• Title/Summary/Keyword: Complex surface

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Review on the mechanism for the reduction of raphide-induced toxicity via processing of Pinelliae Tuber and Arisaematis Rhizoma (포제(炮製)에 의한 반하(半夏)와 천남성(天南星)의 침상결정 유발 독성 감소 기전 고찰)

  • Kim, Jung-Hoon;Lee, Guemsan;Choi, Goya;Kim, Young-Sik;Lee, Seungho;Kim, Hongjun
    • The Korea Journal of Herbology
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    • v.36 no.5
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    • pp.15-27
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    • 2021
  • Objectives : The processing of Pinelliae Tuber and Arisaematis Rhizoma is a crucial step to reduce the severe acrid irritation mainly due to the needle-like crystals (raphides). Ginger, alum and bile juice have been used as adjuvant materials for the processing. Methods : Bibliographic research on ancient processing and experimental processing was performed to investigate the toxicity reduction mechanisms of the processing with ginger, alum and bile juice. Results : Ginger has been a major adjuvant for the processing of Pinelliae Tuber, followed by alum and bile juice since Song (宋) and Myeong (明) dynasties, and Arisaematis Rhizoma has been mainly used as Damnamseong (膽南星). The raphides consisting of calcium oxalate, lectin, agglutinin and polysaccharides can induce acrid irritation and the inflammatory reactions. The lipophilic components in the ginger denatured the structure of raphides and 6-gingerol-contained ginger extract attenuated the inflammatory reaction. The calcium ion (Ca2+) of calcium oxalate was substituted to the aluminium ion (Al3+) of the alum, which damaged the calcium oxalate structure. Lectin attached to the surface of raphides was dissolved in alum solution and consequently its structure was denatured. The cholate in the bile juice formed the complex with the oxalate anion or the calcium cation. Moreover, the enzymes activated by Lactobacillus or Bifidobacterium during the fermentation promoted the fragmentation of oxalate. Conclusion : The adjuvant materials damaged the raphides by denaturing or degrading the calcium oxalate, resulting in the reduction of acrid irritation. Further experimental studies would support the toxicity reduction mechanism of the processing.

Development of Panel-Based Rapid Aerodynamic Analysis Method Considering Propeller Effect (프로펠러 효과를 반영 가능한 패널 기반 신속 공력 해석 기법 개발)

  • Tai, Myungsik;Lee, Yebin;Oh, Sejong;Shin, Jeongwoo;Lim, Joosup;Park, Donghun
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.49 no.2
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    • pp.107-120
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    • 2021
  • Electric-powered distributed propulsion aircraft possess a complex wake flow and mutual interference with the airframe, due to the use of many propellers. Accordingly, in the early design stage, rapid aerodynamic and load analysis considering the effect of propellers for various configurations and flight conditions are required. In this study, an efficient panel-based aerodynamic analysis method that can take into account the propeller effects is developed and validated. The induced velocity field in the region of propeller wake is calculated based on Actuator Disk Theory (ADT) and is considered as the boundary condition at the vehicle's surface in the three-dimensional steady source-doublet panel method. Analyses are carried out by selecting an isolated propeller of the Korea Aerospace Research Institute (KARI)'s Quad Tilt Propeller (QTP) aircraft and the propeller-wing configuration of the former experimental study as benchmark problems. Through comparisons with the results of computational fluid dynamics (CFD) based on actuator methods, the wake velocity of propeller and the changes in the aerodynamic load distribution of the wing due to the propeller operation are validated. The method is applied to the analysis of the Optional Piloted Personal Aerial Vehicle (OPPAV) and QTP, and the practicality and validity of the method are confirmed through comparison and analysis of the computational time and results with CFD.

Calculations of the Single-Scattering Properties of Non-Spherical Ice Crystals: Toward Physically Consistent Cloud Microphysics and Radiation (비구형 빙정의 단일산란 특성 계산: 물리적으로 일관된 구름 미세물리와 복사를 향하여)

  • Um, Junshik;Jang, Seonghyeon;Kim, Jeonggyu;Park, Sungmin;Jung, Heejung;Han, Suji;Lee, Yunseo
    • Atmosphere
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    • v.31 no.1
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    • pp.113-141
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    • 2021
  • The impacts of ice clouds on the energy budget of the Earth and their representation in climate models have been identified as important and unsolved problems. Ice clouds consist almost exclusively of non-spherical ice crystals with various shapes and sizes. To determine the influences of ice clouds on solar and infrared radiation as required for remote sensing retrievals and numerical models, knowledge of scattering and microphysical properties of ice crystals is required. A conventional method for representing the radiative properties of ice clouds in satellite retrieval algorithms and numerical models is to combine measured microphysical properties of ice crystals from field campaigns and pre-calculated single-scattering libraries of different shapes and sizes of ice crystals, which depend heavily on microphysical and scattering properties of ice crystals. However, large discrepancies between theoretical calculations and observations of the radiative properties of ice clouds have been reported. Electron microscopy images of ice crystals grown in laboratories and captured by balloons show varying degrees of complex morphologies in sub-micron (e.g., surface roughness) and super-micron (e.g., inhomogeneous internal and external structures) scales that may cause these discrepancies. In this study, the current idealized models representing morphologies of ice crystals and the corresponding numerical methods (e.g., geometric optics, discrete dipole approximation, T-matrix, etc.) to calculate the single-scattering properties of ice crystals are reviewed. Current problems and difficulties in the calculations of the single-scattering properties of atmospheric ice crystals are addressed in terms of cloud microphysics. Future directions to develop physically consistent ice-crystal models are also discussed.

A study of the space sterilization device using atmospheric-pressure DBDs plasma (대기압 유전체장벽방전을 적용한 플라즈마오존 공간살균장치에 관한 연구)

  • Oh, Hee-Su;Lee, Kang-yeon;Park, Ju-Hoon;Jeong, Byeong-Ho
    • Journal of the Korea Convergence Society
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    • v.13 no.3
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    • pp.281-289
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    • 2022
  • Plasma ozone is utilized in a variety of applications in the field of sterilization due to its high sterilization performance. Dielectric materials used in DBD(dielectric barrier discharges) are mainly polymer, quartz and ceramics. These dielectric layers have the advantage of limiting the amount of supplied electron charge and allowing plasma to occur evenly on the surface of dielectric. Actually, the target or environment for sterilization is often a complex structure, so research and academic study are needed by utilizing the concept of space sterilization. In this study, the device is applied to generate DBD plasma at atmospheric pressure for disinfection due to the effectiveness in producing radicals and ozone. The generator of plasma ozone is a basic structure of dielectric barrier discharge by placing ceramic tube dielectrics and stainless steel electrical conductors at regular intervals. Various applications can be developed based on the proposed design method. Plasma ozone generation for space sterilization device is recognized as an excellent sterilization device. Through the design and verification of the device, we intend to establish an optimal design of the spatial sterilization device and provide the basis data for sterilization applications.

A case study of ground subsidence analysis using the InSAR technique (InSAR 기술을 이용한 지반침하분석 사례연구)

  • Moon, Joon-Shik;Oh, Hyoung-seok
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.24 no.2
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    • pp.171-182
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    • 2022
  • InSAR (Interferometry SAR) technique is a technique that uses complex data to obtain phase difference information from two or more SAR image data, and enables high-resolution image extraction, surface change detection, elevation measurement, and glacial change observation. In many countries, research on the InSAR technique is being conducted in various fields of study such as volcanic activity detection, glacier observation in Antarctica, and ground subsidence analysis. In this study, a case of large ground settlement due to groundwater level drawdown during tunnelling was introduced, and ground settlement analyses using InSAR technique and numerical analysis method were compared. The maximum settlement and influence radius estimated by the InSAR technique and numerical method were found to be quite similar, which confirms the reliability of the InSAR technique. Through this case study, it was found that the InSAR technique reliable to use for estimating ground settlement and can be used as a key technology to identify the long-term ground settlement history in the absence of measurement data.

Numerical Analysis of Wind Environment around Sungnyemun Gate Using a Computational Fluid Dynamics Model (전산유체역학 모델을 이용한 숭례문 주변의 풍환경 수치해석)

  • Son, Minu;Kim, Do-Yong
    • Journal of Conservation Science
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    • v.37 no.3
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    • pp.209-219
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    • 2021
  • In this study, the wind environment in an urban area near Sungneymun gate was numerically investigated in the cases of inflow directions. The wind fields for the target area were simulated using Geographic Information System data and Computational Fluid Dynamics model. Results, including vector fields, three-dimensional wind velocity components, and wind speeds, were analyzed to examine flow characteristics. Wind direction variability affected by buildings was shown in the target area. The complex flows around Sungneymun did not depend on the inflow direction as a boundary condition. The wind speed around Sungneymun was generally 3 times stronger at 14 m above ground level (AGL) compared to the surface wind at 2 m AGL and relatively high in the case of easterly inflow. The effect of wind was also analyzed to be relatively significant at the southeast side of Sungneymun. Thus, it was suggested that the assessment of wind environment affected by high-rise and high-density buildings should be necessary for the architectural heritage in urban areas.

Generation of single stranded DNA with selective affinity to bovine spermatozoa

  • Vinod, Sivadasan Pathiyil;Vignesh, Rajamani;Priyanka, Mani;Tirumurugaan, Krishnaswamy Gopalan;Sivaselvam, Salem Nagalingam;Raj, Gopal Dhinakar
    • Animal Bioscience
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    • v.34 no.10
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    • pp.1579-1589
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    • 2021
  • Objective: This study was conducted to generate single stranded DNA oligonucleotides with selective affinity to bovine spermatozoa, assess its binding potential and explore its potential utility in trapping spermatozoa from suspensions. Methods: A combinatorial library of 94 mer long oligonucleotide was used for systematic evolution of ligands by exponential enrichment (SELEX) with bovine spermatozoa. The amplicons from sixth and seventh rounds of SELEX were sequenced, and the reads were clustered employing cluster database at high identity with tolerance (CD-HIT) and FASTAptamer. The enriched nucleotides were predicted for secondary structures by Mfold, motifs by Multiple Em for Motif Elicitation and 5' labelled with biotin/6-FAM to determine the binding potential and binding pattern. Results: We generated 14.1 and 17.7 million reads from sixth and seventh rounds of SELEX respectively to bovine spermatozoa. The CD-HIT clustered 78,098 and 21,196 reads in the top ten clusters and FASTAptamer identified 2,195 and 4,405 unique sequences in the top three clusters from the sixth and seventh rounds, respectively. The identified oligonucleotides formed secondary structures with delta G values between -1.17 to -26.18 kcal/mol indicating varied stability. Confocal imaging with the oligonucleotides from the seventh round revealed different patterns of binding to bovine spermatozoa (fluorescence of the whole head, spot of fluorescence in head and mid- piece and tail). Use of a 5'-biotin tagged oligonucleotide from the sixth round at 100 pmol with 4×106 spermatozoa could trap almost 80% from the suspension. Conclusion: The binding patterns and ability of the identified oligonucleotides confirms successful optimization of the SELEX process and generation of aptamers to bovine spermatozoa. These oligonucleotides provide a quick approach for selective capture of spermatozoa from complex samples. Future SELEX rounds with X- or Y- enriched sperm suspension will be used to generate oligonucleotides that bind to spermatozoa of a specific sex type.

A Study on Expression of the Film (2019) : Focusing on Genre-Shifting Characters and Actors' Acting (영화 <기생충>(2019)의 표현성 연구 : 장르를 변주하는 캐릭터와 배우의 연기를 중심으로)

  • Lee, A-Young
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.6
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    • pp.77-89
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    • 2020
  • The film "Parasite" portrays Korea's history and its present in a space that clearly represents the real world's hierarchy as a vertical structure. It demonstrates the problems of an insurmountable reality and the elements of various conflicts occurring below the surface of Korean society through a complex mix of human emotions and relationships. The most realistic yet unrealistic characters cross boundaries between being victims and perpetrators, defamiliarizing ordinary scenes from everyday life through their small mistakes, strange obsessions, bizarre behavior, anxious psychology, and desperate struggles. This study analyzes the expression of the film "Parasite" through its characters with the belief that the film expresses director Bong Joon-ho's consistent cinematic philosophy of taking reality beyond the traditional rules of film genres. By doing so, Bong creates a feature of the expression that shifts genres as the characters' personalities amplify related behaviors, conflicts and questions, and that this is the core of the unique nuance and distinct humor of this film. In addition, the personalities of the characters interact with all the film's elements (cinematic techniques, space, props, etc.), evoking effects of various meanings, which are transmitted through the actors'images and acting. In this respect, the study analyzes how the actors were cast in order to realistically reproduce the characters of the actors, how their acting was harmonized with the film's elements, and its features as well as how they were expressed.

WQI Class Prediction of Sihwa Lake Using Machine Learning-Based Models (기계학습 기반 모델을 활용한 시화호의 수질평가지수 등급 예측)

  • KIM, SOO BIN;LEE, JAE SEONG;KIM, KYUNG TAE
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.27 no.2
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    • pp.71-86
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    • 2022
  • The water quality index (WQI) has been widely used to evaluate marine water quality. The WQI in Korea is categorized into five classes by marine environmental standards. But, the WQI calculation on huge datasets is a very complex and time-consuming process. In this regard, the current study proposed machine learning (ML) based models to predict WQI class by using water quality datasets. Sihwa Lake, one of specially-managed coastal zone, was selected as a modeling site. In this study, adaptive boosting (AdaBoost) and tree-based pipeline optimization (TPOT) algorithms were used to train models and each model performance was evaluated by metrics (accuracy, precision, F1, and Log loss) on classification. Before training, the feature importance and sensitivity analysis were conducted to find out the best input combination for each algorithm. The results proved that the bottom dissolved oxygen (DOBot) was the most important variable affecting model performance. Conversely, surface dissolved inorganic nitrogen (DINSur) and dissolved inorganic phosphorus (DIPSur) had weaker effects on the prediction of WQI class. In addition, the performance varied over features including stations, seasons, and WQI classes by comparing spatio-temporal and class sensitivities of each best model. In conclusion, the modeling results showed that the TPOT algorithm has better performance rather than the AdaBoost algorithm without considering feature selection. Moreover, the WQI class for unknown water quality datasets could be surely predicted using the TPOT model trained with satisfactory training datasets.

Estimation and Evaluation of Reanalysis Air Temperature based on Mountain Meteorological Observation (산악기상정보 융합 기반 재분석 기온 데이터의 추정 및 검증)

  • Sunghyun, Min;Sukhee, Yoon;Myongsoo, Won;Junghwa, Chun;Keunchang, Jang
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.24 no.4
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    • pp.244-255
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    • 2022
  • This study estimated and evaluated the high resolution (1km) gridded mountain meteorology data of daily mean, maximum and minimum temperature based on ASOS (Automated Surface Observing System), AWS (Automatic Weather Stations) and AMOS (Automatic Mountain Meteorology Observation System) in South Korea. The ASOS, AWS, and AMOS meteorology data which were located above 200m was classified as mountainous area. And the ASOS, AWS, and AMOS meteorology data which were located under 200m was classified as non-mountainous area. The bias-correction method was used for correct air temperature over complex mountainous area and the performance of enhanced daily coefficients based on the AMOS and mountainous area observing meteorology data was evaluated using the observed daily mean, maximum and minimum temperature. As a result, the evaluation results show that RMSE (Root Mean Square Error) of air temperature using the enhanced coefficients based on the mountainous area observed meteorology data is smaller as 30% (mean), 50% (minimum), and 37% (maximum) than that of using non-mountainous area observed meteorology data. It indicates that the enhanced weather coefficients based on the AMOS and mountain ASOS can estimate mean, maximum, and minimum temperature data reasonably and the temperature results can provide useful input data on several climatological and forest disaster prediction studies.