• 사상체질의학회지
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• 제24권1호
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• pp.54-65
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• 2012

1. Objective : The purpose of this study is to investigate the effects of TAM (Taraxacum mongolicum) on Th2 cytokine production in MC/9 mast cells. 2. Methods : The effects of TAM was analyzed by ELISA and Real-time PCR in MC/9 mast cells. Levels of IL-5, IL-13 were measured using enzyme-linked immunosorbent assays(ELISA). mRNA levels of IL-4, IL-5, IL-6, IL-13 were analyzed with Real-time PCR. 3. Results : 1) TAM inhibited the IL-4 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 2) TAM inhibited the IL-13 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 3) TAM inhibited the IL-4 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4) TAM inhibited the IL-5 mRNA expression significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$. 5) TAM inhibited the IL-6 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 6) TAM inhibited the IL-13 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4. Conclusions : These results indicate that TAM (Taraxacum mongolicum) has the effect of decreasing the Th2 cytokine production in the MC/9 mast cell.

• 생물환경조절학회지
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• 제10권2호
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• pp.69-74
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• 2001

본 연구에서는 참대라 과실의 생장을 직경 43mm와 52mm의 아크릴파이프 처리로 억제시켜, 과실 생장에 따른 과실조직의 수분 함량과 건물중 변화에 대한 과실의 전당 및 전분 농도를 조사하였다. 과실의 생체중, 건물중과 수분 함량은 파이프 처리에 의해 감소하였으나, 과실이 비대함에 따라 일정한 비율로 증가하였다. 직경 43 mm 아클릴파이프처리 과실은 과실 생장 제3기 동안 수분 함량 증가가 정지되었고 과실의 수확기 적기에는 건물률이 다른 처리보다 높았다. 당농도는 아크릴파이크 처리의 과실에 있어, 일시적으로 증가한 후에 무처리 과실의 농도까지 감소하였다. 그때에 전분 농도와 건물률은 처리간에 차이가 없었다. 그러므로, 아크릴파이프로 처리로 과실의 비대가 억제된 과실의 당 농도는 과실의 수분함량 감소에 따른 것으로 생각되었다.

• 대한수의학회지
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• 제45권1호
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• pp.121-125
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• 2005

The present study was carried out to produce the hematological and blood chemical findings after hypophysectomy in rats. Hypophysectomy was performed by the parapharyngeal method and the sham surgery was performed for the control group. Two weeks after the operation, the body weight of the hypophysectomized and control rats was measured daily for 5 days. We deleted the rats the weight gain of which is less than 5 g during 5 days from the hypophysectomy group. The successful operation rate was approximately 40%. In the hypophysectomized and control rats, their blood samples were collected from posterior vena cava after celiotomy under generally anesthesia with ether. Hematological parameters such as erythrocyte count, leukocyte count, hemoglobin concentration, hematocrit level, and platelet count were determined by Animal Blood Counter. The erythrocyte count, hemoglobin concentration, and hematocrit level were lower significantly (p<0.01), and the leukocyte count was lower significantly (p<0.05) in hypophysectomy group compared with control group. But the plate count did not show significant difference (p>0.05) between hypophysectomy group and control group. Also, blood chemical parameters such as glucose, blood urea nitrogen (BUN), aspartate animotransferase, albumin, total protein, cholesterol, calcium, and magnesium in serum were determined. Except BUN concentration, all parameters were not affected by hypophysectomy. But the BUN concentration was higher significantly (p<0.01) in hypophysectomy group compared with control group.

• Advances in environmental research
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• 제4권1호
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• pp.1-15
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• 2015

A pot experiment was conducted to assess the effects of red pepper (Capsicum annuum) and coriander (Coriandrum sativum) on seedling growth of wheat (Triticum aestivum). The aqueous extracts treatment of red pepper and coriander showed a significant (p < 0.05) reduction in root, shoot and seedling length, number of leaves and seedling dry weight of wheat (T. aestivum) as compared to control. The inhibitory different effect on growth of wheat (T. aestivum) was directly proportional to the increasing concentration (1, 2, 3, 4 and 5%) of aqueous extracts of red pepper and coriander as compared to control treatment (0%). The root, shoot, seedling length and number of leaves of T. aestivum significantly p < 0.05 decreased at 5% concentration of red pepper as compared to control. The root, shoot and seedling growth of T. aestivum was also significantly reduced at 1, 2, 3, 4 and 5% concentration of coriander as compared to control. The root, shoot and leaves dry weight of T. aestivum at 5% coriander extract treatment concentration decreased as compared to control. The tolerance in seedlings of T. aestivum to red pepper and coriander extract treatment was dose dependent as compared to control. The seedlings of T. aestivum showed low percentage of tolerance to pepper extract treatment than coriander extract treatment.

• 약학회지
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• 제47권2호
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• pp.98-103
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• 2003

The purpose of this study was to investigate the effect of flavone (20 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (40 mg/kg) orally coadministered in rats. The plasma concentration of paclitaxel in combination with flavone was increased significantly (coadministration p＜0.05, pretreatment p＜0.0l) compared to that of control. Area under the plasma concentration-time curve (AVC) of paclitaxel with flavone was significantly (coadministration p＜0.05, pretreatment p＜0.0l) higher than that of control. Peak concentration (Cmax) of paclitaxel with flavone were significantly increased (coadministration p＜0.05, pretreatment p＜0.01) compared to that of control. Time to peak concentration (Tmax) of paclitaxel with flavone decreased significantly (p＜0.05) than that of control. The total body clearance (CLt) and elimination rate constant ($\beta$) of paclitaxel with flavone were significantly reduced (p＜0.05) compared to those of control. Half-life (t$_{1}$2/) of paclitaxel with flavone was significantly prolonged (p＜0.05) compared to that of control. Based on these results, it might be concluded that flavone may enhance bioavailability of paclitaxel through the inhibition of cytochrome P450 and P-glycoprotein, which are engaged in paclitaxel absorption and metabolism in liver and gastrogintestinal mucosa, respectively.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2001년도 제18차 정기총회 및 학술발표 PROCEEDINGS
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• pp.86-88
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• 2001

본 시험은 broiler performance, litter N농도가 어떻게 유지되며, NH3 gas 농도가 사료에 ammino acid와 Vitamin D를 보충하여 litter에 Alum을 첨가하여 저수준 단백질 수준을 감소시키는지 결정하기 위해 실시하였다. 이 실험은 각각 처리마다 3반복 90마리를 세가지의 다른 단백질 수준을 가지고서 starter period(1-214)와 grower period(22-420)로 나누었다. 단백질처리는 각기 starter에는 평균 23.0(control 71), 20.4(W)와 18.0(73)%로 grower에서는 21.0(control 71), l9.3(n) and 17.o(73)%로 구성된다. control과 비교하면 ammino acid 수준은 비슷하다. Alum은 rice bran kg당 2009에 Control을 제외하고 각 처리구에 혼합했다. 결과는 3wks와 6wks 동안 급여한 사료에서 Control이하인 저수준 단백질은 feed gain은 증가하였으며, feed intake와 weight gain은 감소하였다. 그러나 처리간에는 유의차(P<0.05)가 없었으며 Alum을 litter에 혼합할 때(P<0.05) 저수준 단백질은 NH3 gas농도가 74.8-80.9% 감소되었다. litter에 Alum을 첨가하는 조작은 NH3 gas농도를 감소시킨다는 것을 보여준다.

• 한국환경보건학회지
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• 제38권1호
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• pp.51-56
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• 2012

Objectives: High concentrations of airborne particulate matters (PM) can affect the health of passengers using public transportation. The objectives of this research were to develop a PM control system for a railway cabin and to evaluate the performance of the device under conditions of an actual journey. Methods: This study measured the concentrations of $PM_{10}$ and $PM_{2.5}$ simultaneously in a reference cabin and a cabin with the PM control device. Results: The average $PM_{10}$ concentration in the reference cabin was 100 ${\mu}g/m^3$, and the $PM_{10}$ concentration in the cabin with the control device was 79 ${\mu}g/m^3$. While the overall control efficiency of the control device was 15.4%, reduction was more effective for peak $PM_{10}$ concentration. However, $PM_{2.5}$ levels did not differ greatly between the reference cabin and the cabin with the control device. The ratio of $PM_{2.5}$ to $PM_{10}$ was 0.37. $PM_{10}$ concentrations in cabins were not associated with ambient concentrations, indicating that the main sources of $PM_{10}$ were present in cabins. Additionally, average $CO_2$ concentration in the cabins was 1,359 ppm, less than the maximum of 2,000 ppm set out by the Korean Ministry of Environment's guideline. The $CO_2$ concentration in cabins was significantly associated with the number of passengers: the in-cabin concentration = $23.4{\times}N+460.2$, where N is the number of passengers. Conclusions: Application of the PM control device can improve $PM_{10}$ concentration, especially at peak levels but not $PM_{2.5}$ concentration.

• 한국전산유체공학회지
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• 제14권4호
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• pp.62-66
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• 2009

The control of particle concentration distribution in a pipe with an orifice and a sheath air is numerically investigated. When using Eulerian approach, there is no great change in the concentration distribution by the shape of orifice and molecular diffusivity. As the Reynolds number becomes small, the effect of orifice on the concentration distribution is decreased. For small Reynolds number, the concentration distribution can be effectively controlled by using a sheath air. The effect of the sheath air on the concentration distribution is increased, as the Reynolds number becomes small.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1993년도 Fifth International Fuzzy Systems Association World Congress 93
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• pp.1366-1369
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• 1993

This paper presents a simulation study on two self-learning control systems for a fuzzy prediction model of CO (carbon monoxide) concentration:linear control and fuzzy control. The self-learning control systems are realized by using Widrow-Hoff learning rule which is a basic learning method in neural networks. Simulation results show that the learning efficiency of fuzzy controller is superior to that of linear controller.

• 한국환경보건학회지
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• 제26권3호
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• pp.25-31
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• 2000

In order to assess the accumulation levels of cadmium and other metals(Zn, Cu, Ca and Fe) in fish bodies, an experimental study was performed by raising fry of "Oryzias latipes" in the water containing cadmium 0.03 ppm, cadmium 0.03 ppm + zinc 0.03 ppm and in the tap water(control group) were made. In the results the concentration of Cd in fish bodies were increased with advancing exposure time in Cd 0.03 ppm treated group and 0.03 ppm + Zn 0.03 ppm treated group, but there was no significantly different between both groups with Cd concentration in each week. The concentration of Zn in fish bodies was no changed with advancing exposure time in control group and Cd 0.03 ppm + Zn 0.03 ppm treated group were significantly different from control and Cd 0.03 ppm treated group. The concentration of Cu, Ca and Fe in fish bodies were increased with advancing exposure time, and control group was higher than any other groups. Simple correlation analysis showed that the positive correlation between Cd and Zn, Cu and Ca, Fe, Ca and Fe, but Cd was negative correlation with Cu, Ca and Fe. In conclusion, we investigated a tendency that the concentration of Cd and Zn in fish bodies tended to increase with the lapse of time, but Cu was unchanged and those of Ca and Fe were decreased in administrating the trace dose of Cd and Zn in water. in water.