• Title/Summary/Keyword: Covid19

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e-Pharmacophore modeling and in silico study of CD147 receptor against SARS-CoV-2 drugs

  • Nisha Kumari Pandit;Simranjeet Singh Mann;Anee Mohanty;Sumer Singh Meena
    • Genomics & Informatics
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    • v.21 no.2
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    • pp.17.1-17.12
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    • 2023
  • Coronavirus has left severe health impacts on the human population, globally. Still a significant number of cases are reported daily as no specific medications are available for its effective treatment. The presence of the CD147 receptor (human basigin) on the host cell facilitates the severe acute respiratory disease coronavirus 2 (SARS-CoV-2) infection. Therefore, the drugs that efficiently alter the formation of CD147 and spike protein complex could be the right drug candidate to inhibit the replication of SARS-CoV-2. Hence, an e-Pharmacophore model was developed based on the receptor-ligand cavity of CD147 protein which was further mapped against pre-existing drugs of coronavirus disease treatment. A total of seven drugs were found to be suited as pharmacophores out of 11 drugs screened which was further docked with CD147 protein using CDOCKER of Biovia discovery studio. The active site sphere of the prepared protein was 101.44, 87.84, and 97.17 along with the radius being 15.33 and the root-mean-square deviation value obtained was 0.73 Å. The protein minimization energy was calculated to be -30,328.81547 kcal/mol. The docking results showed ritonavir as the best fit as it demonstrated a higher CDOCKER energy (-57.30) with correspond to CDOCKER interaction energy (-53.38). However, authors further suggest in vitro studies to understand the potential activity of the ritonavir.

The Influence of Risk-Taking Propensity and Personality Characteristics on Entrepreneurship Intention of Chinese College student: Focused on The Moderating Effect of Entrepreneurship Education (중국 대학생의 위험감수성과 성격5요인의 창업의도에 미치는 영향 창업교육의 조절효과)

  • Kaifeng Wen;Moon-Hong Kim
    • Asia-Pacific Journal of Business
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    • v.14 no.1
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    • pp.93-112
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    • 2023
  • Purpose - Due to the outbreak and spread of COVID-19, companies have reduced their hiring needs in the short term, reducing employment opportunities for most university students and putting pressure on their employment since 2019. This study aims to improve university students' employment options and increase the possibility of entrepreneurship. Design/methodology/approach - In this study, a research survey is conducted on 4-year Chinese university students who have received entrepreneurship education courses, and statistical tests are conducted using SPSS 26.0 and PROCESS 3.3 model 1. The main focus of the study is on the effects of risk perception and five personality factors on entrepreneurial intentions of Chinese university students and the effect of entrepreneurship education on the moderation of entrepreneurial intentions. Findings - The results of the study show that the risk perception of Chinese university students have a significant effect on the will to start a business. Five personality factors have a significant effect on entrepreneurial intentions. Entrepreneurship education has a moderating role in the relationship between risk perception and entrepreneurial intention, and the entrepreneurship education support has a moderating role in the relationship between the influence of five personality factors and entrepreneurial intentions. Research implications or Originality - The results of the study reveal that Chinese university students' exposure to entrepreneurship education support positively influenced entrepreneurial intentions. Such results imply that university students gain information and knowledge related to entrepreneurship through the entrepreneurship education support, which leads to positive perceptions and motivation towards entrepreneurship.

Customer satisfaction and skin care shop selection factors in the pandemic era impact on revisit intention (팬데믹 시대의 피부관리숍 선택요인이 고객만족도와 재방문 의도에 미치는 영향)

  • Byoung Ock Lee;Soo Nam Hong
    • Journal of the Korea Fashion and Costume Design Association
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    • v.25 no.2
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    • pp.83-95
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    • 2023
  • The purpose of this study was to identify the effect of skin care salons' decision factors on customer satisfaction and revisit intention during the COVID-19 pandemic. The subjects of this study were 220 women in their 20s to 50s who reside in Seoul and the Gyeonggi-do area and are users of skin care salons. The data was statistically analyzed using SPSS V.25.0 and detailed research results are as follows. For the analysis of this study, frequency analysis, factor analysis, reliability verification, independent sample T-Test, one-way analysis of variance, post hoc test, Duncan test, and regression analysis were conducted. First, as a result of examining whether skin care salon decision factors during the pandemic have a positive (+) effect on customer satisfaction, hygienic environment satisfaction and service environment satisfaction, which are sub-factors of customer satisfaction, had a significant effect on professionalism, kind service, and distance, which are sub-factors of decision factors, and are independent variables. Second, as a result of examining whether skin care salon decision factors during the pandemic have a positive (+) effect on revisit intention, decision factors, which are independent variables, including professionalism, kind service, price, and distance showed significant effects on human revisit intention, As for physical revisiting intention, only kind service, distance, and professionalism showed significant effects, while price did not have a significant effect. Third, as a result of examining whether customer satisfaction during the pandemic has a positive (+) effect on revisiting intention, the service environment satisfaction and hygienic environment satisfaction, which were sub-factors of independent variables, showed significant results for human and physical revisit intentions. In this study, service environment and hygienic environment satisfaction were important variables for skin care salon decision factors. Professionalism and kind service were important for human revisit intention. Therefore, overall service environment, hygiene, and safety should be prioritized to increase revisit intention and efforts must be made to retain and improve customer satisfaction

Research on how to promote fashion brands in the e-commerce era - Focusing on the work of a fashion PR agency - (e-커머스 시대 패션브랜드 홍보 방법에 관한 연구 - 패션홍보대행사 업무를 중심으로 -)

  • Song Ae Park
    • Journal of the Korea Fashion and Costume Design Association
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    • v.25 no.2
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    • pp.17-29
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    • 2023
  • The digital environment, which has been rapidly developing since the beginning of the 21st century, has become more specific due to COVID-19, and marketing strategies are rapidly changing to suit purchasing activities of Generation MZ, whose online purchases are becoming the center of their lives. A public relations agency is generally responsible for all aspects of making a client's product or service visible to the public through various forms of media. Among them, a company that performs only fashion-related tasks is called a "fashion PR agency". Now, the fashion industry is also centered on the e-commerce environment, and various digital marketing strategies have been developed and directly related to sales. This study examined the current status of online media and digital marketing, analyzes the aspects of fashion brand promotion strategies and methods in the e-commerce era, focusing on the work of fashion PR agencies, and suggests the direction of new online and offline promotion methods based on marketing and technological aspects. As a result of the study, first, theories on strategies for online media and digital marketing were examined, and found that the amount of online promotion has recently increased and become more specialized. Second, this study examines the concept of fashion PR agencies and analyzed their main tasks through interviews with fashion PR professionals. Third, based on successful online fashion promotion cases, the study analyzed fashion promotion strategies and methods that are being integrated online and offline in the e-commerce era. The main methods included SNS strategy, content strategy, performance strategy, influencer strategy, and event strategy, and it is suggested that integrated management is necessary for consistent brand image management, and an IMC (Integrated Marketing Communication) strategy, which intensively manages all strategies, should be employed.

Design and Implementation of Customer access management system utilized OpenCV (OpenCV를 활용한 고객 출입 관리시스템 설계 및 구현)

  • Hong, Du-pyo;Kim, Seung-Beom;Yoo, Yean-Jun;Lee, Jae-Hoon;Hong, Seok-min
    • Proceedings of the Korea Information Processing Society Conference
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    • 2021.11a
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    • pp.1101-1104
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    • 2021
  • 최근 COVID-19(코로나 바이러스 감염증) 확산에 따라 다양한 분야에서 힘든 상황이 이어지고 있다. 중앙 재난 안전 대책본부에 따르면 지난 2월 한 달간 코로나 안전신고는 약 2만 5천 건의 방역수칙 위반 신고가 들어온 것으로 집계됐다. 이에 따라 음식점 및 매장은 QR코드. 수기 작성을 통한 동선 체크, 온도 검사 등 코로나 확산을 방지하기 위한 방법을 시행하고 있지만 이는 단지 코로나 확산 방지를 위한 대책 일뿐 소상공인의 매장 운영이나 안정적인 영업 유지 등 직접적인 영향을 줄 수 없다. 이에 본 논문은 OpenCV를 활용한 고객 출입 관리 시스템을 제안한다. 본 시스템은 OpenCV 영상처리기술을 활용하여 매장을 방문하는 고객의 나이, 성별을 수집하여 주요 고객층 분석, 출입 현황 및 이용 시간을 파악한다. 본 시스템은 코로나 확진자 동선 파악을 위한 역학조사와 소상공인의 효율적인 매장 운영 시간을 분석하여 '코로나 확산 방지', '소상공인 매출 증가'의 기대 효과를 얻을 수 있다. 향후, 제안하는 기법의 실질적인 검증을 위해 실제 매장 환경에서의 테스트가 필요하다.

The MICE Participants' Importance & Performance Analysis on Smart Tourism Technology Attributes (스마트관광기술 속성에 대한 MICE 참가자의 중요도-실행도 분석)

  • Eun-Soo, Lee
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.4
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    • pp.437-443
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    • 2023
  • We investigates MICE participants's evaluation on the application of smart tourism technology by comparing their importance and performance. Date were collected from MICE participants who had attended in hybrid MICE in recent five years, The three dimensions of smart tourism technology were event management, extension of contents, and community. We found that event management and community affected on overall satisfaction of MICE participants. The result of paired t-test revealed that there were significant differences in audience interaction, webinar, virtual showcase, communication by social hub, virtual marketplace, and matchmaking The importance-performance matrix also indicated that matchmaking, virtual marketplace, audience interaction, communication by social hub, and webinar were major weakness and should be improved in the future.

A study on DVB-SI based additional information transmission method of data service linked with movie information TV program (영화정보 프로그램 연동형 데이터서비스의 DVB-SI 기반 부가정보 전송 방법에 관한 연구)

  • Kwangilm KO
    • Convergence Security Journal
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    • v.22 no.2
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    • pp.91-98
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    • 2022
  • Because the movie has the characteristics of a cultural product where experience is important, a promotional strategy is used to convert viewers into movie audiences by providing indirect experiences of movies through professional movie information programs. Considering that the movie information program is a strategic publicity medium that raises the audience's intention to watch a movie, a study on the data service that provides useful additional information to the viewer in conjunction with the movie information program is meaningful. Against this background, this study contains the core research contents in the development of data service linked with movie information program. Specifically, additional information of the movie information program was defined. And to provide the additional information to the data service, the digital broadcasting international standard DVB-SI-based additional information transmission method was devised.

A Study on Design Preference and Wearing Satisfaction for Children's Masks (유아동 마스크 선호도 및 착용 만족도 분석에 관한 연구)

  • Ji Eun Kim;Eunyoung Lee
    • Fashion & Textile Research Journal
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    • v.25 no.1
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    • pp.82-91
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    • 2023
  • The children who are part of this study are compelled to wear masks at educational facilities for an extended period of time as they continue to be exposed to Asian dust, fine dust, and COVID-19. However, use of masks is currently causing them a lot of inconvenience. This study aimed to gather basic data for the development of a mask that is suitable and comfortable for children to wear. A total of 331 children aged 1 to 9 were investigated through their parents in terms of their lifestyle, mask wearing and purchasing status, mask preferences, mask inconvenience, and mask improvement. According to the survey on mask use, the proportion of children aged 1-3 years old and wearing ultra-small/XS masks, 4-6 year olds wearing small/S, and 7-9 year olds wearing small/S was the highest. More than 80% of children were wearing masks with a standard filter of KF80 or higher. The purchase criteria for children's masks were found to be excellent in terms of wearing comfort and meeting the filter standards. According to the survey on inconvenience of wearing masks, the majority of those surveyed expressed the need to develop children's masks of different sizes. Furthermore, they experienced various kinds of inconveniences from adult masks, such as the material quality and length of earring bands; it was deduced that these aspects need to be taken care of. The vertical folding type was the most popular in the mask design for children. Children have to wear masks for a prolonged period of time, but they are experiencing lot of inconvenience, which need to be addressed.

Image-Based Skin Diagnosis Using AI Technology Combine with Survey System for Review of Integrated Skin Diagnosis Function (이미지 기반 AI 피부 진단 기술과 문진을 결합한 통합 피부진단 기능에 관한 고찰)

  • Park, Hakgwon;Lim, Young-Hwan;Park, Hyeokgon;Hwang, Joongwon;Lee, Sangran;Cho, Eunsang;Lin, Bin
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.3
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    • pp.463-468
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    • 2022
  • The prolonged of the Post Corona made many industry's paradigm. It's become very important In the industries products that customers directly touch and use. To cope with this situation, The Cosmetics industry has recently introduced various untact services. many customers would like to try these new services. Typically, online survey services recommend personalized products. but these services reached its limit later. This paper research how to recommend products and define skine type with AI Image diagnosis module combine with legacy survey system.

Research on the Zero Trust Trend Analysis and Enterprise Security Enhancement (제로트러스트 동향 분석 및 기업 보안 강화 연구)

  • Min Gyu Kim;Chanyoung Kang;Sokjoon Lee
    • Smart Media Journal
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    • v.12 no.5
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    • pp.46-57
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    • 2023
  • As the COVID-19 pandemic and the development of IT technology have led to the gradual popularization of remote and telecommuting, cloud computing technology is advancing, and cyber attack techniques are becoming more sophisticated and advanced. In response to these trends, companies are increasingly moving away from traditional perimeter-based security and adopting Zero Trust to strengthen their security. Zero Trust, based on the core principle of doubting and not trusting everything, identifies all traffic and grants access permissions through a strict authentication process to enhance security. In this paper, we analyze the background of Zero Trust adoption and the adoption policies and trends of countries that are proactively promoting its implementation. Additionally, we propose necessary efforts from governments and organizations to strengthen corporate security and considerations for companies when applying Zero Trust.