• Korean Journal of Clinical Laboratory Science
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• v.51 no.3
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• pp.351-359
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• 2019

Neurocognitive testing commonly uses the MMSE (Mini-Mental State Examination) to evaluate the overall cognitive function of patients at outpatient clinics, but the MMSE has recently been extensively used in the SNSB II (Seoul Neuropsychological Screening Battery II) for making diagnoses. We retrospectively investigated the results of routine neurocognitive tests and the results of the blood tests of 120 elderly patients who had been referred to a South Central Medical Center from 2017 to 2018 and who had been examined at a public health center. These subjects' space-time capability was high on the sub-region of the global deterioration scale (GDS). GDS showed a significant increase as the Na decreased on the electrolyte analysis. The subjects' concentration, their language-based orientation for space and time, their memory, and their scores for the frontal lobe function on GDS showed statistically significant reductions (P<0.001) For the normal and abnormal groups according to the ALT and creatinine levels, the frontal/execute function areas showed statistically significant differences (P<0.001) as well as negative correlation between GDS and ALT (P<0.01). In conclusion, this study provides basic information to develop test items that are important for patient screening and diagnosis, and several routine blood chemistry factors provide basic information for diagnosing and assessing the status and progress of cognitively impaired patients.

• Korean Journal of Cognitive Science
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• v.18 no.2
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• pp.113-138
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• 2007

The effects of schema on accurate and false memories of items in a scene were investigated in two experiments: Recognition of items in a scene was tested immediately in Experiment 1 and three days later in Experiment 2. In both experiments, the following three variables were manipulated: Exposure time (250ms or 10000ms), picture mode (completed pictures or scrambled pictures), and manipulation mode (missing item or substituted item). Experiment 1 had yielded three important results: First, although accurate memory for presented items got increased when the exposure time was longer, false memory of the critical lures was not changed. Second, false memory of critical lures in the missing condition, where there was not any conflict between verbatim information and gist information, was higher than that of the substituted condition, where verbatim information of the item that replaced the lure was in conflict with the gist information. Third, accurate memory for atypical items in the substituted rendition, which had replaced the critical lures and in conflict with the schema, was higher than that in the missing condition. In Experiment 2, recognition test were administered 72 hours after the participants saw the picture. The three effects mentioned in Experiment 1 had disappeared in Experiment 2. The results of Experiment 2 might be due to the selective weakening of verbatim information compared to the persistence of the gist (or schematic) information. The results of Experiments 1 and 2 showed that false memory of critical lures is more persistent than the accurate memory of non-critical information. Theoretical implications of the results were considered in terms of the function of the verbatim and gist information.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.4
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• pp.397-405
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• 2019

Quantitative electroencephalography (QEEG) has been widely used in research and clinical fields. QEEG has been widely used to objectively document cerebral changes for the purpose of identifying the electrophysiological biomarkers across various clinical symptoms and for the stimulation of specific cortical regions associated with cognitive function. In electroencephalography (EEG), the difference in quantitative and qualitative analyses is discriminated not by its measurement methods and relevant clinical or research environments, but by its analysis methods. When performing a qualitative analysis, it is possible for a medical technologist or experienced researchers to read the EEG waveforms to exclude artifacts. However, the quantitative analysis is still based on mathematical modeling, and all EEG data are included for the analysis, leading the results to be affected by unexpected artifacts. In the hospital setting, the case that the medical technologists in charge of the EEG test perform academic research has been little reported, compared to other clinical physiological measurement-based research. This is because there are few laboratories specialized in clinical physiological research. In this respect, this study is expected to be utilized as a basic reference material for medical technologists, students, and academic researchers, all of whom would like to conduct a quantitative analysis.

• Journal of Korean Society of Forest Science
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• v.112 no.1
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• pp.93-104
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• 2023

Life expectancy is increasing due to the aging of the population, which is in turn exacerbating problems such as the prevalence of various geriatric diseases. This study was established to provide basic data for the expansion of forest healing activities for the elderly by systematically analyzing the literature on how such activities affect this age group. For the collection of studies, the Korean databases RISS, KISS, Korea Med, and Science On were used, while PubMed, Cochrane Central, MDPI, and Google Scholar were used to identify reports published elsewhere. To assess the quality of the methodology used in the collected studies, the risk of bias was analyzed using Cochrane's RoB2 and RoBANS. Among 1,856 reports initially identified, 21 were finally selected for analysis in this study, which were limited to research papers on forest healing activities for the elderly published between 2000 and January 2022. In this review, the subjects were those aged 60 or older, with a total of 750 participants, ranging from at least 7 to a maximum of 88 per study. The analysis showed that the most frequently performed tests in each category were on depression as a psychological indicator in 7 studies, MMSE(Mini Mental State Examination) as a cognitive indicator in 2 studies, on blood pressure as a physiological indicator in 4 studies, on melatonin as a biochemical indicator in 2 studies, and on body fat and muscle strength as physical indicators in 3 studies. Of the 21 studies, 19 used two or more test items, with psychological indicators being most commonly measured. For the future application of forest healing activities for the elderly, various forest healing programs to prevent cognitive function decline should be developed and distributed, and follow-up studies should be continuously presented to provide the basis for forest healing activities.

• Food Science and Biotechnology
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• v.17 no.3
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• pp.594-597
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• 2008

Natural products have been used to treat many neurological illnesses such as Alzheimer's disease. In the present study, the effects of the water extract of smoke-dried skipjack tuna (WSST), which is used as a traditional seasoning in Japan, as well as its fractions on acetylcholinesterase (AChE) inhibition in vitro and on memory in scopolamine-induced amnesia mice in vivo were evaluated. Bio-Rad P-2 gel permeation chromatography revealed the presence of 7 peaks and AChE significantly inhibited peak 3 and 5. When in vivo behavioral studies were conducted, a passive avoidance test revealed that treatment with 50 and 100 mg/kg WSST as well as with fraction 3 and 5 improved the loss in memory retention induced by scopolamine. These results suggest that skipjack tuna extract and its fractions improve memory deficits and that these substances are suitable for use in healthy foods designed to improve memory deficits induced by aging and Alzheimer's disease.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.3
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• pp.799-818
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• 2014

Spectrum sensing is a key technical challenge for cognitive radio (CR). It is well known that multi-cycle cyclostationarity (MC) detector is a powerful method for spectrum sensing. However, conventional MC detector is difficult to implement due to its high computational complexity. This paper pays attention to the fact that the computation complexity can be reduced by simplifying the test statistic of conventional MC detector. Based on this simplification process, an improved MC detector is proposed. Compared with the conventional one, the proposed detector has the low-computational complexity and sufficient-accuracy on sensing performance. Subsequently, the sensing performances are further investigated for the cases of Rayleigh, Nakagami-m, Rician, composite Rayleigh fading-lognormal shadowing and composite Nakagami fading-lognormal shadowing channels, respectively. Furthermore, the square-law combining (SLC) is introduced to improve the detection capability over fading-shadowing channels. The corresponding closed-form expressions of average detection probability are derived for each case by the moment generation function (MGF) approach. Finally, illustrative and analytical results show that the efficiency and reliability of proposed detector and the improvement on sensing performance by SLC over composite fading-shadowing channels.

• Journal of Korea Game Society
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• v.9 no.4
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• pp.45-56
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• 2009

It is necessary for young children to integrate the sense of sight, hearing, touch, etc. for developing their emotion and cognition. Thanks to Information and Communication Technology (ICT) development, young children have more opportunities to use various senses in learning process. However, ICT learning method is more focusing on the sense of sight and hearing, and lacks of integrated recognition and this fact leads to the reason why ICT can not be used as a main education tool. Therefore, this study evaluated the influence of wUbi-Pen(haptic device) on cognition using a computer puzzle program. The results show that young children using a haptic pen have greater intention and performance in object assembly, mazes, picture completion in K-WPPSI test than those of non-using haptic pen. This implies that haptic function should be considered in ICT material and indeed useful in various cognition-related symptoms and diseases.

• Food Science of Animal Resources
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• v.34 no.1
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• pp.106-114
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• 2014

Folic acid, one of the B group of vitamins, is an essential substance for maintaining the functions of the nervous system, and is also known to decrease the level of homocysteine in plasma. Homocysteine influences the lowering of the cognitive function in humans, and especially in elderly people. In order to determine the strains with a strong capacity to produce folic acid, 190 bacteria were isolated from various kinds of jeotgal and chungkuk-jang. In our test experiment, JA71 was found to contain $9.03{\mu}g/mL$ of folic acid after 24 h of incubation in an MRS broth. This showed that JA71 has the highest folic acid production ability compared to the other lactic acid bacteria that were isolated. JA71 was identified as Lactobacillus plantarum by the result of API carbohydrate fermentation pattern and 16s rDNA sequence. JA71 was investigated for its physiological characteristics. The optimum growth temperature of JA71 was $37^{\circ}C$, and the cultures took 12 h to reach pH 4.4. JA71 proved more sensitive to bacitracin when compared with fifteen different antibiotics, and showed most resistance to neomycin and vancomycin. Moreover, it was comparatively tolerant of bile juice and acid, and displayed resistance to Escherichia coli, Salmonella Typhimurium, and Staphylococcus aureus with restraint rates of 60.4%, 96.7%, and 76.2%, respectively. These results demonstrate that JA71 could be an excellent strain for application to functional products.

• Korean Journal of Human Ecology
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• v.18 no.1
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• pp.145-155
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• 2009

The purpose of this study is to examine the university students' awareness and attitudes on functional clothing materials, and to explore the effects of subjects' characteristics on the relationship between their attitudes to and images of the functional clothing materials. A total of 500 questionnaires were distributed to university students and 409 of which were used in data analysis. The data were statistically analyzed by frequency, factor analysis, reliability analysis, correlation analysis, t-test, ANOVA. The results were as follows: students thought that the first and foremost 'function' of functional clothing materials is their light-weight. The functions that consumers practically demanded are water-repellency and high absorbency & quick drying. It showed that students have an image that functional clothing materials have special, good and satisfactory qualities. Goretex and Coolmax were the most selected as brands of functional clothing materials which students knew. Attitudes to functional clothing materials revealed positively in the cognitive, behavioral and affectional attitudes. The attitudes had no significant differences according to sex and their major, but they had significant differences by subjects' amount of allowance, frequency of sports participation and sports ability. In other words, the more amount of allowance they get, the more frequently students do exercise, and the higher sports ability they have, the more positive attitude they have. The study says, in conclusion, that their conception of functional clothing materials has positive relations with their attitudes toward them.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.4
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• pp.173-179
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• 2004

Amyloid ${\beta}-peptide\;(A{\beta})$ contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against $A{\beta}-induced$ toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated $A{\beta}-induced$ apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.