• Korean Journal of Pharmacognosy
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• v.13 no.3
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• pp.122-128
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• 1982

In order to investigate the pharmacological action of combined preparation of crude drugs, 'Oyo-Tang' were studied. 'Oyo-Tang' consist of Glycyrrhizae Radix, Ephedrae Herba, Armenicae Semen, Platycodi Radix and Nepetae Herba. They have widely been prescribed in Oriental Medicine for controlling of cough, asthma, nasal abstraction, pharygeal pain and hoarseness. Experimental studies were implemented on analgesic, sedativc, anticonvulsive and ileum relaxing actions. The results of the studies were as follows; Significant anticonvulsive action was recognized by fraction IIII. Sedative and analgesic actions were noted by fraction I and III. Relaxing action was shown on the extracted ileum in mice, antagonistic actions were seen on $BaCl_2-induced$ contraction of the ileum of mice and Histamine-induced contraction of the ileum of guinea-pigs that the relaxing effect of the intestinal smooth muscle was recognized.

• Journal of Korea Water Resources Association
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• v.31 no.5
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• pp.529-538
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• 1998

The flow configurations at open channel junctions are analyzed by 2-D depth averaged mathematical model. The governing factors of the flow at the junction are found to be discharge ratio between tributary flow and the post confluence combined flow, and confluence angle. Analyzed by these two factors are flow patterns and flow depth variation at the confluence, discharge ratio above which the flow upstresm from the junction is affected by the tributary flow and the geometries of a recirculation region. Further, the flow contraction in the downstream region and the deflection of the tributary flow in the main channel were investigated. The numerical results are compared with the existing experimental data fairly well.

• Korean Journal of Acupuncture
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• v.17 no.1
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• pp.75-80
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• 2000

Fructus Aristolochiae has been used in Korea for many centuries as a treatment for various disease.The purpose of the present study is to determine the effect of Fructus Aristolochiae on norepinephrine(NE) induced blood vessel contraction in rabbits. Rabbit(2 kg, male) were killed by $CO_2$ exposure and a segment (8-10mm) of each rabbit was cut into equal segments and mounted in a tissue bath. Contractile force was measured with force displacement transducers under 2-3 g loading tension. The dose of norepinephrine(NE) which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for NE ($10^{-6}{\sim}10^{-3}M$). Contractions evoked by NE ($ED_{50}$) were inhibited significantly by Fructus Aristolochiae in abdominal aorta and femoral artery. Fructus Aristolochiae inhibited the relaxation pretreated propranolol and L-NNA in femoral artery. But Fructus Aristolochiae did not effect the relaxation pretreated ODQ in femoral artery and abdominal aorta. These results indicate that Fructus Aristolochiae can relax NE induced contraction of rabbit blood vessel selectively, and that this relaxation relates to nitric oxide synthesis and sympathetic action.

• International Journal of Air-Conditioning and Refrigeration
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• v.11 no.1
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• pp.1-9
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• 2003

The examinations of the operating mechanism of an oscillating capillary tube heat pipe (OCHP) using the visualization method revealed that the working fluid in the OCHP oscillated to the axial direction by the contraction and expansion of vapor plugs. The contraction and expansion were due to the formation and extinction of bubbles in the evaporating and condensing part, respectively The actual physical mechanism, whereby the heat which was transferred in such an OCHP was complex and not well understood. In this study, a theoretical model of the OCHP was developed to model the oscillating motion of working fluid in the OCHP. The differential equations of two-phase flow were applied and simultaneous non-linear partial differential equations were solved. From the analysis of the numerical results, it was found that the oscillating motion Of working fluid in the OCHP was affected by the operation and design conditions such as the heat flux, the charging ratio of working fluid and the hydraulic diameter of flow channel. The simulation results showed that the proposed model and solution could be used for estimating the operating mechanism in the OCHP.

• Korean Journal of Bronchoesophagology
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• v.4 no.1
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• pp.64-72
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• 1998

This study aimed at observing the effect of diazepam on the contractility of trachealis muscle isolated from canine trachea, possible involvement of central or peripheral type benzodiazepine receptor, and the calcium related mechanism of action of diazepam. Trachealis muscle strips of 15 mm long were suspended in an isolated organ bath containing 1 ml of physiologic salt solution maintained at $37^{\circ}C$, and aerated with 95% $O_2$ /5% $CO_2$. Isometric myography was performed. Diazepam reduced the basal tone concentration dependently, and this inhibitory action was not affected by neither flumazenil, a central benzodiazepine receptor antagonist, nor PK11195, a peripheral benzodiazepine receptor antagonist. Pretreatment with diazepam showed the inhibitory effect on the concentration-response curves to agonists such as bethanechol, 5-hydroxytryptamine and histamine. Diazepam also caused concentration-related inhibition of contraction with potassium chloride 30 mM. The effect of diazepam on the basal tone and potassium chloride-induced contraction with calcium channel blockers were compared. Similar results were obtained in canine trachealis with verapamil, nifedipine and diltiazem. These results suggest that diazepam relax an airway muscle not via specific receptors but by a similar action as calcium channel blockers in canine trachealis muscle.

• Journal of Biomedical Engineering Research
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• v.34 no.4
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• pp.163-169
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• 2013

The purpose of this study was to verify exercise effect of horse riding exercise according to estimate basal physical fitness and activities of daily living(ADL) function in the aged. Participants were nineteen peoples who have no impediment of activity. They performed horse riding exercise using SRider(Neipplus, Co., Korea) at sixty minutes a day. Exercise has progressed three days a week for eight weeks. We measured trunk flexion, sit up, whole body reaction, leg strength and maximal oxygen uptake as basal physical fitness. Also three meter gait, single stance with eyes opened and single stance with eyes closed as ADL function were estimated once a month. The result of legs strength and whole body reaction showed the higher significantly than before the exercise. Moreover, the result of three meter walking ability only increased significantly among the ADL function. This means that horse riding exercise might be activated continuous muscular contraction with maintained tonus of muscle. We thought that continuous movement of horse riding could be lead to isometric muscle contraction in lower limbs. Our study found that horse riding exercise could improve lower strengths and muscle reaction for exercise effect. Also we suggested that horse riding exercise could be adapted to exercise methods that could provide rehabilitation and treatment enough for the aged or disabled person.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.11
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• pp.107-118
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• 2008

In this study, lower extremity joint kinematics and kinetics and lumbar lordosis were investigated for two different symmetrical lifting techniques(squat and stoop) using the three-dimensional motion analysis. Twenty-six male volunteers lifted boxes weighing 5, 10 and 15kg by both squat and stoop lifting techniques. There were not significant differences in maximum lumbar joint moments between the two techniques. The hip and ankle contributed the most part of the support moments during squat lifting, and the knee flexion moment played an important role in stoop lifting. The hip, ankle and lumbar joints generated power and only the khee joint absorbed power in the squat lifting. The knee and ankle joints absorbed power, the hip and lumbar joints generated power in the stoop lifting. The bi-articular antagonist muscles' co-contraction around the knee joint during the squat lifting and the eccentric co-contraction of the gastrocnemius and semitendinosus were found to be important for straightening up during the stoop lifting. At the time of lordotic curvature appearance in the squat lifting, there were significant correlations in all three lower extremity joint moments with the lumbar joint. Differently, only the hip moment had significant correlation with the lumbar joint in the stoop lifting. In conclusion, the knee extension which is prominent kinematics during the squat tilling was produced by the contributions of the kinetic factors from the hip and ankle joints(extensor moment and power generation) and the lumbar extension which is prominent kinematics during the stoop lifting could be produced by the contributions of the knee joint kinetic factors(flexor moment, power absorption, bi-articular muscle function).

• The Journal of the Korea Contents Association
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• v.18 no.1
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• pp.173-184
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• 2018

In human walking, muscle co-contraction which produces simultaneous activities of multiple muscles is important in motor control mechanism of the central nervous system. This study aims to understand positive and negative covariation mechanism of inter-muscle activities during walking. In this study, we measured electromyography (EMG) in leg muscles. To identify motor modules, we recored EMG from 4 leg muscles bilaterally (the tibialis anterior, medial gastrocnemius, rectus femoris and medial hamstring muscles) and performed non-negative matrix factorization (NMF) and principa component analysis (PCA). Then, we computed covariation values from various combinations between muscles or motor modules and used two-way repeated measures analysis of variance to identify significantly different covariation patterns between muscle combinations. As the results, we found significant differences between covariation values of muscle combinations (p < 0.05). muscle groups within the same motor modules produced the positive covariations. However, there were strong negative covariation between motor modules. There was negative covariation in all muscle combination. Stable inter-module negative covariation suggests that motor modules may be the control unit in the complex motor coordination.

• Korean Journal of Applied Biomechanics
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• v.29 no.2
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• pp.79-88
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• 2019

Objective: The aim of this study was to determine the peak torques of the knee and ankle joint and local stability of the lower extremity's joints, and muscle activation patterns of the lower extremity's muscles between fallers and non-fallers in the elderly women during walking. Method: Four elderly women (age: $74.5{\pm}5.2yrs.$; height: $152.1{\pm}5.6cm$; mass: $55.3{\pm}5.4kg$; preference walking speed: $1.19{\pm}0.06m/s$) who experienced falls within six months since experiment had been conducted (falls group) and thirty-six subjects ($74.2{\pm}3.09yrs.$; height: $153.6{\pm}4.9cm$; mass: $56.7{\pm}6.4kg$; preference walking speed: $1.24{\pm}0.10m/s$) who had no experience in falls (non-falls group) within this periods participated in this study. They were measured torque peaks of the knee and ankle joint using a Human Norm and while they were walking on a treadmill at their natural pace, kinematic variables and EMG signals were collected with using a 3-D motion capture system and a wireless EMG system, respectively. Lyapunov Exponent (LyE) was determined to observe the dynamic local stability of the lower extremity's joints, and muscles activation and their co-contraction index were also analysed from EMG signals. Hypotheses between falls and non-falls group were tested using paired t-test and Mann-Whitey. Level of significance was set at p<.05. Results: Local dynamic stability in the adduction-abduction movement of the knee joint was significantly lower in falling group than non-falling group (p<.05). Conclusion: In conclusion, muscles which act on the abduction-adduction movement of the knee joint need to be strengthened to prevent from potential falls during walking. However, a small number of samples for fallers make it difficult to generalize the results of this study.

• Korean Journal of Applied Biomechanics
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• v.31 no.2
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• pp.140-147
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• 2021

Objective: The purpose of this study is to identify the mechanism of changes in maximum voluntary torque with the magnitude and duration of pre-activation torque during voluntary isometric knee extension. Method: 11 male subjects (age: 25.91±2.43 yrs., height: 173.12±3.51 cm, weight: 76.45±7.74 kg) participated in this study. The subjects were required to produce maximal voluntary isometric torque with a particular pre-activation torque condition. The properties of pre-activation torque consisted of the combinations of 1) three levels of magnitude, e.g., 32 Nm, 64 Nm, 96 Nm, and 2) two levels of duration, e.g., 1 sec, and 3 sec; thus, a total of six conditions were given to the subjects. The force and EMG data were measured using the force transducers and wireless EMG sensor, respectively. Results: The results showed that the maximum voluntary torque increased the most with relatively large and fast (96 Nm, 1 sec) pre-activation condition. Similarly, with relatively large and fast (96 Nm, 1 sec) preactivation, it was found that the integrated EMG (iEMG) of the agonist muscles increased, while no significant changes in the co-contraction of the antagonist muscles for the knee extension. Also, the effect of pre-activation conditions on the rate of torque development was not statistically significant. Conclusion: The current findings suggest that relatively larger in magnitude and shorter in duration as the properties of pre-activation lead to a larger magnitude of maximal voluntary torque, possibly due to the increased activity of the agonist muscles during knee extension.