• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3817-3825
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• 2015

Background: The human protein methyl-transferase DOT1L catalyzes the methylation of histone H3 on lysine 79 (H3K79) at homeobox genes and is also involved in a number of significant processes ranging from gene expression to DNA-damage response and cell cycle progression. Inhibition of DOT1L activity by shRNA or small-molecule inhibitors has been established to prevent proliferation of various MLL-rearranged leukemia cells in vitro, establishing DOT1L an attractive therapeutic target for mixed lineage leukemia (MLL). Most of the drugs currently in use for the MLL treatment are reported to have low efficacy, hence this study focused on various natural compounds which exhibit minimal toxic effects and high efficacy for the target receptor. Materials and Methods: Structures of human protein methyl-transferase DOT1L and natural compound databases were downloaded from various sources. Virtual screening, molecular docking, dynamics simulation and drug likeness studies were performed for those natural compounds to evaluate and analyze their anti-cancer activity. Results: The top five screened compounds possessing good binding affinity were identified as potential high affinity inhibitors against DOT1L's active site. The top ranking molecule amongst the screened ligands had a Glide g-score of -10.940 kcal/mol and Glide e-model score of -86.011 with 5 hydrogen bonds and 12 hydrophobic contacts. This ligand's behaviour also showed consistency during the simulation of protein-ligand complex for 20000 ps, which is indicative of its stability in the receptor pocket. Conclusions: The ligand obtained out of this screening study can be considered as a potential inhibitor for DOT1L and further can be treated as a lead for the drug designing pipeline.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.1-6
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• 2009

To overcome the stability problem of hydrophilic quantum dot (Q-dot), cellular uptake of hydrophobic instead of hydrophilic Q-dot was studied in the hope to find a simple method to use Q-dot as a cellular imaging probe. Hydrophobic Q-dot and poly-L-lactic acid (PLLA) were co-dissolved in chloroform to prepare stable films. Due to the cellular compatibility of PLLA, adherent cells were cultured on the film to observe the degree of Q-dot uptake and cytotoxicity of the prepared films. The results show that Q-dots were absorbed into NIH3T3 and EMT6 cells. Cellular uptake was also observed when hydrophobic Q-dots were coated directly on a glass plate. PLLA/Q-dot film and Q-dot coated on glass plate did not show major cytotoxicity. In vivo tumor model was also used to show the uptake of Q-dot from the PLLA/Q-dot film to the tumor site.

• Communications of the Korean Mathematical Society
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• v.11 no.3
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• pp.695-706
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• 1996

In the control system $ \dot{x} = f(t,x(t)) + g(t,x(t))\dot{u}, x(0) = \bar{x}, t \in [0,T], $ this paper shows that the map from u with $L^1(m)$-topology to $x_u$ with $L^1(\mu)$-topology is Lipschitz continuous where f is $C^1$, $\mu$ is the Stieltjes measure derived from the function g which is not smooth in the variable t and $x_u$ is the solution of the above system corresponding to u under the assumption that $\dot{u}$ is bounded.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.7 no.4
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• pp.681-693
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• 1995

A new set of capillary tube selection charts for R-22 is proposed. The set of charts takes into account of the roughness effect on the mass flow rate. For this purpose, a set of numerical model is developed and a series of experiments is conducted to verify the numerical model. A numerical model is used to calculated the mass flow rate for several sets of tube diameter, length, inlet pressures and degree of subcooling. The outlet of the tube is controlled to be at critical condition. The experimental flow rate is compared with calculated values. The calculated values are consistently less than the experimental ones except for the flow rate range below 40kg/hr. The deviation is within 10---. Based on the nunmerical model and results of experiments, the set of capillary tube selection charts for R-22 is constructed. The set of charts consists of standard capillary tube chart(L=2030mm, d=1.63mm, ${\varepsilon}=2.5{\mu}m$), non -standard flow factor(${\phi}_1$) chart, and non-standard roughness factor(${\phi}_2$) chart. The mass flow rate, flow factor, and the roughness factor are defined respectively as; $\dot{m}={\phi}_1{\phi}_2\dot{m}_{standard}\\{\phi}_1=\frac{\dot{m}(L,\;d,\;\varepsilon_{standard})}{\dot{m}_{standard}(L_{standard},\;d_{standard},\;{\varepsilon}_{standard})}\\{\phi}_2=\frac{\dot{m}(L_{standard},\;d_{standard},\;{\varepsilon})}{\dot{m}_{standard}(L_{standard},\;d_{standard},\;{\varepsilon}_{standard})}$.

• Publications of The Korean Astronomical Society
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• v.4 no.1
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• pp.16-30
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• 1989

We present recent data of absolute measurements of flux emmitted in the visible continua of some galactic Wolf-Rayet stars, carried out by means of a two-channel scanner built up cooperatively by the Observatoire de Lyon and the Laboratoire d'Astronomie Spatiale. Our measurements lead to the determination of stellar angular diameters which enable us to compute log $L_*/L_{\odot}$ and to locate the WR stars in the HR diagram: The WR stars are cooler than the zero age main sequence (ZAMS) and the WN7, WN8 types appear more luminous than other subclasses. The stellar wind terminal velocities, $V_{\infty}$, deduced from the empirical relation of the effective temperatures by Underhil1(1983) and $V_{\infty}$ adopted from the work of Willis(1982) show about 2,000km/s. We derived the rate of mass loss for the program stars from the formula, $\dot{M}={\varepsilon}(T_{eff})\;L/V_{\infty}{\cdot}c$ by using the obtained effective temperatures, luminosities and $V_{\infty}$ in this work. Their values range from $\dot{M}=1.4{\times}10^{-5}$ to $\dot{M}=5.8{\times}10^{-5}\;\dot{M}_{\odot}/yr$.

• Current Optics and Photonics
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• v.3 no.2
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• pp.143-149
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• 2019

Shape ellipticity dependence of the exciton fine energy levels in CdTe and CdSe nanocrystal quantum dots were compared theoretically by considering the crystal structure and the Coulomb interaction of an electron and a hole. While quantum dot ellipticity changes from an oblate to prolate quantum dot via spherical shape, both the fine energy levels and the dipole moment in wurtzite structure of a CdSe quantum dot change linearly for ellipticity. In contrast, CdTe quantum dots were found to show a level crossing between the bright and dark exciton states with a significant change of the dipole moment due to the cubic structure. Shape ellipticity dependence of the optical nonlinearities in CdTe and CdSe nanocrystal quantum dots was also calculated by using semiconductor Bloch equations. For a spherical shape quantum dot, only $1^L$ dominates the optical nonlinearities in a CdSe quantum dot, but both $1^U$ and $0^U$ contribute in a CdTe quantum dot. As excitation pulse area becomes strong (${\sim}{\pi}$), the optical nonlinearities of both CdSe and CdTe quantum dots are mainly governed by absorption saturation. However, in the case of a prolate CdTe quantum dot, the real part of the nonlinear refractive index becomes relatively significant.

• Journal of the Korean Institute of Gas
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• v.15 no.1
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• pp.30-34
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• 2011

This paper presents a strength safety evaluation of composite pressure container for hydrogen fuel tanks with a storage capacity of 104 liter and 70MPa pressure. The carbon fiber composite container is manufactured by an aluminum liner of Al6061-T6 and composite multi-layers of hoop winding layer in circumferential direction, $12^{\circ}C$ inclined winding layer and $70^{\circ}C$winding layer in helical direction respectively. The FEM results on the strength safety of composite fuel tanks were evaluated with a criterion of design safety of US DOT-CFFC and KS B ISO 11119-2 codes. The FEM computed results indicate that the proposed design model of 104 liter composite container is safe based on two strength safety codes. But, the computed results of carbon fiber fuel tanks based on US DOT-CFFC code is safer compared with that of KS B ISO 11119-2. Thus the hydrogen gas pressure container of 70MPa may be evaluated and designed by US DOT-CFFC code for more strength safety.

• Proceedings of the Korean Society Of Semiconductor Equipment Technology
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• 2005.09a
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• pp.137-141
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• 2005

Quantum dot(QD) 메모리용 silicon nano-particle을 corona 방전방법에 의해 상온에서 대량 발생하는 방법을 개발하였다. Silicon QD는 SiH4 가스를 코로나 방전 영역을 통과시켜 발생시켰으며, 코로나 전압은 2.75kV를 사용하였다. SiH4 몰농도 $0.33{\times}10^{-7}\;mol/l$ 일 경우 발생된 QD입자 크기는 약 10nm이며 기하학적 표준편차(geometric standard deviation)는 1.31이었다. 이 조건에서 nonvolatile quantum dot semiconductor memory (NVQDM)를 제작하였으며, 이렇게 제작된 NVQDM flat band voltage는 1.5 volt였다.

• Journal of Radiation Protection and Research
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• v.17 no.1
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• pp.43-56
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• 1992

As one of the methods to ameliorate the ray effects which are the nature of anomalous computational effects due to the discretization of the angular variable in discrete ordinates approximations, a computational program, named TWODET (TWO dimensional Discrete Element Transport), has developed in 2 dimensional cartesian coordinates system using the discrete elements method, in which the discrete angle quadratures are steered by the spatially dependent angular fluxes. The results of the TWODET calculation with K-2, L-3 discrete angular quadratures, in the problem of a centrally located, isotropically emitting flat source in an absorbing square, are shown to be more accurate than that of the DOT 4.3 calculation with S-10 full symmetry angular quadratures, in remedy of the ray effect at the edge flux distributions of the square. But the computing time of the TWODET is about 4 times more than that of the DOT 4.3. In the problem of vacuum boundaries just outside of the source region in an absorbing square, the results of the TWODET calculation are shown severely anomalous ray effects, due to the sudden discontinuity between the source and the vacuum, like as the results of the DOT 4.3 calculation. In the probelm of an external source in an absorbing square in which a highly absorbing medium is added, the results of the TWODET calculation with K-3, L-4 show a good ones like as, somewhat more than, that of the DOT 4.3 calculation with S-10.

• Journal of the Korean Society of Propulsion Engineers
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• v.9 no.4
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• pp.31-38
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• 2005

In this paper, the combustion characteristics of a hybrid propulsion system were studied with various L/D(length vs diameter) ratio of the single po.1 type solid fuel. Experiments were performed for 2 cases with the fixed grain port diameter and fuel length respectively. For the first case, results show that there are no large variations for regression rates as the L/D ratio changes. And as the L/D ratio increases, the O/F ratio decreases and thrust, characteristic velocity tends to increase. For the second case, there is no large change for O/F ratio, thrust and characteristic velocity as L/D ratio changes. On the other hand, as the L/D ratio decreases, only the regression rate tends to increase. Experimentally, exponent n in $\dot{r}=a{G_0}^n$ was found about 0.5 and then the O/F ratio was shown nearly constant. In the experiment, PE and gas oxygen were used as a fuel and an oxidizer.