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http://dx.doi.org/10.14374/HFS.2021.29.1.33

Effect of Jesaeng-sinkihwan on Renal Dysfunction in Ischemia/Reperfusion-Induced Acute Renal Failure Mouse  

Han, Byung Hyuk (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Lee, Hyeon Kyoung (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Jang, Se Hoon (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Tai, Ai Lin (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Yoon, Jung Joo (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Kim, Hye Yoom (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Lee, Yun Jung (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Lee, Ho Sub (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Kang, Dae Gill (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
Publication Information
Herbal Formula Science / v.29, no.1, 2021 , pp. 33-44 More about this Journal
Abstract
Renal ischemia-reperfusion injury(IRI), an important cause of acute renal failure (ARF), cause increased renal tubular injury. Jesaeng-sinkihwan (JSH) was recorded in a traditional Chines medical book named "Bangyakhappyeon (方藥合編)". JSH has been used for treatment of diabetes and glomerulonephritis with patients. Here we investigate the effects of Jesaeng-sinkihwan (JSH) in a mouse model of ischemic acute kidney injury. The animals model were divided into four groups at the age of 8 weeks; sham group: C57BL6 male mice (n=9), I/R group: C57BL6 male mice with I/R surgery (n=9), JSH Low group: C57BL6 male mice with surgery + JSH 100 mg/kg/day (n=9) and JSH High group: C57BL6 male mice with surgery + JSH 300 mg/kg/day (n=9). Ischemia was induced by clamping the both renal arteries during 25 min, and reperfusion was followed. Mouse were orally given with JSH (100 and 300 mg/kg/day during 3 days after surgery. Treatment with JSH significantly ameliorates creatinine clearance(Ccr), Creatinine (Cr) and blood urea nitrogen(BUN) in obtained plasma. . Treatment with JSH reduced kidney inflammation markers such as Neutrophil Gelatinase Associated Lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). JSH also reduced the periodic acid schiff (PAS) staining intensity and picro sirius red staining intensity in kidney of I/R group. These findings suggest that JSH ameliorates tubular injury including renal dysfunction in I/R induced ARF mouse.
Keywords
Jesaeng-sinkihwan (JSH); Ischemia/Reperfusion; acute renal failure; creatinine clearance; renal-dysfunction; renal-fibrosis;
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