• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.200-205
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• 2004

Uterine leiomyoma is the most common tumor in the female genital tract. Although the tumor is benign, it is of paramount importance since it often causes profuse menstrual bleeding, pressure symptoms, and infertility. Nevertheless, the etiology and patholphysiology of this abnormality remain poorly understood. The traditional definitive treatment for uterine leiomyomas is hysterectomy and, even today, symptomatic leiomyomas are the leading cause of hysterectomy in Korea. Clearly, the development of a safe, effective, and nonsurgical method of treatment for leiomyoma would be of great benefit to many women. The present study was designed to investigate the effect of Rhubarb on apoptosis in uterine leiomyoma cells. Results demonstrate that Rhubarb inhibited cell growth in dose-dependent manner. Cell growth significantly decreased to 60% of control in the treatment of Rhubarb (300㎍/㎖). Associated with the decreased response, there was a concomitant and significant delay of subG1 8.32% above baseline in the treatment of Rhubarb (300㎍/㎖). The delay of subG1 showed a dose-dependent manner, as evidenced by the flow cytometry. The reduced cellular viability on exposure to Rhubarb may represent the induction of apoptosis, at least in part, as concomitantly evidenced by enhanced DNA fragmentation, PARP cleavage and caspase 9 and decreased pro-caspase 3. In addition, Rhubarb decreased clAP1 expression levels in dose-dependent manner. Talcen together, there results suggest that Rhubarb can produce a potent inhibition effect of apoptosis and implicate the delay of G1 phase in the cell cycle and pathways of caspase 3 and 9 in the mechanism underlying inhibitory apoptosis effect of Rhubarb.

• Journal of IKEEE
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• v.9 no.2 s.17
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• pp.123-135
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• 2005

3GPP RLC protocol specification adopted a window-controlled selective-repeat ARQ scheme for provisioning reliable data transmission. Inevitably, the re-ordering issue arises in the 3GPP's ARQ since it belongs to the selective-repeat ARQ clan. A long re-ordering time results in the degradation of throughput and delay performance, and may invoke the overflow of the re-ordering buffer. Also, the re-ordering time must be regulated to meet the requirements of some services which are both loss-sensitive and delay-sensitive. In the 3GPP's ARQ, we may deflate the occupancy of the re-ordering buffer by reducing the window size and/or length of the status report period. Such a decrease, however, deteriorates the throughput and delay performance and encroaches the resource of the reverse channel. Aiming at reducing the occupancy at the re-ordering buffer while suppressing the degradation of throughput and delay performance, we propose threshold-dependent occupancy control schemes, identified as post-threshold and pre-threshold schemes, as supplements to the 3GPP's ARQ. For judging the effectiveness of the proposed schemes, we investigate peak occupancy, maximum throughput and average delay in the practical environment involving fading channels. From the simulation results, we observe that the proposed schemes invoke the performance trade-off between occupancy and throughput in general. Also, we reveal that the post-threshold scheme is able to improve the throughput and delay performance of the ordinary 3GPP's ARQ without inflating the occupancy of the re-ordering buffer.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.323-327
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• 1995

A new air knife system for coating thickness control in hot dip galvanizing process had been developed and installed on the CGL in Pohang Steel Works, POSCO. This new system consists of air knives with remotely adjustable nozzle slot and an automatic control system which can control both longitudinal and traverse coating deviations. Based on the optimal control algorithm, a traverse coating deviation control was designed. The controller controls the lip profile of the air knives with flexible structure according to the deviation of coating weight. From the measured values which are dependent on the strip width, the lip gaps are calculated with optimal algorithm and the model of the coating deviation. Time delay between knives and a coating thickness gauge is solved by the Smith Predictor.

• Fire Science and Engineering
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• v.18 no.2
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• pp.27-33
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• 2004

An accurate knowledge of the AIT(Autoignition temperatures) of chemicals is important in developing appropriate prevention and control measures in industrial fire protection. The AITs describe the minimum temperature to which a substance must be heated, without the application of a flame or spark, which will cause that substance to ignite. The measurement AITs are dependent upon many factors. namely initial temperature. pressure, volume, fuel/air stoichiometry. catalyst material, concentration of vapor, ignition delay time. This study measured the AITs of acids from ignition delay time by using ASTM E659-78 apparatus which was produced in the year 1994. The experiment AITs were a good agreement with the calculated AITs by the proposed equations with a few A.A.P.E.(average absolute percent error) and A.A.D.(average absolute deviation).

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.11
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• pp.1096-1103
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• 2010

This paper proposes CDC (Continuous Damping Control) algorithm and verifies in multi-body dynamic vehicle. In order to distinguish a road profile on driving, waviness calculated by the filtered vertical-accelerations of sprung and unsprung masses is introduced. Sky-hook control is used at a low waviness road and constant damping level control is used at a high waviness road, where the hard damping level is determined by waviness, roll rate, acceleration, and deceleration. The damping levels of ride, anti-roll, anti-squat, and anti-dive modules are calculated by tuning parameters which is dependent upon vehicle velocity. Therefore this high tunable algorithm is useful to improve the ride and handling performance under various driving conditions. In the simulations, tire and dampers are modelled by SWIFT (Short Wavelength Intermediate Frequency Tire) model and 1st order delay model, and results are compared with conventional damper's.

• 제어로봇시스템학회:학술대회논문집
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• 1990.10b
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• pp.878-883
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• 1990

There have been many approaches to solve the disturbance rejection problem in the control of LTI systems with state independent disturbances or possibly nonlinear state dependent disturbances. From the view point of each actuator, robot manipulators can be modeled as the second class of systems. With this model, M.Nakao et al. [1] introduced a decentralized control scheme based on interference estimation which is simple in its implementation and robust to the coupled dynamics and parameter variations. This paper systematically generalizes the control scheme to arbitrary finite dimensional LTI systems with disturbances. In doing so, we develop a disturbance observer theory for solving the disturbance rejection problem. We also present a discrete version of the theory with discussion of sampling and time-delay effects.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2007.04a
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• pp.372-375
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• 2007

본 논문은 시간 변동 시간 지연을 가지는 선형 Neutral 시스템에 관한 관측기 설계에 대해서 논의한다. 시간 지연을 가지는 시스템의 안정도를 판별하기 위하여 Lyapunov-Krasovskii의 이론을 도입한다. 시스템의 안정도를 위한 조건으로 시간 변동 시간 지연에 종속적인 충분조건을 제시한다. 선형 행렬 부등식을 이용하여 관측기의 이득값을 설계하며, 오차 상태 방정식의 안정도를 판별한다. 본 논문의 결과는 Luenberger가 제안한 관측기의 일반적인 결과를 나타낸다. 모의실험을 통해 논문의 결과를 입증하였다.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.4
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• pp.60-67
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• 2010

Delay reduction of vehicles at the intersection is highly dependent on the signal operation method. Most previous traffic operations have focused on minimizing delay by adjust traffic offset. However, these methods have limitation in solving traffic problem if the volume reaches or exceeds the capacity. In this paper, it was analyzed that the effectiveness of various signal operation methods such as left-turn prohibition, and using protected mixed with permitted left turn using the traffic data from Daejeon city. In case of the left-turn prohibition of a intersection, the control delay reduced from 54.2 seconds to 22.7 seconds and especially, the delay of the southbound was drastically reduced. In addition, the delay was highly reduced from 27.0 seconds to 12.1 seconds when the operation system was changed to use protected mixed with permitted left turn.

• Proceedings of the KIEE Conference
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• 2005.07d
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• pp.2483-2485
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• 2005

이 논문에서는 시간 지연 선형시스템에 대하여 시간 지연에 종속인 새로운 $H_{\infty}$ 제어에 관한 결과를 제시한다. 새롭게 제시된 Lyapunov-Krasovskii 후보 함수를 이용하여 시간지연 선형시스템에 대한 보다 개선된 시간지연 종속 $L_2$이득 안정화 조건을 유도한 후, 이 결과를 바탕으로 시간지연 선형시스템에 대한 상태 궤환 $H_{\infty}$제어기 설계방법을 제시한다. 제시되는 결과들은 LMI 형태로 주어지고, 또한 예제를 통하여 제시된 결과의 유용성을 보인다.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.2
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• pp.139-144
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• 2011

We consider the stabilization problem for a class of networked control systems with random delays in the discrete-time domain. The controller-to-actuator and sensor-to-controller time-delays are modeled as two Markov chains, and the resulting closed-loop systems are Markovian jump nonlinear systems with two modes. The T-S (Takagi-Sugeno) fuzzy model is employed to represent a nonlinear system with Markovian jump parameters. The aim is to design a fuzzy controller such that the closed-loop Markovian jump fuzzy system is stochastically stable. The necessary and sufficient conditions on the existence of stabilizing fuzzy controllers are established in terms of LMIs (Linear Matrix Inequalities). It is shown that fuzzy controller gains are mode-dependent. Finally, a simulation example is presented to illustrate the effectiveness of the proposed design method.