• 대한예방의학회:학술대회논문집
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• 1994.02b
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• pp.265-269
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• 1994

A brief review is presented of the strengths and weaknesses of historical controls, data banks, and randomized trials in the evaluation of clinical treatment. Use of pre randomized versus postrandomized informed consent is discussed. Recommendations are made for the development of an appropriate clinical research strategy.

• Korean Journal of Clinical Pharmacy
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• v.25 no.2
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• pp.111-119
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• 2015

Background: It is thought that drug use of parents is related to that of young children. The status of drug among young children's parents and a correlation of with parents and their children on drug use was surveyed by questionnaire. Method: The questionnaire is composed of 34 items, and the data was collected by 108 parents of young children from March to April of 2012. Results: On the basis of the analysis results, the following conclusions were drawn. About half of parents thought the minimum use of drug was better for health, and 44% parents thought drug is essential for cure. When parents had queries on prescription, they mostly consult with doctors and pharmacists. Most parents had a household medicine. A fever reducer was the most common household medicine (92.5%). They pick the household medicine by consulting with pharmacist. Parents usually checked the expiration date of drug before they use and they dumped the drugs when the expiration date was due (82.4%). Over half of young children and their parents took a dietary supplements. They got an information about a dietary supplement by associates (30.5%) and internet (19.4%). Most parents tried to follow the directions as prescribed. However, more than half of the parents stopped taking the drug when the symptoms disappeared. Conclusion: Drug use of parents and that of young children had a very strong positive correlation, suggesting that correct drug use of parents have an impact on their young children's drug use.

• Journal of Hospice and Palliative Care
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• v.13 no.1
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• pp.1-6
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• 2010

The purpose of clinical trials is to find evidences for the effects of experimental new drugs or treatments on human. For the successful clinical trials, it is not sufficient to use statistics only for the analyses of collected data, but it is necessary to extend the usage of statistics in various ways. At the beginning of the study, one needs to use statistics for systematically and concretly planning the study. For this, we discussed the usage of statistics in defining the effect, determining the sample size, statistical analyses, and so on.

• Korean Journal of Clinical Pharmacy
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• v.23 no.2
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• pp.114-122
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• 2013

Background: Drugs should be evaluated in appropriate subjects representing potential population to take the drugs. This study focuses on gender factor and aims to make known the appropriateness of considering gender difference on clinical evaluation of drug with domestic data related to drug use. Methods: To understand gender difference shown in drug use, three types of domestic statistical data (prevalence of chronic disease, number of outpatient with major concerning disease, and consumption of medicine) were analyzed and compared according to gender. Results: Three of fifteen chronic diseases which were analyzed, showed significantly higher prevalence in women than in men, and three were vice versa. Meanwhile, the sex ratio of outpatients was significantly different in 22 major concerning diseases. Among the drug groups coded by Anatomical Therapeutic Chemical (ATC) Classification System, the consumption of most drug groups was generally higher in women than in men except for one group coded G (genito-urinary system and sex hormones). Conclusion: Gender difference should be considered in domestic clinical evaluation of drug and domestic guidance for reflecting gender difference should be established.

• Journal of Korean Medicine for Obesity Research
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• v.7 no.1
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• pp.23-29
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• 2007

Background : Mahuang (Ephedra sinica) has been used widely to treat respiratory disease in traditional medicine for over thousands years. Mahuang preparations contain approximately $0.75{\sim}1%$ ephedrine alkaloids. Recently in North America, the Eephedra alkaloids has aroused a controversy due to its adverse effects in those using whole extracts as "dietary supplements" for weight loss or athletic performance enhancement. Objective : To discuss the need for clinical practice guidelines on the use of Mahuang. Results and Conclusion : It is widely assumed that Mahuang is one of the useful medicines and is safe for human body. Most of scientific literatures support that the safety of Mahuang prescription in common dosage. However, it has been claimed that there were some warnings and apprehensions about the harmfulness of Mahuang as dietary supplements. This article does not negate the fact that it is necessary to pay more attention for use of Mahuang in clinical situations. We assert that the establishment of clinical practice guideline on the use of Mahuang, which is based on scientific materials and consensus, is required in traditional medicine.

• Korean Journal of Adult Nursing
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• v.12 no.3
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• pp.369-383
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• 2000

The purpose of this study was to understand clinical nurses' knowledge and attitudes on pain management. The subject of the study were 254 nurses working at two hospitals affiliated with a university in Seoul. The questionnaires included four areas: general knowledge on pain, knowledge on the use of analgesia, knowledge and implementation on the pain assessment scales and pain interventions and nurses' general characteristics. The data were analyzed with descriptive statistics, analysis of variance, LSD test and t-test using SPSS statistical package. The results were as follows. 1. The mean score of the general pain knowledge was 61.46 and that of knowledge on the use of analgesia was 52.19. 2. Most nurses(74%) answered with hesitation about injecting narcotic analgesia to patients. 3. The pain assessment scale which nurses knew (57.5%) and used(48.0%) extremely was a simple descriptive scale. 4. The pain intervention which nurses knew (94.5%) and implemented(92.1%) extremely was to inject analgesia. 5. The number of nurses who had learned about pain management was 49 of 254(19.3%). 6. Nurses' knowledge on the use of analgesia was of relevance to having learned pain management, but general pain knowledge was not so relevant. According to this research, I suggest the following. 1. It is necessary to develop an education program with actual practice and intervention which nurses can perform for themselves. 2. It is necessary to continuously educate about pain management in clinical wards.

• The Journal of Korean Medical History
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• v.25 no.2
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• pp.97-103
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• 2012

Introduction : Sasang Constitutional Medicine (SCM) is one of the most popular specialty in Korean traditional medicine. After Donguisusebowon (東醫壽世保元), the book initiated SCM at first, there have been several books related with SCM. Through this study on Donguisasangsinpyeon (東醫四象新編), we intend to present clinical application of SCM and the spread of its use. Methods and Discussion : Firstly, we will examine the author's life and philosophy, and consider various editions of Donguisasangsinpyeon. And we will attempt content analysis to the preface, foreword, afterword, and main text. Using these methods, we will show that Donguisasangsinpyeon not only succeed the theory of Donguisusebowon faithfully, but also expand the clinical use of SCM. Conclusions : Donguisasangsinpyeon is the first SCM-based clinical book after Donguisusebowon. And the book can also be valued for its adoption of explanatory diagrams that help people select customized prescriptions conveniently and easily.

• Journal of Hospice and Palliative Care
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• v.24 no.3
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• pp.184-193
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• 2021

Purpose: This study attempted to develop clinical guidelines to help patients use hospice and palliative care (HPC) at an appropriate time after writing physician orders for life-sustaining treatment (POLST) by identifying the characteristics of HPC use of patients with terminal cancer. Methods: This retrospective study was conducted to understand the characteristics of HPC use of patients with terminal cancer through decision tree analysis. The participants were 394 terminal cancer patients who were hospitalized at a cancer-specialized hospital in Seoul, South Korea and wrote POLST from January 1, 2019 to March 31, 2021. Results: The predictive model for the characteristics of HPC use showed three main nodes (living together, pain control, and period to death after writing POLST). The decision tree analysis of HPC use by terminal cancer patients showed that the most likely group to use HPC use was terminal cancer patients who had a cohabitant, received pain control, and died 2 months or more after writing a POLST. The probability of HPC usage rate in this group was 87.5%. The next most likely group to use HPC had a cohabitant and received pain control; 64.8% of this group used HPC. Finally, 55.1% of participants who had a cohabitant used HPC, which was a significantly higher proportion than that of participants who did not have a cohabitant (1.7%). Conclusion: This study provides meaningful clinical evidence to help make decisions on HPC use more easily at an appropriate time.

• Korean Journal of Clinical Pharmacy
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• v.32 no.2
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• pp.133-143
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• 2022

E-cigarettes were considered safe at the early stage of market entry because they were thought not to contain harmful ingredients such as nicotine and because the smoke emitted was vapor. For this reason, the use of e-cigarettes as a safer alternative to tobacco cigarettes or as a smoking cessation aid has emerged. However, the study results on the effectiveness of e-cigarettes for smoking cessation are mixed. In response to the increased use of e-cigarettes, foreign countries have implemented various regulations, such as utilizing e-cigarettes for smoking cessation with a prescription in Australia; however, South Korea is still standing firm on recommending not to use e-cigarettes at all. Therefore, the effectiveness of e-cigarettes for smoking cessation and the regulatory trends of e-cigarette use overseas will be reviewed to discuss the future direction in South Korea needs to take.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.11a
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• pp.23-39
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• 2006

The application of the knowledge from the Human Genome Project to clinical medicine will be through both industrial drug development and the application of pharmacogenomics (PG) to patient care. The slow uptake of clinical innovations into clinical practice can be frustrating, but understanding the history of acceptance and sustaining medical innovation is critically important to position PG to succeed. This primarily means that PG tests must have legitimacy; they must be thoroughly validated, must be cost-effective, must be widely accepted by medical practitioners, must be supported by public policy, and must have a way of being easily incorporated into current medical practice. They must also lead to actionalble decisions by health care providers for their patients. Innovative PG assays should be tested in the best US laboratories, and reimbursement for testing must be accepted at the federal and state level. The companies providing these PG tests should be capable of supporting the interpretation and use of the test throughout medical practice. Advances such as the addition of PG information to drug labeling and the routine use of validated biomarkers to determine choice of cancer chemotherapy have been made. The PG research community must pay attention to the principles that have been previously described for acceptance and sustaining medical innovations in order for PG to be widely accepted in clinical medical practice.