• 약학회지
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• 제47권2호
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• pp.110-119
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• 2003

The purpose of the present study was to kinetically investigate the carrier-mediated uptake in the hepatic transport of organic anions, and to simulate the ″in vivo counter-transport″ phenomena, using kinetic model which was developed in this study. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of ″counter-transport″ phenomenon. To examine the inhibitory effects on the initial uptake of a ligand by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. The initial plasma disappearance curves of a organic anion were then kinetically analyzed based on a flow model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). Moreover, ″in vive counter-transport″ phenomena were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The ″in vivo counter-transport″ phenomena in the hepatic transport of a organic anion were well demonstrated by incorporating the carrier-mediated process. However, the ″in vivo counter-transport″ phenomena may be also explained by the enhancement of back diffusion due to the displacement of intracellular binding. In conclusion, one should be more cautious in interpreting data obtained from so-called ″in vivo counter-transport″ experiments.

• 약학회지
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• 제49권4호
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• pp.275-283
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• 2005

The purpose of the present study was to kinetically investigate the carrier-mediated uptake in the hepatic transport of organic anions, and to simulate the 'in vivo counter-transport' phenomena, using kinetic model which was developed in this study. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of 'counter-transport' phenomenon. To examine the inhibitory effects on the initial uptake of organic anions by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. Effects of bromophenol blue (BPB) or bromosulfophthalein (BSP) on the plasma disappearance curves of a 1-anilino-8-naphthalene sulfonate (ANS) were then kinetically analyzed based on a flow model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). Moreover, 'in vivo counter-transport' phenomena were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The 'in vivo counter-transport' phenomena in the hepatic transport of a organic anions were well demonstrated by incorporating the carrier-mediated process. However, the 'in vivo counter-transport' phenomena may be also explained by the enhancement of back diffusion due to the displacement of intracellular binding. In conclusion, one should be more cautious in interpreting data obtained from so-called 'in vivo counter-transport' experiments.

• Journal of Pharmaceutical Investigation
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• 제22권4호
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• pp.289-300
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• 1992

The counter-transport phenomena in the hepatic transport of 1-anilino-8-naphthalene sulfonate (ANS) were kinetically investigated by analyzing the plasma disappearance-time profiles and the transport into the isolated hepatocytes. In vivo "counter transport phenomena" were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of counter-transport phenomenon. To examine the inhibitory effects on the initial uptake of a ligand by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. The initial plasma disappearance curves of ANS were then kinetically analyzed based on a two-compartment model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). No effects on the initial plasma disappearance rates of ANS were observed after preloading of bromophenol blue (BPB) or rose bengal (RB) in the liver. Inhibitory effect of BPB or RB on the initial uptake (or efflux) rates of ANS by the isolated hepatocytes were not observed, suggesting that the true counter transport mechanism is not working. In conclusion, checking the preloading effects of transstimulation on the initial uptake of a ligand by the liver could be a useful criterion for carrier cycling and common use of the same carrier between two ligands. However, one cannot exclude those possibilities even if the preloading effects cannot be observed.

• 전기화학회지
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• 제11권1호
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• pp.51-58
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• 2008

고분자 전해질 연료전지의 성능향상을 위한 방법으로 유동채널의 형상을 변경한 많은 연구가 진행되어 왔으나 동일한 유동채널 형상에서 유동방향 변경에 따른 연구는 많이 진행되지 못하였다. 본 연구에서는 동일한 반응면적과 동일한 유동채널의 고분자 전해질 연료전지의 수소와 산소의 유동방향을 Co-flow에서 Counter-flow로 변경될 경우의 연료전지의 성능변화를 분석하기 위하여 연료극과 공기극이 포함된 3차원 수치해석모델을 개발하였다. 개발된 수치해석모델을 활용하여 Co-flow와 Counter-flow의 유동채널 내부의 압력손실, 반응물질의 농도분포, 고분자 전해질 막을 통한 Water Transport, 고분자 전해질 막의 이온전도도 및 I-V 성능곡선을 비교하였다. 그 결과 반응물질의 농도분포, Water Transport, 고분자 전해질 막의 이온전도도가 우수한 Counter-flow 유동조건에서의 성능이 Co-flow 유동조건에 비하여 더욱 우수하였다.

• 한국안전학회지
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• 제5권3호
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• pp.39-43
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• 1990

The transport of phenol from waste water through the liquid surfactant membrane containing Aliquat 336 as a carrier was analyzed by a theoretical model. Extraction experiments was carried out to investigate the effect of process parameters, such as mixing intensity, concentration of sodium hydroxide in internal aqueous solution, and counter anions, and initial phenol concentration in waste water at $25^{\circ}C$. It was found that transport rate of phenol increased with increasing pH differents. The transport rate of phenol in waste water was influenced by counter anions.

• JSTS:Journal of Semiconductor Technology and Science
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• 제10권2호
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• pp.130-133
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• 2010

This paper presents a study of the influence of variation of counter doping thickness on short channel effect in symmetric double-gate (DG) nano MOSFETs. Short channel effects are estimated from the computed values of current-voltage (I-V) characteristics. Two dimensional Quantum transport equations and Poisson equations are used to compute DG MOSFET characteristics. We found that the transconductance ($g_m$) and the drain conductance ($g_d$) increase with an increase in p-type counter-doping thickness ($T_c$). Very high value of transconductance ($g_m=38\;mS/{\mu}m$) is observed at 2.2 nm channel thickness. We have established that the threshold voltage of DG MOSFETs can be tuned by selecting the thickness of counter-doping in such device.

• International Journal of Railway
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• 제2권3호
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• pp.127-130
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• 2009

The system improves the safety and efficiency of railway transport, combining the advanced axle-counter with single-track semiautomatic block. Using computer, to accomplish relay-based semiautomatic block logic operation and axle-counter to check section status, it will further increase the performance of railway transport. Safety-related communication is one of the important topics in railway signal system. By referring to relevant safety-related communication standards, to research on safety-related communication of Micro-computer automatic block between Railway Stations System, the thesis introduces the basic requirements, concept model, codes, and the process, etc.

• Biotechnology and Bioprocess Engineering:BBE
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• 제3권1호
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• pp.24-31
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• 1998

The separation and concentration of L-phenylalanine (L-Phe) using a supported liquid membrane (SLM) is investigated. A cation complex agent, di-2-ethylhexyl phosphoric acid (D2EHPA), is used as a carrier in the SLM with n-Heptane as a solvent. The reaction order and equilibrium constant in the formation reaction of L-phe-carrier complex are obtained from the extraction experiment. A mathematical model for a carrier mediated counter transport process is proposed to estimate the diffusion coefficient of L-phe-carrier complexly in the liquid membrant. Permeation experiments of L-phe using a SLM are performed under various operating conditions and optimum conditions for the transport of L-phe are obtained. Concentration of L-phe in the strip phase against its concentration is observed. Transport rate of glucose through liquid membrane is less than that of L-phe in the competitive transport of L-phe and glucose. And the existence of glucose reduced the transport rate of L-phe. The performance of separation with continuous strip phase is increased due to the dilution effect in the strip phase.

• 멤브레인
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• 제13권2호
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• pp.125-129
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• 2003

은염이 함유된 고분자 전해질을 이용한 올리핀 촉진수송 분리막은 고체상에서 높은 올레핀/파라핀 분리 성능을 나타내었다 본 연구에서는, 프로필렌/프로판 분리 선택도와 투과도의 성능을 향상시키기 위해 아미노산의 일종인 valine을 고분자 전해질막에 첨가하였다. FT-lR 분광학을 통해 valine의 양이온과 은염의 음이온이 상호작용을 하고, 그 결과 valine은 은이온의 활성도를 증가시킴을 알 수 있었다. 따라서 valine을 포함하고 있는 촉진수송 분리막은 valine이 없을 때보다 더 높은 선택도와 투과도를 나타내었다.

• 대한기계학회논문집B
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• 제27권9호
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• pp.1262-1272
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• 2003

A two-dimensional direct numerical simulation is performed to investigate the dynamic behaviors of a single vortex in counter reacting and non-reacting flow field. A predictor-corrector-type numerical scheme with a low Mach number approximation is used in this simulation. A 16-step augmented reduced mechanism is adopted to treat the chemical reaction. The budget of the vorticity transport equation is examined to reveal a mechanism leading to the formation, destruction and transport of a single vortex according to the direction of vortex generation in reacting and non-reacting flows. The results show that air-side vortex has more larger strength than that of fuel-side vortex in both non-reacting and reacting flows. In reacting flow, the vortex is more dissipated than that in non-reacting flow as the vortex approach the flame. The total circulation in reacting flow, however, is larger than that in non-reacting flow because the convection transport of vorticity becomes much large by the increased velocity near the flame region. It is also found that the stretching and the convection terms mainly generate vorticity in non-reacting and reacting flows. The baroclinic torque term generates vorticity, while the viscous and the volumetric expansion terms attenuate vorticity in reacting flow. Furthermore, the contribution of volumetric expansion term on total circulation for air-side vortex is much larger than that of fuel-side vortex. It is also estimated that the difference of total circulation near stagnation plane according to the direction of vortex generation mainly attributes to the convection term.