• Food Science and Biotechnology
• /
• 제14권6호
• /
• pp.732-737
• /
• 2005

The combinational effect of gamma irradiation and moist heating on the trypsin inhibitor activity (TIA) in soaked and dried soybeans was evaluated by measuring the inhibition using N-benzoyl-DL-arginine-p-nitroanilide (BAPNA) as substrate. Gamma irradiation significantly decreased the TIA level in soybean at doses above 5 kGy, and the $ID_{50}$ (the gamma irradiation dose required to reach 50% inhibition) value for TIA was 13.53 kGy. Soaking prior to gamma irradiation significantly lowered the $ID_{50}$ to 8.44 kGy, and the soaking process enhanced the efficiency to inactivate TIA by as much as 48%. When soaking prior to gamma irradiation was followed by subsequent mild heating ($60^{\circ}C$) process, the $IT_{50}$ (heating time required to reach the 50% inhibition of TIA) value at even 1 kGy (5.28 min) was greatly reduced by over 50% compared to the level for the no-soaking process. In addition, the activation energy of soaking prior to gamma irradiation at 1 kGy was 2.45 kcal/mole, which was also about 50% lower than the 5.10 kcal/mole of dried soybean gamma-irradiated. Based on these results, soaking prior to gamma irradiation is an effective method for TIA inhibition. Furthermore, a combination of two or more processing methods such as soaking, heating and gamma irradiation is much more effective than any single processing method.

• 한국음향학회지
• /
• 제18권1호
• /
• pp.45-52
• /
• 1999

본 논문에서는 HDTV 비디오 신호를 처리함에 있어 신호의 병목현상을 없애주고 신호의 원활한 처리를 위해 새로운 알고리듬을 적용하여 54MHz의 동작 주파수를 갖는 패커를 제안하고 설계하였다. 또한 제안된 패커의 성능을 검증하기 위해 조합논리를 이용한 ROM 테이블 구조를 갖는 DCT 계수 부호화부를 함께 설계하므로써 DCT 계수 부호화부의 출력을 제안된 패커의 입력 데이타로 사용하였다. 본 논문의 회로는 VHDL 코드를 이용하였고 SYNOPSYS tool의 $0.65{\mu}m$ 공정을 이용한 모델링과 시뮬레이션을 수행하였다.

• 동의생리병리학회지
• /
• 제23권6호
• /
• pp.1431-1443
• /
• 2009

In order to investigate the therapeutic effect of SSC, NC/Nga animal model resembling the AD-like symptoms were used to measure the changes in cytokines and histology. SSC prescription group showed significant decrease in the atopic dermatitis clinical index by 40.2% compared to that of the control. The SSC prescription had significant effect on immune cells that are related to inducing AD symptoms. SSC prescription also increased the ratio of immune cells in DLN that were not directly involved in AD symptoms. SSC prescription group showed significant decrease in the level of cytokines within spleen cells and DLN. The prescription also decreased the level of immunoglobulin IgE levels in serum by 25.3%. The thickness of epidermis and dermis as well as the precipitation of erythrocytes were also observed. The results indicate the therapeutic effect of SSC in the treatment of atopic dermatitis through immune modulation. The study will provide a broader applications in the treatment of atopic dermatitis. Particularly, skin regeneration effect and supplemental use of topical application of SS in atopic dermatitis treatment had been reported previously, and further investigation on the dose dependent effect as well as skin irritation studies of SS should be followed.

• Nutrition Research and Practice
• /
• 제1권3호
• /
• pp.195-199
• /
• 2007

Inositol hexaphosphate ($IP_6$) is a major constituent of most cereals, legumes, nuts, oil seeds and soybean. Previous studies reported the anticancer effect of $IP_6$ and suggested that co-treatment of $IP_6$ with inositol may enhance anticancer effect of $IP_6$. Although the anticancer effect of $IP_6$ has been intensively studied, the combinational effect of $IP_6$ and inositol and involved mechanisms are not well understood so far. In the present study, we investigated the effect of $IP_6$ and myo-inositol (MI) on cell cycle regulation and apoptosis using PC3 prostate cancer cell lines. When cell, were co-treated with $IP_6$ and MI, the extent of cell growth inhibition was significantly increased than that by $IP_6$ alone. To identify the effect of $IP_6$ and MI on apoptosis, the activity of caspase-3 was measured. The caspase-3 activity was significantly increased when cells were treated with either $IP_6$ alone or both $IP_6$ and MI, with no significant enhancement by co-treatment. To investigate the effect of $IP_6$ and MI of cell cycle arrest, we measured p21 mRNA expression in PC3 cells and observed significant increase in p21 mRNA by $IP_6$. But synergistic regulation by co-treatment with $IP_6$ and MI was not observed. In addition, there was no significant effect by co-treatment compared to $IP_6$ treatment on the regulation of cell cycle progression although $IP_6$ significantly changed cell cycle distribution in the presence of MI or not. Therefore, these findings support that $IP_6$ has anticancer function by induction of apoptosis and regulation of cell cycle. However, synergistic effect by MI on cell cycle regulation and apoptosis was not observed in PC3 prostate cancer cells.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제15권11호
• /
• pp.4122-4144
• /
• 2021

In this fast-paced technological world, the Internet of Things is a ground breaking technology which finds an immense role in the present electronic world which includes different embedded sensors, devices and most other things which are connected to the Internet. The IoT devices are designed in a way that it helps to collect various forms of data from varied sources and transmit them in digitalized form. In modern era of IoT technology data security is a trending issue which greatly affects the confidentiality of important information. Keeping the issue in mind a novel light encryption strategy known as LCB is designed for IoT devices for optimal security. LCB exploits the benefits of Feistel structure and the architectural benefits of substitution permutation network both to give more security. Moreover, this newly designed technique is tested on (Virtex-7) XC7VX330T FPGA board and it takes much little area of 224 GE (Gate Equivalent) and is extremely fast with very less combinational path delay of 0.877 ns. An in-depth screening confirms the proposed work to promise more security to counter cryptographic attacks. Lastly the Avalanche Effect (AE) of LCB showed as 63.125% and 63.875% when key and plaintext (PT) are taken into consideration respectively.

• Toxicological Research
• /
• 제19권3호
• /
• pp.189-195
• /
• 2003

The protective effects of BNs-3 and BNs-7, extracts of citrous orange peel, on the obesity induced by ad libitum feeding a cholesterol-containing diet to rats were investigated. The animals were fed on the diet including cholesterol (0.5%) with or without the citrous orange peel extracts BNs-3 (5%) and/or BNs-7 (0.1%) for 8 weeks. The ad libitum feeding a diet containing cholesterol to rats from 6 weeks of age increased the body weight gain compared with that of rats fed on a normal diet. Such an increase in body weights was markedly attenuated by the addition of BNs-3 or BNs-7 to the diet. Especially, a combinational feeding on BNs-3 and BNs-7 significantly reduced the body weight gain below that of normal diet-fed animals. Interestingly, the weights of abdominal adipose tis-sues surrounding epididymides were greatly reduced by the citrous orange peel extracts, in parallel with the decrease in body weights. In addition, blood concentrations of lipids including cholesterol were also lowered by the combinational treatment with BNs-3 and BNs-7. Taken together, it is suggested that the obesity and overweight produced by unrestricted overfeeding on diet with cholesterol may be partially due to the accumulation of abdominal adipose tissues, around the epididymides in rats, and that citrous orange peel extracts might exert antiobese activities by reducing the adipose tis-sues as well as blood lipid concentrations.

• 한국가축번식학회지
• /
• 제27권3호
• /
• pp.187-195
• /
• 2003

체외 성숙시킨 M II기 난자의 여러 화학물질간의 중복 및 병용처리를 실시하여 수핵란으로서 적합한 활성화 조건과 활성화 후 자체 탈핵을 유도함으로써 보다 효율적인 탈핵 여건을 확립하고자 본 연구를 실시하였다. 1. Ethanol을 사용하여 6-DMAP 또는 cycloheximide 간의 단독, 중복, 그리고 병용처리를 실시한 결과, 활성화율, 난할율 및 체외 발달율에서 단독처리와 병용처리간의 차이는 없었으나 중복처리시 유의적으로 저하되었다(P<0.05). 2. $Ca^{2+}$ ionophore를 가지고 활성화 조건별로 처리하였을 경우, 6-DMAP와 병용 처리가 활성화율, 난할율 및 체외 발달율에서 각각 80.8%, 78.3%, 40.6%로 단독처리시의 58.0%, 62.9%, 27.0%보다 유의적으로 높았고(P<0.05), 또한 cycloheximide와의 병용처리도 활성화 및 난할율에서 단독처리와의 유의적 차이를 보였다(P<0.05). 그러나 중복처리시에는 효과를 나타내지 못하였다. 3. 탈핵전 수핵란에 미리 활성화 처리를 한 후 핵이식란을 재구성 한 결과 탈핵율 및 세포 융합율에서 90.7%, 71.8%로 활성화 처리하지 않은 것 77.8%, 61.1% 보다 유의적으로 높았다(P<0.05). 그러나 난할율 및 체외 발달율에서는 유의적으로 저하되었다(38.7%, 19.3% vs 68.8%, 30.6%, P<0.05). 또한 변성율도 활성화 처리하지 않은 구에 비해 유의적으로 높게 나타났다(P<0.05). 이상의 결과로 미루어 탈핵전 활성화하여 수핵란으로 이용할 경우 $Ca^{2+}$ ionophore와 6-DMAP를 병용 처리가 가장 효과적이며, 주입되는 체세포와 수핵란 간의 적정한 세포주기의 조절이 효율적인 돼지 복제수정란 생산을 위해 필요할 것이다.

• 한국축산식품학회지
• /
• 제35권2호
• /
• pp.248-257
• /
• 2015

Effects of double packaging (combinational use of aerobic and vacuum conditions) and antioxidants on physicochemical properties in irradiated restructured chicken rolls were determined. Chicken breast treated with antioxidants (none, sesamol+a-tocopherol) was used to process restructured chicken breast rolls. The sliced rolls were vacuum, aerobic, or double packaged (vacuum for 7 d then aerobic for 3 d) and electron beam irradiated at 2.5 kGy. Color, 2-thiobarbituric acid reactive substances (TBARS), oxidation reduction potentials (ORP), and volatile profiles of the samples were determined at 0 and 10 d. Irradiation made restructured chicken rolls redder (p<0.05), and the increased redness was more distinct in irradiated vacuum-packaged than irradiated aerobic or double packaged meats. TBARS values of antioxidant-treated double packaged rolls were lower than even nonirradiated vacuum-packaged meat, and those were distinct at 10 d (p<0.05). ORP and lipid oxidation values were lower in irradiated vacuum and double packaged samples than those in irradiated aerobic packaged ones at 0 d (p<0.05). Irradiation of restructured chicken rolls increased the amount of total volatiles. Considerable amounts of off-odor volatiles were reduced or not detected by double packaging and antioxidant treatment at 10 d. Therefore, the combined use of antioxidants and double packaging would be useful to reduce redness and control the oxidative quality changes of irradiated restructured chicken rolls

• 한국전자거래학회지
• /
• 제12권1호
• /
• pp.73-87
• /
• 2007

세계 주요 기업들을 중심으로 비즈니스 프로세스를 보다 표준화하고, 명확화하려는 움직임이 어느 때보다 두드러지고 있다. BPM은 이러한 시도를 구현할 수 있는 적합한 도구로서 주목받고 있다. 최근 BPM으로 구현된 프로세스를 보다 효율적으로 실행하는 것이 이슈로 대두되고 있다. 본 논문에서는 프로세스 효율성을 크게 프로세스 엔진과 업무담당자 관점에서 이를 해결하고자 한다. 프로세스 엔진 관점에서는, 엔진이 사용자에게 업무를 얼마나 효율적으로 전달하는지 바라본다. 업무담당자 관점에서는, 전달된 업무를 각 업무담당자가 어떻게 처리하는지에 주목한다. 본 연구는 각 단계에서만 효율성을 고려해왔던 과거 연구와는 달리, 두 단계에서 모두 효율적일 수 있는 방법론을 제안하며, 이를 실험을 통해 유효성을 검증한다.

• 전자공학회논문지C
• /
• 제36C권2호
• /
• pp.46-53
• /
• 1999

본 논문에서는 HDTV 비디오 신호를 처리함에 있어 신호의 병목현상을 없애주고 신호의 원활한 처리를 위해 새로운 알고리듬을 적용하여 54MHz의 동작 주파수를 갖는 패커를 제안하였다. 또한 제안된 패커의 성능을 검증하기 위해 조합논리를 이용한 ROM 테이블 구조를 갖는 DCT 계수 부호화부를 함께 설계하므로써 DCT 계수 부호화부의 출력을 제안된 패커의 입력 데이타로 사용하였다. 본 논문에서 제안된 회로는 VHDL 코드를 이용하여 설계하였고 SYNOPSYS tool의 $0.65{\mu}m$ 공정을 이용한 모델링과 시뮬레이션을 수행하였다.