• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2008년도 추계학술대회 논문집 Vol.21
• /
• pp.148-148
• /
• 2008

Low-k dielectric materials are an alternative plan to improve the signal propagation delay, crosstalk, dynamic power consumption due to resistance and parasitic capacitance generated the decrease of device size. Now, various materials is studied for the next generation. Diethoxymethlysiliane (DEMS) precursor using this study has two ethoxy groups along with one methyl group attached to the silicon atoms. SiCOH thin films were deposited on p-type Si(100) substrate by Plasma Enhanced Chemical Vapor Deposition (PECVD) using DEMS. In this study, we studied the effect of oxygen($O_2$) flow rate for DEMS to characteristics of thin films. The characteristics of thin films deposited using DEMS and $O_2$ evaluated through refractive index, dielectric constant(k), surface roughness, I-V(MIM:Al / SiCOH / Ag), C-V(MIM), deposition rate.

• BMB Reports
• /
• 제44권1호
• /
• pp.11-21
• /
• 2011

During the last decade small regulatory RNA (srRNA) emerged as central players in the regulation of gene expression in all kingdoms of life. Multiple pathways for srRNA biogenesis and diverse mechanisms of gene regulation may indicate that srRNA regulation evolved independently multiple times. However, small RNA pathways share numerous properties, including the ability of a single srRNA to regulate multiple targets. Some of the mechanisms of gene regulation by srRNAs have significant effect on the abundance of free srRNAs that are ready to interact with new targets. This results in indirect interactions among seemingly unrelated genes, as well as in a crosstalk between different srRNA pathways. Here we briefly review and compare the major srRNA pathways, and argue that the impact of srRNA is always at the system level. We demonstrate how a simple mathematical model can ease the discussion of governing principles. To demonstrate these points we review a few examples from bacteria and animals.

• The Journal of Korean Physical Therapy
• /
• 제12권1호
• /
• pp.163-172
• /
• 2000

The purpose of this study was to provide experimental evidence and theoretical background for the applicability of bilateral transfer paradigm to the rehabilitation programs for children with hemiplegic cerebral palsy. Children with hemiplegia, which means unilateral motor disabilities, display abnormal motor and postural patterns of the affected side due to hemiparesis, spasticity, and sensory disorders, resulting in a decreased motor abilities of the affected side compared to unaffected side. Accordingly, they tend to rely on the unaffected limb for everyday activities, which further deteriorates the functions of the affected side by causing associated reaction, abnormal postural patterns, and hypertonus. Rehabilitation programs developed for children with hemiplegic cerebral palsy include neurodevelopmental treatment, application of cast or splint to unaffected limb, neuromuscular electrical stimulation, and task oriented model. These programs, however, have several drawbacks, such as discontinuity in treatment effect and psychological hatred to the force use of the affected side. In order to solve these problems and enhance the efficiency of the rehabilitation programs, it is required to maximize the use of the affected side without hatred. Characteristics of the control system, such as temporal coupling and spatial assimilation between limbs and neural crosstalk at different levels of central motor pathway, suggest that the bilateral transfer paradigm may enhance the efficiency of the rehabilitation programs for children with hemiplegic cerebral palsy.

• 대한전자공학회논문지SD
• /
• 제41권10호
• /
• pp.51-56
• /
• 2004

광소자의 재료물질로서 특성이 우수하며 열광학계수가 큰 silicon을 기반으로 한 SOI (Silicon-on-insulator)를 사용하여 열광학 1×2 광스위치를 제안, 제작하였다. SOI wafer는 도파로가 형성될 상위 Si 층(n=3.5)과 클래딩 영역이 될 산화막 매립층(n=1.5) 그리고 기판인 Si인 3층으로 이루어진다. BPM(Beam propagation method) 전산모의를 통해 20dB 이상의 누화특성을 갖는 단일모드의 1×2 비대칭 y-분기 광도파로를 형성하고, 열확산 전산모의를 통해 금속열선을 설계 제작하였다. 제작된 광스위치는 약 3.5 watts의 구동 전력에서 20dB 이상의 채널간 누화가 측정되었다.

• International Journal of Oral Biology
• /
• 제44권2호
• /
• pp.50-54
• /
• 2019

Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial muscle contraction, salivary secretion, and tooth development. However, knowledge regarding physiological crosstalk between melatonin and nAChRs is limited. In the present study, the melatonin-mediated modulation of nAChR functions using bovine adrenal chromaffin cells, a representative model for the study of nAChRs, was investigated. Melatonin inhibited the nicotinic agonist dimethylphenylpiperazinium (DMPP) iodide-induced cytosolic free $Ca^{2+}$ concentration ($[Ca^{2+}]_i$) increase and norepinephrine secretion in a concentration-dependent manner. The inhibitory effect of melatonin on the DMPP-induced $[Ca^{2+}]_i$ increase was observed when the melatonin treatment was performed simultaneously with DMPP. The results indicate that melatonin inhibits nAChR functions in both peripheral and central nervous systems.

• Journal of Ginseng Research
• /
• 제46권1호
• /
• pp.54-61
• /
• 2022

Ginseng has been widely studied due to its various therapeutic properties on various diseases such as cardiovascular disease (CVD). Cardiovascular disease has been canonically known to be caused by high levels of low-density lipoproteins (LDL) in the bloodstream, in addition to the impaired vasodilatory effects of cholesterol. However, current research on CVD has revealed a cascade of mechanisms involving a series of events that contribute to the progression of CVD. Although this has been elucidated and summarized in previous studies the detailed correlation between platelet aggregation and innate immunity that plays an important role in CVD progression has not been thoroughly summarized. Furthermore, immune cell subtypes also contribute to the progression of plaque formation in the subendothelial layer. Thrombus formation and the coagulation cascade also have a vital role in the progression of atherosclerosis. Hence, in this mini review we aim to elucidate, summarize, and propose the potent therapeutic effect of ginseng on CVD, mainly on platelet aggregation, plaque formation, and thrombus formation.

• 한국통신학회논문지
• /
• 제30권8A호
• /
• pp.697-704
• /
• 2005

온도보상 패키지를 적용하여 1000Hz 채널간격을 갖는 DWDM용 8채널 광다중화기를 제작하였다. 8채널 광다중화기는 전광섬유형 Mach Zehnder 간섭계(MZI)를 3단으로 다단 연결하여 제작되었으며, 광 다중화기 채널별 출력파장의 삽입손실을 균일하게 하기 위하여 파장에 대한 삽입손실변화가 적은 파장무의존형 커플러(WFC)를 이용하여 전광섬유형 MZI를 제작하였다. 전용 제작 장치를 이용하여, 전광섬유형 MZI를 제작하였으며, 미세한 파장을 조절하기 위해서, $CO_2$ 레이저를 이용하였다. 광 다중화기의 출력중심파장이 주위온도변화에 영향을 받지 않도록 하기 위해서 별도의 외부 온도제어기를 사용하지 않은 온도보상 패키지가 적용되었다. 제작된 8채널 광 다중화기는 평균 삽입손실 2.1dB, 5.5dB에서의 통과대역폭이 0.8nm 이며, 2.1dB의 채널 Crosstalk를 갖는 특성을 얻을 수 있었다. 이때 편광의존 손실은 0.06dB이며, $60^{\circ}C$ 정도의 주위온도 변화에 대해서 출력파장 0.05nm이내에서 변하도록 제작할 수 있다.

• BMB Reports
• /
• 제55권11호
• /
• pp.565-570
• /
• 2022

Pulmonary arterial hypertension (PAH) is a progressive and devastating disease whose pathogenesis is associated with a phenotypic switch of pulmonary arterial vascular smooth muscle cells (PASMCs). Bone morphogenetic protein (BMP) signaling and potassium two pore domain channel subfamily K member 3 (KCNK3) play crucial roles in PAH pathogenesis. However, the relationship between BMP signaling and KCNK3 expression in the PASMC phenotypic switching process has not been studied. In this study, we explored the effect of BMPs on KCNK3 expression and the role of KCNK3 in the BMP-mediated PASMC phenotypic switch. Expression levels of BMP receptor 2 (BMPR2) and KCNK3 were downregulated in PASMCs of rats with PAH compared to those in normal controls, implying a possible association between BMP/BMPR2 signaling and KCNK3 expression in the pulmonary vasculature. Treatment with BMP2, BMP4, and BMP7 significantly increased KCNK3 expression in primary human PASMCs (HPASMCs). BMPR2 knockdown and treatment with Smad1/5 signaling inhibitor substantially abrogated the BMP-induced increase in KCNK3 expression, suggesting that KCNK3 expression in HPASMCs is regulated by the canonical BMP-BMPR2-Smad1/5 signaling pathway. Furthermore, KCNK3 knockdown and treatment with a KCNK3 channel blocker completely blocked BMP-mediated anti-proliferation and expression of contractile marker genes in HPAMSCs, suggesting that the expression and functional activity of KCNK3 are required for BMP-mediated acquisition of the quiescent PASMC phenotype. Overall, our findings show a crosstalk between BMP signaling and KCNK3 in regulating the PASMC phenotype, wherein BMPs upregulate KCNK3 expression and KCNK3 then mediates BMP-induced phenotypic switching of PASMCs. Our results indicate that the dysfunction and/or downregulation of BMPR2 and KCNK3 observed in PAH work together to induce aberrant changes in the PASMC phenotype, providing insights into the complex molecular pathogenesis of PAH.

• The Korean Journal of Physiology and Pharmacology
• /
• 제21권2호
• /
• pp.161-168
• /
• 2017

Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-$1{\alpha}$ and K562) in vitro using $Transwell^{(R)}$ co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological changes, but had no effect on the proliferation of TF-$1{\alpha}$ and K562 cells. To identify the factors secreted from PVCs, conditioned media harvested from PVC cultures were analyzed by antibody arrays. We identified a set of cytokines, including persephin (PSPN), a neurotrophic factor, and a key regulator of oral squamous cell carcinoma progression. Supplementation with PSPN significantly increased the proliferation of A549 cells. These results suggested that PVCs produced a differential effect on the proliferation of cancer cells in a cell-type dependent manner. Further, secretome analyses of PVCs and the elucidation of the molecular mechanisms could facilitate the discovery of therapeutic target(s) for lung cancer.

• 한국전자파학회논문지
• /
• 제20권1호
• /
• pp.67-74
• /
• 2009

본 논문에서는 광 이중 측파대역 변조 방식과 16 QAM(Quadrature Amplitude Modulation) 신호를 이용한 부반송파/파장 분할 다중화 시스템의 성능을 부반송파 채널 간격, 누화 전력 량(crosstalk power), BER(Bit-Error Rate) 특성을 통해 연구하고 있다. 광 전송 링크에서 분산 특성과 자기 위상 변조, 상호 위상 변조와 같은 비선형 현상을 고려하였을 때 BER특성을 살펴보았다. 컴퓨터 시뮬레이션 결과, 부반송파/파장 분할 다중화 시스템의 성능을 결정짓는 주도적인 인자는 마흐-젠더 변조기의 비선형 특성과 부반송파 채널 간격으로 관찰되었다. 광섬유의 분산에 의한 영향만 고려했을 때는 전송거리가 증가함에 따라 높은 주파수에 있는 부반송파 채널의 BER 성능이 나빠졌으나, 분산과 비선형 효과를 함께 고려되었을 경우 광섬유에 입사하는 전력이 클 때 높은 주파수에 있는 부반송파 채널에서 약간의 BER 성능 향상을 확인할 수 있었다.