• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.383-390
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• 2018

Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome with an increasingly prevalent etiology, yet not fully understood. It has been thought that vitamin D, complex B vitamin levels and homocysteine are associated with environmental factors and are important in ASD. The aim of this study was to examine serum vitamin D, vitamin D receptor (VDR), homocysteine, vitamin B6, vitamin B12 and folate levels in ASD. Methods: In this study, serum vitamin D and VDR, homocysteine, vitamins B6, B12 and folate levels were determined in 60 patients with ASD (aged 3 to 12 years) and in 45 age-gender matched healthy controls. In addition, calcium, phosphorus and alkaline phosphatase, which are associated with vitamin D metabolism, were measured from serum in both groups. ASD severity was evaluted by the Childhood Autism Rating Scale (CARS). Results: Serum vitamin D and VDR were substantially reduced in patients with ASD in comparision to control group. However, homocysteine level was significantly higher and vitamin B6, vitamin B12 and folate were also reduced in patients with ASD. Total CARS score showed a positive association with homocysteine and a negative correlation with vitamins D,B6, B12, folate and VDR. Conclusion: This comprehensive study, which examines many parameters has shown that low serum levels of vitamins D, B6, B12, folate and VDR as well as high homocysteine are important in the etiopathogenesis of ASD. However, further studies are required to define the precise mechanism(s) of these parameters and their contributions to the etiology and treatment of ASD.

• Applied Biological Chemistry
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• v.51 no.3
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• pp.159-163
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• 2008

Xylogone sphaerospora ${\beta}$-mannanase was purified by Sephadex G-100 column chromatography. The specific activity of the purified enzyme was 8.44 units/ml protein, representing an 56.27-folds purification of the original crude extract. The final preparation thus obtained showed a single band on SDS-polyacrylamide gel electrophoresis. The molecular weight was determined to be 42kDa. Konjac glucomannan was hydrolyzed by the purified ${\beta}$-mannanase, and then the hydrolysates was separated by activated carbon column chromatography. The main hydrolysates were composed of D.P. (Degree of Polymerization) 3 and 4 glucomannooligosaccharides. For elucidate the structure of D.P 3 and 4 glucomannooligosaccharides, sequential enzymatic action was performed. D.P 3 and 4 were identified as M-G-M and M-M-G-M (G- and M- represent glucosidic and mannosidic link-ages). To investigate the effects of konjac glucomannooligosaccharides on in vitro growth of Bifido-bacterium longum, B. bifidum, B. infantis, B. adolescentis, B. animalis, B. auglutum and B. breve. Bifidobacterium spp. were cultivated individually on the modified-MRS medium containing carbon source such as D.P. 3 and D.P. 4 glucomannooligosaccharides, respectively. B. longum and B. bifidum grew up 3.9-fold and 2.8-fold more effectively by the treatment of D.P. 4 glucomannooligosaccharides, compared to those of standard MRS medium. Especially, D.P. 4 was more effective than D.P. 3 glucomannooligosaccharide on the growth of Bifidobacterium spp.

• Journal of the Korean Ceramic Society
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• v.40 no.11
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• pp.1090-1095
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• 2003

In this paper, the modeling and design of high-Q multilayer passives and multilayer diplexer for GSM/DCS applications designed and fabricated using these passives have been investigated.. To miniaturize the system, configurations of inductor and capacitor have involved a square spiral structure and a vertically-interdigitated capacitor similar to 3D interdigital structure, respectively. Multilayer diplexers for GSM/DCS applications were designed and fabricated to apply high-Q multilayer passives to practical systems, which were designed by the proposed structural and equivalent circuit model. LPF for GSM band had the passband insertion loss of less than 0.55 dB, the return loss of more than 12 dB, and the isolation level of more than 26 dB by locating attenuation pole at 1800 MHz. HPF for DCS band had the passband insertion loss of less than 0.82 dB, the return loss of more than 11 dB, and the isolation level of more than 38 dB by locating attenuation pole at 930 MHz.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.25 no.1
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• pp.12-17
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• 1989

A field experiment was carried out of confirm the effect of underwater sound on the luring of fish school of chub mackerel in the coast of Idousyo Island. Underwater sound that was made use of luring of fish school was pure sound and interval pure sound which the frequencies of the sound were 150Hz and 200Hz, respectively. The results of the observation of hooking and recording paper of fish finder indicate that the effect of emitting sound at 20m in the depth of water was remarkable for the luring of fish school of chub mackerel. The vertical pure sound pressure level at 150Hz and 200Hz of the water layer that was lured the fish school of chub mackerel were 140.1dB and 146.dB at 30m, 121.0dB and 126.6dB at 70m and 141.9dB and 120.5dB at 120m in the depth of water, respectively.

• Korean Journal of Plant Resources
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• v.28 no.6
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• pp.682-689
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• 2015

Abeliophyllum distichum Nakai (A. distichum) has been reported to exert the inhibitory effect on angiotensin converting enzyme and aldose reductase. Recently, our group found that branch extracts of A. distichum (EAFAD-B) induce apoptosis through ATF3 activation in human colon cancer cells. However, anti-cancer reagents exert their activity through the regulation of various molecular targets. Therefore, the elucidation of potential mechanisms of EAFAD-B for anti-cancer activity may be necessary. To elucidate the potential mechanism of EAFAD-B for anti-cancer activity, we evaluated the regulation of cyclin D1 in human colon cancer cells. EAFAD-B decreased cellular accumulation of cyclin D1 protein. However, cyclin D1 mRNA was not changed by EAFAD-B. Inhibition of proteasomal degradation by MG132 attenuated EAFAD-B-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with EAFAD-B. In addition, EAFAD-B induced cyclin D1 phosphorylation at threonine-286 and the point mutation of threonine-286 to alanine attenuated EAFAD-B-mediated cyclin D1 proteasomal degradation. Inhibitions of both ERK1/2 by PD98059 and NF-κB by a selective inhibitor, BAY 11-7082 suppressed cyclin D1 downregulation by EAFAD-B. From these results, we suggest that EAFAD-B-mediated cyclin D1 downregulation may result from proteasomal degradation through its threonine-286 phosphorylation via ERK1/2-dependent NF-κB activation. The current study provides new mechanistic link between EAFAD-B and anti-cancer activity in human colon cancer cells.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2001.11a
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• pp.231-234
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• 2001

위성방송 수신을 위한 S-band용 LNB를 유전율3.48, 기판두께 0.762mm의 기판을 사용하여 NF=0.9 dB, 변환이득 56dB, Gain Flatness +0.7dB/27MHz을 만족하도록 설계하였으며 대역통과필터는 원하는 대역내에서 삽입손실 -2dB, 반사계수 -l2dB 이하의 결과를 얻었다. 발진기는 3.62GHz에서 6.17dBm의 출력을 나타내었으며 위상잡음은 중심주파수 3.62GHz의 100kHz offset 지점에서 -98 dBc/Hz의 특성을 얻었다.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2000.11a
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• pp.146-149
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• 2000

SiGe HUT뜰 이용하여 Cellular 주파수 대역(824-849 MHz)에서 MMIC 상향 주파수 혼합기와 가변이득 증폭기를 설계하였다. 동작 전압은 2.7 V 이며, 이중평형 구조의 상향 주파수 혼합기는 12 dB의 변환이득, -0.6 dBm의 1dB 이득압축 출력전력, 30 dB 이상의 LO-RF 단자 격리도 특성, 1.25의 LO-VSWR. 1.34의 RF-VSWR을 가지며, 상호컨덕턴스형 가변이득 증폭기는 35 dB의 최대 선형이득, 13 dBm의 1dB 이득압축 출력전력, 42dB의 가변이득, 23dB의 3차 상호변조 교점 출력전력(OIP$_3$), 1.27의 입력 VSWR, 1.1의 출력 VSWR 특성을 보인다.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.7
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• pp.1255-1260
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• 2009

Microstrip interdigital filter is designed with the width and length of a resonator, the gap distance between resonators and the location of a tap. When designing filters, it is a benefit to design with few design parameters comparing to many design parameters. In this paper we design and implement two microstrip interdigital filters operating in the UWB(Ultra Wide-Band) frequency band, one using a fixed width of a resonator and the other using a different width of resonators. The test results of the implemented filters show that the low-band high filter with a fixed width has the insertion loss of 1.49dB, -10dB band width of 720MHz, -35.7dBattenuation at 4.8GHzand below -13dB of S11. The filter with a different width of resonators has the insertion loss of 1.6dB, -10dBbandwidth of 1.63GHz and below-8dBof S11.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.6
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• pp.875-882
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• 2021

To minimize occupational noise induced hearing loss, it is recommended that workers should not be exposed to noise levels exceeding 85 dBA for over 8 h. In the present study, noise exposure levels were measured for seven workers based on their tasks on a training ship. The A-weighted noise exposure level (L_ex,24h) was measured by taking into account the A-weighted equivalent continuous sound level (L_Aeq,i), duration (h) and noise contribution (L_ex,24h,i) from the workers' locations. Results are thus obtained for different job categories as follows: officer group L_ex,24h=56.1 dB, navigation crew L_ex,24h=58.9 dB, navigation cadet L_ex,24h=62.0 dB, ship's cook L_ex,24h=64.3 dB, engine cadet L_ex,24h=91.1 dB, engineer L_ex,24h=91.1 dB, and engine crew L_ex,24h=95.1 dB. It was determined that the engineers, engine crews, and engine cadets in charge of machinery must wear hearing protection devices. By wearing hearing protection devices when working in highly noisy engine rooms, it is estimated that the noise expose levels could be reduced by the following amounts: engineer L_ex,24h=23.1 dB, engine Crew L_ex,24h=24.4 dB, and engine cadet L_ex,24h=21.5 dB. Moreover, if the no. 2 lecture room and mess room bottom plates in the cadets accommodations were improved to the 64 mm A-60-class floating plates, then further reductions are possible as follows: navigation cadet L_ex,24h=4.3 dB and engine cadet L_ex,24h=1.8 dB.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.6
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• pp.63-70
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• 2012

This paper discussed on the directive gain improvement method of the U-type ultra wide-band(UWB) planar patch antenna model with CPW feeding. For directive gain improvement, the U-type printed patch antenna model with CPW feeding is reconstructed as a microstrip structure by adding a reflection plane with aperture slot. The reflection coefficient of the reconstructed antenna is less than -6.5 dB(VSWR < 3.3) to the characteristic impedance of $50.08{\Omega}$ and showed the directive radiation patterns with the directive gain of 7.5 dBi ~ 10.1 dBi, the front-back ratio of 17.8 dB ~ 28.7 dB and the range of -3dB radiation angle over ${\pm}30^{\circ}$ to the main beam direction of ${\theta}=0^{\circ}$.