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Investigation Study on Gender Difference Based on Korean Data Related to Drug Use  

Rhee, Su-Jin (College of pharmacy, Chungnam National University)
Lee, Byung-Yo (College of pharmacy, Chungnam National University)
Kwon, Kwang-Il (College of pharmacy, Chungnam National University)
Publication Information
Korean Journal of Clinical Pharmacy / v.23, no.2, 2013 , pp. 114-122 More about this Journal
Abstract
Background: Drugs should be evaluated in appropriate subjects representing potential population to take the drugs. This study focuses on gender factor and aims to make known the appropriateness of considering gender difference on clinical evaluation of drug with domestic data related to drug use. Methods: To understand gender difference shown in drug use, three types of domestic statistical data (prevalence of chronic disease, number of outpatient with major concerning disease, and consumption of medicine) were analyzed and compared according to gender. Results: Three of fifteen chronic diseases which were analyzed, showed significantly higher prevalence in women than in men, and three were vice versa. Meanwhile, the sex ratio of outpatients was significantly different in 22 major concerning diseases. Among the drug groups coded by Anatomical Therapeutic Chemical (ATC) Classification System, the consumption of most drug groups was generally higher in women than in men except for one group coded G (genito-urinary system and sex hormones). Conclusion: Gender difference should be considered in domestic clinical evaluation of drug and domestic guidance for reflecting gender difference should be established.
Keywords
Gender difference; Chronic disease; Major concerning disease; Drug consumption;
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1 Johnson TL. A women's Health Research Agenda. J Women's Health 1993; 2(2): 95-8.   DOI
2 Merkatz RB, Junod SW. Historical background of changes in FDA policy on the study and evaluation of drugs in women. Acad Med 1994; 69(9): 703-7.   DOI
3 허정선, 김경희, 윤인경 등. Physician's Desk Reference에 나타난 성별차이 분석. 한국임상약학회지 2011; 21(1): 22-9.
4 2008 국민건강통계. 보건복지부 질병관리본부, 2009.
5 2009 국민건강통계. 보건복지부 질병관리본부, 2010.
6 2010 국민건강통계. 보건복지부 질병관리본부, 2011.
7 2008년도 환자조사. 보건복지부 한국보건사회연구원, 2009.
8 2009년도 환자조사. 보건복지부 한국보건사회연구원, 2010.
9 2010년도 환자조사. 보건복지부 한국보건사회연구원, 2011.
10 2011년도 환자조사. 보건복지부 한국보건사회연구원, 2012.
11 2008년도 의약품 소비량 및 판매액 통계 심층분석. 보건복지부 한국보건사회연구원, 2009.
12 2009년도 의약품 소비량 및 판매액 통계 심층분석. 보건복 지부 한국보건사회연구원, 2010.
13 2010년도 의약품 소비량 및 판매액 통계 심층분석. 보건복지부 한국보건사회연구원, 2011.
14 보도자료: 임상경쟁력 강화로 국내 임상 비약적 발전. 식품의약품안전청, 2012.
15 Berlin JA, Ellenberg SS. Inclusion of women in clinical trials. BMC Med 2009; 7: 56.   DOI
16 Guideline for the study and evaluation of gender differences in the clinical evaluation of drugs. Food and Drug Administration, 1993.
17 Prout MN, Fish SS. Participation of women in clinical trials of drug therapies: a context for the controversies. Medscape Womens Health 2001; 6(5): 1.
18 Considerations for inclusion of women in clinical trials and analysis of data by sex. Health Canada, 2012.
19 Krieger N. Gender, sexes, and health: what are the connections--and why does it matter? Int J Epidemiol 2003; 32(4): 652-7.   DOI
20 Pinn VW. Sex and gender factors in medical studies: implications for health and clinical practice. JAMA 2003; 289(4): 397-400.   DOI
21 Annandale E, Hunt K. Gender inequalities in health. Buckingham: Open University Press, 2000.
22 Mastroianni AC, Faden R, Federman D, et al., Women and health research: ethical and legal issues of including women in clinical studies. Washington, DC: National Academy Press, 1994.
23 Uhl K, Parekh A, Kweder S. Females in clinical studies: where are we going? Clin Pharmacol Ther 2007; 81(4): 600-2.
24 Brandt EN Jr. Some thoughts about women's health and its evolution. J Gend Specif Med 1998; 1(1): 48-9.
25 Pinn VW. An affirmation of research and health care for women in the 21st century. J Gend Specif Med 1998; 1(1): 50-3.
26 Kirschstein RL. Research on women's health. Am J Public Health 1991; 81(3): 291-3.   DOI