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http://dx.doi.org/10.5657/kfas.2003.36.6.573

Responses of Renal Mixed Function Oxidase System in Rockfish (Sebastes schlegeli) Administered with 4-Nonylphenol  

JEON Joong-Kyun (Kangnung Nationai University/EMBRC)
LEE Ji-Seon (Kangnung Nationai University/EMBRC)
SOHN Young-Chang (Kangnung Nationai University/EMBRC)
HONG Gyong-Pyo (Marine Living Resources Research Division, KORDI)
SHIM Won Joon (South Sea Institute, KORDI)
KIM Pyong-Kih (Gangwon Provincial University)
HAN Chang-Hee (Division of Life Science, Dong-Eui University)
Publication Information
Korean Journal of Fisheries and Aquatic Sciences / v.36, no.6, 2003 , pp. 573-577 More about this Journal
Abstract
Effects of 4-nonylphenol (4-NP) on mixed function oxygenase (MFO) in the kidneies of rockfish (Sebastes schlegeli) were investigated. The cytochrome P45O (CYP) contents and NADPH cytochrome P450 reductase, NADH cytochrome b5 reductase and 7-ethoxyredorufin-O-deethylase (EROD) activities of microsome, glutathione S-transferase (GST) activity of cytosol in rockfish exposed to 4-NP for 7 days using an intraperitoneal injection (25 mg/kg) were quantitatively determined. The GST activity of rockfish exposed to 4-NP were higher, up to 5.2 times higher, than those in the control fish. The activities of NADPH-and NADH-dependent reductases were inhibited. On the other hand, CYP contents and EROD activity of the 4-NP exposed fish demonstrated neither an increasing or decreasing trend.
Keywords
4-Nonylphenol; Sebastes schlegeli; Kidney; Cytochrome P450; EROD; Glutathione S-transferase;
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