• 제목/요약/키워드: Decreasing function

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Comparative Effects of Oyster Mushrooms on Lipid Profile, Liver and Kidney Function in Hypercholesterolemic Rats

  • Alam, Nuhu;Amin, Ruhul;Khan, Asaduzzaman;Ara, Ismot;Shim, Mi-Ja;Lee, Min-Woong;Lee, U-Youn;Lee, Tae-Soo
    • Mycobiology
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    • 제37권1호
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    • pp.37-42
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    • 2009
  • Comparative effects of oyster mushrooms on plasma and fecal lipid profiles and on liver and kidney function were evaluated in hyper and normocholesterolemic rats. Feeding of hypercholesterolemic rats a 5% powder of oyster mushrooms (Pleurotus ostreatus, P. sajor-caju and P. florida) reduced the plasma total cholesterol level by 37%, 21% and 16%, respectively and reduced the triglyceride level by 45%, 24% and 14%, respectively. LDL/HDL ratio decreased by 64%, 45% and 41% for P. sajor-caju, P. ostreatus and P. florida fed rats, respectively. Mushroom feeding also reduced body weight in hypercholesterolemic rats. However, it had no adverse effect on plasma bilirubin, creatinin and urea nitrogen level. Mushroom feeding also increased the total lipid and cholesterol excretion in the feces. The present study reveals that feeding of 5% oyster mushroom powder does not have detrimental effects on the liver and kidneys rather may provide health benefits for the cardiovascular-related complication by decreasing the atherogenic lipid profiles.

비선형 강도함수를 가진 NHPP 소프트웨어 신뢰성장 모형에 관한 비교 연구 (The Comparative Study for NHPP Software Reliability Growth Model Based on Non-linear Intensity Function)

  • 김희철
    • 융합보안논문지
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    • 제7권2호
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    • pp.1-8
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    • 2007
  • 유한고장수를 가진 비동질적인 포아송 과정에 기초한 모형들에서 잔존 결함 1개당 고장 발생률 (강도함수)은 일반적으로 상수, 혹은 단조증가 및 단조 감소 추세를 가지고 있다. 본 논문에서는 기존의 소프트웨어 신뢰성 모형인 Goel-Okumoto 모형 강도함수를 재조명하고 이 분야에 적용 될수 있는 보다 넓은 왜도와 첨도를 가지는 Burr모형 강도 함수 및 의료정보분야 및 여러 분야에서 널리 사용되는 2모수 카파(Kappa(2)) 분포 모형 강도함수를 제안하여 비교하고자 한다. 수치적인 예에서는 고장 간격시간으로 구성된 NTDS(Naval Tactical Data System)자료를 이용하였고 모수추정 방법은 최우추정법과 일반적인 수치해석 방법인 이분법을 사용하여 모수 추정을 실시하였다. 그리고 모형 설정과 선택 판단기준은 편차 자승합을 이용한 적합도 검정이 사용되었다.

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치매노인부양자의 자아분화와 적응변인 간의 관계에 대한 연구 (A Study on the Relationships between Self-Differentiation and Adaptability Factors for Senior Dementia Patients' Care Givers)

  • 형성훈
    • 대한가정학회지
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    • 제49권5호
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    • pp.97-115
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    • 2011
  • The focus of this study was on the self-differentiation level of families with an elderly member suffering from dementia. Based on 340 questionnaires collected in Seoul and Gyeonggi, the study intended to explain the adaptation issues of those families. The variables of interest, which might be related to the self-differentiation, were chronic anxiety(i.e. stress), the family function, psychosomatic symptoms and the family's adaptation to care-giving. As a result of analyzing the effects of the variables potentially related to the self-differentiation level of care-giving families, the findings from this study were as follow. With decreasing self-differentiation level of the family caring for an elderly member suffering from dementia, the levels of stress and psychosomatic symptoms were significantly increased, but the family function and the adaptation to care-giving tended to decrease. Conversely, with increasing self-differentiation, the levels of stress and psychosomatic symptoms were significantly decreased, while the family function and adaptation to care-giving were promoted.

고농도 U-46619에 의한 혈관의 수축에 대한 Resveratrol의 억제 작용에서 MEK 활성 또는 Rho-kinase 활성의 변화: 내피 비의존적 수축성 조절 (The Effect of Resveratrol on U-46619 (High Concentration)-induced Vasoconstriction Regulating MEK or Rho-kinase Activity)

  • 제현동
    • 약학회지
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    • 제55권2호
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    • pp.138-144
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    • 2011
  • The aim of present study was to investigate the possible influence and related mechanism of resveratrol on U-46619 (high concentration)-induced vasoconstriction. Agonist-induced vascular smooth muscle contractions involve the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in resveratrol-induced relaxation in rat aortae contracted with high U-46619. We hypothesized that MEK or Rho-kinase inhibition plays a role in vascular relaxation evoked by resveratrol in rat aortae. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Resveratrol fully inhibited U-46619 in low concentration-induced contraction regardless of endothelial function. However, resveratrol partially decreased U-46619 in high concentration-induced contraction regardless of endothelial function. Interestingly, only in U-46619 (high concentration)-induced contraction, no significant decrease was observed in phospho-ERK1/2 levels and slight decrease in phospho-MYPT1 levels suggesting that additional pathways different from them or endothelial nitric oxide synthesis might be involved in the vasorelaxation. In conclusion, in high U-46619-contracted rat aortae, resveratrol showed relaxation response regardless of endothelial function significantly but slightly decreasing MYPT1 phosphorylation rather than ERK1/2 phosphorylation.

PC1D 시뮬레이션을 이용한 결정질 실리콘 태양전지의 도핑 프로파일 모델링 (The Doping Profile Modeling of Crystalline Silicon Solar Cell with PC1D simulation)

  • 최성진;유권종;송희은
    • 한국태양에너지학회:학술대회논문집
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    • 한국태양에너지학회 2011년도 추계학술발표대회 논문집
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    • pp.149-153
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    • 2011
  • The PC1D is widely used for modeling the properties of crystalline silicon solar cell. Optimized doping profile in crystalline silicon solar cell fabrication is necessary to obtain high conversion efficiency. Doping profile in the forms of a uniform, gaussian, exponential and erfc function can be simulated using the PC1D program. In this paper, the doping profiles including junction depth, dopant concentration on surface and the form of doping profile (gaussian, gaussian+erfc function) were changed to study its effect on electrical properties of solar cell. As decreasing junction depth and doping concentration on surface, electrical properties of solar cell were improved. The characteristics for the solar cells with doping profile using the combination of gaussian and erfc function showed better open-circuit voltage, short-circuit current and conversion efficiency.

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노닐페놀을 주사한 조피볼락의 신장 MFO (mixed function oxidase)의 반응 (Responses of Renal Mixed Function Oxidase System in Rockfish (Sebastes schlegeli) Administered with 4-Nonylphenol)

  • 전중균;이지선;손영창;홍경표;심원준;김병기;한창희
    • 한국수산과학회지
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    • 제36권6호
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    • pp.573-577
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    • 2003
  • Effects of 4-nonylphenol (4-NP) on mixed function oxygenase (MFO) in the kidneies of rockfish (Sebastes schlegeli) were investigated. The cytochrome P45O (CYP) contents and NADPH cytochrome P450 reductase, NADH cytochrome b5 reductase and 7-ethoxyredorufin-O-deethylase (EROD) activities of microsome, glutathione S-transferase (GST) activity of cytosol in rockfish exposed to 4-NP for 7 days using an intraperitoneal injection (25 mg/kg) were quantitatively determined. The GST activity of rockfish exposed to 4-NP were higher, up to 5.2 times higher, than those in the control fish. The activities of NADPH-and NADH-dependent reductases were inhibited. On the other hand, CYP contents and EROD activity of the 4-NP exposed fish demonstrated neither an increasing or decreasing trend.

농촌 노인을 위한 보건진료소 중심의 포괄적 건강증진 프로그램의 효과 검증 (Effectiveness of a Comprehensive Health Promotion Program based on the Primary Health Care Post for Rural Elders)

  • 김영숙;강영실;하영미
    • 한국농촌간호학회지
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    • 제14권2호
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    • pp.30-37
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    • 2019
  • Purpose: This study was done to develop a comprehensive health promotion program based on the primary health care post, and then to examine the effectiveness of the program for rural elders. Methods: A single group pre-test post-test design was used, for 3 months and the 51 participants received the comprehensive health promotion program based on the primary health care post. Effectiveness of the intervention was measured immediately after the comprehensive health promotion program. Results: There were significant differences between pre-test and post-test on cognitive function (p=.001), depression (p=.001), systolic blood pressure (p=.001), blood sugar (p=.013), and cholesterol (p=.018). Conclusion: The comprehensive health promotion program based on the primary health care post was found to be effective for rural elders by improving cognitive function and physiological indicators and decreasing their depression.

실무적 적용 관점에서 신뢰성 분포의 유형화 모형의 고찰 (Review of Classification Models for Reliability Distributions from the Perspective of Practical Implementation)

  • 최성운
    • 대한안전경영과학회지
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    • 제13권1호
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    • pp.195-202
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    • 2011
  • The study interprets each of three classification models based on Bath-Tub Failure Rate (BTFR), Extreme Value Distribution (EVD) and Conjugate Bayesian Distribution (CBD). The classification model based on BTFR is analyzed by three failure patterns of decreasing, constant, or increasing which utilize systematic management strategies for reliability of time. Distribution model based on BTFR is identified using individual factors for each of three corresponding cases. First, in case of using shape parameter, the distribution based on BTFR is analyzed with a factor of component or part number. In case of using scale parameter, the distribution model based on BTFR is analyzed with a factor of time precision. Meanwhile, in case of using location parameter, the distribution model based on BTFR is analyzed with a factor of guarantee time. The classification model based on EVD is assorted into long-tailed distribution, medium-tailed distribution, and short-tailed distribution by the length of right-tail in distribution, and depended on asymptotic reliability property which signifies skewness and kurtosis of distribution curve. Furthermore, the classification model based on CBD is relied upon conjugate distribution relations between prior function, likelihood function and posterior function for dimension reduction and easy tractability under the occasion of Bayesian posterior updating.

원발성 답증성 간경변에 대한 장기간 한방 치험례 (Long-term Clinical Case of Primary Biliary Cirrhosis Treated with Traditional Korean Medicine)

  • 이준수;홍상훈;김강산;박상은
    • 대한한방내과학회지
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    • 제37권2호
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    • pp.182-188
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    • 2016
  • Objective: This study was designed to assess the clinical effect of traditional Korean medicine on primary biliary cirrhosis.Method: We provided herbal medicine and acupuncture therapy to a 38-year-old male patient who complained about jaundice, itching, and fatigue. During a six-day hospital stay, we checked any changes in symptoms and conducted liver function tests (such as aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP], and gamma-glutamyl transferase [GGT], among others) to evaluate any improvement.Results: We observed that herbal medicine and acupuncture therapy appeared to decrease the symptoms of primary biliary cirrhosis. During each hospital stay, the symptoms and liver function test both showed improvement, especially in ALP.Conclusion: Based on the therapeutic results of the six-day hospital stay, we report improved primary biliary cirrhosis symptoms and a decreasing tendency in ALP and GGP levels following treatment with traditional Korean medicine.

FOOTPRINT AND MINIMUM DISTANCE FUNCTIONS

  • Nunez-Betancourt, Luis;Pitones, Yuriko;Villarreal, Rafael H.
    • 대한수학회논문집
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    • 제33권1호
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    • pp.85-101
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    • 2018
  • Let S be a polynomial ring over a field K, with a monomial order ${\prec}$, and let I be an unmixed graded ideal of S. In this paper we study two functions associated to I: The minimum distance function ${\delta}_I$ and the footprint function $fp_I$. It is shown that ${\delta}_I$ is positive and that $fp_I$ is positive if the initial ideal of I is unmixed. Then we show that if I is radical and its associated primes are generated by linear forms, then ${\delta}_I$ is strictly decreasing until it reaches the asymptotic value 1. If I is the edge ideal of a Cohen-Macaulay bipartite graph, we show that ${\delta}_I(d)=1$ for d greater than or equal to the regularity of S/I. For a graded ideal of dimension ${\geq}1$, whose initial ideal is a complete intersection, we give an exact sharp lower bound for the corresponding minimum distance function.