• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.2
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• pp.104-119
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• 2013

Purpose: The purpose of this study is to recognize menstrual pattern, stress, digestive disorder of female college students who have oligomenorrhea and effects of Gamiguibi-tang. Methods: We researched 30 female students who responded to have menstrual irregulation at ${\bigcirc}{\bigcirc}$ college by questionnaires investigating their menstruation, stress, digestive disorder, and changes of symptoms before and after taking Gamiguibi-tang. Results: 1. There was statistical correlation between menstrual pattern and Qi-Stasis Questionnaire symptoms. 2. There was statistical correlation between menstrual pattern and digestive disorder symptoms. 3. There was statistical correlation between improvement of Qi-Stasis Questionnaire symptoms and usage of Gamiguibi-tang. 4. There was statistical correlation between improvement of digestive disorder symptoms and usage of Gamiguibi-tang. Conclusions: This study showed the stress and digestive disorder symptoms are effectively relieved by Gamiguibi-tang. By this result we expect that Gamiguibi-tang can be used for oligomenorrhea caused by stress or digestive disorder.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.3
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• pp.106-123
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• 2016

Objectives: This study aimed to verify the classification of atopic dermatitis into the digestive and respiratory disorder on the basis of a literature study.Methods: We searched for the term "atopic dermatitis" in KISS, RISS, NDSL, DBPIA, and OASIS. On further filtering the searched paper further by including the terms "Korean medicine", "literature study" and excluding "acupuncture", we found eight papers relevant to the literature study of atopic dermatitis. The reviewed papers included keywords of Oriental medicine such as Sub-yeol (濕熱), Bi-heo (脾虛), Poong-sub (風濕), Hyeol-heo (血虛). We classified keywords as "digestive system" or "respiratory system" and compared the clinical symptoms of classified Each category keywords.Results: Atopic dermatitis was classified into four categories : acute digestive disorder, chronic digestive disorder, acute respiratory disorder, and chronic respiratory disorder. The four categories of atopic dermatitis showed differences based on region, dermal symptoms, associated symptoms, and affected age group.Conclusions and Discussions: This study suggests a new theory of Atopic dermatitis classification. The theory is similar to that stated in former classification; however, it focuses on the digestive and respiratory disroder. All of atopic dermatitis into digestive disorder show both digestive symptoms and dermal symptoms. However, atopic dermatitis into respiratory disorder shows only respiratory symptoms. Thus, this study can establish a relationship between Western and Oriental medicine's study of atopic dermatitis using keywords such as "digestive disorder" and "respiratory disorder".

• Journal of Society of Preventive Korean Medicine
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• v.11 no.2
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• pp.41-70
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• 2007

The purpose of this study was to identify a tendency in patients who seek oriental medical service and factors influencing patient satisfaction. The study was conducted with 1,520 residents of a community during the period from February 5, 2005 through June 30, 2005 using a questionnaire. This study results are summarized as follows : 1. Of subjects who sought oriental medical service, 66.2% had musculoskeletal disorder and connective tissue disease, 18.9% had digestive tract disease, 16.4% had respiratory disease, 8.2% had endocrinemetabolic disease, 7.5% had circulatory disease and the remaining subjects had other diseases(p<0.001). 2. Of subjects who sought oriental medical service for the treatment of musculoskeletal disorder, 84.9% preferred acupuncture. Of those who had digestive tract diseases, 47.0% preferred packaged herbal medicine. Of those who had respiratory disease, 63.0% preferred packaged herbal medicine. 3. Acupuncture was the most often sought by subjects with musculoskeletal disorder. Packaged herbal medicine was sought by subjects with respiratory disease, digestive tract disease, endocrine-metabolic disease or circulatory disease. Tablet-type herbal medicine was sought by subjects with musculoskeletal disorder or digestive tract disease. Combined therapy was sought by subjects with musculoskeletal disorder, digestive tract disease, hematopoietic disease or immune disorder. 4. The level of satisfaction with oriental medical service was higher in subjects with circulatory disease, subjects with digestive tract disease, subjects with neurological disorder and subjects with musculoskeletal disorder in descending order. Of total subjects, 39.4% experienced side effects of oriental medical care, 38.1% experienced side effects of herbal medicine. About 51.9% considered the price of herbal medicine costly while 23.2% considered it reasonable. 5. Subjects' knowledge of herbal medicine was measured as $29.2{\pm}3.83$ out of 42 scores or 69 out of 100 points, indicating a low knowledge level. Subjects' knowledge was influenced by occupation, religion, side effects, sex, age, residence area, the type of insurance. These variables explained 15.2% of the variance. 7. Of total subjects, 56.8% were satisfied with oriental medical service. Patient satisfaction varied with occupation, religion, the type of insurance, health state and treatment outcomes. These variables explained 37.3% of the variance. Conclusion : The majority of subjects were satisfied with oriental medical service. However, oriental medical care are not widely used to treat all kinds of diseases while its use skews to a small categories of diseases. It is therefore necessary for the government and oriental medical service providers to develop new therapy approaches for the treatment of a broader range of diseases.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.4
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• pp.50-56
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• 2013

Objectives The purpose of this study is to evaluate the effect of the herbal medicine in treating digestive system problem on children's growth. Methods We studied 135 children who visited ${\bigcirc}{\bigcirc}$ oriental medical hospital to treat digestive system problem from March 2010 to February 2012. We measured their height and body weight on their first time visit and a year later. We compared them using the Growth Statistics Curve made by the Korean Association of Pediatrics, 2007. Results Generally, total children's average height and weight were significantly increased after the herbal medicine. The difference between the height and weight of treated children and the average height and weight was significant. Conclusions Herbal medicine to treat disorder of digestive system helped growth of children.

• Preventive Nutrition and Food Science
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• v.18 no.2
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• pp.104-110
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• 2013

Presence of Helicobacter pylori is associated with an increased risk of developing upper gastrointestinal tract diseases. Antibiotic therapy and a combination of two or three drugs have been widely used to eradicate H. pylori infections. Due to antibiotic resistant drugs, new drug resources are needed such as plants which contain antibacterial compounds. The aim of this study was to investigate the ability of GutGard$^{TM}$ to inhibit H. pylori growth both in Mongolian gerbils and C57BL/6 mouse models. Male Mongolian gerbils were infected with the bacteria by intragastric inoculation ($2{\times}10^9$ CFU/gerbil) 3 times over 5 days and then orally treated once daily 6 times/week for 8 weeks with 15, 30 and 60 mg/kg GutGard$^{TM}$. After the final administration, biopsy samples of the gastric mucosa were assayed for bacterial identification via urease, catalase and ELISA assays as well as immunohistochemistry (IHC). In the Mongolian gerbil model, IHC and ELISA assays revealed that GutGard$^{TM}$ inhibited H. pylori colonization in gastric mucosa in a dose dependent manner. The anti-H. pylori effects of GutGard$^{TM}$ in H. pylori-infected C57BL/6 mice were also examined. We found that treatment with 25 mg/kg GutGard$^{TM}$ significantly reduced H. pylori colonization in mice gastric mucosa. Our results suggest that GutGard$^{TM}$ may be useful as an agent to prevent H. pylori infection.

• Korean Journal of Health Education and Promotion
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• v.21 no.1
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• pp.319-328
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• 2004

The purpose of this study was to examine the relation between thoracic scoliosis and gastroenteric disorder. In this article, We surveyed sixty two patients and investigated through a questionnaire the health and meal habits, digestive trouble levels, stress levels(BEPSI-K), and the stress response index(SRI). Participants were classified according to each group in over $10^{\circ}$(vertebral scoliosis), under $10^{\circ}$(functional scoliosis) and made a diagnosis of X-ray of scoliosis grade. The data was took statistics on two group by independent t-test, chi-square test with SPSS/PC+ 10.0 program. The statistically significance was a p＜.05 and the following results were obtained； 1. In general characteristics, The thoracic scoliosis was as many as women, weight 50∼60kg, height 160∼170cm, married person. 2. Relations between health and meal habit with thoracic scoliosis was not statistically significant(p＞.05). 3. Relations between thoracic scoliosis and digestive trouble level was statistically significance (p＜.05). 4. Relations between thoracic scoliosis and incidence rate of internal disease was statistically significant(p＜.05). 5. Relations between thoracic scoliosis and stress(BEPSI-K) was statistically significant(p＜.05). 6. Relations between thoracic scoliosis and stress(SRI) was statistically significant(p＜.05). These results lead us to the conclusion that thoracic scoliosis influences digestive trouble, incidence rate of internal disease and stress. However, there results are not easy to explain because of the limitations of a few subjects and a single comparison. Therefore, further research on this study thoroughgoing inspection would clarify the association of thoracic scoliosis and gastroenteric disorders.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.8
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• pp.1072-1079
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• 2013

The NLRP12 (NLR family, pyrin domain containing 12) serves as a suppressor factor in the inflammatory response and protects the host against inflammation-induced damage. In the present study, we aimed to study the polymorphisms of NLRP12 gene and its association with susceptibility to non-specific digestive disorder (NSDD) in rabbits. We re-sequenced the entire coding region of the rabbit NLRP12 gene and detected a total of 19 SNPs containing 14 synonymous and five non-synonymous variations. Among them, the coding SNP (c.1682A>G), which would carry a potential functional implication, was subsequently subjected to genotyping for case-control association study (272 cases and 267 controls). The results revealed that allele A was significantly protective against NSDD with an odds ratio value of 0.884 (95% confidence interval, 0.788 to 0.993; p = 0.038). We also experimentally induced NSDD in growing rabbits by feeding a fibre-deficient diet and subsequently investigated NLRP12 mRNA expression. The mRNA expression of NLRP12 in healthy status was significantly higher than that in severe NSDD (p = 0.0016). The highest expression was observed in individuals carrying the protective genotype AA (p = 0.0108). These results suggested that NLRP12 was significantly associated with the NSDD in rabbits. However, the precise molecular mechanism of NLRP12 involving in the development of rabbit NSDD requires further research.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.12
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• pp.2076-2081
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• 2013

The objective of this study is to investigate the gastric emptying and gastrointestinal transit improvement effect of DL-methionine methylsulfonium chloride (MMSC) in functional dyspepsia animal models. Cisplatin causes nausea, vomiting, and inhibition of gastric emptying. Rats were divided into four groups: G1 (normal group), G2 (gastric emptying induced by cisplatin), G3 (gastric emptying induced by cisplatin with itopride 30 mg/kg pretreatment), and G4 (gastric emptying induced by cisplatin with MMSC 4 mg/kg pretreatment). Immediately after an oral administration of a liquid meal (phenol red), delayed gastric emptying was induced by cisplatin (10 mg/kg (i.p.)). After 20 min in the cisplatin administration, the animals were sacrificed. In rats treated with cisplatin, the gastric emptying rate was significantly reduced. On the other hand, MMSC reversed the reduction of gastric emptying induced by cisplatin. And also, MMSC caused to travel FITC-dextran more significantly longer distance than the control, which is based on the values of the mean geometric center in the atropine driven delayed gastrointestinal transit animal models. Furthermore, MMSC drastically increased the gastrointestinal transit in rats, considerably increased the values of the mean geometric center (MGC), compared to the control, which was comparable to that of mosapride. These results suggest that MMSC could be an effective component for the treatment of functional dyspepsia.

• The Journal of Internal Korean Medicine
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• v.44 no.6
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• pp.1109-1117
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• 2023

Tongue acupuncture is not only a body acupuncture treatment for the tongue but also a new microacupuncture treatment. Tongue acupuncture is a very promising treatment from a diagnostic and therapeutic point of view. According to several studies, Guan's tongue acupuncture and tri-tongue acupuncture are frequently used. Tongue acupuncture can be used for dysphagia, dysarthria, aphasia, insomnia, autism spectrum disorder, burning mouth syndrome, and cerebral palsy.

• Journal of Oriental Neuropsychiatry
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• v.13 no.2
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• pp.41-56
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• 2002

The Analysis of MMPI and Clinical Study was carried out the 28 patients with somatoform disorder and depressive disorder who were treated in Daejeon University Oriental Hospital from 19 June 2001 to 17 April 2002. The results were summarized as follows. 1. The ratio of female was higher, especially in the depressive disorder, the ratio of female was higher and in the age distribution, the 40 aged were higher frequence. 2. In the somatoform disorder, symptoms appeared to be busy in physical symptoms, and they were in descending order the digestive organs system, head and face portion and musculoskeletal system symptoms, in the depressive disorder, appeared to be busy in psychosomatic system symptoms and in the prescription drugs, soyosan(逍遙散), punsimkiyyin(分心氣飮) were used to be busy. 3. In the scales of L, F, K, somatoform disorder showed ${\wedge}$ typed graph, and depressive disorder showed ${\vee}$ typed graph. 4. In the somatoform disorder, scales of Hs, Hy, D, Pa were higher, and in the depressive disorder, scales of Hy, Hs, Pd, D were higher. 5. In the scales of Hs, D, Hy, somatoform disorder showed ${\vee}$ typed graph, and depressive disorder showed/typed graph. 6. the average of T-scores and the ratio over 65 score and 70 score showed common distribution.