• Bulletin of the Korean Mathematical Society
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• v.57 no.1
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• pp.51-68
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• 2020

In this paper, the author considers the nonparametric regression model with negatively orthant dependent random variables. The wavelet procedures are developed to estimate the regression function. For the wavelet estimator of unknown function g(·), the almost sure consistency is derived and the complete consistency is established under the mild conditions. Our results generalize and improve some known ones for independent random variables and dependent random variables.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.13-13
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• 2000

This paper considers delay-dependent guaranteed cost control for uncertain time-delay systems with norm-bounded parametric uncertainties. A new delay-dependent condition for the existence of the guaranteed cost control law is presented in terms of linear matrix inequalities (LMI). An algorithm involving convex optimization is proposed to design a controller which guarantees the suboptimal minimum of the guaranteed cost of the closed-loop system for all admissible uncertainties.

• Journal of the Korean Mathematical Society
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• v.56 no.5
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• pp.1247-1263
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• 2019

In ordered trees, two randomly chosen vertices are said to be dependent if one lies under the other. If not, we say that they are independent. We consider several classes of ordered trees with uniform updegree requirements and find the generating functions for the trees with two marked dependent/independent vertices. As a result, we compute the probability for two vertices being dependent/independent. We also count such trees by the distance between two independent vertices.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.546-551
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• 2001

We have previously shown that, in circular muscle cells of the lower esophageal sphincter (LES) isolated by enzymatic digestion, contraction in response to maximally effective doses of acetylcholine (ACh) or Inositol Triphosphate ($IP_3$) depends on the release of $Ca^{2+}$ from intracellular stores and activation of a $Ca6{2+}$-calmodulin (CaM)-dependent pathway. On the contrary, maintenance of LES tone, and response to low doses of ACh or $IP_3$ depend on a protein kinase C (PKC) mediated pathway. In the present investigation, we have examined requirements for $Ca6{2+}$ regulation of the interaction between CaM- and PKC-dependent pathways in LES contraction. Thapsigargin (TG) treatment for 30 min dose dependently reduced ACh-induced contraction of permeable LES cells in free $Ca6{2+}$ medium. ACh-induced contraction following the low level of reduction of $Ca6{2+}$ stores by a low dose of TG ($10^{-9}{\;}M$) was blocked by the CaM antagonist, CCS9343B but not by the PKC antagonists chelerythrine or H7, indicating that the contraction is CaM-dependent. After maximal reduction in intracellular $Ca{2+}$ from $Ca6{2+}$stores by TG ($10^{-6}{\;}M$), ACh-induced contraction was blocked by chelerythrine or H7, but not by CCS9343B, indicating that it is PKC-dependent. In normal $Ca^{2+}$medium, the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was also CaM-dependent, whereas the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was PKC-dependent. We examined whether PKC activation was inhibited by activated CaM. CCS 7343B Inhibited the CaM-induced contraction, but did not inhibit the DAC-induced contraction. CaM inhibited the DAC-induced contraction in the presence of CCS 9343B. This inhibition by CaM was $Ca{2+}$dependent. These data are consistent with the view that the switch from a PKC-dependent pathway to a CaM dependent pathway can occur and can be regulated by cytosolic $Ca{2+}$ in the LES.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.1
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• pp.15-22
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• 2009

This study was undertaken to elucidate the underlying mechanisms of ATP depletion-induced membrane transport dysfunction and cell death in renal proximal tubular cells. ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide(KCN)/0.1 mM iodoacetic acid(IAA), and membrane transport function and cell viability were evaluated by measuring $Na^+$-dependent phosphate uptake and trypan blue exclusion, respectively. ATP depletion resulted in a decrease in $Na^+$-dependent phosphate uptake and cell viability in a time-dependent manner. ATP depletion inhibited $Na^+$-dependent phosphate uptake in cells, when treated with 2 mM ouabain, a $Na^+$ pump-specific inhibitor, suggesting that ATP depletion impairs membrane transport functional integrity. Alterations in $Na^+$-dependent phosphate uptake and cell viability induced by ATP depletion were prevented by the hydrogen peroxide scavenger such as catalase and the hydroxyl radical scavengers(dimethylthiourea and thiourea), and amino acids(glycine and alanine). ATP depletion caused arachidonic acid release and increased mRNA levels of cytosolic phospholipase $A_2(cPLA_2)$. The ATP depletion-dependent arachidonic acid release was inhibited by $cPLA_2$ specific inhibitor $AACOCF_3$. ATP depletion-induced alterations in $Na^+$-dependent phosphate uptake and cell viability were prevented by $AACOCF_3$. Inhibition of $Na^+$-dependent phosphate uptake by ATP depletion was prevented by antipain and leupetin, serine/cysteine protease inhibitors, whereas ATP depletion-induced cell death was not altered by these agents. These results indicate that ATP depletion-induced alterations in membrane transport function and cell viability are due to reactive oxygen species generation and $cPLA_2$ activation in renal proximal tubular cells. In addition, the present data suggest that serine/cysteine proteases play an important role in membrane transport dysfunction, but not cell death, induced by ATP depletion.

• Journal of the Korea Concrete Institute
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• v.18 no.4 s.94
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• pp.479-487
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• 2006

This paper deals with a research about the time-dependent behavior analysis for pre-tensioned high-performance concrete(HPC) members. By improving AASHTO-LRFD(2004) method for predicting the creep and shrinkage of normal concrete, and the relaxation of prestressing tendon, a time-dependent behavior analysis of high-performance concrete structures has been introduced. Two methods, the step-function method and the time-step method have been incorporated in the time-dependent analysis. The developed program can predict the initial and time-dependent losses of prestressing forces and the deflections of high-performance concrete structures. The present model has been verified by comparing with the experimental results from the test of time-dependent behaviors of pre-tensioned members using high-performance concrete. From this, the current model gives good relations with the experimental results, but the AASHTO method is not good for the prediction of time-dependent behaviors of high-performance concrete members.

• Journal of the Korean Home Economics Association
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• v.44 no.7 s.221
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• pp.177-188
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• 2006

This study evaluated 26 elderly residents living independently in 4 group homes for their abilities in daily living and analyzed their behaviors of space occupancy and activities of daily living. The aim of the study was to identify the relationships between the physical environments of the group homes and the daily activities of the residents. The results of this study are summarized as follows. 1) Most residents in the group home considered bathing and cooking to be the most difficult of their living activities. The residents were categorized into "Independent," "Semi-dependent" and "Dependent" groups, on the basis of their ADL and IADL scores, and individual groups were examined. On ADL scorelt was shown, then, that 65.4% of the residents were was independent in ADL, but there was no any significant difference in IADL between the independent, semi-dependent and dependent groups. In addition, there was a difference in ADL and IADL among the groups. The independent group's residents were shown to be independent in ADL and IADL, whereas the but those of the semi-dependent and dependent groups' residents were lower in IADL than in ADL. 2) When their behaviors of space occupancy were examined, it appeared that the independent group showed a different space sharing pattern among individual residents, with a wide range of behavior of space occupancy. Meanwhile, The semi-dependent group mostly shared a common space with simple activities of daily living while no any service low leisure program was provided. However, the dependent group mainly consisted of residents who had a low level of independence in ADL and IADL, so that their behaviors of space occupancy were entirely negative.

• Journal of KIISE:Information Networking
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• v.30 no.2
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• pp.167-178
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• 2003

In mobile computing environments, queries based on the location of mobile clients (MCs) may cause different results. We say that the data of these results are location dependent data (LDD). Location-dependent queries to LDD need to be processed in conjunction with the geographical distance. The efficiency of query processing may also be increased by LDD relationship, etc. But there is the problem of fuzziness about how the distance used in location-dependent queries is evaluated and the data regions are organized. In this paper, we quantify the fuzziness of a location-dependent fuery on LDD. And we propose data regions for LDD, called LDD regions, by relationship of accessed data and the degree of distance between data objects and MCs' locations. In simulation studies we show that the number of database access for location-dependent queries, which have several settings on MCs' favor and two granularity of regions, can be smaller in proposed LDD regions than that in geographical regions.

• Industrial Engineering and Management Systems
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• v.4 no.1
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• pp.1-22
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• 2005

This paper presents new scheduling heuristics, namely Mean Progressive Weighted Tardiness Estimator (MPWT) Heuristic Method and modified priority rules with sequence-dependent setup times consideration. These are designed to solve job shop scheduling problems with new performance measures - progressive weighted tardiness penalties. More realistic constraints, which are inter-machine overlapping sequence-dependent setup times, are considered. In real production environments, inter-machine overlapping sequence-dependent setups are significant. Therefore, modified scheduling generation algorithms of active and nondelay schedules for job shop problems with inter-machine overlapping sequence-dependent setup times are proposed in this paper. In addition, new customer-based measures of performance, which are total earliness and progressive weighted tardiness, and total progressive weighted tardiness, are proposed. The objective of the first experiment is to compare the proposed priority rules with the consideration of sequence-dependent setup times and the standard priority rules without setup times consideration. The results indicate that the proposed priority rules with setup times consideration are superior to the standard priority rules without the consideration of setup times. From the second experiment and the third experiment to compare the proposed MPWT heuristic approach with the efficient priority rules with setup times consideration, the MPWT heuristic method is significantly superior to the Batched Apparent Tardiness Cost with Sequence-dependent Setups (BATCS) rule, and other priority rules based on total earliness and progressive weighted tardiness, and total earliness and tardiness.

• Journal of the Korean Statistical Society
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• v.29 no.1
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• pp.9-16
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• 2000

This article addresses the problem of maximum likelihood estimation in ARCH regression with lagged dependent variables. Some topics in asymptotics of the model such as uniform expansion of likelihood function and construction of a class of MLE are discussed, and the regularity property of MLE is obtained. The error process here is possibly non-Gaussian.