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A Retrospective Study on the Effect of Herbal Extracts Combined with Conventional Therapy on Blood Glucose in Type 2 Diabetes Mellitus (제2형 당뇨병 환자에게 한방의료보험용 혼합엑기스산제와 경구혈당강하제 병용요법이 혈당 변화에 미치는 영향)

  • Jeong, Su-min;Noh, Ji-won;Lee, Min-seung;Yang, Hee-gwon;Ahn, Young-min;Ahn, Se-young;Lee, Byeong-chul
    • The Journal of Internal Korean Medicine
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    • v.41 no.6
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    • pp.1231-1244
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    • 2020
  • Objective: This study was conducted to report the glucose-lowering effect and safety of herbal extracts in patients with type 2 diabetes mellitus. Methods: We investigated 21 patients with type 2 diabetes mellitus who were administered Daeshiho-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san at Kyung-Hee University Korean Medical Hospital from 2014 to 2019. The hypoglycemic effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS) and 2-hour postprandial glucose (PP2) levels. For safety assessment, the effects of herbal extracts on liver and kidney function were analyzed by liver function tests, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and kidney function tests, including blood urea nitrogen (BUN) and creatinine (Cr). Patients were stratified according to their glycated hemoglobin (<6.5 or >6.5) levels and the kind of herbal extract used for treatment. Results: After administration of herbal extracts, FBS and PP2 significantly decreased to 20.24 mg/dL and 35.0 mg/dL respectively. Subgroup analysis revealed that, regardless of the glycated hemoglobin level, FBS and PP2 were significantly reduced in both groups. The safety profile showed no significant difference before and after taking herbal extracts. Conclusions: Daeshigo-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san may show the further glucose-lowering effects on patients with type 2 diabetes mellitus who have already treated with anti-hyperglycemic agents.

Improvement of Acid Digestion Method by Microwave for Hazardous Heavy Metal Analysis of Solid Refuse Fuel (고형연료제품의 유해중금속 분석을 위한 마이크로파 산 분해법의 개선)

  • Yang, Won-Seok;Park, Ho-Yeun;Kang, Jun-Gu;Lee, Young-Jin;Lee, Young-Kee;Yoon, Young-Wook;Jeon, Tae-Wan
    • Journal of Korea Society of Waste Management
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    • v.35 no.7
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    • pp.616-626
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    • 2018
  • The quality standards of solid refuse fuel (SRF) define the values for 12 physico-chemical properties, including moisture, lower heating value, and metal compounds, according to Article 20 of the Enforcement Rules of the Act on Resource Saving and Recycling Promotion. These parameters are evaluated via various SRF Quality Test Methods, but problems related to the heavy metal content have been observed in the microwave acid digestion method. Therefore, these methods and their applicability need improvement. In this study, the appropriate testing conditions were derived by varying the parameters of microwave acid digestion, such as microwave power and pre-treatment time. The pre-treatment of SRF as a function of the microwave power revealed an incomplete decomposition of the sample at 600 W, and the heavy metal content analysis was difficult to perform under 9 mL of nitric acid and 3 mL of hydrochloric acid. The experiments with the reference materials under nitric acid at 600 W lasted 30 minutes, and 1,000 W for 20 or 30 minutes were considered optimal conditions. The results confirmed that a mixture of SRF and an acid would take about 20 minutes to reach $180^{\circ}C$, requiring at least 30 minutes of pre-treatment. The accuracy was within 30% of the standard deviation, with a precision of 70 ~ 130% of the heavy metal recovery rate. By applying these conditions to SRF, the results for each condition were not significantly different and the heavy metal standards for As, Pb, Cd, and Cr were satisfied.

Effectiveness Evaluation of Displacement Accommodatable Pressure Measuring Jig for Quality Assessment of Pressure Application Device (압력 인가 장치의 품질관리를 위한 변위 수용이 가능한 압력 측정용 지그의 유효성 평가)

  • Mun, Chang-Su;Jun, Sung-Chul;Noh, Si-Cheol
    • Journal of the Institute of Convergence Signal Processing
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    • v.21 no.2
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    • pp.61-66
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    • 2020
  • Recently, a variety of electric anesthetics devices have been developed and used in clinical practice to reduce the fatigue of the operator during local anesthesia for dental procedures and to compensate for the disadvantages of manual anesthesia device. In this electric anesthesia injection device, the accurate and constant delivery of pressure for drug infusion is a very important performance factor. In order to evaluate the accuracy of the transfer pressure, a small pressure gauge using a load cell is often used, but since the elastic body inside the load cell may not be able to accommodate a sufficient displacement, an error may occur when evaluating pressure performance. For these reasons, in this study, we proposed and evaluated a silicon-chrome steel (Si-Cr steel) spring jig that can accommodate relatively large displacements that can be used when evaluating the performance of a pressure-controlled pressure application device using a load cell type pressure gauge. As a result of the pressure transmissibility test and repeated measurement results using a commercial dental anesthesia injection device, a more stable result was obtained when using a spring jig, and it was confirmed that the frequency of abnormally high measurement was reduced.

Effect of Jesaeng-sinkihwan on Renal Dysfunction in Ischemia/Reperfusion-Induced Acute Renal Failure Mouse (제생신기환이 허혈-재관류로 유발된 급성 신부전 마우스에 미치는 효과)

  • Han, Byung Hyuk;Lee, Hyeon Kyoung;Jang, Se Hoon;Tai, Ai Lin;Yoon, Jung Joo;Kim, Hye Yoom;Lee, Yun Jung;Lee, Ho Sub;Kang, Dae Gill
    • Herbal Formula Science
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    • v.29 no.1
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    • pp.33-44
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    • 2021
  • Renal ischemia-reperfusion injury(IRI), an important cause of acute renal failure (ARF), cause increased renal tubular injury. Jesaeng-sinkihwan (JSH) was recorded in a traditional Chines medical book named "Bangyakhappyeon (方藥合編)". JSH has been used for treatment of diabetes and glomerulonephritis with patients. Here we investigate the effects of Jesaeng-sinkihwan (JSH) in a mouse model of ischemic acute kidney injury. The animals model were divided into four groups at the age of 8 weeks; sham group: C57BL6 male mice (n=9), I/R group: C57BL6 male mice with I/R surgery (n=9), JSH Low group: C57BL6 male mice with surgery + JSH 100 mg/kg/day (n=9) and JSH High group: C57BL6 male mice with surgery + JSH 300 mg/kg/day (n=9). Ischemia was induced by clamping the both renal arteries during 25 min, and reperfusion was followed. Mouse were orally given with JSH (100 and 300 mg/kg/day during 3 days after surgery. Treatment with JSH significantly ameliorates creatinine clearance(Ccr), Creatinine (Cr) and blood urea nitrogen(BUN) in obtained plasma. . Treatment with JSH reduced kidney inflammation markers such as Neutrophil Gelatinase Associated Lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). JSH also reduced the periodic acid schiff (PAS) staining intensity and picro sirius red staining intensity in kidney of I/R group. These findings suggest that JSH ameliorates tubular injury including renal dysfunction in I/R induced ARF mouse.

A Study on the Flora and its Introduced Disturbing Plants in Damyang Area of Mudeungsan National Park, Korea (무등산국립공원 담양 지구의 식물상과 생태계교란 식물에 관한 연구)

  • Lee, Jong-Won;Lee, Suhong;Kang, Shin-Ho
    • Korean Journal of Plant Resources
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    • v.34 no.1
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    • pp.103-113
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    • 2021
  • This study was investigated to find out the distribution of flora and remarkable plants and factors and management measures for influx of wild disturbed plants in the Damyang area of Mudeungsan National Park. The field survey was carried out 8 times from May 2019 to October 2020. First of all, in the Damyang area of Mudeungsan National Park, a total of 603 taxa in 107 families, 349 genera, 531 species, 57 varieties, 5 subspecies and 10 forms. This result was found to be about 12.33% of the total 4,881 taxa of vascular plants in Korea. In addition, Rare plants were classified as 15 taxa. Floristic special and Korean endemic plants were identified as 85 taxa and 13 taxa, respectively. Lastly, the naturalized plants that appeared in the Damyang area of Mudeungsan National Park were observed in 45 taxa with 45 species of 16 families and 36 genera. Moreover the naturalization rate was 7.46% and the urbanization index was calculated to be 14.01%. The wild disturbed plants were found in a total of 4 taxa. Especially, a sheep sorrel(Rumex acetosella) was focused on managing for physica and biological control at Sinseondae Eoksaepyungjeon.

Changes in sedimentary structure and elemental composition in the Nakdong Estuary, Korea (낙동강 하구역 퇴적구조 및 원소조성 변화에 관한 연구)

  • Kim, Yunji;Kang, Jeongwon;Park, Seonyoung
    • Journal of Wetlands Research
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    • v.23 no.3
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    • pp.213-223
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    • 2021
  • To understand the sedimentary environment of Scirpus planiculmis habitat (Myeongji and Eulsuk tidal flats) in the Nakdong Estuary, this study analyzed the statistical parameters (sorting, skewness, and kurtosis) of grain size data and the major (Al, Fe, Mn, Mg, Ca, Na, K, Ti, and P), minor (Li, Sc, V, Cr, Co, Ni, Cu, Zn, Sr, Zr, Cs, Pb, Th, and U), and rare earth elements (REEs) in sediment cores. For Myeongji, the sediment structure of the upper part of the cores was poorly sorted, more finely skewed, and more leptokurtic due to construction of the West gate. By contrast, the Eulsuk cores all differed due to the contrasting floodgate operation patterns of the West and East gates. The linear discriminate function (LDF) results corresponded to the statistical parameters for grain size. At the Eulsuk tidal flat (sites ES05 and ES11), elemental distributions were representative of Al-, Fe- and Ca-associated profiles, in which the elements are largely controlled by the accumulation of their host minerals (such as Na- and K-aluminosilicate and ferromagnesium silicate) and heavy detrital minerals at the sites. Detrital minerals including the aluminosilicates are major factors in the elemental compositions at ES05, diluting the REE contents. However, clay minerals and Fe-oxyhydroxides, as well as REE-enriched heavy minerals, appeared to be controlling factors of the elemental composition at ES11. Therefore, the mineral fractionation process is important in determining the elemental composition during sedimentation, which reflects the depositional condition of riverine-saline water mixing at both sites.

A Study on Health Risk Assessment by Exposure to Organic Compounds in University Laboratory (대학 실험실에서의 유기화합물 노출에 의한 건강위험성 평가에 관한 연구)

  • Sim, Sanghyo;Won, Jung-II;Jeon, Hasub;Kim, Dowon
    • The Journal of Korean Society for School & Community Health Education
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    • v.22 no.4
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    • pp.49-60
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    • 2021
  • Objectives: Laboratories have various latent physical, chemical, biological, and ergonomical factors according to the diversification and fusion of research and development activities. This study aims to investigate the chemical exposure concentrations of college laboratories and evaluate their health risks, and use them as basic data to promote the health of college students. Methods: The sampling and analysis of harmful chemicals in the air in laboratories were performed using Method 1500 of the U.S. National Institute for Occupational Safety and Health (NIOSH)의 Method 1500. The harmful chemicals in the laboratories were divided into carcinogenic and non-carcinogenic chemicals. Risk assessment was performed using the cancer risk (CR) for carcinogenic chemicals and using the hazard index (HI) for non-carcinogenic chemicals. Results: The harmful chemicals in college laboratories consisted of acetone, diethyl ether, methylene chloride, n-hexane, ethyl acetate, chloroform, tetrahydrofuran, toluene, and xylenes. They showed the highest concentrations in laboratories A (acetone 0.001~2.34ppm), B (chloroform 0.95~6.35ppm), C (diethyl ether 0.08~8.68ppm), and D (acetone 0.07~14.96ppm). The risk assessment result for non-carcinogenic chemicals showed that the HI of methylene chloride was 2.052 for men and 2.333 for women, the HI of N-hexane was 4.442 for men and 5.05 for women. Thus, the HI values were higher than 1. The risk of carcinogenic chemicals is determined by an excess cancer risk (ECR) value of 1.0×10-5, which means that one in 100,000 people has a cancer risk. The ECRs of chloroform exceeded 1.0×10-5 for both men and women, indicating the possibility of cancer risk. Conclusion: College laboratories showed the possibility of non-carcinogenic health risks for methylene chloride, n-hexane, tetrahydrofuran (THF), toluene, and xylenes, and carcinogenic health risks for chloroform, methylene chloride. However, this study used the maximum values of measurements to determine the worst case, and assumed that the subjects were exposed to the corresponding concentrations continuously for 8 hours per day for 300 days per year. In consideration of the nature of laboratory environment in which people are intermittently exposed, rather than continuously, to the chemicals, the results of this study has an element of overestimation.

Validation of the Korean Version of the Posttraumatic Growth Inventory-Expanded (외상 후 성장 척도 확장판(The Posttraumatic Growth Inventory-Expanded: PTGI-X)의 한국판 타당화 연구)

  • Kim, Si Hyeong;Lim, Sujeong;Shin, Jiyoung;Lee, Deok Hee;Lee, Dong Hun
    • Korean Journal of Culture and Social Issue
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    • v.26 no.3
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    • pp.195-220
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    • 2020
  • The purpose of this study was to validate the Korean version of the post-traumatic growth inventory-expanded(K-PTGI-X), which has been widely used to assess posttraumatic growth. The PTGI-X is a measure of the addition of the items to measure the existential growth as the need for modification to the factors of the 'increase of spiritual interest' in the existing PTGI is suggested. We examined the factor structure, reliability, and validity of a Korean version of the PTGI-X among 625 Korean adults who have experienced trauma events. First, EFA confirmed the appropriate PTGI-X factor structure and found that the 4-factor structure was the most appropriate. Next, as a result of CFA, it was found that the model to which correlation between items was added to the 4-factor model was good. Next, testing internal consistency, CR, and AVE of the K-PTGI-X showed that PTGI-X's items are reliable. Also, we tested the concurrent validity and discriminative validity. All of the K-PTGI-X scales significantly correlated with measures of deliberate rumination and core-belief except for the intrusive rumination. Finally, to add an understanding of K-PTGI-X, t-test according to demographic variables was conducted. Recommendations for future research and implications were discussed.

A Flora of Vascular Plants of Seondalsan Mountain (Bonghwa-gun, Gyeongsangbuk-do) (선달산(경상북도 봉화군) 일대의 관속식물상)

  • AN, Min Woo;Jeong, Seon;Kim, Jae Young;Jo, Hyeong Jun;Heo, Tae Im;Lee, Hye Jeong;Seo, Eul Won;Chung, Gyu Young
    • Korean Journal of Plant Resources
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    • v.35 no.2
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    • pp.289-316
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    • 2022
  • This study was investigated to elucidate the distribution of vascular plants and their usefulness of Seondalsan Mountain (1,236 m) in Bonghwa-gun, Gyeongsangbuk-do. The surveys were carried out 20 times from April in 2014 to October in 2020. The vascular plants of Seondalsan Mountain was consisted a total of 638 taxa based on the voucher specimens; 96 families, 341 genera, 562 species, 18 subspecies, 53 varieties, 5 forms. 20 taxa of the Korean endemic plants were recorded and 1 taxa of Critically Endangered (CR), 3 taxa of Vulnerable (VU) and 9 taxa of Least Concern (LC), designated by Korean Forest Service as rare plants, were investigated in this region. Furthermore, V, IV and III degrees of floristic regional indicator plants, designated by the National Institute of Ecology, were included 1 taxa, 11 taxa and 28 taxa, respectively. Among them, edible, medicinal, fragrant, industrial, ornamental, ecological restoration, forage/compost plants were included 440 taxa, 505 taxa, 19 taxa, 234 taxa, 335 taxa, 214 taxa and 269 taxa respectively. In addition, 30 taxa of naturalized plants were observed.

Expression of Morphogenic Protein Genes in Juvenile Red Spotted Grouper (Epinephelus akaara) with Deformity (붉바리(Epinephelus akaara) 기형 발생 치어의 형태형성 유전자 발현)

  • You, Jin Ho;Mun, Seong Hee;Oh, Hyeon Ji;Baek, Hea Ja;Lee, Young-Don;Lee, Chi Hoon;Kwon, Joon Yeong
    • Journal of Marine Life Science
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    • v.4 no.1
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    • pp.38-43
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    • 2019
  • The deformity occurring at the early developmental stage of red spotted grouper (Epinephelus akaara) causes detrimental effects on the process of juvenile production. In this study, we have compared the expressions of several key genes (insulin like growth factor 1: IGF-1, bone morphogenic protein 4: BMP4, peroxisome proliferator-activated receptors γ: PPARγ, matrix Gla protein: MGP) for morphogenesis between normal and 2 types (cephalic and jaw) of deformed juvenile fish. Expression of these genes were investigated in the brain, liver and muscle of each group of fish (n=20) by real-time PCR. Expression of IGF-1 and BMP4 mRNA in the brain and liver showed significant difference between normal and deformed fish (p<0.05). However, no difference was observed in the expression of PPARγ and MGP mRNA between normal and deformed fish in any tissues. It seems certain that IGF-1 and BMP4 are associated with the state of deformity in juvenile red spotted grouper.