• International Journal of Industrial Entomology and Biomaterials
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• v.27 no.1
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• pp.159-165
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• 2013

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor (TGF-${\beta}$) superfamily and are involved in osteoblastic differentiation. The largest TGF-${\beta}$ superfamily subgroup shares genetic homology with human BMPs (hBMPs) and silkworm decapentaplegic (dpp). In addition, hBMPs are functionally interchangeable with Drosophila dpp. Bombyx mori dpp may induce bone formation in mammalian cells. To test this hypothesis, we synthesized the 1,285-base pairs cDNA of full-length B. mori dpp using total RNAs obtained from the fat body of 3-day-old of the $5^{th}$ instar larvae and cloned the cDNA into the pCEP4 mammalian expression vector. Next, B. mori dpp was expressed in C3H10T1/2 cells. The target cells transfected with the pCEP4-Bm dpp plasmid showed biological functions similar to those of osteogenic differentiation induction growth factors such as hBMPs. We determined the relative mRNA expression rates of Runt-related transcription factor 2 (RUNX2), osterix, osteocalcin, and alkaline phosphatase (ALP) to validate the osteoblast-specific differentiation effects of B. mori dpp by performing quantitative real-time RT-PCR. Interestingly, mRNA expression levels of the 3 marker genes except RUNX2, in cells expressing B. mori dpp were much higher than those in control cells and C3H10T1/2 cells transfected with pCEP4. These results suggested that B. mori dpp signaling regulates osterix expression during osteogenic differentiation via RUNX2-independent mechanisms.

• Health Policy and Management
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• v.15 no.3
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• pp.1-16
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• 2005

This study was planned to investigate the relationship between development levels of learning organization and organization effectiveness in Hospital. Data were collected from 285 respondents who have participated in 'Learning Organization Project'(response rate =$50.5\%$). Structured questionnaire were applied by self administrated survey for two weeks since 2003 May. Main results were as follows; In the result of factor analysis, four factor were created and almost questionnaire items were classified into as same categories as theoretical concepts. Cronbach's a coefficient also showed over 0.7 in all categories. This result means that measurement tool to evaluate the development level of learning organization is valid and reliable. In the comparison of the development level of learning organization by participants' specialties, managerial workers perceived the lowest construction level, while medical technicians evaluated it as the highest level. In regression analysis, the perception levels of work environment, task and human aspect showed positive relationship with job competency significantly. For job satisfaction, levels of task and human aspects had positive relationship significantly. In addition, for organizational commitement, levels of organization and human aspect were positive predictors. Finally, for the satisfaction about experience of learning organization project, levels of environment, task and hmm aspects were related positively. We concluded from these result that the positive relationship between construction levels of learning organization and organization effectiveness was extended to hospital, besides industrial fields. We recommend the introduction and facilitation of learning organization project in various settings to improve the competency of knowledge management in individual and organizational levels.

• The Journal of the Korea Contents Association
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• v.20 no.1
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• pp.217-232
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• 2020

The purpose of this study is to organize prior research related to e-commerce activation factors available to stakeholders in the online distribution industry, and to conduct FGI with e-commerce experts to calculate the importance of each factor in order based on the 3 Level Service Model of Kwon Hyeog-in (2010), the key factors derived through the preceding study and the FGI were structured and the weighting of each factor was derived using AHP methodology. In the higher factors, the private sector (0.542) > communes (0.237) > public (0.2222) appeared to be important. Sub-factories included 'search service development' (0.0970)', 'recommendation service development (0.0805)', 'consumer needs analysis (0.0534)', 'consumer consumption pattern analysis (0.0505)' and 'other platform-linked service development (0.0450)', in the order of weighting down, indicating each of the factors within the top 15 priority. The results of this study will be utilized throughout the e-commerce industry as well as e-commerce enterprises, providing an academic foundation for the rapidly growing e-commerce ecosystem.

• Clinical and Experimental Reproductive Medicine
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• v.22 no.2
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• pp.163-170
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• 1995

Growth factors (GFs) produced by the embryo or by the maternal reproductive tract have been reported to regulate the embryonic development and differentiation. Among GFs, EGF as a mitogen plays a role in mitosis and functional differentiation of trophectoderm cells in mouse. The present study was carried out to investigate the effect of EGF on development of mouse embryos and to localize EGF in the mouse oocytes and embryos, which has been reported to be detected in the reproductive tract in mammals. To investigate the effect of EGF on the development of the embryo, mouse 2-cell embryos were cultured to blastocysts stage in Ham's F10 medium, treated with EGF(10-50 ng/ml) for 72 hrs. Immunocytochemistry was performed from oocyte to blastocyst stage with anti-EGF and anti-Mouse IgG, in order to determine the stage which EGF would be expressed in mouse. Exogenous EGF (more than 10 ng/ml) in the culture medium improved the developmental and hatching rates in the mouse embryos. As a result of immunocytochemistry, the embryonic EGF was expressed after the late 4-cell stage. EGF is thought to enhance preimplantation embryonic development and hatching. Exogenous EGF in the culture medium is thought to activate EGF receptor in the late 4-cell embryos and to enhance blastulation and hatching in mouse embryos. It is concluded that EGF enhances the developmental and hatching rates in the mouse embryos.

• International Area Studies Review
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• v.12 no.3
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• pp.269-291
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• 2008

MICE industry has been accepted as a growing and profitable tour market to improve profitability of vulnerable domestic tourism industry. To explore the influence of development factors of Korea MICE industry on authorities' role and ripple effects, this study examined the perception of MICE experts. The development factor were suggested to include 'marketing' and 'human resources' and the ripple effects were presented into two factors of economic and national promotion. The results reveal that marketing and human resources development had significant influence on authorities' role. The results also show that authorities' role had significant influence on ripple effects of economic and promotional effects.

• Communications of Mathematical Education
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• v.33 no.3
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• pp.255-273
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• 2019

In order to help students to understand the essence of prime concepts, this study looked at the history of prime concept development and analyzed how to introduce the concept of textbooks. In ancient Greece, primes were multiplicative atoms. At that time, the unit was not a number, but the development of decimal representations led to the integration of the unit into the number, which raised the issue of primality of 1. Based on the uniqueness of factorization into prime factor, 1 was excluded from the prime, and after that, the concept of prime of the atomic context and the irreducible concept of the divisor context are established. The history of the development of prime concepts clearly reveals that the fact that prime is the multiplicative atom is the essence of the concept. As a result of analyzing the textbooks, the textbook has problems of not introducing the concept essence by introducing the concept of prime into a shaped perspectives or using game, and the problem that the transition to analytic concept definition is radical after the introduction of the concept. Based on the results of the analysis, we have provided several pedagogical implications for helping to focus on a conceptual aspect of prime number.

• Journal of Climate Change Research
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• v.5 no.3
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• pp.189-197
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• 2014

Carbon footprint of apple was a sum of $CO_2$ emission in the step of manufacturing waste of agri-materials, and greenhouse gas emission during apple cultivation. Input amount of agri-materials was calculated on 2007 Income reference of Apple by Rural Development Administration. Emission factor of each agri- materials was based on domestic data and Ecoinvent data. $N_2O$ emission factor was based on 1996 IPCC guideline. Carbon dioxide was emitted 0.64 kg $CO_2$ to produce 1 kg apple fruit, and carbon dioxide was emitted 43.6% in the step of the manufacturing byproduct fertilizer, 1.3% in the step of the manufacturing single fertilizer, 4.7% in the step of the manufacturing composite fertilizer, 6.3% in the step of the manufacturing agri-chemicals, 14.6% in the step of the manufacturing fuel, 11.5% in the step of the fuel combustion, 17.7% of $N_2O$ emission by nitrogen application and 0.18% of disposal of agri-materials. It is needed for farmers to use fertilization recommendation based on soil testing (soil. rda.go.kr) because scientific fertilization is a major tools to reduce carbon dioxide of apple production. The fertilization recommendation could be also basic data in Measurable-ReporTablele-Verifiable (MRV) system for carbon footprint.

• Journal of People, Plants, and Environment
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• v.21 no.6
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• pp.461-471
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• 2018

The role of urban agriculture should not be limited as a small-scale crop cultivation activity as it was, but it has to be considered as an entire process of a agriculture activity for the restoration of the city community. This study is based on the assumption that there has been a significant change in urban lifestyle and urban farming preference, considering the overall improvement in standard of living after implementation of five day work week system. It was conducted for urban citizens who were interested in actual urban agriculture for ages 19 and over who visited the Korea Urban Agriculture Exhibition in 2018. Only 115 valid samples were used for the empirical analysis. To analyze the demographic characteristics and effects of urban agriculture, frequency analysis and descriptive statistics were conducted. In order to analyze the reliability and validity of the measurement variables of the effect, the variables that deteriorate the validity were removed and 15 variables of the urban agricultural effect were selected. According to the result of factor analysis, three factors were extracted as follows: socially sustainable effect, negative effect and economically sustainable effect. In order to examine the effects of urban agriculture depending on income level, the one-way ANOVA, which is a statistical technique for verifying differences in the sample means, was performed. The psychological stability of people, the recovery of humanity through communion with nature, and the vitalization of agriculture linked with local agriculture had significant correlations with income level. The negative effect showed no significant correlation with income level. The improvement of the local environment was found to have an impact in relation with income level. We expect that there will be more studies on policies for the new types and models of urban agriculture in order to make it easier for urban citizens to approach it.

• Journal of Technology Innovation
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• v.27 no.1
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• pp.79-100
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• 2019

Despite the importance of manufacturing to the national economy, the sharp decline in the share of employment is a common problem faced by developed countries, including Korea. In particular, science and technology jobs are important in terms of policy because they are directly related to the quality of employment and industrial competitiveness, but previous research on this is insignificant. This study analyzed the effects of new product development, new process development, open innovation, and government R&D support on science and technology job creation after subdividing manufacturing industry by technology regime. As a result of the analysis, it was confirmed that the development of new products contributed to the expansion of science and technology jobs, but the development of new processes decreased science and technology jobs. In addition, open innovation has the effect of reducing science and technology jobs due to outsourcing of research and development functions, and government R&D support contributes to creating science and technology jobs in traditional industries with low demand for technological innovation.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.604-610
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• 2021

Human capital is the defining value of the national economy under market conditions. The manifestation of human capital is realized as an intellectual and creative capital, theoretically grounded and proven. The realization of intellectual capital is realized through the research creativity of scientists and researchers, and creative capital is manifested through artists and thinkers. Accordingly, creativity in market conditions forms a separate source of income and is an essential article in the formation of the GDP of the national economy. This research aims to analyze human capital from the perspective of cultural and creative industries. Research methods: systematization; comparative analysis of individual indicators of advanced countries of the world on the training system; statistical, taking into account macroeconomic indicators to assess the level of national creativity potential; system and logical analysis; method of information synthesis. Research results. The structural and quantitative composition of the factors of intellectual and creative capital formation has been systematized. The article proves that the unique properties of human capital, knowledge, creativity, experience and professional skills are the push factors of creativity development of the national economy and provide the priority development of creative and cultural industry that allows generating the added value on the national scale. The functions of creativity in the sphere of cultural industries are highlighted. It is noted that education and creativity of both intellectual and creative capital are the forming basis. The research of the world's advanced countries on the creativity index has pointed out the Netherlands as the leading country in the quantitative measurement of creativity. The economic development factors of the Netherlands were analyzed from the position of economic creativity, which allowed the formation of a two-factor model providing priority development of creativity in the cultural and creative industries.