• 한국실내디자인학회논문집
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• 제15권1호
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• pp.30-38
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• 2006

The new aspect of contemporary architectural design is the computer simulation of morphogenesis and evolution of the organic body. Morphogenesis and evolution is the kind of emergence that is the process of complex pattern formation from simpler rules in complex system. The development comprises the sequence of pattern formation, differentiation, morphogenesis, growth. This study analyzes the application methodology of various biomorphism in contemporary architecture. The methods of generative application by computation in architecture are self-organization, differentiation, growth algorithm via MoSS. And the methods of evolution by computation are genetic algorithm, multi-parameter in environments, phylogenetic cross-over, competing as natural selection, mutation+external constraints, generative algorithm+genetic algorithm via Genr8.

• 가정과삶의질연구
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• 제32권3호
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• pp.115-135
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• 2014

The purpose of this study was to develop a "Family Play Therapy Program" using puppets to decrease attachment problems for families with children having attachment problems and to examine its effectiveness. The participants were an experimental group of 16 individuals(8 children with attachment problems whose ages ranged from 4 to 5 and 8 mothers) and a control group of 16 individuals (8 children with attachment problems whose ages ranged from 4 to 5 and 8 mothers). The experimental group was treated through the Family Play Therapy Program, which involved the use of puppets and was held for twelve sessions twice a week. The changes in the participants were measured in order to examine the effects of the program. The researcher measured children's emotional and behavioral expression(TBP), the mothers' sense of self(Self-Differentiation Scale), personal relationships(ECR-R), and the perception of family functions(ICPS-FFS) both before and after the FPT program and compared their differences. The MIM Rating Scale and Marschak Behavior Rating Scale were administered to examine the interactions between mothers and children, and 1:1 interviews were also conducted. The data thus gathered were used for non-parametric analysis(Mann-Whitney U test and Wilcoxon rank sum test)using SPSS WIN 17.0. The results of this study were as follows: First, the program had a positive effect on children's emotional expression. After the problem were over, negative emotional and behavioral expression in the experimental group decreased. Second, the program had a positive effect on mothers' self-differentiation and personal relationships. Third, the program had a positive effect on changes in the interaction behaviors between the mother and child. Fourth, the program had a partially positive effect on the responses from their group developmental stages, especially on the subscale of both a program for the reinforcement of mothers' emotions and family play program utilizing puppets.

• BMB Reports
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• 제49권12호
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• pp.655-661
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• 2016

Polymer brush is a soft material unit tethered covalently on the surface of scaffolds. It can induce functional and structural modification of a substrate's properties. Such surface coating approach has attracted special attentions in the fields of stem cell biology, tissue engineering, and regenerative medicine due to facile fabrication, usability of various polymers, extracellular matrix (ECM)-like structural features, and in vivo stability. Here, we summarized polymer brush-based grafting approaches comparing self-assembled monolayer (SAM)-based coating method, in addition to physico-chemical characterization techniques for surfaces such as wettability, stiffness/elasticity, roughness, and chemical composition that can affect cell adhesion, differentiation, and proliferation. We also reviewed recent advancements in cell biological applications of polymer brushes by focusing on stem cell differentiation and 3D supports/implants for tissue formation. Understanding cell behaviors on polymer brushes in the scale of nanometer length can contribute to systematic understandings of cellular responses at the interface of polymers and scaffolds and their simultaneous effects on cell behaviors for promising platform designs.

• 수산해양교육연구
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• 제27권1호
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• pp.125-132
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• 2015

The purpose of this study was to search the concept and meaning of performance assessment(PA) in the classroom, and the to proposed some strategies to apply PA. The result of this study was presented below. First, differentiation strategy is necessary in the evaluation goal. Individualization will be an example of differentiation strategy in the evaluation of group goal. Second, various strategies are needed based on the subjects of evaluation. Self-evaluation, peer-evaluation, and small group-evaluation are some examples evaluation for the subjects. Third, there is a need for phase-strategy assessment. For the class associated performance assessment, we have to consider the evaluation activities based on the time likes before (pre), on, and after class. How to select the evaluation task is also one of the key sucess factors for improving the class associated performance assessment.

• IMMUNE NETWORK
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• 제11권6호
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• pp.336-341
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• 2011

T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection, should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg) development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.

• 한국실내디자인학회논문집
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• 제17권3호
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• pp.156-164
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• 2008

Through staggering advancements of technology and network as we know them as digital revolution, we have established a foundation of space in which we can express reality by eliminating the boundaries between expression, space, and movement. There are many ongoing approaches that aim to overcome the physically-fixed property of space where the mathematical-geometric notion of Voronoi Diagram is one of them. Although the repetitive increment based on self-organization during the process in which space is generated by the Voronoi Diagram forms a pattern and focuses on the formation, its pattern is not restricted to a single method of expression but evolves over self-control. The result of having analyzed spaces generated by the Voronoi Diagram in this study can be summarized as follows. First, the Voronoi computation method with self-organization property creates multiple levels, increments, and evolves through feedbacks among changes with the slightest order and in the absence of control. Secondly, after forming a pattern through such feedbacks comes the differentiation phase due to the presence of different properties. Thirdly, a space that has gone through the generation process retransforms through active interaction between changes and it obtains ambiguous boundaries and a repetitive pattern. This leads to an evolution of space through repetitive increments based on self-organization. Such flexible space creation is supported by various digital technologies where we believe a converging application of these studies, sciences, engineering concepts, and space design is and effective and new method in terms of space creation.

• Journal of information and communication convergence engineering
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• 제9권5호
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• pp.615-618
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• 2011

Living cells generate the cell cycle or apoptosis, depending on the course will be repeated. If an error occurs during this period of life in order to maintain the cells in the peripheral cells find the error portion. These cellular functions were applied to the system to simulate the circuit. Circuit implementation of the present study was constructed the redundant structure in order to found the error quickly. Self-repairing of digital systems as an advanced form of fault-tolerance has been increasingly receiving attention according as digital systems have been more and more complex and speed-up especially for urgent systems or those working on extreme environments such as deep sea and outer space. Simulating the process of cell differentiation algorithm was confirmed by the FPGA on the counter circuit. If an error occurs on the circuit where the error was quickly locate and repair. In this paper, we propose a novel self-repair architecture for fast and robust fault-recovery that can easily apply to real, complex digital systems. These Self-Repairing Algorithms make it possible for the application digital systems to be alive even though in very noisy and extreme environments.

• 한국경영과학회지
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• 제37권4호
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• pp.73-93
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• 2012

In recent years, service delivery systems employing a self-service approach have been rapidly spreading. Since a self-service system provides a lower product price, it attracts more customers. However, some system managers are still hesitant to accept a self-service system, because there is no systematic model to predict its performance. Therefore, this research attempts to provide a systematic and quantitative model to predict the performance of a self-service system, focused specifically on a self-service gas station. Under this model, the traditional queuing theory was adopted to describe the general self-service process, but it is also assumed that some changes occur in both the customer arrival rate and the service performance rate. In particular, the price elasticity was introduced to capture the change in the customer arrival rate, and the existence of learning effect and helpers were assumed to design the changed service performance rate. Under these assumptions, a simulation model for a self-service gas station is established, and three performance measurements, such as average number of customers, average waiting time, and Utilization are observed, depending on the changes in price difference and helper-operating time. In this research, the optimal operation strategy for price differentiation and helper-operating time is proposed in accordance with the level of the customer learning rate. Although this research confines the scope of the study to the self-service gas station model, the results of this research can be applied to any type of self-service system.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility
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• pp.177-177
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• 2006

• 생명과학회지
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• 제23권4호
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• pp.471-478
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• 2013

인체 중간엽 줄기세포는 다양한 세포로의 분화 및 자가증식 할 수 있는 능력뿐만 아니라 질병치료에 대한 치료적 잠재력을 가지고 있다. 줄기세포 분화의 분자 기작에 대한 이해는 줄기세포 이식의 치료 효능을 향상시킨다. 본 연구에는 인체 중간엽 줄기세포의 골분화에서 NFAT5의 역할을 밝혔다. 특이적 siRNA의 transfection으로 인한 NFAT5의 억제는 인체 중간엽 줄기세포의 골분화를 현저히 감소시켰으며, NF-${\kappa}B$ promoter 활성화 또한 세포의 증식이나 지방 세포로의 분화에 영향 없이 감소 시켰다. NFAT5의 발현 억제는 기본적으로 유도되는 NF-${\kappa}B$의 활성화와 TNF-${\alpha}$에 의해서 유도되는 NF-${\kappa}B$의 활성화를 감소시켰으나, TNF-${\alpha}$에 의해서 유도되는 NF-${\kappa}B$의 분해에는 아무런 영향을 주지 않았다. 이번 연구를 통해 NFAT5가 NF-${\kappa}B$ 경로를 조절함으로써 인체 중간엽 줄기 세포의 골분화에 아주 중요한 역할을 하는 것을 확인 할 수 있었다.