• Journal of the Korean Applied Science and Technology
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• v.36 no.3
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• pp.930-941
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• 2019

The purpose of this study was to investigate the effect of health assessment practical education through scenario on communicative competence, critical thinking diposition and academic achievement among nursing students' in university. A nonequivalent control group pretest-posttest design was used to measure. A survey was held to the students who are taking a health assessment practical class for 2grade in J university in Chungbuk and P university in G-do. Participants in a health assessment practical through scenario class and traditional health assessment class were 35 experiment group students and 34 control group students who attended 16 weeks. Effects were evaluated through pre and post tests that included measurements. As a result, the experimental group is more capable of communicative competence (t=2,797, p=.007), critical thinking disposition(t=2,406, p=.019), ability to collecting information(t=2,977, p=.004), problem awareness competence(t=3.584, p=.001) has increased statistically significantly than the control group. Therefore, Therefore, this study could be used that health assessment practical education through scenarios to improve nursing students' communicative competence, critical thinking disposition, collecting information competence, and problem awareness competence.

• The Journal of the Convergence on Culture Technology
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• v.7 no.3
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• pp.27-34
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• 2021

The purpose of this study was to investigate the effect of ethical decision making confidence in nursing students and to provide the basic data of to control ethical decision making confidence. Data were collected from 205 nursing students in B city and analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple regression using SPSS/WIN 22.0. The degree of ethical decision making confidence in nursing students was 3.83±.62. There were significant differences in ethical decision making confidence with respect to gender(t=2.118, p=.037), achivement of life(F=3.851, p=.023). There was positive correlation between ethical decision making confidence and ethical value(r=.153, p=.028), critical thinking disposition(r=.477, p<.001), and professional self concept(r=.566, p<.001). The factors affecting the ethical decision making confidence of the study subjects were critical thinking disposition(β=.254, p<.001), professional self concept(β=.418, p<.001), with an explanatory power of 35.1%. Through this research requires the fellow study to determine the factors affecting ethical decision making confidence of nursing students.

• Journal of Korea Entertainment Industry Association
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• v.15 no.4
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• pp.255-265
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• 2021

The purpose of this study was to examine the effects of Kahoot!(Game-based Student Response System) on nursing education. This study used an one group Pretest-posttest design. Participants were 179 nursing students from one D university located in Gwangju, Korea. The Kahoot!(Game-based Student Response System) was provided for 6 times. Data were collected between August 26 and October 25, 2019. The collected data was analyzed by descriptive statistics, paired t-test, pearson's correlation coefficient and stepwise multiple regression using IBM SPSS 21.0 program. The results showed that learning engagement(t=-6.257, p=.000) was significantly higher than levels before Kahoot!(Game-based Student Response System), critical thinking disposition(t=-2.163, p=.032) was significantly higher than levels before Kahoot!(Game-based Student Response System), problem solving ability(t=-3.032, p=.003) was significantly higher than levels before Kahoot!(Game-based Student Response System). Significant relationships were found among learning engagement(r=.375, p=.000), critical thinking disposition(r=.286, p=.000), problem solving ability(r=.291, p=.000) and learning satisfaction. The results of stepwise multiple regression indicates that learning engagement(β=.307, p=.000), problem solving ability(β=.158, p=.041) predicts 15.2% in learning satisfaction(F=16.905, p=.000). In conclusion, Kahoot!(Game-based Student Response System) is effective in improving learning engagement and problem solving ability to nursing education.

• Journal of Convergence for Information Technology
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• v.10 no.10
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• pp.100-108
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• 2020

The purpose of this study is to identify the differences in self-efficacy, clinical performance ability, and critical thinking disposition after applying education integrated educational virtual reality simulation to training and outside school clinical practice to nursing college students and to provide them as basic data for effective practical education. This study was conducted from June 8 to July 3, 2020, and enrolled in the 3rd year of university in G city, and 30 subjects who did not receive virtual reality simulation training or outside school clinical training at all. Data were analyzed by Paired t-test. As a result of the study, the result of pretest and posttest to each group showed statistically significant improvements in self-efficacy, clinical performance ability, and critical thinking disposition. As a results of the study, education integrating virtual reality simulation training and clinical practice for nursing students to improves clinical performance ability, improves critical thinking, and self-efficacy, so it is thought that various virtual reality simulation training must be suitable for clinical situations before practice is necessary.

• Journal of the Korean School Mathematics Society
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• v.9 no.1
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• pp.1-17
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• 2006

This thesis analyzed the effects of cooperative learning blended with TAI(Team Assisted Individualization) and STAD(Student Team Achievement Division) models on the students' ability of problem solving in mathematics in order to discover what kind of effects would give to their ability of that, and would promote their disposition and attitude to learn mathematics. The results of this study were as follows : First, the learning method blended with TAI and STAD models was more effective in the students' ability of problem solving in mathematics than traditional learning method because of the blended model's characteristics; positive interdependence, individual accountability, team recognition, curriculum materials. Second, the learning method blended with TAI and STAD models was more effective in sub-elements - self-confidence, adaptability, will, curiosity and value - of mathematical disposition than traditional learning method. And the learning method blended with TAI and STAD models was more effective in sub-elements - self-consciousness of mathematics and interests - of mathematical attitude than traditional learning method. In conclusion, the learning method blended with TAI and STAD models could affect to not only the students' ability of problem solving in mathematics but also the students' several affective factors.

• Journal of Pharmaceutical Investigation
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• v.37 no.5
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• pp.297-303
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• 2007

The purposes of this study were to clarify the involvement of P-glycoprotein (P-gp) in the efflux of levosulpiride in knockout mice that lack the mdr1a1b gene and to evaluate the relationship between the genetic polymorphisms in MDR1 gene (exon 21) and levosulpiride disposition in healthy Korean subjects. After oral administration ($10\;{\mu}g/g$) of levosulpiride to mdr1a/1b(-/-) and wild-type mice, plasma and brain samples were obtained at 45 min. We also investigated the genotype for MDR1 (exon 21) gene in humans using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A single oral dose of 25 mg levosulpiride was administered to 58 healthy subjects, who were based on the MDR1 genotype for the G2677T SNP. Blood samples were taken up to 36 hr after dosing. The concentrations of levosulpiride in mouse plasma and brain were statistically significant difference between the two animal groups (P<0.05). In addition, the average brain-to-plasma concentration ratio (Kp) of levosulpiride was 3.4-fold (P<0.01) higher in the mdr1a/1b(-/-) mice compared with the wild-type mice. We also found that the values of $AUC_{0-{\infty}$, partial AUC ($AUC_{0-4h}$) and $C_{max}$ were significantly different between homozygous 2677TT subjects and the subjects with at least one wild-type allele (GG and GT subjects, P=0.012 for $AUC_{0-{\infty}$; P=0.008 for $AUC_{0-4h}$; P=0.038 for $C_{max}$). The results confirm that levosulpiride is a P-gp substrate in vivo, and clearly demonstrate the effect of SNP 2677G>T in exon 21 of the MDR1 gene on levosulpiride disposition.

• YAKHAK HOEJI
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• v.39 no.6
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• pp.636-644
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• 1995

Comparison of bioavailabflity (BA) of three brands of ranitidine (RT) tablets has been studied m rats. The purpose of this study was to characterize the pharniacolunetics of RT tablets in the rat and to coinpare phannacolunetic parameters of three brands of RT tablets. In addition, it was investigated whether plasma RT concentrations m humans can be predicted from pharmacokinetic parameters obtained in rats. RT was administered intravenously in dose of RT.HCI 10mg/kg and orally in dose of RT.HCI 50mg/kg as solution or crushed sample of thablets. Plasma RT concentrations were determned by HPLC. Plasma RT concentrations as a function of time were fitted to two compartment model. Plasma RT concentrations declined with a terminal half life ($t_{{1}/2{\betha}}$) of 40.9 min. The plasma RT concentration-time curve showed two peak plasma concentrations following an oral administration of solution or crushed sample in rats like humans. No significant difference among pharmacokinetic parameters was observed except $T_{max2}$ (p<0.05). The BA for crushed sample A, B and C were found to be 54.6 40.7 and 40.0%, respectively. Equivalence of $C_{max1}$ and $T_{max2}$ were guaranteed in this study. However, it was concluded that three brands of RT tablets are bioequivalent, taking the following characteristics of RT into consideration;(1) rapid onset of the effect is not required, (2) $C_{max1}$ and $T_{max2}$ do not seem to influence the effectiveness of the drug during a long-term treatment by the usual administration of twice a day. Results from this study were combined with plarmacokinetic data for RT in dogs and humans to develop a basis for interspecies scale-up of the disposition characteristics of the drug. there were similarities in the general disposition of the drug. Allometric relationships were sought between pharmacokinetic parameters nd species body weight. Significant interspecies correlations were found for total body clearance($Cl_{t}$) and steady state volume of distribution ($Bd_{ss}$). Thus, plasma RT concentrations in humans can be predicted from pharmacokinetic parameters obtained in rats.

• Journal of the Korean Applied Science and Technology
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• v.35 no.4
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• pp.1359-1368
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• 2018

The purpose of this study was to identify factors related to clinical competence of nursing students and to contribute to the education plan of the undergraduate course for the enhancement of clinical competence. The subjects of the study were 227 students in the 4th grade in the college of nursing. Clinical competence based on the general characteristics of the subject, critical thinking disposition, and core basic nursing skills achievement was conducted by an independent t-test, pearson's corelation coefficient, and linear regression model was used for statistical analysis to investigate factors influencing clinical competence. The results showed that intellectual fairness of critical thinking, achievement in middle and low level of core basic nursing skills had an effect on nursing students' clinical competence, and the higher score had the better clinical competence. Based on the results of this study, it is necessary to improve intellectual fairness and core basic nursing achievement of nursing students and to prepare an educational program to develop the achievement of high level.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.613-621
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• 2021

The purpose of this study was conducted to provide emergency nursing class using evidence-based practice (EBP) and to examine its effects. This study was a one-group pretest-posttest experimental design. Data were collected from 54 students in the third year of nursing at a university, between September 2, 2019 and December 9, 2019. An emergency nursing class using EBP consisting of 5-step EBP components was provided through 13 sessions. Lectures, team-based learning, and case-based learning were provided. Data were analyzed using SPSS/WIN 21.0 program with descriptive statistics and paired t-test. After the class, there were significant increase in EBP beliefs (t=-2.76, p=.008) and EBP competency (t=-5.035, p<.001). However, critical thinking disposition was not significantly increased. The findings indicate that emergency nursing classes using evidence-based practice is an efficient teaching-learning method to improve EBP beliefs and competency.

• Journal of Pharmaceutical Investigation
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• v.40 no.5
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• pp.269-275
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• 2010

P-gp plays a critical role in drug disposition and represents a mechanism for the development of multidrug resistance. Flavonoids, a major class of natural compounds widely present in foods and herbal products, have been shown to inhibit P-gp. Therefore, the aim of this study was to identify new candidate chemosensitizers by screening various plant extracts. The ability of natural plant extracts to inhibit P-gp activity was assessed by measuring cellular accumulation of calcein AM, daunorubicin and vincristine in P-gp overexpressing MDCKII-MDR1 cells. Among more than 800 plant extracts, eight were found to inhibit P-gp activity. Curcuma aromatica extract produced greatest inhibition, followed by Curcuma longa and Dalbergia odorifera extracts. Extracts of Aloe ferox, Curcuma zedoariae rhizome, Zanthoxylum planispinum, and Ageratum conyzoides showed moderate inhibitory effects. Curcumin and quercetin exhibited similar inhibition of P-gpmediated efflux of daunorubicin and vincristine, and flavones had a lesser effect. When chemosensitizing effect was evaluated by measuring daunorubicin sensitivity to MDCKII-MDR1 cells in the presence of natural plant extracts, Curcuma aromatica showed the most potent chemosensitizing effect based on daunorubicin cytotoxicity. In conclusion, natural plant extracts such as Curcuma aromatica can potently inhibit P-gp activity and may have potential as a novel chemosensitizers.