• Journal of Genetic Medicine
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• v.16 no.2
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• pp.49-54
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• 2019

Purpose: Potocki-Lupski syndrome (PTLS), is a recently identified, rare genomic disorder. The patients are affected by infantile hypotonia, poor growth and developmental delay. Facial dysmorphism may not be obvious in some patients. PTLS is associated with microduplication at chromosome 17p11.2. In the current study, three Korean patients are reported with their clinical and genetic features. Materials and Methods: The clinical findings of each patient were reviewed. Karyotyping and multiplex ligation-dependent probe amplification (MLPA) analyses were done for genetic diagnoses. Results: All the patients did not have the characteristic dysmorphic features, such as broad forehead, triangular face, asymmetric smile and palpebral fissures. On the other hand, all three patients were affected by variable degree of developmental delay, poor oral intake, failure to thrive, and language development disorders. Chromosome 17p11.2 duplication was identified by conventional karyotyping analysis only in one patient, whereas the other confirmed by MLPA analyses. Conclusion: Delayed development was mostly commonly observed in our patients without distinct dysmorphic facial features. In this respect, genomic screening in patients with developmental delay would identify more cases with PTLS to understand their long-term clinical courses with the development of adequate psychological and rehabilitation education program.

• Korean Journal of Construction Engineering and Management
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• v.14 no.4
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• pp.164-171
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• 2013

In urban planning, road facility is used not only for the transportation purpose but also for the utility line space purpose such as electrical, gas, tele communication, heating, water, sewer, and so on. However, since these utilities are built by many different groups, it becomes very difficult to communicate each other. Delay in one party can cause another party's schedule delay but they don't commuicate often. Also, some delay in utility work can cause frequent pavement cut. And, this will impact on construction cost, schedule delay, low quality, user complain and cost. This study developed spatiotemporal decision model to prevent prequent utility cut for mega project such as new urban development project. In addition, this study developed utility cut management system to manage utility cut schedule under pavement. Finally, developed system was applied to new urban development project and verified there effectiveness.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4339-4347
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• 2014

Purpose: This study aimed at exploring treatment delay (TD) among cancer patients in China with an attempt to develop a practical methodology facilitating frontline Chinese clinicians in promoting earlier cancer diagnosis and treatment. Materials and Methods: The study comprised framework development, qualitative interviews and paired factor rating. Framework development utilized systematic literature review, soft systems thinking and consensus groups. Qualitative interviews employed a checklist of open questions soliciting information about all the domains included the framework from cancer patients drawn via stratified randomized sampling of inpatients at 10 hospitals in Hefei, China. Paired factor rating used a self-developed computer aid and the interviewed patients as referring cases to weigh the relative importance of the factors listed in the framework in terms of their contributions to specific components of total delay (TD). Results: a) A conceptual framework was proposed consisting of a 6-step path to TD and 36 category determinants. b) A total of 227 patients were interviewed; their TD was 267.3 mean or 108 median days ranging from 0 to 2475 days; average appraisal, illness, behavioral, preparation and treatment delay accounted for 52.1%, 9.4%, 0.30%, 8.8% and 29.4% of the TD respectively. Individual side factors were rated substantially more important than environmental side factors (60% vs. 40%); most influential TD factors included cancer symptoms, overall health, family relations and knowledge about cancer and health. Conclusions: The framework proposed together with the interviewing and rating approaches used provide a potential new methodology for understanding cancer patients' TD and promoting earlier cancer treatment.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.33 no.1
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• pp.16-23
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• 2022

Objectives: Early detection of developmental issues in infants and necessary intervention are important. To identify the comorbid conditions, a comprehensive evaluation is required. The study's objectives were to 1) generate scale items by identifying and eliciting concepts relevant to young children (12-71 months) with developmental delays, 2) develop a comprehensive screening tool for developmental delay and comorbid conditions, and 3) assess the tool's validity and cut-off. Methods: Multidisciplinary experts devised the "Infant Comprehensive Evaluation for Neurodevelopmental Delay (ICEND)," an assessment method that comes in two versions depending on the age of the child: 12-36 months and 37-71 months, through monthly seminars and focused group interviews. The ICEND is composed of three parts: risk factors, resilience factors, and clinical scales. In parts 1 and 2, there were 41 caretakers responded to the questionnaires. Part 3 involved clinicians evaluating ten subscales using 98 and 114 questionnaires for younger and older versions, respectively. The Child Behavior Checklist, Strengths and Difficulties Questionnaire, Infant-Toddler Social Emotional Assessment, and Korean Developmental Screening Test for Infants and Children were employed to analyze concurrent validity with the ICEND. The analyses were performed on both typical and high-risk infants to identify concurrent validity, reliability, and cut-off scores. Results: A total of 296 people participated in the study, with 57 of them being high-risk (19.2%). The Cronbach's alpha was positive (0.533-0.928). In the majority of domains, the ICEND demonstrated a fair discriminatory ability, with a sensitivity of 0.5-0.7 and specificity 0.7-0.9. Conclusion: The ICEND is reliable and valid, indicating its potential as an auxiliary tool for assessing neurodevelopmental delay and comorbid conditions in children aged 12-36 months and 37-71 months.

• Journal of the Korea Society for Simulation
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• v.16 no.1
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• pp.1-9
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• 2007

The development of efficient Qualify of Service (QoS) routing algorithms in high speed networks is extremely difficult to achieve, because in order to operate, divergent services require various quality conditions. If the parameter of concern is to measure the delay on a specific link, the routing algorithm obtains the Least Delay (LD) path. Meanwhile, if the parameter is to measure the link cost, the Least Cost (LC) path is calculated. The Delay Constrained Least Cost (DCLC) path problem of the mixed issues on the LD and LC has been shown to be NP-hard. The path cost of LD path is relatively more expensive than that of the LC path, and the path delay of the LC path is relatively higher than that of the LD path in the DCLC problem. In this paper, we introduce the new factor for balancing cost and delay. The simulation result shows that our introduced factor is satisfied to solve the DCLC problem.

• Proceedings of the KSR Conference
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• 1999.05a
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• pp.25-32
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• 1999

Development of the personal rapid transit system is reviewed from its invention stage to its current development stage in the world. Also, the special features of each PRT system and the reasons of delay of PRT application in cities are described briefly.

• Korean Journal of Remote Sensing
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• v.22 no.3
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• pp.229-234
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• 2006

In tactical theater, it is crucial to detect ground moving targets and to locate them precisely. This problem can be resolved by using SAR (Synthetic Aperture Radar) sensors providing GMTI (Ground Moving Target Indication) capability. In general, to implement a robust GMTI sensor is not simple because of the strong competitions between target signals and clutter signals from the ground, and low speed of moving targets. Contrary to the case that a delay canceller is mostly suitable for ground surveillance radars, DPCA (Displaced Phase Centered Antenna) or STAP (Space Time Adaptive Processing) techniques have been widely adapted for GMTI function of modern airborne radars. In this paper, a new scheme of DPCA using two passive antennas with vertical separation is proposed, which also provides good clutter cancellation performance. The proposed scheme realizes full azimuth coverage for DPCA operation on an airborne platform, which is impossible with classical DPCA configuration. Simulations using various conditions have been performed to validate the proposed scheme, and the results are acceptable.

• Journal of Positioning, Navigation, and Timing
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• v.6 no.3
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• pp.125-133
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• 2017

Time comparison is necessary for the verification and synchronization of the clock. Two-way satellite time and frequency (TWSTFT) is a method for time comparison over long distances. This method includes errors such as atmospheric effects, satellite motion, and environmental conditions. Ionospheric delay is one of the significant time comparison error in case of the carrier-phase TWSTFT (TWCP). Global Ionosphere Map (GIM) from Center for Orbit Determination in Europe (CODE) is used to compare with Bernese. Thin shell model of the ionosphere is used for the calculation of the Ionosphere Pierce Point (IPP) between stations and a GEO satellite. Korea Research Institute of Standards and Science (KRISS) and Koganei (KGNI) stations are used, and the analysis is conducted at 29 January 2017. Vertical Total Electron Content (VTEC) which is generated by Bernese at the latitude and longitude of the receiver by processing a Receiver Independent Exchange (RINEX) observation file that is generated from the receiver has demonstrated adequacy by showing similar variation trends with the CODE GIM. Bernese also has showed the capability to produce high resolution IONosphere map EXchange (IONEX) data compared to the CODE GIM. At each station IPP, VTEC difference in two stations showed absolute maximum 3.3 and 2.3 Total Electron Content Unit (TECU) in Bernese and GIM, respectively. The ionospheric delay of the TWCP has showed maximum 5.69 and 2.54 ps from Bernese and CODE GIM, respectively. Bernese could correct up to 6.29 ps in ionospheric delay rather than using CODE GIM. The peak-to-peak value of the ionospheric delay for TWCP in Bernese is about 10 ps, and this has to be eliminated to get high precision TWCP results. The $10^{-16}$ level uncertainty of atomic clock corresponds to 10 ps for 1 day averaging time, so time synchronization performance needs less than 10 ps. Current time synchronization of a satellite and ground station is about 2 ns level, but the smaller required performance, like less than 1 ns, the better. In this perspective, since the ionospheric delay could exceed over 100 ps in a long baseline different from this short baseline case, the elimination of the ionospheric delay is thought to be important for more high precision time synchronization of a satellite and ground station. This paper showed detailed method how to eliminate ionospheric delay for TWCP, and a specific case is applied by using this technique. Anyone could apply this method to establish high precision TWCP capability, and it is possible to use other software such as GIPSYOASIS and GPSTk. This TWCP could be applied in the high precision atomic clocks and used in the ground stations of the future domestic satellite navigation system.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• v.y2005m4
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• pp.92-95
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• 2005

The present work has been developed the type of non-electric and delay explosive bolt which does not need power supply device and has the delay function in the operation of the explosive bolt. Separation device system could be minimized because of non-electric power supply system. In order to prove the mechanism of operation, the present work used to ignite the initiator the power of air resistance caused front aviation object. we can be founded from the present work that the changes in the operation load influence directly the ignition of the initiator. The design of non-electric and delay explosive bolt is the most suitable the separation system necessary to reduce the velocity of aviation object and safe landing of parachute system.

• Journal of Astronomy and Space Sciences
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• v.34 no.4
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• pp.281-288
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• 2017

The first Korea lunar orbiter, Korea Pathfinder Lunar Orbiter (KPLO), has been in development since 2016. After launch, the KPLO will execute several maneuvers to enter into the lunar mission orbit, and will then perform lunar science missions for one year. Among these maneuvers, the lunar orbit insertion (LOI) is the most critical maneuver because the KPLO will experience an extreme velocity change in the presence of the Moon's gravitational pull. However, the lunar orbiter may have a delayed LOI burn during operation due to hardware limitations and telemetry delays. This delayed burn could occur in different captured lunar orbits; in the worst case, the KPLO could fly away from the Moon. Therefore, in this study, the burn delay for the first LOI maneuver is analyzed to successfully enter the desired lunar orbit. Numerical simulations are performed to evaluate the difference between the desired and delayed lunar orbits due to a burn delay in the LOI maneuver. Based on this analysis, critical factors in the LOI maneuver, the periselene altitude and orbit period, are significantly changed and an additional delta-V in the second LOI maneuver is required as the delay burn interval increases to 10 min from the planned maneuver epoch.