• 센서학회지
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• 제20권3호
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• pp.145-150
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• 2011

In this paper, we designed a tunable microstrip patch antenna using RF MEMS switches. The design and simulation of the antenna were performed using a high frequency structure simulator(HFSS). The antenna was designed for use in the ISM band and either operates at 2.4 GHz or 5.7 GHz achieving -10 dB return-loss bandwidths of 20 MHz and 180 MHz, respectively. In order to obtain high efficiency and improve the ease of integration, a high resistivity silicon(HRS) wafer on a glass substrate was used for the antenna. The antenna achieved high gains: 8 dB at 5.7 GHz and 1 dB at 2.4 GHz. The RF MEMS DC contact switches were simulated and analyzed using ANSYS software.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1995년도 춘계학술대회논문집
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• pp.162-169
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• 1995

An improved nonparametric tool description based on successive refined monparametric patches is proposed and therlated criterion for refinement is also discussed . In the proposed sheme, any required order of tool surface conformity can be achieved by employing successive refinements accoring to the suggested criterion. By using the suggested adaptive tool refinement technique based on the nonparametric patch tool description, the locally refined nonparametric tool surface with economic memory size and sufficient accuracy as well as with favorable charateristics for contact treatment can be obtained directly form the parametric patch related with commerical CAD system. Computation is carried out for a chosen complex sheet forming example of an actual autobody panel in order to verify the validity and the efficiency of the developed tool surface description.

• 한국CDE학회논문집
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• 제2권2호
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• pp.122-129
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• 1997

Ball rolling blending is a popular technique for blending between parametric surfaces. The ball rolling blend surface is conceptually a trajectory of a ball rolling between two base sufaces. It is constructed by sweeping a circular arc along a ball contact curve pair. Since a ball rolling blend surfaces does not have a polynomial form like a Bezier surface patch, it is impossible to apply this method directly to a commercial CAD/CAM system. In this paper an algorithm is developed to approximate a ball rolling blend surface into Bezier surface patches. Least square method is applied to obtain proper Bezier surface patches under a given tolerance. The Bezier surface patches have degree three or more and guarantee VC1-continuity.

• Journal of Pharmaceutical Investigation
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• 제27권4호
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• pp.303-311
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• 1997

Proliposomal patch of clenbuterol, ${\beta}_2-agonist$ bronchodilator, was prepared and its feasibility as a novel transdermal drug delivery system was examined. Proliposomal granules containing clenbuterol was prepared by a standard method using sorbitol and lecithin with (Rx 2) or without cholesterol (Rx 1). The porous structure of sorbitol in the proliposomes was maintained allowing tree flowability of the granules. Following contact with water, the granules were converted probably to liposomes almost completely within several minutes. It indicates that proliposomes may be hydrated, when they are applied on the skin under occlusive condition in vivo, by the sweat to form liposomes. Clenbuterol release from Rx 1 and Rx 2 proliposomes to pH 7.4 isotonic phospate buffer (PBS) across cellulose membrane (mol. wt. cut-off of 12000-14000) was retarded significantly compared with that from the mixture of clenbuterol powder and blank proliposomes. Interestingly, proliposomes prepared with lecithin and cholesterol (i.e., Rx 2 proliposomes) showed much more retarded release of clenbuterol than proliposomes prepared only with lecithin (i.e.. Rx 1 proliposomes), indicating that clenbuterol release from proliposomes can be controlled by the addition of cholesterol to the proliposomes. Proliposomal patches were prepared using PVC film as an occlusive backing sheet, two sides adhesive tape (urethane, 1.45 mm thickness) as a reservoir for proliposome granules and Millipore MF-membrane (0.45 mm pore size) as a drug release-controlling membrane. Rx 1 or Rx 2 proliposomes containing 4.6 mg of clenbuterol were loaded into the reservoir of the patch. Clenbuterol release from the patches to pH 7.4 PBS was determined using USP paddle (50 rpm)-over-disc release method. Clenbuterol release from the proliposomal patches was much more retarded even than from a matrix type clenbuterol patch (Boehringer Ingelheim ltd). Being consistent with clenbuterol release from the proliposomal granules, the release from the patches was highly dependent on the presence of cholesterol in the proliposomes : Patches containing Rx 2 proliposomes showed several fold slower drug release than patches containing Rx 1 proliposomes. When the patch containing Rx 1 proliposomes was applied on to the back of a hair-removed rat, clenbuterol concentration in the rat blood was maintained during 6-72 hrs. Transdermal absorption of clenbuterol from the patch was accelerated when the patch was prehydrated with 50 ml of pH 7.4 PBS before topical application. Above results indicate that sustained transdermal delivery of clenbuterol is feasible using proliposomal patches if the cholesterol content and pore size of the release rate-controlling membrane of patches, for example, are appropriately controlled.

• 폴리머
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• 제33권2호
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• pp.111-117
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• 2009

본 연구를 통해 역이온 영동(reverse iontophoresis)을 이용한 무채혈 혈당 측정시스템의 patch sensor에 사용되는 효소 고정형 수화젤의 생체적합성 여부를 확인하고자 하였다. 아크릴레이트 계열의 단량체를 사용하여 일정한 unit의 효소가 고정된 수화젤을 합성하였다. 합성된 수화젤의 물성분석을 위해 FT-IR spectrometer를 이용하여 구조분석을 하고 DSC를 이용하여 열적 안정성을 확인하였다. 또한, UV-Vis spoctrophotometer를 이용하여 표준품 대비 50% 이상의 효소 활성도를 확인하였다. 표면의 효소 고정화 확인을 위해 SEM을 이용하여 확인한 결과 효소가 고정화되어 있음을 확인하였다. 수화젤은 환자의 피부에 직접적으로 접촉됨으로써 접촉 시 무해성을 평가하기 위하여, ISO-10993에 의하여 세포독성(cytotoxicity), 피내반응(intracutaneous reactivity), 피부자극(skin irritation) 및 감작성(maximization sensitization) 시험을 실시하였고 이를 통해 생체적합성이 우수하다는 것을 확인하였다.

• Journal of Oral Medicine and Pain
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• 제25권4호
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• pp.355-364
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• 2000

This study was to find dental materials causing hypersensitivity reactions by carrying out patch tests in the patients with oral mucosal lesions to investigate the possibility of hypersensitivity reactions in etiology of oral mucosal lesions. 31 patients (female 26, male 5, age range 24-72 years) with oral mucosal lesions were classified as patient group, and 41 volunteers (female 24, male 17, age range 23-40 years) without oral mucosal lesion, systemic disease and history of allergy as control group. The obtained results were as follows: 1. There were various dental restorations in most of patient group and control group, 29(94%) in 31 patient group, 35(85%) in 41 control group. 2. Among sites of oral mucosal lesions, buccal mucosa was the most common site with 60%, followed by gingiva with 24%, tongue with 16%. Lesions in contact with restorations were highly 90% in tongue and 89% in buccal mucosa, but comparatively lower 53% in gingiva. 3. The ratio of positive reactions to the patch test in patient group was significantly higher than the control group (p<0.05). 4. Dental materials causing positive reactions to the patch test were mainly mercury(19%), potassium dichromate(16%), cobalt chloride(16%) in patient group, cobalt chloride(17%) in control group. 5. In 20 patients with lichen planus, 8 patients(40%) showed positive reactions to the patch test.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2002년도 추계학술대회논문초록집
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• pp.337.2-337
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• 2002

When vehicle travelling along the track which has irregularity such as vortical profile, dynamic forces arise at the Wheel/Rail contact patch by wheel/rail interaction. In particular short wavelength irregularities on dipped joint and small stiffness of connecting rail bring about intense wheel/rail dynamic effects at higher speed. In the paper, a new model for dipped joint rail is developed to study dynamic behavior of track. (omitted)

• 대한화장품학회지
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• 제3권1호
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• pp.40-84
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• 1973

Synopsis-The difficulties of immunological nonienclature are discussed, the term ALLERGY defined and the various types of HYPERSENSITIVITY reactions are listed and characterized. Evidence for the association of Type I and Type 11 hypersensitivity reactions with COSMETICS is discussed. A table of cosmetic ingredients which have been implicated as SENSITIZERS are given. PREDICTIVE PATCH TESTS for contact sensitizers on GUINEA-PIGS and man are evaluated. The difficulties of testing for ALLERGENS likely to produce Type I hypersensitivity are discussed. IN VITRO tests for sensitizers are mentioned. The failure of all standard tests in the detection of weak sensitizers is emphasized.asized.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2000년도 춘계학술대회 논문집
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• pp.135-142
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• 2000

This Paper describes a characteristics of wheel wear of high speed train running on the conventional line. Conventional line has many curved tracks that cause severe wheel flange wear. The influences of lubrication, cant deficiency, owe radius on wheel wear are also described considering the operation performance of the highspeed trainset. A method of calculation using contact patch work model is presented far determination of the evolution by wear of railway wheels.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 추계학술대회논문집
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• pp.322-325
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• 2007

This paper suggests a non-contact sensor for measuring bending vibration of a non-metallic cylinder in two orthogonal directions simultaneously. Recent research shows that a solenoid can pick up bending vibrations of a nonmetallic cylinder based on the reversed Lorentz force mechanism if an electrical conductive patch is attached to the cylinder. In this work, pairs of specially designed patches are used to make two independent paths for the current induced by bending vibrations, which enables the measurement of bending vibrations along two orthogonal directions simultaneously. The working performance of the developed sensor was verified by using two accelerometers.