• Title/Summary/Keyword: Data-driven Research

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Differential Chemokine Signature between Human Preadipocytes and Adipocytes

  • Rosa Mistica C. Ignacio;Carla R. Gibbs;Eun-Sook Lee;Deok-Soo Son
    • IMMUNE NETWORK
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    • v.16 no.3
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    • pp.189-194
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    • 2016
  • Obesity is characterized as an accumulation of adipose tissue mass represented by chronic, low-grade inflammation. Obesity-derived inflammation involves chemokines as important regulators contributing to the pathophysiology of obesity-related diseases such as cardiovascular disease, diabetes and some cancers. The obesity-driven chemokine network is poorly understood. Here, we identified the profiles of chemokine signature between human preadipocytes and adipocytes, using PCR arrays and qRT-PCR. Both preadipocytes and adipocytes showed absent or low levels in chemokine receptors in spite of some changes. On the other hand, the chemokine levels of CCL2, CCL7-8, CCL11, CXCL1-3, CXCL6 and CXCL10-11 were dominantly expressed in preadipocytes compared to adipocytes. Interestingly, CXCL14 was the most dominant chemokine expressed in adipocytes compared to preadipocytes. Moreover, there is significantly higher protein level of CXCL14 in conditioned media from adipocytes. In addition, we analyzed the data of the chemokine signatures in adipocytes obtained from healthy lean and obese postmenopausal women based on Gene Expression Omnibus (GEO) dataset. Adipocytes from obese individuals had significantly higher levels in chemokine signature as follows: CCL2, CCL13, CCL18-19, CCL23, CCL26, CXCL1, CXCL3 and CXCL14, as compared to those from lean ones. Also, among the chemokine networks, CXCL14 appeared to be the highest levels in adipocytes from both lean and obese women. Taken together, these results identify CXCL14 as an important chemokine induced during adipogenesis, requiring further research elucidating its potential therapeutic benefits in obesity.

Development and Assessment of LSTM Model for Correcting Underestimation of Water Temperature in Korean Marine Heatwave Prediction System (한반도 고수온 예측 시스템의 수온 과소모의 보정을 위한 LSTM 모델 구축 및 예측성 평가)

  • NA KYOUNG IM;HYUNKEUN JIN;GYUNDO PAK;YOUNG-GYU PARK;KYEONG OK KIM;YONGHAN CHOI;YOUNG HO KIM
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.29 no.2
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    • pp.101-115
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    • 2024
  • The ocean heatwave is emerging as a major issue due to global warming, posing a direct threat to marine ecosystems and humanity through decreased food resources and reduced carbon absorption capacity of the oceans. Consequently, the prediction of ocean heatwaves in the vicinity of the Korean Peninsula is becoming increasingly important for marine environmental monitoring and management. In this study, an LSTM model was developed to improve the underestimated prediction of ocean heatwaves caused by the coarse vertical grid system of the Korean Peninsula Ocean Prediction System. Based on the results of ocean heatwave predictions for the Korean Peninsula conducted in 2023, as well as those generated by the LSTM model, the performance of heatwave predictions in the East Sea, Yellow Sea, and South Sea areas surrounding the Korean Peninsula was evaluated. The LSTM model developed in this study significantly improved the prediction performance of sea surface temperatures during periods of temperature increase in all three regions. However, its effectiveness in improving prediction performance during periods of temperature decrease or before temperature rise initiation was limited. This demonstrates the potential of the LSTM model to address the underestimated prediction of ocean heatwaves caused by the coarse vertical grid system during periods of enhanced stratification. It is anticipated that the utility of data-driven artificial intelligence models will expand in the future to improve the prediction performance of dynamical models or even replace them.

Reviews in Medical Geography: Spatial Epidemiology of Vector-Borne Diseases (벡터매개 질병(vector-borne diseases) 공간역학을 중심으로 한 보건지리학의 최근 연구)

  • Park, Sunyurp;Han, Daikwon
    • Journal of the Korean Geographical Society
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    • v.47 no.5
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    • pp.677-699
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    • 2012
  • Climate changes may cause substantial changes in spatial patterns and distribution of vector-borne diseases (VBD's), which will result in a significant threat to humans and emerge as an important public health problem that the international society needs to solve. As global warming becomes widespread and the Korean peninsula characterizes subtropical climate, the potentials of climate-driven disease outbreaks and spread rapidly increase with changes in land use, population distributions, and ecological environments. Vector-borne diseases are typically infected by insects such as mosquitoes and ticks, and infected hosts and vectors increased dramatically as the habitat ranges of the VBD agents have been expanded for the past 20 years. Medical geography integrates and processes a wide range of public health data and indicators at both local and regional levels, and ultimately helps researchers identify spatiotemporal mechanism of the diseases determining interactions and relationships between spatial and non-spatial data. Spatial epidemiology is a new and emerging area of medical geography integrating geospatial sciences, environmental sciences, and epidemiology to further uncover human health-environment relationships. An introduction of GIS-based disease monitoring system to the public health surveillance system is among the important future research agenda that medical geography can significantly contribute to. Particularly, real-time monitoring methods, early-warning systems, and spatial forecasting of VBD factors will be key research fields to understand the dynamics of VBD's.

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A Study on Environmental Impact Assessment System of Seoul City (서울시 환경영향평가 제도에 대한 연구)

  • Kim, Im-Soon;Han, Sang-Wook
    • Journal of Environmental Impact Assessment
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    • v.16 no.6
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    • pp.467-483
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    • 2007
  • Environmental Impact Assessment (EIA) is a kind of planning technique to seek ways to minimize environmental impact, a scheme to encourage sustainable development. With the launch of the Ministry of Environment in 1980, the EIA was introduced in Korea. Its full operation was initially driven by regulations on documenting EIA reports in 1981, which was piloted as a decision-making scheme where final decision were made at the development department after considering opinions suggested by the Ministry of Environment. At that time, dominance of the economic logic overwhelmed environ-friendly opinions, but thanks to the fourth revision of the Environmental Conservation Law in 1986, private projects came to be included on the EIA list. This was a turning point for the EIA to become a regulatory system. Local governments are also conducting the EIA regardless of the national-level EIA. In order to prevent and resolve increasingly severe environmental problems in Seoul in advance due to various construction projects, the Seoul Metropolitan Government, for the first time as a local government in Korea, legislated city decrees to introduce the EIA which has been underway from September 1, 2002. In particular, the Seoul government, unlike the Ministry of Environment, has included construction works on the list of evaluation projects, adopting the scoping and screen procedure scheme. In addition, complementing operational setbacks, the city government has revised and implemented decrees and enforcement laws on the Impact Assessment on Environment, Transportation and Disasters by shortening the consultation period, eliminating the submission of reports on construction, and expanding the waiver requirements in consultation over the reports. Therefore, development measures for the EIA scheme of the Seoul Metropolitan Government will be the target of the research. To that end, the up-to-date data of the Ministry of Environment, the Seoul government and local governments was collected, and latest materials from the EU, previous research and the Internet were gathered for analyses. By doing so, the flow of the EIA was reviewed, and the EIA schemes of local governments under the national EIA were analyzed. Furthermore, based on the Seoul government's recent data on the EIA based on the decrees, the background and legislation of the Seoul government's EIA were analyzed along with the developments for the environmental organizations. Setbacks were derived from the implementation period, evaluation procedures, consultation period and details of the EIA, and corresponding development measures were proposed.

Development of Grid-Based Conceptual Hydrologic Model (격자기반의 개념적 수문모형의 개발)

  • Kim, Byung-Sik;Yoon, Seon-Kyoo;Yang, Dong-Min;Kwon, Hyun-Han
    • Journal of Korea Water Resources Association
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    • v.43 no.7
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    • pp.667-679
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    • 2010
  • The distributed hydrologic model has been considerably improved due to rapid development of computer hardware technology as well as the increased accessibility and the applicability of hydro-geologic information using GIS. It has been acknowledged that physically-based distributed hydrologic model require significant amounts of data for their calibration, so its application at ungauged catchments is very limited. In this regard, this study was intended to develop a distributed hydrologic model (S-RAT) that is mainly based on conceptually grid-based water balance model. The proposed model shows advantages as a new distributed rainfall-runoff model in terms of their simplicity and model performance. Another advantage of the proposed model is to effectively assess spatio-temporal variation for the entire runoff process. In addition, S-RAT does not rely on any commercial GIS pre-processing tools because a built-in GIS pre-processing module was developed and included in the model. Through the application to the two pilot basins, it was found that S-RAT model has temporal and spatial transferability of parameters and also S-RAT model can be effectively used as a radar data-driven rainfall-runoff model.

The development of water circulation model based on quasi-realtime hydrological data for drought monitoring (수문학적 가뭄 모니터링을 위한 실적자료 기반 물순환 모델 개발)

  • Kim, Jin-Young;Kim, Jin-Guk;Kim, Jang-Gyeng;Chun, Gun-il;Kang, Shin-uk;Lee, Jeong-Ju;Nam, Woo-Sung;Kwon, Hyun-Han
    • Journal of Korea Water Resources Association
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    • v.53 no.8
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    • pp.569-582
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    • 2020
  • Recently, Korea has faced a change in the pattern of water use due to urbanization, which has caused difficulties in understanding the rainfall-runoff process and optimizing the allocation of available water resources. In this perspective, spatially downscaled analysis of the water balance is required for the efficient operation of water resources in the National Water Management Plan and the River Basin Water Resource Management Plan. However, the existing water balance analysis does not fully consider water circulation and availability in the basin, thus, the obtained results provide limited information in terms of decision making. This study aims at developing a novel water circulation analysis model that is designed to support a quasi-real-time assessment of water availability along the river. The water circulation model proposed in this study improved the problems that appear in the existing water balance analysis. More importantly, the results showed a significant improvement over the existing model, especially in the low flow simulation. The proposed modeling framework is expected to provide primary information for more realistic hydrological drought monitoring and drought countermeasures by providing streamflow information in quasi-real-time through a more accurate natural flow estimation approach with highly complex network.

Proposal for the 『Army TIGER Cyber Defense System』 Installation capable of responding to future enemy cyber attack (미래 사이버위협에 대응 가능한 『Army TIGER 사이버방호체계』 구축을 위한 제언)

  • Byeong-jun Park;Cheol-jung Kim
    • Journal of Internet Computing and Services
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    • v.25 no.1
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    • pp.157-166
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    • 2024
  • The Army TIGER System, which is being deployed to implement a future combat system, is expected to bring innovative changes to the army's combat methods and comabt execution capability such as mobility, networking and intelligence. To this end, the Army will introduce various systems using drones, robots, unmanned vehicles, AI(Artificial Intelligence), etc. and utilize them in combat. The use of various unmanned vehicles and AI is expected to result in the introduction of equipment with new technologies into the army and an increase in various types of transmitted information, i.e. data. However, currently in the military, there is an acceleration in research and combat experimentations on warfigthing options using Army TIGER forces system for specific functions. On the other hand, the current reality is that research on cyber threats measures targeting information systems related to the increasing number of unmanned systems, data production, and transmission from unmanned systems, as well as the establishment of cloud centers and AI command and control center driven by the new force systems, is not being pursued. Accordingly this paper analyzes the structure and characteristics of the Army TIGER force integration system and makes suggestions for necessity of building, available cyber defense solutions and Army TIGER integrated cyber protections system that can respond to cyber threats in the future.

Research Trend and Futuristic Guideline of Platform-Based Business in Korea (플랫폼 기반 비즈니스에 대한 국내 연구동향 및 미래를 위한 가이드라인)

  • Namn, Su Hyeon
    • Management & Information Systems Review
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    • v.39 no.1
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    • pp.93-114
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    • 2020
  • Platform is considered as an alternative strategy to the traditional linear pipeline based business. Moreover, in the 4th industrial revolution period, efficiency driven pipeline business model needs to be changed to platform business. We have such success stories about platform as Apple, Google, Amazon, Uber, and so on. However, for those smaller corporations, it is not easy to find out the transformation strategy. The essence of platform business is to leverage network effect in management. Thus platform based management can be rephrased as network management across the business functions. Research on platform business is popular and related to diverse facets. But few scholars cover what the research trend of the domain is. The main purpose of this paper is to identify the research trend on platform business in Korea. To do that we first propose the analytical model for platform architecture whose components are consumers, suppliers, artifacts, and IT platform system. We conjecture that mapping of the research work on platform to the components of the model will make us understand the hidden domain of platform research. We propose three hypotheses regarding the characteristics of research and one proposition for the transitional path from pipeline to platform business model. The mapping is based on the research articles filtered from the Korea Citation Index, using keyword search. Research papers are searched through the keywords provided by authors using the word of "platform". The filtered articles are summarized in terms of the attributes such as major component of platform considered, platform type, main purpose of the research, and research method. Using the filtered data, we test the hypotheses in exploratory ways. The contribution of our research is as follows: First, based on the findings, scholars can find the areas of research on the domain: areas where research has been matured and territory where future research is actively sought. Second, the proposition provided can give business practitioners the guideline for changing their strategy from pipeline to platform oriented. This research needs to be considered as exploratory not inferential since subjective judgments are involved in data collection, classification, and interpretation of research articles.

An Evaluation on the Operating of Fisheries Extension Services (어촌지도사업의 평가)

  • 최정윤
    • The Journal of Fisheries Business Administration
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    • v.17 no.2
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    • pp.65-106
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    • 1986
  • 1, The Purpose of Study This is a study on the Evaluation of the operating of Fisheries Extension Services of Korea, for performing the activities such as guiding fisheries technique as well as offering industrial information to the fishermen in fishing village. By doing so, the Fisheries Extension Sevices(FES) can materialize the continued growth of fisheries, the social and economic development of fishing village, and the increase in income by enhancing the knowledge level of Fishermen, etc. In performing fisheries policy, this activity plays a great role on the research and development activity, and it has become practical since 1976 in Korea. In order to meet immediately with the problem of fisheries technical innovation and rapid environmental changes surrounding the fisheries, the fishermen should not only enhance their scientific and comprehensive capacity in fisheries technique but abtain various effective information. Generally, as most of all the fishemen are poor in the managerial structure and scattered in fishing villages, they have little opportunity in the contact of information. As a result, it is nessessary for the FES to perform the fishing business by the extension service officials who has received special training and acquired fisheries know-how in these fields. And yet, FES is under the unfullfilled circumstance in such factors as manpower, technical know-how, equipment, and the service system etc., which is required in promoting the social, economic development of fishing village and in resolving the high technique demand of fisherman. This study on the fisheries extension services have been studied from those backgrounds. 2. Research Method The data of collecting methods which were necessary in carrying out this study was adopted by the questionaire research on the present extension service activity, through the subject of the extension services (driving agency of the work and the officials), the object(fishemen) and the 3rd observers to the extension services (the authorities concerned). The research sample was taken by the sampling extraction of total 1, 774 men from the above 3 groups. And the research was carried out from August, 1986 to October, 1986, supported from the Fisheries Extension Office (FEO) located in field during the research process. In this study, the levels of the extension operating were determined and estimated in accordance with the extension service method, morale of extension service officials and the extension service system, etc. through the collected data of the research questionaire paper. And based on this result, the essential conditions of the extension services were grasped, and also we tried to present the various activity plan necessary to promote the operating of the extension services. The questionaire research data was calculated by the computer center of National Fisheries University of Pusan, and the total result was again tried on the one demension analysis along with two dimension analysis to search out the relativity between the questionaire, and the statistical test was done $\chi$$^2$test in significance level of l~5%. 3. Contents of Study This study consists of 7 chapters and the contents are as follows : Chapter I : The object and method of the study Chapter II : The assessment and analysis of the extension services Chapter III : The contents and method of the extension services Chapter IV : Analysis of the essential conditions for the extension services Chapter V : The evaluation of activities of extension services Chapter Ⅵ : Conclusion.4. Results and RecommendationTherefore, the results of this study estimated by logical process and analysis are as follows : 1) Most of Korean fishing villages and coastal fishermen have shown much concerns about fisheries technique and social changes, thus many of them were confronted with new problems on how to adapt and to meet changes. 2) Majority of fishermen estimated FEO as an organization of specific technologies with all the thing concerning the fisheries technique in general. Therefore the fishermen wanted to utilize the FEO as an adaptable method for the modern fisheries techniques as well as the environmental changes. 3) In contrast with the fast changes of the fisheries technique, the complexity and variety of technical system and the broadness of fishing village and fishermen, it was revealed that the necessary factors such as the facilities, manpower, budget, and the level of applying techniques of the FEO located in field were highly insufficient. Accordingly, the guiding efficiency was low and the extension services did not provide full solution to the various request from fishermen. 4) It is possible to classify the activation factor for the extension service into two large dimension ; personal dimension relevant to guidance officials and work dimension relevant to the organization. And it was found that the activation level of the work dimension was far lower than the personal dimension between them. So, the activation should be done first in the dimesion to promote the activation of the extension services. 5) The extension services officials are now demoralized in general, thus it is necessary to take reality into consideration : the expense of activity, the adequate endowment of activity scope and the reasonable operation of the position class, etc to enhance its morale. However, in order to do the FES activation, first of all, the systems should be established which is lain unsettled stage until now. And there must be change in the understanding of government i.e. the fisheries extension services are the essential policy subject to build up the base of fisheries growth and modernize the fisheries management. And it should be driven positively with the recognition of the "lasting project".g project".uot;.

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Development of Geometric Moments Based Ellipsoid Model for Extracting Spatio-Temporal Characteristics of Rainfall Field (강우장의 시공간적 특성 추출을 위한 기하학적 모멘트 기반 등가타원 모형 개발)

  • Kwon, Hyun-Han;So, Byung-Jin;Kim, Min-Ji;Pack, Se-Hoon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.31 no.6B
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    • pp.531-539
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    • 2011
  • It has been widely acknowledged that climate system associated with extreme rainfall events was difficult to understand and extreme rainfall simulation in climate model was more difficult. This study developed a new model for extracting rainfall filed associated with extreme events as a way to characterize large scale climate system. Main interests are to derive location, size and direction of the rainfall field and this study developed an algorithm to extract the above characteristics from global climate data set. This study mainly utilized specific humidity and wind vectors driven by NCEP reanalysis data to define the rainfall field. Geometric first and second moments have been extensively employed in defining the rainfall field in selected zone, and an ellipsoid based model were finally introduced. The proposed geometric moments based ellipsoid model works equally well with regularly and irregularly distributed synthetic grid data. Finally, the proposed model was applied to space-time real rainfall filed. It was found that location, size and direction of the rainfall field was successfully extracted.