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Chemical Constituents from the Bark of Phellodendron amurense and Their Cytotoxic Effects on HL-60 Human Leukemia Cells  

Li, Wei (College of Pharmacy, Chungnam National University)
Sun, Ya Nan (College of Pharmacy, Chungnam National University)
Yan, Xi Tao (College of Pharmacy, Chungnam National University)
Yang, Seo Young (College of Pharmacy, Chungnam National University)
Choi, Chun Whan (College of Pharmacy, Chungnam National University)
Kim, Eun Ji (School of Medicine and Institute of Medical Science, Jeju National University)
Kang, Hee Kyoung (School of Medicine and Institute of Medical Science, Jeju National University)
Kim, Young Ho (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.18, no.4, 2012 , pp. 250-253 More about this Journal
Abstract
Phellodendri Cortex, phellodendron bark, has been used as a stomachic for intestinal function control and as an antimicro and anti-inflammatory agent. In this phytochemical study, eight compounds, berberine (1), palmatine (2), syringin (3), (+)-syringaresinol di-O-${\beta}$-D-glucopyranoside (4), salvadoraside (5), citrusin B (6), osmanthuside H (7), and kelampayoside A (8), were isolated from the bark of Phellodendron amurense. Their structures were elucidated by comparing spectroscopic data with reported values. Compounds 1 - 8 were evaluated for cytotoxic activity against HL-60 human promyelocytic leukemia cells in vitro. Among them, compounds 1 and 2 reduced the viability of HL-60 cells significantly, with $IC_{50}$ values of 26.0 and $18.5{\mu}M$, respectively.
Keywords
Phellodendron amurense; Rutaceae; Cytotoxicity; HL-60 leukemia cells;
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