• Journal of Ship and Ocean Technology
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• v.8 no.4
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• pp.45-55
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• 2004

How to achieve engineering collaboration among diverse engineering activities is one of the key topics in manufacturing fields nowadays. The infrastructure for collaborative engineering is essential, and it can be realized by information technologies and intelligent engineering applications in digital environments. Digital Manufacturing is a technology to facilitate effective product developments and agile productions by computer models representing the physical and logical schema and the behavior of real manufacturing systems including products, processes and factories. A digital factory as a well-designed and integrated digital environment is incorporated in it. In this paper, digital manufacturing is recommended as a good strategy for collaborative engineering, especially in product developments and productions. By business process analysis and some case studies, we suggested sophisticated digital models are very useful to concurrent and collaborative engineering. It is expected that digital manufacturing is a very good strategy for achieving dramatic time and cost savings in many engineering activities of many manufacturing industries, including machinery, automotive and shipbuilding.

• Journal of Microbiology and Biotechnology
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• v.19 no.6
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• pp.573-581
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• 2009

The complex enzyme pool secreted by the phytopathogenic fungus Fusarium graminearum in response to glucose or hop cell wall material as sole carbon sources was analyzed. The biochemical characterization of the enzymes present in the supernatant of fungal cultures in the glucose medium revealed only 5 different glycosyl hydrolase activities; by contrast, when analyzing cultures in the cell wall medium, 17 different activities were detected. This dramatic increase reflects the adaptation of the fungus by the synthesis of enzymes targeting all layers of the cell wall. When the enzymes secreted in the presence of plant cell wall were used to hydrolyze pretreated crude plant material, high levels of monosaccharides were measured with yields approaching 50% of total sugars released by an acid hydrolysis process. This report is the first biochemical characterization of numerous cellulases, hemicellulases, and pectinases secreted by F. graminearum and demonstrates the usefulness of the described protein cocktail for efficient enzymatic degradation of plant cell wall.

• Advances in Traditional Medicine
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• v.10 no.4
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• pp.271-277
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• 2010

We tested to determine if Mori Cortex Radicis extract has antioxidant activities and its potential mechanism of action was explored. Anti-oxidative effects were tested by measuring free radical and nitric Oxide (NO) scavenging activity, and reducing power. Since iNOS and COX-2 are important enzymes responsible for the production of free radicals in the cell, Mori Cortex Radicis extract was tested as to whether it could inhibit iNOS and COX-2 expression in LPS stimulated Raw cells. 70% methanolic extract of Mori Cortex Radicis exerted significant DPPH free radical and NO scavenging activities. In addition, the Mori Cortex Radicis extract exerted dramatic reducing power with maximal activity observed at 1 mg/ml (11-fold over control). Production of iNOS induced by LPS was significantly inhibited by the Mori Cortex Radicis extract, suggesting it could inhibit NO production by suppressing iNOS expression. COX-2 induced by LPS was also significantly inhibited by the Mori Cortex Radicis extract. The extract contains well known antioxidant components including phenolics, flavonoids and anthocyanin at the concentration of 0.23 mg/g, 42.97 mg/g and 12.08 mg/g, respectively. These results suggest that 70% methanolic extract of Mori Cortex Radicis exerts significant anti-oxidant activity via inhibiting iNOS and COX-2 induction.

• Korean Journal of Food Science and Technology
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• v.10 no.4
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• pp.423-430
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• 1978

Since 1950 there has been a dramatic progress in rationalization of the production of sweet potato and potato starch in Japan. This enabled dextrose industry by enzymatic process to develop rapidly due to the success of enzymatic liquefaction and saccharification. Isomerization of glucose to fructose has been studied, and the immobilization of isomerases prompted its products on industrial scale in 1970. Another advance is the development of effective methods of producing high purity maltose. A malto-hexaose forming amylase was discovered in 1971 and attempts are being made for its pharmaceutical utilization. Saccharification of cellulose by cellulase has been studied. Conversion of starch to other polysaccharides is another example for the numerous Japanese activities.

• Journal of Distribution Research
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• v.2 no.1
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• pp.197-213
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• 1997

It is becoming very difficult for a single company to perform every process and activity required to bring its product or service to market in a competitive manner. Consequently, we are observing a dramatic paradigm shift, with companies moving from performing all activities in-house to selective outsourcing for non-core elements of their business. Through outsourcing, companies can focus on their core competencies, reduce costs, improve quality and increase flexibility. Companies today can no longer afford to ignore the potential opportunities realized through mutually beneficial outsourcing relationships with third-party suppliers. The outsourcing opportunities exist in almost every business process. Many successful companies have implemented effective outsourcing relationships with third party suppliers to gain competitive advantage in a wide range of areas. However, in terms of logistics, it is not so easy to find those companies in our country. Consequently, this paper reviews previous researches and describes several topics in third party logistics such as advantages and disadvantages, how can we select third party suppliers, and so on.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.591-596
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• 2001

Micron-size mechanical devices are becoming more prevalent, both in commercial applications and in scientific inquiry. Within the last decade, a dramatic increase in research activities has taken place, mostly due to the rapidly expanding growth of applications in areas of MEMS(Micro-Electro-Mechanical Systems), bioengineering, chemical systems, and advanced energy systems. In this study, we have described the effects of vortex viscosity variation on the flowfields in a micro-slot between rotating surfaces of revolution using a micropolar fluid theory. In order to solve this problem, we have used boundary layer equations and applied non-zero values of the microrotation vector on the wall. The results are compared with the corresponding flow problems for Newtonian fluid. Results show that the coefficient $\delta$ controls the main part of velocity ${\upsilon}_x$ and the coefficient M controls the main part of microrotation component ${\Omega}_{\theta}$.

• Annals of Clinical Neurophysiology
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• v.22 no.1
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• pp.41-45
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• 2020

Acute sarcoid myositis is rarely complicated by sarcoidosis, and steroid therapy is considered the standard treatment. We experienced a patient with acute sarcoid myositis who did not respond to aggressive high-dose corticosteroid therapy, but showed a dramatic improvement after the addition of weekly low-dose oral methotrexate (MTX). This intervention allowed the resumption of normal daily activities after 6 months. Our case strongly suggests that MTX should be considered in patients with acute sarcoid myositis that is resistant to corticosteroid therapy.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.1978-1983
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• 2008

With the increase in population, the area of human activities has expanded, resulting in the dramatic increase in the need for transportation system. Various infrastructures necessary for efficient logistics, however, have not been supplied enough and the logistics efficiency in Korea is in a bad situation now. As a result of the situation, the demand for the railroad transportation system that can provide large volume transportation has increased dramatically. An electric railway system is composed of high-tech subsystems, among which main electric equipment such as motors and converter are critical components determining the performance of electric vehicle. Among the on-board equipments, traction equipment is important part that has influence on safety and performances of vehicles. We is studied for high-speed train of foreign countries. From this research, we knows that axle weight of HEMU-400x is reasonable within 13ton.

• Asia pacific journal of information systems
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• v.13 no.3
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• pp.63-84
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• 2003

Business process redesign(BPR) has been widely adopted as an organizational change method since 1990s as the competitive pressures have forced organizations to constantly change. Although BPR has provided successful stories to gain dramatic improvement in performance and has been promoted as an enabler of organizational change, many organizations have faced serious challenges with widely mixed results due to the lack of understanding for potential organizational conflicts and the improper targeting of critical processes in the initial stage of BPR. This paper proposes a cognitive map based method to help organizational members identify potential organizational conflicts, capture core business activities, and suggests guidelines to lead to the necessary organizational change. A computerized tool has been developed to support the real world cases. Working procedure of the proposed method is illustrated with its application to the real BPR project of a dairy company.

• BMB Reports
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• v.47 no.3
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• pp.149-157
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• 2014

The recent dramatic improvements in high-resolution mass spectrometry (MS) have revolutionized the speed and scope of proteomic studies. Conventional MS-based proteomics methodologies allow global protein profiling based on expression levels. Although these techniques are promising, there are numerous biological activities yet to be unveiled, such as the dynamic regulation of enzyme activity. Chemical proteomics is an emerging field that extends these types proteomic profiling. In particular, activity-based protein profiling (ABPP) utilizes small-molecule probes to monitor enzyme activity directly in living intact subjects. In this mini-review, we summarize the unique roles of smallmolecule probes in proteomics studies and highlight some recent examples in which this principle has been applied.