• Korean Journal of Pharmacognosy
• /
• v.11 no.3_4 s.43
• /
• pp.212-218
• /
• 1980

• Cross-Cultural Studies
• /
• v.35
• /
• pp.269-291
• /
• 2014

China has countless ancient books that contain thousand years of continuously recorded history across every generation. It is essential to organize the ancient cultural literature in order to better communicate. The study of ancient Chinese literature recently has become a subject of priority. Shi-Ji, one of the representative documents, is used for record keeping because of its experience with ancient Chinese historic materials and artifacts. This draft of Shi-ji is based on ancient Chinese research methods with the purpose to explore the character, phonology, syntax, exegesis and collation of historical value.

• Journal of Ginseng Research
• /
• v.47 no.1
• /
• pp.9-22
• /
• 2023

As a famous herbal medicine in China and Asia, ginseng (Panax ginseng C. A. Meyer) is also known as the "King of All Herbs" and has long been used in medicine and healthcare. In addition to the obvious biological activities of ginsenosides, ginseng polysaccharides (GPs) exhibit excellent antitumor, antioxidant stress, and immunomodulatory effects. In particular, GPs can exert an antitumor effect and is a potential immunomodulator. However, due to the complexity and diversity in the structures and components of GPs, their specific physicochemical properties, and underlying mechanisms remain unclear. In this article, we have summarized the factors influencing the antitumor activity of GPs and their mechanism of action, including the stimulation of the immune system, regulation of the gut microbiota, and direct action on tumor cells

• Journal of Ginseng Research
• /
• v.46 no.2
• /
• pp.235-247
• /
• 2022

Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular mechanisms involved. Methods: The effects of ginsenoside Rg3 on heart and mitochondrial function were investigated by treating TAC-induced heart failure in mice. The mechanism of ginsenoside Rg3 for improving heart and mitochondrial function in mice with heart failure was predicted through integrative analysis of the proteome and plasma metabolome. Glucose uptake and myocardial insulin sensitivity were evaluated using micro-positron emission tomography. The effect of ginsenoside Rg3 on myocardial insulin sensitivity was clarified by combining in vivo animal experiments and in vitro cell experiments. Results: Treatment of TAC-induced mouse models with ginsenoside Rg3 significantly improved heart function and protected mitochondrial structure and function. Fusion of metabolomics, proteomics, and targeted metabolomics data showed that Rg3 regulated the glycolysis process, and Rg3 not only regulated glucose uptake but also improve myocardial insulin resistance. The molecular mechanism of ginsenoside Rg3 regulation of glucose metabolism was determined by exploring the interaction pathways of AMPK, insulin resistance, and glucose metabolism. The effect of ginsenoside Rg3 on the promotion of glucose uptake in IR-H9c2 cells by AMPK activation was dependent on the insulin signaling pathway. Conclusions: Ginsenoside Rg3 modulates glucose metabolism and significantly ameliorates insulin resistance through activation of the AMPK pathway.

• Journal of Ginseng Research
• /
• v.47 no.6
• /
• pp.714-725
• /
• 2023

Background: Our previous investigation indicated that the preparation of Panax ginseng Meyer (P. ginseng) inhibited melanogenesis. It comprised salicylic acid (SA), protocatechuic acid (PA), p-coumaric acid (p-CA), vanillic acid (VA), and caffeic acid (CA). In this investigation, the regulatory effects of P. ginseng phenolic acid monomers on melanin production were assessed. Methods: In vitro and in vivo impact of phenolic acid monomers were assessed. Results: SA, PA, p-CA and VA inhibited tyrosinase (TYR) to reduce melanin production, whereas CA had the opposite effects. SA, PA, p-CA and VA significantly downregulated the melanocortin 1 receptor (MC1R), cycle AMP (cAMP), protein kinase A (PKA), cycle AMP-response element-binding protein (CREB), microphthalmia-associated transcription factor (MITF) pathway, reducing mRNA and protein levels of TYR, tyrosinase-related protein 1 (TYRP1), and TYRP2. Moreover, CA treatment enhanced the cAMP, PKA, and CREB pathways to promote MITF mRNA level and phosphorylation. It also alleviated MITF protein level in α-MSH-stimulated B16F10 cells, comparable to untreated B16F10, increasing the expression of phosphorylation glycogen synthase kinase 3β (p-GSK3β), β-catenin, p-ERK/ERK, and p-p38/p38. Furthermore, the GSK3β inhibitor promoted p-GSK3β and p-MITF expression, as observed in CA-treated cells. Moreover, p38 and ERK inhibitors inhibited CA-stimulated p-p38/p38, p-ERK/ERK, and p-MITF increase, which had negative binding energies with MC1R, as depicted by molecular docking. Conclusion: P. ginseng roots' phenolic acid monomers can safely inhibit melanin production by bidirectionally regulating melanin synthase transcription. Furthermore, they reduced MITF expression via MC1R/cAMP/PKA signaling pathway and enhanced MITF post-translational modification via Wnt/mitogen-activated protein kinase signaling pathway.

• Journal of international Conference on Electrical Machines and Systems
• /
• v.2 no.4
• /
• pp.441-446
• /
• 2013

A thermal model of power modules based on the physical dimension and thermal properties is proposed in this paper. The heat path in the power module is considered as a one-dimensional heat transfer in the model. The method of the parameters extraction for the model is given in the paper. With high speed and accuracy, the thermal model is suit for electrothermal simulation. The proposed model is verified by experimental results.

• Korean Journal of Human Ecology
• /
• v.23 no.3
• /
• pp.557-569
• /
• 2014

As the number of Chinese students in Korea has significantly increased, the problems of students' life and academic achievement has appeared obviously. Utilizing an analysis on the relationship between the life satisfaction of Chinese students in Korea and the degree of internet addiction, the purposes of this research are to improve the quality of Chinese students' life and to contribute to the growth of Chinese students in Korea. A questionnaire-type survey was conducted on 350 Chinese college students in Daegu. The results of this study are as follows: First, the used time on internet games, chat and on-line TV differs from gender, the duration of internet games and their academic performance. Second, there are significant differences by gender, Korean ability, and academic performance in the life satisfaction of Chinese students in Korea. Third, Chinese college students in Korea are more addicted in the internet than Korean or Chinese college students at their own country. Fourth, the longer playing online game, the longer watching online TV, the less communicating with the Koreans, and the less satisfying with non -study related activities, the more Chinese college students of studying in Korea are addicted in the internet.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.33 no.3
• /
• pp.69-85
• /
• 2020

Objectives : The purpose of this study is to investigate the trend of Tranditional Chinese Medicine for Otitis Media with Effusion(OME) in Chinese journals. Methods : Chinese National Knowledge Infrastructure(CNKI) and Wanfang med online were used to search Chinese studies which were published from January, 2010 to April, 2020. Results : Among Chinese studies, Exterior-releasing medicinal(解表藥) and Heat-clearing medicinal(淸熱藥) were the most frequently used. The herbs which used the most frequently are Bupleuri Radix(柴胡), Acori Graminei Rhizoma(石菖蒲). All of studies have reported that Tranditional Chinese Medicine is effective for Otitis Media with Effusion. Conclusions : In analysis of selected studies, Tranditional Chinese Medicine is more effective than Western Medicine Treatments. Recurrence rates and side effects of OME can be reduced by cotreatment of Tranditional Chinese Medicine and Western Medicine Treatments.

• Asian Journal of Business Environment
• /
• v.8 no.3
• /
• pp.33-41
• /
• 2018

Purpose - This study focused on the attitude differences towards harmony-focused Ad and uniqueness-focused Ad, also those towards brand advertised in each of the two type Ads between self-construals. Research design, data, and methodology - Main survey was conducted online with the people in China, and collected 107 data through harmony Ad questionnaire and 109 data through uniqueness Ad questionnaire. Anova and t-test were used to verify hypotheses. Results - First, More positive attitude towards harmony-focused Ad and the brand in it there was at interdependent Chinese consumers than at independent Chinese consumers. Second, the independent Chinese consumers and the interdependent Chinese consumers did not form significant attitude difference towards uniqueness-focused Ad. However the independent Chinese consumers showed more positive attitude towards the brand in the uniqueness-focused Ad than the interdependent Chinese consumers. Conclusions - By highlighting the attributes of Chinese consumers' self-construal, to appeal to interdependent Chinese consumers, marketers should develop harmony-focused advertisement, and they should appeal to independent Chinese consumers by using uniqueness-focused advertisement. However the harmony might be pursued as the main content in the overall environment by Chinese people. Therefore it is necessary for the marketers to consider the harmony even when appealing them by emphasizing the uniqueness.

• Journal of Korean Medical classics
• /
• v.32 no.3
• /
• pp.1-15
• /
• 2019

Objectives : The purpose of this study is to find the pronunciations suitable for the meanings of Chinese characters because the pronunciations of Chinese characters with multi-pronunciations in the "Huangdineijing" are written differently in Chinese character dictionaries(字典) and in Korean Medical dictionaries(韓醫學辭典) respectively. Methods : First, the annotations for pronunciations in the "Leijing" were searched, upon which the frequently mispronounced 16 Chinese characters in the "Huangdineijing" were selected. Then these selected Chinese characters were compared and considered with reference to Chinese character dictionaries(published in China and Korea), and Korean Medical dictionaries. Results & Conclusions : It was discovered that in "Leijing" there were 1,537 annotations that used 'FanQie(反切)', 'Pronunciation(音)', 'Replaceable character(通用)', 'Same character (同字)', 'Four intonations(四聲)' etc. In some places, there were additional meanings of the Chinese characters. It was found that 16 Chinese characters were susceptible to wrong pronunciations in the "Huangdineijing", for which the appropriate pronunciations in regards to the meaning of the sentences were determined.