• Journal of Life Science
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• v.16 no.2 s.75
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• pp.266-273
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• 2006

This study is investigated the effect of selenium against neurotoxicity induced by MPTP(1-methy-4-phenyl-propion-oxypiperidine) in mice. In order to demonstrate neuroprotective activity of selenium, mice were administrated orally with selenium(25, 50, 100 ${\mu}g/kg$, once/day) for 10 days, and MPTP(10 mg/kg) was injected subcutaneously into the mice for 6 days from the beginning 1hr before selenium treatment. Test of rota road activity was inhibited by treatment with selenium in MPTP-induced neurotoxicity group when compared to MPTP treatment group in normal mice. Monoamine oxidase(MAO)-B activity and cerebral lipid peroxide content were significantly decreased in the treatment of selenium in MPTP-induced neurotoxicity group when compared to MPTP treatment group in normal mice and MAO-A was not affected. Activities of cerebral superoxide dismutase, catalase and glutathione peroxidase were significantly increased in the treatment of selenium in MPTP-induced neurotoxicity group when compared to MPTP treatment group in normal mice. These results suggest that selenium might be estimated the result from the cooperative action of its inhibitory effect on monoamine oxidase-B with that of the enhancement of antioxidant(SOD, catalase, GSH-Px) defence ability.

• Korean Business Review
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• v.12
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• pp.255-274
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• 1999

Electronic Commerce (EC) is a relatively new and has been attracting a considerable amount of attention. Even though it is still in an introductory stage, growth rates are impressively high and its economic importance will continue to grow. Electronic Commerce is born to be global because its connectivity using the Internet is universal. As Electronic Commerce accelerates the globalization, it will also increase both the interdependence of national economies in different countries and the need for international cooperation and coordination. Electronic Commerce is really a global challenge that requires global solutions. For this reason, Electronic Commerce becomes an important agenda in major international cooperative organizations including APEC, OECD, and G7 (G8). However, current international discussions on Global Electronic Commerce are initiated mostly by the United States and European Union (EU). The objective of this paper is to raise awareness creation activities in which the international cooperation is needed for promoting the global electronic marketplace in Asia. For this purpose, this paper reviews the approaches of U.S. and European countries (or European Union), and suggests an development framework on the basis of the reviews. The framework is used to analyze current issues around Electronic Commerce, and identify some fields which require coherent work among researchers in different countries.

• Korean Security Journal
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• no.24
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• pp.67-90
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• 2010

Today, the police alone can not prevent a crime. And the police is limited to meet for people's the increased needs on public safety. So the police and the community needs the cooperation of a variety of resources. Police in cooperation with community resources to respond to the crime's most professional and the private sector is a private security. However, the role of private security for cooperation policing is insufficient in South Korea. So for this study to build a cooperative policing in South Korea as private security for the following four kinds of directions are presented. First, as a private security of the United States and Japan, specializes in diversified business sectors. Simple human-oriented private security of the building security get out. Instead, take the high-tech crime prevention or industry complex security should be changed to a professional organization. Second, the interaction between police and private security should be increased. Police and private security through regular meetings between the need for mutual interests and build consensus is needed. The role of private security companies to be represented on the Security Association of South Korea's active role in the matter. Third, efforts to improve the image of private security activities and the publiciy activity of private security is needed. Some of the private security in an effort to escape a negative image to the people and actively promote a positive image is necessary. Finally, for South Korea to the level the cooperation between the police and private security are required to develop system models. Front-line policing priority in the field and the mutual understanding between the police and private security in an effort to have a positive perception is needed. Equal partners, especially the police and private security to private security companies to have recognized experts in their own recruitment and training should be improved by strengthening the expertise.

• Korean Security Journal
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• no.50
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• pp.241-261
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• 2017

Despite the trend and severity of industrial technology outflow crime, little research has been conducted about the effect of police force on that kind of crime in Korea. Consequently, this research preliminarily empirically examined relationship between foreign affairs police forces such as policemen, budget, establishing special investigation unit and the arrest of industrial technology outflow crime due to the limit of related data. Research findings can be summarized as follows. A statistically significant positive relationship was found between foreign police budget and the arrest of crime in the country. On the contrary, foreign police force is not significantly associated with the arrest and occurrence of crime overseas. Based on the result, the effect of the police force such as hardware factors including policemen, budget on the industrial technology outflow crime seemed to be weak. Consequently, considering police alternatives from previous researches, several implications such as reinforcement of foreign police force by increasing personnel and organizational innovation, enriching training program, strengthening the domestic and foreign cooperative network between police and related bodies can be suggested. Also, the improvement of the formal statistics on the industrial technology outflow crime and strenthening public relations can be recommended.

• Journal of The Korean Association For Science Education
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• v.20 no.3
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• pp.384-395
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• 2000

Recently performance assessments have been recommended as an alternative to traditional assessment methods such as multiple-choice written test. Performance assessment is suggested to facilitate students' creativity, participation and learning motivations in science classes. In this study, performance assessment materials were developed for a biology unit of middle school science 1, 'Plants Around Us', and then the assessment materials were applied to assess students' understandings and attitudes related to each topic of the unit. A total of 186 7th grade students at a southern large city participated in this study. From the study, the following were obtained: 1. Various type of the performance assessment materials, such as observation report, peer evaluation, interview have been developed for the unit 'Plants around us.' 2. Students' understandings on the topics appeared to be sound, and the students' interest and cooperative problem-solving abilities have been cultivated through the small group activities. The science classes became more student-centered. 3. Teacher's burden has increased due to the practices of performance assessment, but it could be handled by teacher's commitment and management skills. 4. The students' responses to performance assessments were positive, in general.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2419-2423
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• 2015

Background: There are few choices for treatment of advanced cancer patients who do not respond to or tolerate conventional anti-cancer treatments. Therefore this study aimed to deploy the benefits and clinical efficacy of continuous dendritic cell-cytokine induced killer cell infusions in such patients. Materials and Methods: A total of 381 infusions (from 67 advanced cases recruited) were included in this study. All patients underwent peripheral blood mononuclear cell apheresis for the following cellular therapy and dendritic cells-cytokine induced killer cells were expanded in vitro. Peripheral blood T lymphocyte subsets were quantified through flow cytometry to address the cellular immunity status. Clinical efficacy and physical activities were evaluated by RECIST criteria and Eastern Cooperative Oncology Group scores respectively. Logistic regression model was used to estimate the association between cellular infusions and clinical benefits. Results: An average of $5.7{\pm}2.94{\times}10^9$ induced cells were infused each time and patients were exposed to 6 infusions. Cellular immunity was improved in that cytotoxic $CD8^+CD28^+$ T lymphocytes were increased by 74% and suppressive $CD8^+CD28^-$ T lymphocytes were elevated by 16% (p<0.05). Continuous infusion of dendritic cells-cytokine induced killer cells was associated with improvement of both patient status and cellular immunity. A median of six infusions were capable of reducing risk of progression by 70% (95%CI 0.10-0.91). Every elevation of one ECOG score corresponded to a 3.90-fold higher progression risk (p<0.05) and 1% increase of $CD8^+CD28^-$ T cell proportion reflecting a 5% higher risk of progression (p<0.05). Conclusions: In advanced cancer patients, continuous dendritic cell-cytokine induced killer cell infusions are capable of recovering cellular immunity, improving patient status and quality of life in those who are unresponsive to conventional cancer treatment.

• Journal of the Korean Society for Marine Environment & Energy
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• v.9 no.2
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• pp.120-129
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• 2006

This paper aims at investigating the developments and challenges of Northwest Pacific Action Plan (NOWPAP), a regional cooperation mechanism to protect marine environment in Northeast Asia. As one of 16 UNEP's Regional Seas Program, NOWPAP has evolved since its inception in 1994. Based on the belief that a cooperative institution may work more efficiently to address common regional concerns on marine environment, China, Japan, Russia and South Korea have developed NOWPAP under the UNEP's leadership. NOWPAP now has its own independent secretariat, and 4 regional activity centers while expanding its partnership with other institutions. However, NOWPAP must address several challenges that it now faces for better achievement of its goals. They include consideration of unique geopolitical situation in this region, participation of North Korea, incorporation of sustainable development concept in its activities, reconsideration of equal opportunity principle for more efficient cooperation, and securing sufficient financial resources.

• Journal of Digital Convergence
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• v.12 no.6
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• pp.203-213
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• 2014

The purpose of this research is to deduce the effects factor of R&D output and outcome in the aspect of the researcher's intellectual property capacity, and conduct an empirical analysis to see if there is intermediated effect between cooperation of a patent attorney and output. I applied three step, input (researcher's intellectual property capacity and intellectual property environment), output (number of patent and SCI paper), outcome (number of technology transfer, profit), and analyzed the effects of researcher's intellectual property factors on output and outcome through structural equation model. The results are as follows. First, there's no cooperation between a researcher and patent attorney, the researcher's knowledge on patent specification had direct effect on the output. Second, a researcher and an patent attorney cooperate, the cooperative activities have complete mediation effect on the output, and the researcher's will to commercialize the technology has direct effects on the output. Third, the intellectual property environment of the research organization gives direct effects on the researcher's intellectual property capacity, and gives indirect effects on the outcome. this study suggest that it is important to cooperate with external experts in order to excellent R&D outcome.

• Journal of Forest and Environmental Science
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• v.17 no.1
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• pp.47-61
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• 2001

The study was carried out to suggest the development scheme of Forestry Association by the method of member's consciousness inclination analysis. The results are as follows ; 1. Most of Association members perceived the necessity for re-education about cooperative association, especially the research suitable to the characteristics of Korea Forestry. 2. 59.9% of members had negative response against revision of Forestry Association Law, and 39.5% of members had negative opinion about taking exclusive charge of forest working by Forestry Association, noting the need of immediate publicity activities for those charges. 3. Large number of members pointed out that the most serious problems for the management of private forest were the budgetary deficit and the lack of joint marketing system of forest products. 25.9% of members had complaints about the management of their own forests after joining the association. 4. 34.0% of members opposed Proxy Management and 48.8% of members wanted Portion Consignment System. 5. The analysis noted that due to increase of the aged in rural communities, it is necessary to establish Forestry Working Corps, which is under the control of the Government and Forestry Association to supply forestry labor in a appropriate time. 6. Most of Association members liked establishment of Special Association for each forest products.

• Journal of The Korean Association For Science Education
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• v.24 no.3
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• pp.468-480
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• 2004

It has been criticized that there are discrepancy between 'general statements' of the curriculum and subject-matter curricula. The possible reasons for this are as follows: The developers of the general statements were educational curriculum specialists. These specialists were not good enough to develop general statements and guidelines of subject matter curricula reflecting the characteristics of science contents, to examine developed science curriculum, and to give feedback to science curriculum developers. Under the present curriculum developing system where curriculum is developed in ten months or less by the research team commissioned unpredictably and imminently, it might be difficult to develop valid and precise science curriculum reflecting the purport of the general statements and teachers' needs. The inadequacy of these curriculum development processes resulted in (1) inconsistent statement about the school year to be applied to differentiated curriculum, (2) abstract and ambiguous stating about the characteristics, teaching-learning and assessment guidelines of enrichment activities, and (3) failure to reduce science contents to a reasonable level. Therefore curriculum development centers should be designated in advance to do basic research at ordinary times, and organized into a cooperative system among them. Two years or more of developing time and wider participation of scientists are recommended to develop more valid and precise science curriculum. In addition, commentaries on science curriculum should be published before textbook writing begins.