• Structural Engineering and Mechanics
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• 제51권2호
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• pp.277-297
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• 2014

Since the isolation bearings undergo large displacements in base-isolated structures, impact with adjacent structures is inevitable. Therefore, in this investigation, the effect of impact on seismic response of isolated structures mounted on double concave friction pendulum (DCFP) bearings subjected to near field ground motions is considered. A non-linear viscoelastic model of collision is used to simulate structural pounding more accurately. 2-, 4- and 8-story base-isolated buildings adjacent to fixed-base structures are modeled and the coupled differential equations of motion related to these isolated systems are solved in the MATLAB environment using the SIMULINK toolbox. The variation of seismic responses such as base shear, displacement in the isolation system and superstructure (top floor) is computed to study the impact condition. Also, the effects of variation of system parameters: isolation period, superstructure period, size of seismic gap between two structures, radius of curvature of the sliding surface and friction coefficient of isolator are contemplated in this study. It is concluded that the normalized base shear, bearing and top floor displacement increase due to impact with adjacent structure. When the distance between two structures decreases, the base shear and displacement increase comparing to no impact condition. Besides, the increase in friction coefficient difference also causes the normalized base shear and displacement in isolation system and superstructure increase in comparison with bi-linear hysteretic behavior of base isolation system. Totally, the comparison of results indicates that the changes in values of friction coefficient have more significant effects on 2-story building than 4- and 8-story buildings.

• Steel and Composite Structures
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• 제35권1호
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• pp.111-127
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• 2020

The goal of this study is to fill this apparent gap in the area about investigating the effect of porosity distributions on vibrational behavior of FG sectorial plates resting on a two-parameter elastic foundation. The response of the elastic medium is formulated by the Winkler/Pasternak model. The internal pores and graphene platelets (GPLs) are distributed in the matrix either uniformly or non-uniformly according to three different patterns. The model is proposed with material parameters varying in the thickness of plate to achieve graded distributions in both porosity and nanofillers. The elastic modulus of the nanocomposite is obtained by using Halpin-Tsai micromechanics model. The annular sector plate is assumed to be simply supported in the radial edges while any arbitrary boundary conditions are applied to the other two circular edges including simply supported, clamped and free. The 2-D differential quadrature method as an efficient and accurate numerical approach is used to discretize the governing equations and to implement the boundary conditions. The convergence of the method is demonstrated and to validate the results, comparisons are made between the present results and those reported by well-known references for special cases treated before, have confirmed accuracy and efficiency of the present approach. It is observed that the maximum vibration frequency obtained in the case of symmetric porosity and GPL distribution, while the minimum vibration frequency is obtained using uniform porosity distribution. Results show that for better understanding of mechanical behavior of nanocomposite plates, it is crucial to consider porosities inside the material structure.

• Geomechanics and Engineering
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• 제19권5호
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• pp.463-472
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• 2019

The mode perturbation method (MPM) is suitable and efficient for solving the eigenvalue problem of a nonuniform soil deposit whose property varies with depth. However, results of the MPM do not always converge to the exact solution, when the variation of soil deposit property is discontinuous. This discontinuity is typical because soil is usually made up of sedimentary layers of different geologic materials. Based on the energy integral of the variational principle, a new mode perturbation method, the energy-based mode perturbation method (EMPM), is proposed to address the convergence of the perturbation solution on the natural frequencies and the corresponding mode shapes and is able to find solution whether the soil properties are continuous or not. First, the variational principle is used to transform the variable coefficient differential equation into an equivalent energy integral equation. Then, the natural mode shapes of the uniform shear beam with same height and boundary conditions are used as Ritz function. The EMPM transforms the energy integral equation into a set of nonlinear algebraic equations which significantly simplifies the eigenvalue solution of the soil layer with variable properties. Finally, the accuracy and convergence of this new method are illustrated with two case study examples. Numerical results show that the EMPM is more accurate and convergent than the MPM. As for the mode shapes of the uniform shear beam included in the EMPM, the additional 8 modes of vibration are sufficient in engineering applications.

• 한국음향학회지
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• 제30권7호
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• pp.402-407
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• 2011

물리현상의 인과성에 대한 필요충분조건은 Kramers-Kr$\ddot{o}$nig (K-K) 관계식으로 표현된다. 음파에 대한 Kramers-Kr$\ddot{o}$nig 관계식은 음파의 위상속도 분산식과 감쇠계수 분산식 사이의 힐버트 변환 쌍으로 나타난다. 본 연구에서는 400 kHz-1.1 MHz의 고주파 영역에서 물이 찬 다공성 유리구슬 매질에서 측정된 p파 음속 및 감쇠계수를 Waters 등에 의해 얻어진 미분 형태의 Kramers-Kr$\ddot{o}$nig 관계식과 정량적으로 비교했다. 감쇠계수는 주파수의 거듭제곱형태를 따르며, 이때 실험값은 Kramers-Kr$\ddot{o}$nig 관계식과 비교적 정확히 일치한다.

• Bulletin of the Korean Chemical Society
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• 제32권12호
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• pp.4397-4402
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• 2011

The NF-${\kappa}B$ system of transcription factors plays a crucial role in inflammatory diseases, making it an important drug target. We combined quantitative structure activity relationships for predicting the activity of new compounds and quantitative dynamic models for the NF-${\kappa}B$ network with intracellular concentration models. GFA-MLR QSAR analysis was employed to determine the optimal QSAR equation. To validate the predictability of the $IKK{\beta}$ QSAR model for an external set of inhibitors, a set of ordinary differential equations and mass action kinetics were used for modeling the NF-${\kappa}B$ dynamic system. The reaction parameters were obtained from previously reported research. In the IKKb QSAR model, good cross-validated $q^2$ (0.782) and conventional $r^2$ (0.808) values demonstrated the correlation between the descriptors and each of their activities and reliably predicted the $IKK{\beta}$ activities. Using a developed simulation model of the NF-${\kappa}B$ signaling pathway, we demonstrated differences in $I{\kappa}B$ mRNA expression between normal and different inhibitory states. When the inhibition efficiency increased, inhibitor 1 (PS-1145) led to long-term oscillations. The combined computational modeling and NF-${\kappa}B$ dynamic simulations can be used to understand the inhibition mechanisms and thereby result in the design of mechanism-based inhibitors.

• 한국지반공학회지:지반
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• 제14권5호
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• pp.191-204
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• 1998

플라이 애쉬의 폐기물 매립장 대용 차수재로서의 적용성을 평가하기 위하여 실내 실험과 모델 연구를 실시하였다. 실제의 매립장 차수층이 불포화 상태일 수 있는 점을 고려하여, 대용 차수재와 기존의 점토 차수재에서의 포화 및 불포화 상태에서의 물 흐름 특성을 비교하였다. 차수층에서의 오염물 이동 특성을 연구하기 위하여 오염물을 이용한 회분실험을 실시하였으며, 이때 폐놀을 대표 오염물질로 사용하였다. 모델은 물질 수지에 기초하였으며, 유한 차분법과 predictor-corrector법을 이용한 수치 해법으로 풀었고, 연립 미분방정식을 다루는테는 sequential method를 이용했다. 연구 결과 대용 차수재는 기존 차수재보다 폐놀 차단 능력이 더 크고 또 불포화대에서의 차수능력도 더 크다는 것을 알 수 있었다. 또한, 본 연구에서 고려된 흐름조건에서는 차수층을 포화대로 해석할 경우 통과하는 물의 양이 약간 과소평가되고 폐놀 차단 능력은 매우 과소평가됨을 알 수 있었다.

• Structural Engineering and Mechanics
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• 제76권1호
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• pp.141-151
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• 2020

This manuscript tends to investigate influences of nanoscale and surface energy on a static bending and free vibration of piezoelectric perforated nanobeam structural element, for the first time. Nonlocal differential elasticity theory of Eringen is manipulated to depict the long-range atoms interactions, by imposing length scale parameter. Surface energy dominated in nanoscale structure, is included in the proposed model by using Gurtin-Murdoch model. The coupling effect between nonlocal elasticity and surface energy is included in the proposed model. Constitutive and governing equations of nonlocal-surface perforated Euler-Bernoulli nanobeam are derived by Hamilton's principle. The distribution of electric potential for the piezoelectric nanobeam model is assumed to vary as a combination of a cosine and linear variation, which satisfies the Maxwell's equation. The proposed model is solved numerically by using the finite-element method (FEM). The present model is validated by comparing the obtained results with previously published works. The detailed parametric study is presented to examine effects of the number of holes, perforation size, nonlocal parameter, surface energy, boundary conditions, and external electric voltage on the electro-mechanical behaviors of piezoelectric perforated nanobeams. It is found that the effect of surface stresses becomes more significant as the thickness decreases in the range of nanometers. The effect of number of holes becomes significant in the region 0.2 ≤ α ≤ 0.8. The current model can be used in design of perforated nano-electro-mechanical systems (PNEMS).

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5273-5278
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• 2015

Background: Chronic myeloid leukemia (CML) is a stem cell disorder characterized by the fusion of two oncogenes namely BCR and ABL with their aberrant expression. Autophosphorylation of BCR-ABL oncogenes results in proliferation of CML. The study deals with estimation of rate constant involved in each step of the cellular autophosphorylation process, which are consequently playing important roles in the proliferation of cancerous cells. Materials and Methods: A mathematical model was proposed for autophosphorylation of BCR-ABL oncogenes utilizing ordinary differential equations to enumerate the rate of change of each responsible system component. The major difficulty to model this process is the lack of experimental data, which are needed to estimate unknown model parameters. Initial concentration data of each substrate and product for BCR-ABL systems were collected from the reported literature. All parameters were optimized through time interval simulation using the fminsearch algorithm. Results: The rate of change versus time was estimated to indicate the role of each state variable that are crucial for the systems. The time wise change in concentration of substrate shows the convergence of each parameter in autophosphorylation process. Conclusions: The role of each constituent parameter and their relative time dependent variations in autophosphorylation process could be inferred.

• 대한토목학회논문집
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• 제6권2호
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• pp.121-131
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• 1986

?(warping)의 효과(効果)가 포함된 원형곡선부재(圓形曲線部材)의 부재강도(部材剛度)매트릭스를 미분방정식(微分方程式)의 해석적(解析的)인 해(解)를 사용(使用)하여 유도(誘導)하고, 원형곡선부재(圓形曲線部材)의 변위법(變位法)에 의(依)한 정적탄성해석방법(靜的彈性解析方法)을 제시(提示)하였다. 예제(例題)를 통하여 얻어진 결과(結果)는 다른 방법(方法)에 의(依)한 해석결과(解析結果)와 잘 일치(一致)하고 있어, 본(本) 논문(論文)의 정당성을 입증하였고 원형곡선부재(圓形曲線部材)로 구성(構成)된 구조물(構造物)을 해석(解析)할 때 곡선좌표계(曲線座標系)를 사용(使用)하므로써, 한 절점에 연결된 양쪽 부재축(部材軸)의 접선(接線)이 일치(一致)한다면, 국부좌표계(局部座標系)로부터 전체좌표계(全體座標系)로의 변환(變換)이 필요(必要)없음을 보였다. 본(本) 논문(論文)에서 유도(誘導)된 이론(理論)은 P.S. 상자형(箱子桁)의 폐단면(閉斷面) 또는 부재평면(部材平面)과 수직(垂直)인 축(軸)에 대하여 대칭인 개단면(開斷面)을 갖는 수평원형곡선부재(水平圓形曲線部材)로 이루어진 구조물(構造物)의 엄밀(嚴密)한 해석(解析)에 적용(適用)할 수 있다.

• Wind and Structures
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• 제25권2호
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• pp.131-156
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• 2017

This paper deals with the dynamic stability of embedded functionally graded (FG)-carbon nanotubes (CNTs)-reinforced micro cylindrical shells. The structure is subjected to harmonic non-uniform temperature distribution and 2D magnetic field. The CNT reinforcement is either uniformly distributed or FG along the thickness direction where the effective properties of nano-composite structure are estimated through Mixture low. The viscoelastic properties of structure are captured based on the Kelvin-Voigt theory. The surrounding viscoelastic medium is considered nonhomogeneous with the spring, orthotropic shear and damper constants. The material properties of cylindrical shell and the viscoelastic medium constants are assumed temperature-dependent. The first order shear deformation theory (FSDT) or Mindlin theory in conjunction with Hamilton's principle is utilized for deriving the motion equations where the size effects are considered based on Eringen's nonlocal theory. Based on differential quadrature (DQ) and Bolotin methods, the dynamic instability region (DIR) of structure is obtained for different boundary conditions. The effects of different parameters such as volume percent and distribution type of CNTs, mode number, viscoelastic medium type, temperature, boundary conditions, magnetic field, nonlocal parameter and structural damping constant are shown on the DIR of system. Numerical results indicate that the FGX distribution of CNTs is better than other considered cases. In addition, considering structural damping of system reduces the resonance frequency.