• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2369-2374
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• 2014

Background and Aim: Selumetinib is a promising and interesting targeted therapy agent as it may reverse radioiodine uptake in patients with radioiodine-refractory differentiated thyroid cancer. We conduct this metaanalysis to compare the efficacy and safety of selumetinib with current therapies in patients with advanced cancer. Methods: An electronic search was conducted using PubMed/ Medicine, EMBASE and Cochrane library databases. Statistical analyses were carried out using either random-effects or fixed-effects models according to the heterogeneity of eligible studies. Results: Six eligible trials involved 601 patients were identified. Compared with current therapies, treatment schedules with selumetinib did not improve progression free survival (hazard ratio, 0.91; 95%CI 0.70-1.17, P= 0.448), but did identify better clinical benefits (odds ratio, 1.24; 95%CI 0.69-2.24, P = 0.472) and less disease progression (hazard ratio, 0.72; 95%CI 0.51-1.00, P = 0.052) though its impact was not statistically significant. Sub-group analysis resulted in significantly improved progression free survival (hazard ratio, 0.61; 95%CI 0.49-0.57, P = 0.00), clinical benefits (odds ratio, 3.04; 95%CI 1.60-5.77, P = 0.001) and reduced disease progression (hazard ratio, 0.35; 95%CI 0.18-0.67, P = 0.001) in patients administrated selumetinib. Dermatitis acneiform (risk ratio, 9.775; 95%CI 3.143-30.395, P = 0.00) and peripheral edema (risk ratio, 2.371; 95%CI 1.690-3.327, P = 0.00) are the most frequently observed adverse effects associated with selumetinib. Conclusions: Compared with current chemotherapy, selumetinib has modest clinical activity as monotherapy in patients with advanced cancer, but combinations of selumetinib with cytotoxic agents in patients with BRAF or KRAS mutations hold great promise for cancer treatment. Dermatitis acneiform and peripheral edema are the most frequently observed adverse effects in patients with selumetinib.

• Journal of Power Electronics
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• v.17 no.2
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• pp.315-322
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• 2017

LED is a promising new generation of green lighting with the advantages of high efficiency, good optical performance, long lifetime and environmental friendliness. A pulsating current can be used to drive LEDs. However, current with a high peak-to-average ratio is unfavorable for LEDs. A novel control scheme for the ac-dc critical conduction mode (CRM) flyback LED driver is proposed in this paper. By using the input voltage, output voltage and average output current to control the turn-on time of the switch, the peak-to-average ratio of the output current can be reduced. The operation principle is analyzed and an implementation circuit is put forward. Experimental results show the effectiveness of the proposed scheme.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.24 no.5
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• pp.364-369
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• 2011

Analyzing electrical degradation of polycrystalline silicon transistor to applicable at several environment is very important issue. In this research, after fabricating p channel poly crystalline silicon TFT (thin film transistor) electrical characteristics were compare and analized that changed by gate bias with first measurement. As a result on and off current was reduced by variation of gate bias and especially re duce ratio of off current was reduced by $7.1{\times}10^1$. On/off current ratio, threshold voltage and electron mobility increased. Also, when channel length gets shorter on/off current ratio was increased more and thresh old voltage increased less. It was cause due to electron trap and de-trap to gate silicon oxide by variation of gate bias.

• Proceedings of the KIEE Conference
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• 2008.09a
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• pp.69-71
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• 2008

We have developed a current range extension method to obtain the ratio error and phase displacement of a current transformer (CT) by using absolute evaluation method and two different CTs. The method was applied to CTs under test with the current ratios of the range of 5,000 A / 1 A - 20,000 A / 1 A. The ratio error and phase displacement of the CT under test obtained in this study are consistent with those measured at the national institute in Germany using the same CT under test within an expanded uncertainty (k = 2) in the overall current ratios.

• Proceedings of the KIEE Conference
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• 2005.10b
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• pp.573-575
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• 2005

In the steel industry, a steel melting electric arc furnace is used to produce both carbon and alloy steels. Steel scrap which is charged into the furnace is heated by means of electric arc between graphite electrodes and the scrap. In this melting process, current is supplied to the furnace through HCC(high current cable) which connect the furnace and transformer. Four HCCs are assigned to each phase in our system to divide the current. Since a sudden cable breaking result in the shutdown of melting process, an aging detection of HCC is very important for both an improvement of productivity and cost reduction. In this paper, the aging of the HCC is estimated by using the current ratio between four HCCs.

• Proceedings of the KIEE Conference
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• 2005.07b
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• pp.951-953
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• 2005

The current transformer is used for the insulation of measuring instrument, enlargement of measurement scope, standardization of measuring instrument, control of protective device. It's required various performance as the intention of service, site of establishment, insulation. especailly, current transformer has small ratio errors. if current transformer has large ratio error, it's caused a electricity failure. so in this paper, we examine the theory of current transformer, major factor of errors, output performance on over-current.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.06a
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• pp.344-345
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• 2009

The flux-coupling type superconducting fault current limiter(SFCL) is composed of a series transformer and superconducting unit of the YBCO coated conductor. The primary and secondary coils in the transformer were wound in series each other through an iron core and the YBCO coated conductor was connected with secondary coil in parallel. In a normal condition, the flux generated from a primary coil is cancelled out by its structure and the zero resistance of the YBCO thin films. When a fault occurs, the resistance of the YBCO coated conductor was generated and the fault current was limited by the SFCL. In this paper, we investigated the fault current limiting characteristics according to turn ratio in the flux-coupling type SFCL. The experiment results that the fault current limiting characteristics was improved according to turn ratio.

• Journal of Biomedical Engineering Research
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• v.26 no.4
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• pp.215-221
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• 2005

We describe the development of a prototype multi-channel electrical impedance tomography (EIT) system. The EIT system can be equipped with either a single-ended current source or a balanced current source. Each current source can inject current between any chosen pair of electrodes. In order to reduce the data acquisition time, we implemented multiple digital voltmeters simultaneously acquiring and demodulating voltage signals. Each voltmeter measures a differential voltage between a fixed pair of adjacent electrodes. All voltmeters are configured in a radially symmetric architecture to optimize the routing of wires and minimize cross-talks. To maximize the signal-to-noise ratio, we implemented techniques such as digital waveform generation, Howland current pump circuit with a generalized impedance converter, digital phase-sensitive demodulation, tri-axial cables with both grounded and driven shields, and others. The performance of the EIT system was evaluated in terms of common-mode rejection ratio, signal-to-noise ratio, and reciprocity error. Future design of a more innovative EIT system including battery operation, miniaturization, and wireless techniques is suggested.

• Journal of the Microelectronics and Packaging Society
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• v.13 no.4
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• pp.57-63
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• 2006

For chip-stack package applications, Cu filling characteristics into trench vias of $75{\sim}10\;{\mu}m$ width and 3 mm length were investigated with variations of electroplating current density and current mode. At $1.25mA/cm^{2}$ of DC mode, Cu filling ratio higher than 95% was obtained for trench vias of $75{\sim}35{\mu}m$ width. When electroplated at DC $2.5mA/cm^{2}$, Cu filling ratios became inferior to those processed at DC $1.25mA/cm^{2}$. Pulse current mode exhibited Cu filling characteristics superior to DC current mode.

• Proceedings of the KIPE Conference
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• 2014.07a
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• pp.335-336
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• 2014

This paper investigates the design of coupled inductor for minimum inductor current ripple in rapid traction battery charger systems. Based on the general circuit model of coupled inductor together with the operating principles of dc-dc converter, the relationship between the ripple size of inductor current and the coupling factor is derived under the different duty ratio. The optimal coupling factor which corresponds to a minimum inductor ripple current becomes -1, i.e. a complete inverse coupling without leakage inductance, as the steady-state duty ratio operating point approaches 0.5. In an opposite manner, the optimal coupling factor value of zero, i.e. zero mutual inductance, is required when the steady-state duty ratio operating point approaches either zero or one. Coupled inductors having optimal coupling factor can minimize the ripple current of inductor and battery current resulting in a reliable and efficient operation of battery chargers.