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Synthesis and Biocompatibility Study of Hydrogel for Patch Sensor in Non-invasive Glucose Monitoring System  

Kwon, Jeong-Woo (R&D Center, KMH Co., Ltd.)
Kim, Dong-Chul (R&D Center, KMH Co., Ltd.)
Yoon, In-Joon (R&D Center, KMH Co., Ltd.)
Jeong, Yoon-Na (R&D Center, KMH Co., Ltd.)
Jeong, Ji-Young (R&D Center, KMH Co., Ltd.)
Hwang, In-Sik (R&D Center, KMH Co., Ltd.)
Publication Information
Polymer(Korea) / v.33, no.2, 2009 , pp. 111-117 More about this Journal
Abstract
This study aims to verify for humans the suitability of the enzyme-fixed hydrogel used for the patch sensor of the blood sugar testing system without blood sampling, which utilizes reverse iontophoresis. Using acrylate monomers, hydrogel was synthesized to which a certain unit of enzyme is fixed. In order to analyze the material property of the synthesized hydrogel, a structural analysis was performed using FT-IR spectroscopy, while the DSC was used to verify the thermal stability. In addition, with the UV-Vis spectrophotometer, it was verified that the degree of active enzyme is at least 50% greater than the standard product. The SEM was used to verify secure fixation of the enzyme onto the surface. As a result, it was observed that the enzyme is successfully fixed to the surface. Since the hydrogel makes direct contact with a patient's skin, it is essential to evaluate the toxicity when making direct contact with the skin. For that purpose, various sets of tests were undertaken according to the ISO 10993-cytotoxicity, intracutaneous reactivity, skin irritation test and maximization sensitization. Consequently, it was successfully verified that the enzyme-fixed hydrogel have bioavailability.
Keywords
hydrogel; glucose; GluCall; iontophoresis; non-invasive;
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