• Mycobiology
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• v.35 no.1
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• pp.16-20
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• 2007

Hypolipidemic effect of biopolymers extracted from culture broth (CP), mycelia (MP), and fruiting bodies (FP) of Auricularia auricula-judae was investigated in dietary-induced hyperlipidemic rats. The experimental animals were administrated (100 mg/kg body weight) with different biopolymers, daily for 4 weeks. Hypolipidemic effects were achieved in all the experimental groups, however, FP was proved to be the most potent one. The administration of the FP reduced the plasma triglyceride, total cholesterol, low-density lipoprotein cholesterol, and atherogenic index by 24.3, 28.5, 36.4, and 40.9%, respectively, while increased the high-density lipoprotein cholesterol level (9.0%), when compared to the saline (control) administered group.

• Neonatal Medicine
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• v.16 no.1
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• pp.71-75
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• 2009

There are few cases of partial trisomy of 9q, known as partial 9q trisomy syndrome with low birth weight, microcephaly, hypotelorism, beaked nose, small lip, long finger, hypertrophic pyloric stenosis, ventricular septal defect, and mental retardation. We report partial trisomy of 9q derived from a paternal chromosome, which has different features of other syndromes, including prematurity, atrial and ventricular septal defect, patent ductus arteriosus, persistent left superior vena cava, congenital hydronephrosis, and scrotal hernia.

• The Korea Journal of Herbology
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• v.21 no.4
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• pp.109-113
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• 2006

Objectives : In this study, anti-oxidant activity of Taraxacum platycarpum is confirmed to investigate cosmeceutical activity for utilization as a cosmetic ingredients. Methods : In the anti-oxidant and whitening effect experiment, the electron donating ability of Taraxacum platycarpum extracts, their SOD-like activity, and the inhibitory activity of xanthine oxidase, tyrosinase were examined. Results : Radical-scavenging activity of water and ethanol extract was examined using ${\alpha},{\alpha}-diphenyl-{\beta}-picrylhydrazyl$ (DPPH). Water and ethanol extract from Taraxacum platycarpum showed 62.9% and 54.7% at 500 ppm concentration in DPPH radical inhibition, respectively. In the test of superoxide dismutase (SOD)-like activity, water extract showed 63.4% at 1,000 ppm concentration, while ethanol extract showed 49% at 1,000 ppm concentration. In the test of xanthine oxidase inhibition, ethanol extract showed 66.8% at 1,000 ppm concentration. Tyrosinase inhibition effect related to whitening effect showed 36.3% and 54.2% in ethanol extract and water extract at 1,000 ppm concentration, respectively. Conclusion : According to these results, it is possible that the extract of Taraxacum platycarpum can be used as a new natural material of cosmetic industry.

• Neonatal Medicine
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• v.15 no.1
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• pp.89-93
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• 2008

Duplication of chromosome 12p has been rarely reported and are thought to be associated with congenital malformations and impaired development. We report a baby boy born with multiple dysmorphic features and congenital malformations. His karyotype was 46,XY, add(12)(p13.3). He has suffered from intrauterine growth restriction at birth. He showed abnormal cranio-facial findings such as microcephaly, hypognathia, clepft palate and low set ear. He presented with absence of uvula, micropenis and rocker bottom features of both feet, congenital heart disease, poor corticomedullary differentiation of kidney, and sensorineuronal hearing loss. We have been follow up him for seizure disorder and delayed development at out patient department.

• Bulletin of the Korean Chemical Society
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• v.27 no.8
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• pp.1231-1234
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• 2006

• Journal of Acupuncture Research
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• v.34 no.3
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• pp.91-100
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• 2017

Objectives : We conducted a literature search to identify trends with respect to miniscalpel acupuncture points (MAPs) of the cervical region with the aim of providing guidance regarding miniscalpel acupuncture (MA) in the cervical region. Methods : We searched 2 overseas sites (PubMed and Google Scholar) and 5 domestic sites (NDSL, RISS, KISS, OASIS and Korean Traditional Knowledge Portal) for clinical trials of MA of the cervical region. The search terms used were "acupotomy or miniscalpel acupuncture or miniscalpel" and "cervical." Of 73 studies found, 11 were included in this review, 6 of which presented exact MAPs. Owing to the lack of data, we refer to 1 Korean and 4 Chinese articles to analyze the exact location and meaning of the MAPs used in the published studies and to propose other clinically applicable MAPs. Results : We identified 10 of the most commonly used MAPs in the published studies, including those located below the external occipital protuberance, 2-2.5 cm both side down of the external occipital protuberance, 4.5-5 cm both side down of the external occipital protuberance and C3-7 spinous process. Furthermore, we proposed 13 additional MAPs that can be used clinically. Conclusion : We hope that this study will form a basis for the development of MA and hope to improve the safety and reproducibility in future MA studies of the cervical region.

• Journal of Pharmacopuncture
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• v.8 no.2
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• pp.5-10
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• 2005

Objectives : This study was designed to estimate the effects of BU herbal acupuncture theraphy on low back pain of sprain patients by using Visual Analogue Scale(VAS) and pressure algometer. Methods : 13 volunteers were applied to BU herbal acupuncture stimulation on the BL23, BL24, BL25 and BL26 acupoints. The degree of improvement of low back pain of sprain was evaluated by VAS and pain pressure threshold(at the points of BL23 and BL24 before treatment, before 3rd treatment(after herbal acupuncture). Results : In VAS scores, there were significant differences between before and after herbal acupuncture stimulation. But there was no significant difference between before and after herbal acupuncture stimulation in pain threshold. Conclusions : The effectiveness of BU herbal acupuncture theraphy on low back pain of sprain was shown through VAS and pressure algometer. These imply that BU herbal acupuncture theraphy may be useful for low back pain of sprain. Further study is needed about BU herbal acupuncture.

• The Journal of Internal Korean Medicine
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• v.26 no.3
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• pp.652-659
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• 2005

A 69 year-old female patient with Bronchiectasis was treated. She was suffering from cough, sputum, fever, sweating, chills and general weakness. Her symptoms were diagnosed as Pe-Ong(肺癰), and she was administered Wikyung-Tang(葦莖湯). After taking Wikyung-Tang(葦莖湯) her symptoms improved. Results suggest that Wikyung-Tang(葦莖湯) is an effective treatment fer Bronchiectasis. Though, results support a role for oriental medical treatment for lung disease, further research into the effectiveness of oriental medical treatments for various lung disease is needed.

• Journal of Animal Reproduction and Biotechnology
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• v.35 no.2
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• pp.207-213
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• 2020

Cryopreservation is used for blastocyst preservation of most mammalian embryos and is an important technique for breeding. We aimed to compare the efficiency of the cryopreservation method using the standard Cryotop device and the ReproCarrier device, a domestic product manufactured in Korea. The efficacy of the two devices was analyzed based on the survival rate, intracellular levels of reactive oxygen species (ROS), and apoptosis of the vitrified bovine blastocysts. The survival rates of the vitrified-warmed blastocysts were similar between the ReproCarrier group (58.4 ± 17.7%) and Cryotop group (59.9 ± 14.1%). Intracellular ROS levels and apoptotic index were determined by DCFDA staining and TUNEL assay. Changes in intracellular ROS levels, number of total nuclei, and cellular apoptosis of vitrified blastocysts after cryopreservation were not significantly different between the two groups. These results indicate that the ReproCarrier device method is as effective as the standard Cryotop method for vitrification of bovine blastocysts in vitro.

• Natural Product Sciences
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• v.20 no.4
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• pp.274-280
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• 2014

Six compounds were isolated from the n-BuOH fraction of the aerial parts of Aruncus dioicus var. kamtschaticus including: sambunigrin (1), prunasin (2), aruncide A (3), aruncide C (4), 1-O-caffeoyl-${\beta}$-D-glucopyranose (5), and caffeic acid (6). Their structures were confirmed by comparing the spectral data with those reported in the literature. The isolated compounds (1 - 6) were then examined for their cytotoxic effects towards MCF-7, HL-60, and HeLa cancer cell lines, as well as their DPPH radical scavenging activity. The results indicated that compound 4 possessed the strongest inhibitory effect toward HeLa cell line with $IC_{50}$ value of $5.38{\pm}0.92{\mu}M$. Compound 3 possessed selective cytotoxic activity on HL-60 cells with $IC_{50}$ value of $6.27{\pm}0.17{\mu}M$, compound 5 was found as the best in inhibiting proliferation with $IC_{50}$ value of $2.25{\pm}0.09{\mu}M$, and the other compounds showed significant inhibition with $IC_{50}$ values ranging from 6.10 to $11.27{\mu}M$. Compound 5 also displayed the strongest cytotoxic effect toward MCF-7 cell line ($IC_{50}$ $4.32{\pm}0.15{\mu}M$). Both 5 and 6 demonstrated strong radical scavenging activity ($IC_{50}$ $6.87{\pm}0.03$ and $4.33{\pm}0.22{\mu}M$, respectively). Compounds 1 and 5 were isolated for the first time from this plant.