• Journal of Life Science
• /
• v.29 no.2
• /
• pp.256-264
• /
• 2019

Lymphotoxin ${\beta}$ receptor ($LT{\beta}R$), a member of the tumor necrosis factor receptor family, plays an important role in lymphoid tissue's architecture and organogenesis. In contrast, MLCK and ROCK play critical roles in the regulation of stress fiber (SF) formation in cells. To determine whether $LT{\beta}R$ stimulation in fibroblastic reticular cells (FRCs) is involved in these signaling pathways, myosin light chain kinase inhibitor-7 (ML-7) was used to inhibit them. ML7-treated FRCs completely blocked SFs and showed retraction and shrinkage processes comparable to those observed in agonistic anti-$LT{\beta}R$ antibody-treated cells. The inhibition of ROCK activity with Y27632-induced changes in actin cytoskeleton organization and cell morphology in FRCs. Actin bundles rearranged into SFs, and phospho-myosin light chain (p-MLC) co-localized in FRCs. We checked the level of Rho-guanosine diphosphate (RhoGDP)/guanosine triphosphate (GTP) exchange activity using FRC lysate. When $LT{\beta}R$ was stimulated with agonistic anti-$LT{\beta}R$ antibodies, Rho-GDP/GTP exchange activity was markedly reduced. Regarding $LT{\beta}R$ signaling with a focus on MLCK inhibition, we showed that the phosphorylation of MLCs was reduced by $LT{\beta}R$ stimulation in FRCs. Cytoskeleton components, such as tubulin, b-actin, and phospho-ezrin proteins acting as membrane-cytoskeleton linkers, were produced in de-phosphorylation, and they reduced expression in agonistic anti-$LT{\beta}R$ antibody-treated FRCs. Collectively, the results suggested that MLCK and ROCK were simultaneously responsible for SF regulation triggered by $LT{\beta}R$ signaling in FRCs.

• Journal of Korean Library and Information Science Society
• /
• v.53 no.1
• /
• pp.231-263
• /
• 2022

The understanding and capability to utilize artificial intelligence (AI) incorporated technology has become a required basic skillset for the people living in today's information age, and various members of the university have also increasingly become aware of the need for AI education. Amidst such shifting societal demands, both domestic and international university libraries have recognized the users' need for educational content centered on AI, but a user-centered service that aims to provide personalized recommendations of digital AI educational content is yet to become available. It is critical while the demand for AI education amongst university students is progressively growing that university libraries acquire a clear understanding of user intention towards an AI educational content recommender system and the potential factors contributing to its success. This study intended to ascertain the factors affecting acceptance of such system, using the Extended Technology Acceptance Model with added variables - innovativeness, self-efficacy, social influence, system quality and task-technology fit - in addition to perceived usefulness, perceived ease of use, and intention to use. Quantitative research was conducted via online research surveys for university students, and quantitative research was conducted through written interviews of university librarians. Results show that all groups, regardless of gender, year, or major, have the intention to use the AI-related Educational Content Recommendation System, with the task suitability factor being the most dominant variant to affect use intention. University librarians have also expressed agreement about the necessity of the recommendation system, and presented budget and content quality issues as realistic restrictions of the aforementioned system.

• Journal of Venture Innovation
• /
• v.6 no.1
• /
• pp.95-114
• /
• 2023

As the Fourth Industrial Revolution progresses, the importance of startups is becoming more prominent. Additionally, the role of accelerators in ensuring the sustainability of startups is also being emphasized. Therefore, in this study, among the services provided by accelerators to startups, the mentoring service, education service, funding service, and networking service tried to empirically analyze the structural relationship that affects startup performance through the dynamic capabilities of start-ups. To achieve this, we conducted a survey in February 2023 targeting startup CEOs and executives who had experience with accelerator program services. A total of 238 valid responses were analyzed using structural equation modeling with Amos 24. The results of the empirical analysis were as follows. The accelerator program services, including mentoring, education, funding, and networking services, had a significant positive effect on startup dynamic capabilities. Among the accelerator program sub-factors, networking services had the highest impact on startup dynamic capabilities, followed by mentoring, funding, and education services. Furthermore, startup dynamic capabilities were found to have a significant positive effect on startup performance. On the other hand, startup dynamic capabilities were found to mediate the relationship between mentoring, education, funding, networking services, and startup performance. Dynamic capabilities are a critical factor for startups, and the finding that accelerator programs can have a significant impact on startup performance by mediating these dynamic capabilities is significant both academically and practically.

• Journal of Korean Society of Environmental Engineers
• /
• v.38 no.9
• /
• pp.469-475
• /
• 2016

The study is the result of an practical operation analysis for the full scale fishery product wastewater treatment plant with immersed MBR (iMBR) process. Since fishery product industries show a wide range of wastewater generation by the season, design and operation of the equalization basin are very important factor. The aeration system for the equalization basin mixing can save the chemical consumption for followed system through the restriction of acid fermentation. The concentrations of wastewater primary DAF process treated were BOD 2,291 mg/L, $COD_{Mn}$ 530 mg/L, SS 256.8 mg/L, T-N 38 mg/L, T-P 13.5 mg/L respectively. It was considered that iMBR is the most efficient biological process for high salinity content wastewater since It is irrelevant to the capability of the sludge precipitation. SADp and SADm were 0.31, $26.5m^3/hr{\cdot}m^3$ respectively. In iMBR process, the critical F/M ratio was derived at 0.08~0.10 gBOD/gMLSS by analysing the correlations between MLSS, normalized TMP and temperature. The effluent concentrations were BOD 1.8 mg/L, $COD_{Mn}$ 12.4 mg/L, SS 1.0 mg/L, T-N 7.85 mg/L, T-P 0.1 mg/L and removal efficiencies were 99.9%, 97.6%, 96.3%, 95.7%, 97.8% respectively.

• The Korean Journal of Applied Statistics
• /
• v.29 no.3
• /
• pp.409-424
• /
• 2016

This study analyzed the causal relationship among factors that influence the purchase intensions for individual pensions which have a growing importance as a financial means after retirement. For this purpose, structural equation modeling based on the survey data (N = 928) was conducted to analyze psychological factors and financial factors comprehensively. According to empirical results of the structural equation, in the case of non-subscribers of individual pensions, potential longevity and coping efficacy influenced the purchase intensions for individual pensions fully mediated by fear and worry about longevity. Trust in insurers and risk tolerance directly influenced the purchase intensions for individual pensions. These show that trust in insurers is the most important factor in purchase intensions for individual pensions. Also, only trust in insurers give a direct impact on individual pensions in the case of individual pension subscribers. Longevity-related emotional side is expected to help in marketing activities that target potential customers signing individual pensions. In addition, trust in insurers has the greatest impact on new and additional subscriptions that represent critical efforts to improve trust in insurers.

• Journal of the Korea Concrete Institute
• /
• v.15 no.3
• /
• pp.400-408
• /
• 2003

Chloride ion inside concrete destroys the so-called passive film surrounding reinforcing bars inside concrete so that the so-called salt attack accelerates corrosion which is the most critical factor for durability as well as structural safety of reinforced concrete structures. Recently, as a solution of the salt attack, the ground granulated blast-furnace slag(GGBFS) have been used as binder or blended cement more extensively. In this paper, characteristics of chloride ion diffusion for the GGBFS concrete, which is known to possess better resistance to damage due to the chloride ion penetration than ordinary portland cement(OPC) concrete possesses, are analyzed and a chloride ion diffusion model for the GGBFS concrete is proposed by modifying an existing diffusion model for the OPC concrete. The proposed model is verified by comparing diffusion analysis results using the model accelerated chloride penetration test results for concrete specimens as well as field test results for an RC bridge pier. Then, an optimal resistance condition to chloride penetration for the GGBFS concrete is obtained according to degrees of fineness and replacement ratios of the GGBFS concrete. The result shows that the GGBFS concrete has better resistance to chloride ion penetration than OPC concrete has and the resistance is more affected by the replacement ratio than the degree of fineness of the GGBFS.

• Korean Journal of Construction Engineering and Management
• /
• v.14 no.1
• /
• pp.124-132
• /
• 2013

An influx of the population to the city has soared due to industrialization. As times go by, cities become densely populated so Korean government started to construct a number of buildings including apartment housings. Because they have become functionally, structurally, esthetically deteriorated over the past two decades. some improvements are needed. There are mainly two ways to improve old buildings: remodeling and reconstruction. Between the two, the first one is more popular as it is less time-consuming and more eco-friendly. Demolition work comes first for both of them and it should not give negative effects since it is regarded as a CP(Critical path) in the overall process. For this reason, a thorough construction management must be done. The reality, however, demolition is managed by the construction manager's experiences and decisions. If the key factor of demolition which is the planning of manpower and machine equipment, is determined by unscientific and subjective judgments, its period and risk also will increase. In particular, eco-friendly demolition can be more risky because it's been rarely conducted. Therefore, scientific and objective ways of demolition management are needed. In this context, this paper aims at analyzing productivity in each process of demolition focusing on manpower and machinery equipment which are the main parts of demolition assuming that the demands of eco-friendly remodeling demolition projects will be increasing. At the same time, by estimating working period through the output, this paper would be helpful to set up the plans for overall project in earlier stage.

• Journal of Life Science
• /
• v.17 no.8 s.88
• /
• pp.1063-1067
• /
• 2007

The Bcl-2 family proteins play critical roles in regulation of apoptosis, and the balanced interaction of pro- and anti-death members is a key factor in determining the cell fate. Noxa, a BH3-only Bcl-2-family member, has been originally identified as a target gene of p53. To understand the mechanism by which human Noxa (hNoxa) regulates the cell death, we screened the hNoxa binding partner using the yeast two hybrid screening and found that anti-death protein Mcl-1 binds to hNoxa. The binding of hNoxa to Mcl-1 was confirmed by immunoprecipitation in human colon cancer cell line HCT 116 cells. Mcl-1 significantly inhibited the hNoxa-induced cell death in HCT 116 cells. During the cell death induced by hNoxa, Mcl-1 protein was degraded. Its degradation was inhibited by z-VAD-fmk, a pancaspase inhibitor, suggesting caspase is responsible for Mcl-1 degradation in response to hNoxa. Together, the results indicate that hNoxa binds to Mcl-1 that is degraded by cas-pases during hNoxa-induced cell death.

• Journal of the Korean Geotechnical Society
• /
• v.30 no.5
• /
• pp.37-46
• /
• 2014

Geotechnical structures have been analyzed and constructed in various geometry conditions to maintain their stability in accordance with the characteristics of construction design. Shear strengths are generally obtained from triaxial test to apply to design analysis. Geotechnical structures under strip loading, such as earth dam, embankment, and retaining wall, have the strain in a direction, and plane strain condition. Thus, an approximate shear strengths should be applied for stability analysis suitable to ground condition. When applying shear strengths obtained from triaxial tests for slope stability analysis, the evaluation of it may underestimate the factor of safety because the implementation is not suitable for geometry condition. The paper compares shear strengths obtained from triaxial test and plane strain test based on various relative densities using weathered granite soils. Additionally, yield stress is determined by maximum axial strain 15% in triaxial test because of continuous kinematic hardening, but plane strain test can determine a failure point in critical state to evaluate the shear strengths of soils at the second plastic hardening step. This study proposes to perform an appropriate test for many geotechnical problems with plane strain condition.

• Journal of Korean Society of Transportation
• /
• v.33 no.6
• /
• pp.584-597
• /
• 2015

A considerable amount of literature has been published on pedestrian LOS. So far, however, there is a limitation that LOS analysis methodologies has concentrated on quantitative variables such as pedestrian flow rate, speed and space. This paper intended to suggest the accessibility variable which can not be considered on previous study. The factor was defined and quantified using public transport attributes in particular. This study was carried out in three phases: 1. defined accessibility employing public mode location and service information. 2. investigated the relationship between accessibility and pedestrian flow rate 3. developed the model to establish the factors affected to pedestrian LOS. The results showed that accessibility, walkway attribute and land use type affected the pedestrian LOS. Especially, accessibility and commercial area ratio had negative relationship with LOS. Futhermore, pedestrian LOS declined when obstacle of bus station located on the walkway. On the contrary, LOS was upgraded when sufficient effective width or residential area was secured. These results can receive considerable critical attentions related to determination of pedestrian LOS or effective walkway width.