• Journal of Korean Neurosurgical Society
• /
• v.29 no.7
• /
• pp.861-867
• /
• 2000

Purpose : Neuronal migration disorder(NMD) is a major underlying pathology of patients with intractable epilepsy. The role of NMD on seizure susceptibility or epileptogenecity, however, has not been documented. Methods : External irradiation of total amount of 250 cGY was performed to the fetal rats on days 16(E16) and 17(E17) of gestation. After delivery, the rats of 230-260g were decapitated for the histopathologic study. Epileptog-enecity of the NMD was studied by observing electroclinical events after intraperitoneal kainic acid(KA) injection in the control rats and NMD rats. Results : Histopathologic findings revealed focal and/or diffuse cortical dysplasia consisting of dyslamination of the cerebral cortex and appearance of the cytomegalic neurons, neuronal heterotopia in the periventricular white matter, dispersion of the pyramidal layer and the dentate gyrus of the hippocampus, and agenesis of the corpus callosum. Abnormal expression of neurofilaments protein(NF-M/H) was characteristically observed in the dysplastic neurons of the neocortex and hippocampus. Early ictal onset and prolonged ictal activity on EEG and clinical seizures were observed from the NMD rats unlike with the control rats. Conclusions : Exteranl irradiation on the fetal rats produced NMD. And the rats with NMD were highly susceptible to kainic acid provoked seizures. This animal model would be useful to study the pathophysiology of clinically relevant NMDs.

• Asian-Australasian Journal of Animal Sciences
• /
• v.21 no.12
• /
• pp.1766-1772
• /
• 2008

Natto is a Japanese traditional soybean product fermented by Bacillus natto. The effect of natto supplement on the production and qualities of chicken meat was studied since the effective use of various waste foods is required in Japan. Dried natto prepared by heating at $60^{\circ}C$ was added to a basic diet at an amount of below 2%. The supplementation of dried natto did not influence the weights of the carcass, breast and thigh meat, fillet or abdominal fat. Growth of the thighbone such as the length, thickness of cortex bone, and Ca/P ratio in bone ash were not altered by the addition of natto. However, the pH of male meat decreased following the supplementation of dried natto from days 28 to 80. The water-soluble protein content in male thigh meat increased in the group fed 2% natto from days 28 to 80. Free peptides increased in male thigh meat by feeding 2% natto from days 0 to 80. The supplementation of natto increased free glutamic acid in thigh meat regardless of sex. Moreover, the supplementation of natto specifically decreased meat cholesterol in female chickens though the effect was not shown in male chickens.

• The Korean Journal of Physiology
• /
• v.25 no.2
• /
• pp.179-188
• /
• 1991

Effect of a sulfhydryl reagent, p-chloromercuribenzoic acid (PCMB), on the transport of succinate was studied in brush border (BBMV) and basolateral (BLMV) membrane vesicles isolated from rabbit renal cortex. PCMB induced an irreversible inhibition of the $Na^+-dependent$ succinate uptake in a dose-dependent manner with $IC_{50}$ of 55 and $65\;{\mu}M$ in BBMV and BLMV, respectively. The inhibitory effect of PCMB was prevented by a pretreatment of vesicles with dithiothreitol. PCMB did not increase $Na^+$ permeability at concentrations inhibiting succinate uptake. The PCMB inhibition of succinate uptake was due to a change in Vmax, but not in Km. When membrane vesicles were pretreated with PCMB in the presence of unlabelled succinate, the inhibitory effect was significantly reduced. In both BBMV and BLMV, succinate uptake was inhibited by various sulfhydryl reagents with the inhibitory potency of following order: $HgCl_2$>DTNB>PCMBS>PCMB. These results suggest that sulfhydryl groups are essential for dicarboxylate transport and that they may be located at or near substrate binding sites of the transporters in renal brush border and basolateral membranes.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.19 no.3
• /
• pp.724-730
• /
• 2015

The safety-related accident in which the field operators of all sorts of industrial sites don't fasten the seat belt properly and which it generates is the tendency that it increases constantly every year. By sounding the announcement sound in case the operator did not fasten the seat belt and the person seat belt monitoring system proposed in this paper progressed the work the operator fastened the seat belt properly. In addition, at the same time with that, since the administrator monitored the seat belt wearing or no of the operators on a real time basis the safety-related accident which did not wear the safety equipment properly and which it generates was prevented.

• Journal of Chest Surgery
• /
• v.29 no.10
• /
• pp.1170-1172
• /
• 1996

Chest wall hamartoma Is a very rare disease. The female infant was suffered from frequent upper respiratory infection. The chest AP revealed destruction of the ribs and widening of the intercostal space Chest CT demonstrated well-defined solid and cystic extrapleural mass. Chest M Rl revealed high signal and low signal intensities In the mass. In December, 1995, she underwent excision of the mass with partial resection of the ribs and ch st wall reconstruction with thick Cortex patch. The chest wall hamartoma was confirmed with histopathological examination. The postop course was smooth and uneventful.

• IEMEK Journal of Embedded Systems and Applications
• /
• v.13 no.4
• /
• pp.187-194
• /
• 2018

The operating system for IoT should have a small memory footprint and provide low power state, real-time, multitasking, various network protocols, and security. Although the Zephyr kernel, an operating system for IoT, released by the Linux Foundation in February 2016, has these features but errors generated by the user code can generate fatal problems in the system because the Zephyr kernel adopts a single-space method that both the user code and kernel code execute in the same space. In this research, we propose a space separation method, which separates kernel space and user space, to solve this problem. The space separation that we propose consists of three modifications in Zephyr kernel. The first is the code separation that kernel code and user code execute in each space while using different stacks. The second is the kernel space protection that generates an exception by using the MPU (Memory Protection Unit) when the user code accesses the kernel space. The third is the SVC based system call that executes the system call using the SVC instruction that generates the exception. In this research, we implemented the space separation in Zephyr v1.8.0 and evaluated safety through abnormal execution of the user code. As the result, the kernel was not crashed by the errors generated by the user code and was normally executed.

• Natural Product Sciences
• /
• v.18 no.4
• /
• pp.250-253
• /
• 2012

Phellodendri Cortex, phellodendron bark, has been used as a stomachic for intestinal function control and as an antimicro and anti-inflammatory agent. In this phytochemical study, eight compounds, berberine (1), palmatine (2), syringin (3), (+)-syringaresinol di-O-${\beta}$-D-glucopyranoside (4), salvadoraside (5), citrusin B (6), osmanthuside H (7), and kelampayoside A (8), were isolated from the bark of Phellodendron amurense. Their structures were elucidated by comparing spectroscopic data with reported values. Compounds 1 - 8 were evaluated for cytotoxic activity against HL-60 human promyelocytic leukemia cells in vitro. Among them, compounds 1 and 2 reduced the viability of HL-60 cells significantly, with $IC_{50}$ values of 26.0 and $18.5{\mu}M$, respectively.

• YAKHAK HOEJI
• /
• v.41 no.2
• /
• pp.153-160
• /
• 1997

One hundred and seventy crude drugs were screened for prolyl endopeptidase (PEP) inhibitors. Among them, 80% methanolic extract of 18 medicinal plants such as Polygonum cuspi data, Sanguisorba officinalis, Eugenia caryophyllata, Rubus coreanus, Cinnamomum cassia (Cassiae Cortex and Cinammomi Ramulus), Rheum palmatum, Ulmus pumila, Sorbus commixta, Areca catechu, Uncaria sinensis, Terminalia chebula, Caesalpinia sappan, Nelumbo nucifera, Machilus thunbergii, Paeonia moutan, Elscholtzia patrini and Cynomorium coccineum inhibited more than 70% of PEP activity at a concentration of 40 ppm. The active principles of P. moutan, M. thunbergii, T chebula, A. catechu, S. commixta, R. palmatum, R. coreanus, E. caryophyllata and P. cuspidata were transferred into organic solvents, which showed more than 75% inhibition at 5 ppm.

• Toxicological Research
• /
• v.13 no.3
• /
• pp.215-222
• /
• 1997

The features of seizure-related brain injuries in rats poisoned i.p. with diisopropylfiuorophosphate were investigated. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were pretreated i.m. 30 min and 10 min, respectively. before diisopropylfluorophosphate (10 mg /kg, $2LD_50$) poisoning to reduce the mortality and eliminate peripheral signs. Diisopropylfluorophosphate induced severe limbic seizures, and early necrotic and delayed apoptotic brain injuries. The necrotic brain injury, which was closely related to seizure intensity, was exerted as early as 1 hr predominently in hippocampus and piriform cortex. showing spongiform change (malacia) of neurophils in severe cases, in contrast to a typical apoptotic (TUNEL-positive)pattern after 12 hr in thalamus, and a mixed type in amygdala. Nitric oxide content in cerebrospinal fiuid significantly increased after 2 hr, reaching a maximal level at 6 hr. Pretreatment with $_L-N^G$-nitroarginine, an inhibitor of nitric oxide synthase, reduced nitric oxide content and attenuated only apoptotic brain injury in all four brain regions examined without affecting seizure intensity and necrotic injury. Taken together, early necrotic and delayed apoptotic brain injuries induced by diisopropylfiuorophosphate poisoning in rats may be related to seizure intensity and nitric oxide production, respectively.

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.63 no.2
• /
• pp.95-101
• /
• 2014

In this paper, UPS, with a built-in instantaneous sag drop compensation features, was developed to improve performance. The improved UPS, using instantaneous moving average method, compensates by quickly measuring the voltage and series inverter of half-bridge type, using line-interactive method that links with the voltage of the battery and power source, was developed. In addition, by developing a parallel inverter that uses a high-efficiency PWM switching method, overall UPS system was enhanced. To verify the performance of the proposed algorithm, single-phase 5[kVA] UPS systems were designed and the experimental system was constructed. The low-cost type of Cortex-M3 module CPU STM32F103R8T6 (32[bit]) is attached and the switching time of mode transfer was set within 4 [ms]. THD of the linear load operates in less than 3[%], and the stability of the output voltage operates in approximately ${\pm}2[%]$ range. The superior performance of the operations was confirmed with the system set as above.