain price competitiveness, new logistics strategy and packing development is required. As for the long-term countermeasure plan for the government, I have suggested cooperated bonded logistics service for small businesses and operation plan of show room for promising Korean products.

• 한국의류학회지
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• 제36권1호
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• pp.56-67
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• 2012

This research investigates the effect of the antecedents (i.e. specific investment, opportunistic behavior, communications, uncertainty, interdependence, power imbalance, shared value, and flexibility) that influence the trust and commitment of domestic apparel manufacturers toward contractors as well as the effect of trust and commitment on firm performance and relationship satisfaction. A total of 128 apparel manufactures participated in this study. Factor analysis, Cronbach's alpha coefficient, and path analysis were conducted for the statistical analysis. Specific investment, communication, shared value, and flexibility had a positive effect on trust; however, opportunistic behavior had a negative effect. Interdependence, shared value, and flexibility had a positive effect on commitment; however, power imbalance and uncertainty had a negative effect. Trust did not exert an effect on commitment in this research; however, trust and commitment had a positive effect on firm performance; in addition, trust and commitment had a positive effect on relationship satisfaction. The findings offer insight on how to better manage apparel manufacturer-contractor relationships to ensure success.

• Tribology and Lubricants
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• 제34권1호
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• pp.9-15
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• 2018

Modern high-performance automotive turbochargers (TCs) implement ceramic hybrid angular contact ball bearings in series with squeeze film dampers (SFDs) to enhance transient responses, thereby reducing the overall emission levels. The current study predicts the rotordynamic responses of the commercial automotive TCs (compressor wheel diameter = ~53 mm, turbine wheel diameter = ~43 mm, and shaft diameter at the bearing locations = ~7 mm) supported on ball bearings and SFDs for various design parameters of SFDs, including radial clearance, axial length, lubricant viscosity, and rotor imbalance conditions (i.e., amplitudes and phase angles) while increasing rotor speed up to 150 krpm. This study validates the predictive rotor finite element model against measurements of mass, polar and transverse moments of inertia, and free-free mode natural frequencies and mode shapes. A nonlinear rotordynamic model integrates nonlinear force coefficients of SFDs to calculate the transient responses of the TC rotor-bearing system. The predicted results show that SFD radial clearances, as well as phase angles of rotor imbalances, have the paramount effect on the dynamic responses of TC shaft motions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권10호
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• pp.4724-4747
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• 2016

To efficiently reduce on-grid energy consumption, the admission control algorithm in the hybrid energy powered cellular network (HybE-Net) with base stations (BSs) powered by on-grid energy and solar energy is studied. In HybE-Net, the fluctuation of solar energy harvesting and energy consumption may result in the imbalance of solar energy utilization among BSs, i.e., some BSs may be surplus in solar energy, while others may maintain operation with on-grid energy supply. Obviously, it makes solar energy not completely useable, and on-grid energy cannot be reduced at capacity. Thus, how to control user admission to improve solar energy utilization and to reduce on-grid energy consumption is a great challenge. Motivated by this, we first model the energy flow behavior by using stochastic queue model, and dynamic energy characteristics are analyzed mathematically. Then, fuzzy logic based admission control algorithm is proposed, which comprehensively considers admission judgment parameters, e.g., transmission rate, bandwidth, energy state of BSs. Moreover, the index of solar energy utilization balancing is proposed to improve the balance of energy utilization among different BSs in the proposed algorithm. Finally, simulation results demonstrate that the proposed algorithm performs excellently in improving solar energy utilization and reducing on-grid energy consumption of the HybE-Net.

• 복식문화연구
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• 제21권2호
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• pp.220-233
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• 2013

This study examined regarding the moderating effect of length of relationship in the relationship among the antecedent variables (i.e., specific investment, opportunistic behavior, communication, uncertainty, interdependence, power imbalance, shared value, and flexibility) of trust and commitment, trust and commitment and firm performance and relationship satisfaction. A total of 128 apparel manufacturers participated in this study. Flexibility exerted the most positive effect on trust in short-term relationship, followed by specific investment. And opportunistic behavior was found to exert negative effect on trust. Commitment was found to be most negatively affected by power imbalance, followed by interdependence. Trust was shown to be significantly affected by communication, shared value and flexibility in short-term relationship. In the case of long-term relationship, commitment was shown to be significantly affected by uncertainty, interdependence, power imbalance and flexibility. Firm performance was positively affected by both trust and commitment. As for the effect of trust and commitment on relationship satisfaction, relationship satisfaction was also affected by both trust and commitment. In case the length of relationship, firm performance was affected by both trust and commitment. As for the effect of trust and commitment on relationship satisfaction, relationship satisfaction was also affected by both trust and commitment. The result of this research provides valuable data for making a concrete suggestion regarding the strategy for improving trust and commitment for the sake of the desirable relationship between apparel manufacturers and contractors.

• Biomolecules & Therapeutics
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• 제30권3호
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• pp.232-237
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• 2022

Autism spectrum disorder (ASD) having core characteristics of social interaction problems and repetitive behaviors and interests affects individuals at varying degrees and comorbidities, making it difficult to determine the precise etiology underlying the symptoms. Given its heterogeneity, ASD is difficult to treat and the development of therapeutics is slow due to the scarcity of animal models that are easy to produce and screen with. Based on the theory of excitation/inhibition imbalance in the brain with ASD which involves glutamatergic and/or GABAergic neurotransmission, a pharmacologic agent to modulate these receptors might be a good starting point for modeling. N-methyl-D-aspartic acid (NMDA) is an amino acid derivative acting as a specific agonist at the NMDA receptor and therefore imitates the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA selectively binds to and regulates the NMDA receptor, but not other glutamate receptors such as AMPA and kainite receptors. Given this role, we aimed to determine whether NMDA administration could result in autistic-like behavior in adolescent mice. Both male and female mice were treated with saline or NMDA (50 and 75 mg/kg) and were tested on various behavior experiments. Interestingly, acute NMDA-treated mice showed social deficits and repetitive behavior similar to ASD phenotypes. These results support the excitation/inhibition imbalance theory of ASD and that NMDA injection can be used as a pharmacologic model of ASD-like behaviors.

• 동의생리병리학회지
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• 제19권1호
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• pp.242-245
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• 2005

The most common feature of neurodegenerative disease (i.e. Alzheimer's disease, AD) is the increased number of activated microglial cells nearby the pathogenic area of the brain, such as amyloid plaque in AD. An abnormality of protein regulation and an imbalance of clearance against ${\beta}-amyloid\;(A{\beta})$ produced amyloid precursor protein (APP) can turn microglia into the activated feature out of the ramified resting phase. We examined the possibility that ginsenoside Rb1 could attenuate the microglial activation induced by massive $A{\beta}$ that has known to induce a chronic inflammation, which is a major cause of AD by damaging neuronal cells (i.e. apoptosis or necrosis). Aggregated $A{\beta}42\;(5\;{\mu}M)$ peptide was used with lipopolysaccharide (LPS) ($10\;{\mu}g$) for a comparative control up to 48hours. We found that Rb1 reduced the production of nitric oxide as well as proinflammatory cytokines, such as $IL-1{\beta}$ and $TNF-{\alpha}$.