• 아동학회지
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• 제30권2호
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• pp.161-177
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• 2009

In this study of the relationship between preschoolers' visual perception and reading Hangul words, the 287 participants showed significant developmental change in visual perception between three to five years of age. The researcher developed the computer-based screening Test of Visual Perception for Reading (TVPR). Factor analysis confirmed three factors of TVPR : perception of number, direction, and form constancy. These factors correlated highly with four factors of motor-reduced visual perception of the Korean Developmental Test of Visual Perception (Moon et al. 2003). All factors of TVPR explained reading real words and pseudo words; direction and form constancy perception predicted reading low frequency letters. These findings confirm that preschoolers' skills in visual perception contribute to the reading of words in Hangul.

• Clinical and Experimental Pediatrics
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• 제51권9호
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• pp.935-943
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• 2008

Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder characterized by a persistent pattern of inattention and/or hyperactivity, as well as forgetfulness, poor impulse control or impulsivity, and distractibility. The recommended evaluation includes documenting the type and severity of ADHD symptoms, verifying the presence of normal vision and hearing, screening for comorbid psychological conditions, reviewing the child's developmental history and school performance, and applying objective measures of cognitive function. Prevailing opinion characterizes ADHD as a disorder of executive function attributable to abnormal dopamine transmission in the frontal lobes and frontostriatal circuitry. A clearly defined etiology remains unknown, but studies suggest a strong genetic link. The aim of treatment is to decrease symptoms, enhance functionality, and improve well-being for the child and his or her close contacts. Stimulants remain the pharmacological agents of first choice for the management of ADHD, and psychosocial, behavioral and educational strategies that enhance specific behaviors may improve educational and social functioning in children with ADHD.

• 부모자녀건강학회지
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• 제13권1호
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• pp.44-53
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• 2010

Purpose: This study was conducted to identify the educational needs of married immigrant women perceived by their home visiting educator. Methods: Data were collected using in-depth interviews and structured questionnaires during July 1st to 28th, 2009. 5 HVEs participated in focus group interview, and 27 HVEs in the questionnaire survey. Data were analyzed by content analysis and descriptive statistics using SPSS/WIN program. Results: Educational needs of Married Immigrant Women were conjugal and family relationship, child rearing and child health care, health management, sex education, and self-identification. There is no proper teaching materials about child rearing for HVEs. The educational needs of HVEs were physical and cognitive characteristics of child development, developmental screening skill and play according to the each developmental stages of the multi-cultural families. Conclusion: Family relationship, child rearing and child health care, must be stressed in educational program for Married Immigrant Women. To maximize the effectiveness of support for multi-cultural families, it must be developed a systematic educational program and teaching materials according to family developmental stages.

• The Journal of Korean Physical Therapy
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• 제32권1호
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• pp.44-51
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• 2020

Purpose: This study translated the developmental coordination disorder questionnaire'07 (DCDQ'07) into Korean and investigated the psychometric properties of the Korean DCDQ (DCDQ-K) using validation processes. Methods: The subjects were 300 parents with typically developing children aged 5-15 years (162 girls and 138 boys, mean age 9.24 years, SD 2.59) across the country. To develop the Korean DCDQ, a forward-backward-original author feedback-panel meeting-pilot study with parents was done. The internal consistency, test-retest reliability performed two weeks apart, content validity, discriminative validity, convergent validity, and constructive validity were examined with the pre-version of the DCDQ-K. Results: Approximately 15.33% of the subjects were probably shown DCD using DCDQ-K. Significant differences in age and province were observed in the DCDQ-K total score. The reliabilities and validities were good in the DCDQ-K. Conclusion: The DCDQ-K is a reasonable screening tool for DCD children.

• Asian-Australasian Journal of Animal Sciences
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• 제8권5호
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• pp.449-454
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• 1995

The present study was conducted to assess gene expression of bacterial lacZ driven by the SV40 promoter at early developmental stages of bovine embryos. The lacZ gene was linearized with BamHI digestion and introduced into the pronucleus by microinjection at 20 hrs after the commencement of in vitro fertilization. Intact bovine blastocysts were not stained with X-Gal, suggesting that there is no endogenous beta-galactosidase activity in these blastocysts. In contrast, the bovine blastocyst cells microinjected with the lacZ gene exerted a characteristic greenish-blue color originating from the bacterial beta-galactosidase activity, albeit at a low rate, i.e. 2.1% of the total fertilized oocytes injected. It was concluded, therefore, that the lacZ gene driven by the SV40 promoter could be used for an indirect screening method in which the presence of transgene is evaluated from the product of transgene expression.

• 음성과학
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• 제15권2호
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• pp.119-129
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• 2008

The purpose of this study were to develop short form versions of MacArthur-Bates Communicative Development Inventories - Korean and to discuss clinical implications. Two short versions were developed: one for $9\sim17$ month-olds(including 69 words and 17 object manipulation skills) and the other for $18\sim35$ month-olds (including 128 words and 5 grammatical items). Short versions seemed to be representative of full versions and showed developmental validity. Short versions showed concomitant validity with SELSI which is a standardized test for Korean children under 37 month-olds. Norm tables for words and criteria for object manipulation and grammaticality are also provided. M-B CDI-K short versions could be used as a preliminary screening tool to identify Korean children with language impairment economically and efficiently. Cautions using short versions of M-B CDI-K are discussed.

• Journal of Genetic Medicine
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• 제16권2호
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• pp.49-54
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• 2019

Purpose: Potocki-Lupski syndrome (PTLS), is a recently identified, rare genomic disorder. The patients are affected by infantile hypotonia, poor growth and developmental delay. Facial dysmorphism may not be obvious in some patients. PTLS is associated with microduplication at chromosome 17p11.2. In the current study, three Korean patients are reported with their clinical and genetic features. Materials and Methods: The clinical findings of each patient were reviewed. Karyotyping and multiplex ligation-dependent probe amplification (MLPA) analyses were done for genetic diagnoses. Results: All the patients did not have the characteristic dysmorphic features, such as broad forehead, triangular face, asymmetric smile and palpebral fissures. On the other hand, all three patients were affected by variable degree of developmental delay, poor oral intake, failure to thrive, and language development disorders. Chromosome 17p11.2 duplication was identified by conventional karyotyping analysis only in one patient, whereas the other confirmed by MLPA analyses. Conclusion: Delayed development was mostly commonly observed in our patients without distinct dysmorphic facial features. In this respect, genomic screening in patients with developmental delay would identify more cases with PTLS to understand their long-term clinical courses with the development of adequate psychological and rehabilitation education program.

• Reproductive and Developmental Biology
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• 제34권3호
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• pp.153-159
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• 2010

The 34 potently pig pheromonal odorants (1-32, 5755 & 7113) through structure-based virtual screening and ligand-based virtual screening method were selected and their ADMET and pharmacokinetics characters were evaluated and discussed quantitatively. The pheromonal odorants were projected on the following pre-calculated models, Caco-2 cell permeability, blood-brain barrier permeation, hERG inhibition and volume-distribution. From the results of in silico study, it is found that an optimal compound (31) either penetrating or have a little ($P_{caco2}$=-8.143) for Caco-2 cell permeability, moderate penetrating ability ($P_{BBB}$=0.082) for blood-brain barrier permeation, the low QT prolongation ($P_{hERG}$=1.137) for the hERG $K^+$ channel inhibition, and low distribution into tissues ($P_{VD}$=-5.468) for volume-distribution. Therefore, it is predicted that the compound (31) a topical application may be preferable from these based foundings.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제6권1호
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• pp.109-115
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• 1995

2세 10개월된 중증 정신지체아동의 이미증 치료에서 지시따르기 훈련을 통한 장난감 놀이지도(DRO)와 이미증 제재수단으로 얼굴가리개(Facial Screening)가 사용되었다. 이 아동의 이미증은 주로 손가락 빨기, 장난감 입에 넣고 빨기, 주위의 물건에 닥치는 대로 입을 대고 빠는 형태이다 빠는 행위의 발생은 장난감 놀이지도 전에는 15분 당 평균 18.6회였으나, 놀이지도 기간에는 평균 5.4회, 얼굴가리개를 통해 빠는 행위를 제재한 치료기간에는 평균 2.3회로 감소되어, 얼굴가리개의 사용이 이 아동의 이미증 치료에 큰 효과를 보였다. 이 아동은 이미증 이외에 구토행위를 보였는데, 본 연구에서는 구토행위를 치료하지 않았으나, 놀이지도 및 이미증 치료기간 동안 구토행위가 저절로 감소된 현상을 보인 것은 기존 연구에서 밝혀진 바와 같이 한 행동의 치료가 다른 문제행동의 감소에 영향을 줄 수 있음을 증명하고 있다.

• Biomolecules & Therapeutics
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• 제22권5호
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• pp.371-383
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• 2014

The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genetic, molecular, and cellular analysis of human disease-related genes. Recently, C. elegans has been used as an ideal model for the identification and functional analysis of drugs (or small-molecules) in vivo. In this review, we describe conserved oncogenic signaling pathways (Wnt, Notch, and Ras) and their potential roles in the development of cancer stem cells. During C. elegans germline development, these signaling pathways regulate multiple cellular processes such as germline stem cell niche specification, germline stem cell maintenance, and germ cell fate specification. Therefore, the aberrant regulations of these signaling pathways can cause either loss of germline stem cells or overproliferation of a specific cell type, resulting in sterility. This sterility phenotype allows us to identify drugs that can modulate the oncogenic signaling pathways directly or indirectly through a high-throughput screening. Current in vivo or in vitro screening methods are largely focused on the specific core signaling components. However, this phenotype-based screening will identify drugs that possibly target upstream or downstream of core signaling pathways as well as exclude toxic effects. Although phenotype-based drug screening is ideal, the identification of drug targets is a major challenge. We here introduce a new technique, called Drug Affinity Responsive Target Stability (DARTS). This innovative method is able to identify the target of the identified drug. Importantly, signaling pathways and their regulators in C. elegans are highly conserved in most vertebrates, including humans. Therefore, C. elegans will provide a great opportunity to identify therapeutic drugs and their targets, as well as to understand mechanisms underlying the formation of cancer.