• Title/Summary/Keyword: Chemical Exposure

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Characteristics and Co-Occurrence Patterns of Fragrance Allergens in Consumer Chemical Products (생활화학제품의 알레르기반응가능 향료성분 함유 현황 및 동시 출현 패턴 조사)

  • Kim, Soomin;Lee, Kiyoung;Lim, Miyoung
    • Journal of Environmental Health Sciences
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    • v.48 no.4
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    • pp.206-215
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    • 2022
  • Background: Fragrance substances in consumer products can cause adverse health effects such as contact allergy. In South Korea, consumer chemical products must list 26 known fragrance allergens on product labels when they contain more than 0.01%. Fragrance substances are mostly used in combination, so co-exposure can occur via use of a consumer chemical product. Co-exposure to fragrance allergens may show a synergistic effect on the human body. Objectives: The aims of the study were to analyze the characteristics of fragrance allergens in consumer chemical products available on public websites and to identify the co-occurrence patterns of fragrance allergens. Methods: The chemicals in 1,443 ingredient disclosures for consumer chemical products were collected through the Ecolife database. The 26 labelled fragrance allergens were identified by category of consumer chemical product. The co-occurrence patterns of the 26 labelled fragrance allergens were analyzed by frequent pattern mining. The unlabelled fragrance allergens presented by European Union Scientific Committee on Consumer Safety were also identified. Results: Consumer chemical products contained an average of 5.3±4.2 substances among the 26 labelled fragrance allergens. More than 85% of air fresheners, deodorizing agents, and fabric softeners contained at least one of the 26 labelled fragrance allergens. The most frequently contained fragrance allergens were limonene (50.5%), linalool (49.9%), hexyl cinnamal (34.0%), and citronellol (28.3%). 16.7% of consumer chemical products showed a co-occurrence of limonene, linalool, hexyl cinnamal, and citronellol. Thirty-eight unlabelled fragrance allergens were found in the consumer chemical products, with hexamethylindanopyran (25.2%) being the most frequently contained substance. Conclusions: The characteristics and co-occurrence patterns of 26 labelled fragrance allergens would be useful information for the management of co-exposure to fragrance allergens in consumer chemical products. It is necessary for attention to be paid to unlabelled fragrance allergens.

Exposure Assessment of Biogenic Amines as a Chemical Hazard in Commercial Anchovy Fish Sauce from South Korea (멸치액젓의 화학적 위해요소로서의 바이오제닉 아민 노출 평가)

  • Eungyeong Kim;Heeyoung Lee;Sunhyun Park
    • Journal of the FoodService Safety
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    • v.4 no.1
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    • pp.1-6
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    • 2023
  • This study was conducted to evaluate the chemical hazards of 74 kinds of commercial anchovy fish sauce in Korea by measuring their biogenic amine content. The biogenic amines detected in commercial anchovy fish sauce were tryptamine, putrescine, cadaverine, tyramine, spermidine, spermine, and histamine. Among them, histamine content was the highest with an average of 1,439.62±812.62 mg/kg. Excessive intake of histamine could result in chemical food poisoning characterized by high blood pressure, headache, and diarrhea. Accordingly, by simulating histamine exposure (repetition=10,000 times) based on the daily intake of 0.969 g of domestic anchovy fish sauce, we found that the estimated average histamine exposure was 24.49±55.48 ㎍/kg bw/day and that the margins of exposure (MOE) value were 139.18 at 1% and 66,141.07 at 95% of 10,000 simulations (9,500 times). As such, it was confirmed that 9,500 out of 10,000 simulations of MOE analysis significantly exceeded MOE 10. Therefore, the risk of exposure to histamine from ingestion of commercial anchovy fish sauce is approximately very low.

Record Keeping of Employee Exposure to Chemical Hazards under Industrial Safety and Health Law (근로자의 화학물질 노출관련 기록 보존에 관한 연구)

  • Oh, Sangmin;Park, Donguk;Yu, SeoungJae;Jung, Jin Woo;Lim, KyungTaek;Lee, Jaehwan;Ha, Kwonchul
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.23 no.4
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    • pp.367-373
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    • 2013
  • Objectives: Employee exposure record refers to a record containing information about environmental (workplace) monitoring or measuring of a toxic substance or harmful physical agent. The aims of this study were to examine problems related to exposure records and provide some amendments to the Korean Industrial Safety & Health Act for the effective management of chemical substances under the law. Methods: This study performed a literature search and review on legal provisions related to exposure records of a number of different countries, including Korea, the USA, Japan, EU, Germany, and the UK. They were compared and investigated and the amendment of articles was suggested. Results: The results of this study were provided as suggested amendments to the related act. There were a variety of ways of improvement, including a 30-year retention period and the introduction of new access methods, contents, transfer, and maintenance methods. All exposure data elements have to be standardized, including reference to a similar exposure group (SEG), sampling strategy, and circumstances of exposure (e.g., date, shift length, use of personal protective equipment, etc.). The SEGs are described by process, job, task, and environmental agent. Conclusions: This study is expected to provide for the amendment of the related act in order to ensure effective management of exposure records and is helpful for solving the cause and result of occupational disease by keeping exposure records according to the Industrial Safety & Health Act.

An expert system for making durable concrete for chemical exposure

  • Islam, Md. Nazrul;Zain, Muhammad Fauzi Mohd.;Basri, Hassan
    • Computers and Concrete
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    • v.2 no.4
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    • pp.293-307
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    • 2005
  • The development and the main features of an expert system for modeling the requirements of durable concrete in chemical exposure, called the Durable Concrete Advisor for Chemical Exposure (DCACE), are described. The system was developed to help improve the quality of concrete exposed to chemical environment by minimizing mistakes and deficiencies in selecting concrete constituents. Using Kappa-PC expert system shell, an object-oriented model was developed where the rule-based reasoning operates on or across objects. The American Concrete Institute manual of concrete practice was chosen as the main source of knowledge. Other textual sources were also consulted for knowledge acquisition. The major objectives of the research were acquisition and formalization of the relevant knowledge and building an expert system for making durable concrete for chemical exposure regarding sulfate attack, acid attack, seawater attack and carbonation. Similar to most expert systems, this system has explanation facilities, can be incrementally expanded, and has an easy to understand knowledge base. The performance of the system is demonstrated by an example session. The system is user-friendly and can be used as an educational tool.

Development and Application of a Chemical Ranking and Scoring System for the Management of Endocrine Disrupting Chemicals (환경성 내분비계장애물질(EDCs)의 우선관리순위 결정법 개발 및 적용)

  • Lim, Miyoung;Park, Ji Young;Ji, Kyunghee;Lee, Kiyoung
    • Journal of Environmental Health Sciences
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    • v.44 no.1
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    • pp.76-89
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    • 2018
  • Background: Exposure to endocrine disrupting chemicals (EDCs) has been considered one of the main causes of a range of endocrine diseases in modern society. An EDC priority list considering exposure, toxicity, and societal concern should be established for EDC management. Methods: The chemical ranking and scoring (CRS) system for EDCs was based on exposure, toxicity,and societal concern. The exposure score system was based on usage, circulation volume, bioaccumulation, and detection in consumer products. The toxicity score system was based on carcinogenicity and reproductive and developmental toxicity. The societal concern score system was based on domestic or international regulations and mass media reports. Results: A total of 165 EDCs were considered in the CRS system. The top-five priority EDCs were Bis(2-ethylhexyl) phthalate (DEHP), Benzene, Bisphenol A, Dibutyl phthalate (DBP) and Trichloroethylene. Phthalates, bisphenols and parabens were identified as priority chemical groups. Conclusion: We developed a CRS system for EDCs to identify priority EDCs for management. This will be a foundation to provide an EDC management plan based on scientific decision-making.

Effects of Ag Nanoparticle Flow Rates on the Progress of the Cell Cycle Under Continuously Flowing "Dynamic" Exposure Conditions

  • Park, Min Sun;Yoon, Tae Hyun
    • Bulletin of the Korean Chemical Society
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    • v.35 no.1
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    • pp.123-128
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    • 2014
  • In this study, we have investigated the flow rate effects of Ag nanoparticle (NP) suspensions on the progress of the cell cycle by using a microfluidic image cytometry (${\mu}FIC$)-based approach. Compared with the conventional "static" exposure conditions, enhancements in G2 phase arrest were observed for the cells under continuously flowing "dynamic" exposure conditions. The "dynamic" exposure conditions, which mimic in vivo systems, induced an enhanced cytotoxicity by accelerating G2 phase arrest and subsequent apoptosis processes. Moreover, we have also shown that the increases in delivered NP dose due to the continuous supply of Ag NPs contributed dominantly to the enhanced cytotoxicity observed under the "dynamic" exposure conditions, while the shear stress caused by these slowly flowing fluids (i.e., flow rates of 6 and $30{\mu}L/h$) had only a minor influence on the observed enhancement in cytotoxicity.

Nano-safety Management and Exposure Assessment of Nanomaterials Producing Facilities (나노물질 생산시설의 환경노출 평가와 안전관리)

  • Umh, Ha Nee;Roh, Jinkyu;Park, Junsu;Kwak, Byoung Kyu;Lee, Byung Cheon;Choi, Kyunghee;Yi, Jongheop;Kim, Younghun
    • Korean Chemical Engineering Research
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    • v.50 no.1
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    • pp.112-117
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    • 2012
  • With the development of nanotechnology, nano-consumer products have been popularized. For the past 10 years, potential risk of nanomaterials to human and environment have been raised carefully. Especially, workers, who directly handle nanomaterials in laboratories and manfacturers, will lead to direct exposure of nanomaterials. Therefore, direct exposure assessment and field monitoring of nanomaterials are required to assess and manage the nanomaterial exposure to human and environment. In this work, two nano-manufacturing companies, which had plasma and sol-gel processes, were selected to analyze the main exposure source and process with in-situ SMPS (scanning mobility particle sizer) and ex-situ TEM (transmission electron microscopy). The results showed that the colloidal nanoparticle in liquid phase was easily evaporated and monitored by SMPS. Most serious thing is that the workers does not know about the potential risk of nanomaterials, and thus they are not taking proper protection activities, such as PPE (personal protective equipment). Therefore, exposure assessment for nanomaterial handling facilities should be additionally carried out, and nano-safety management protocols are also provided.

Assessment of Chemical Risks in Moroccan Medical Biology Laboratories in Accordance with the CLP Regulation

  • Mourry, Ghita E.;Alami, Rachid;Elyadini, Adil;Hajjaji, Souad El;kabba, Saad El;Zouhdi, Mimoun
    • Safety and Health at Work
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    • v.11 no.2
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    • pp.193-198
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    • 2020
  • Background: Medical laboratory workers are frequently exposed to a wide range of chemicals. This exposure can have adverse effects on their health. Furthermore, a knowledge lack of the chemical risk increases the likelihood of exposure. The chemical risk assessment reduces the risk of exposure to hazardous chemicals and therefore, guarantees health and safety of the workers. Method: The chemical risk assessment was conducted using a modified INRS method, according to the new CLP Regulation, of 11 unit laboratories in a Moroccan medical laboratory. Observation of each workstation and analysis of safety data sheets are key tools in this study. Results: A total of 144 substances and reagents that could affect the health of the analytical technicians were identified. Among these products, 17% are concerned by the low priority risk score, with 55% concerned by the average priority risk score and 28% concerned by the high priority risk score. This study also enabled to better identify the chemical agents that have restrictive occupational exposure limit value and controls were conducted to this effect. On the basis of the results obtained, several corrective and preventive measures have been proposed and implemented. Conclusion: Risk assessment is essential to ensure the health and safety of workers and to meet regulatory requirements. It enables to identify all the risky manipulations and to adopt appropriate preventive measures. However, it is not a one-time activity but it must be continuous in order to master the changes and thus ensure the best safety of all.

Modified Shrinking Core Model for Atomic Layer Deposition of TiO2 on Porous Alumina with Ultrahigh Aspect Ratio

  • Park, Inhye;Leem, Jina;Lee, Hoo-Yong;Min, Yo-Sep
    • Bulletin of the Korean Chemical Society
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    • v.34 no.2
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    • pp.519-523
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    • 2013
  • When atomic layer deposition (ALD) is performed on a porous material by using an organometallic precursor, minimum exposure time of the precursor for complete coverage becomes much longer since the ALD is limited by Knudsen diffusion in the pores. In the previous report by Min et al. (Ref. 23), shrinking core model (SCM) was proposed to predict the minimum exposure time of diethylzinc for ZnO ALD on a porous cylindrical alumina monolith. According to the SCM, the minimum exposure time of the precursor is influenced by volumetric density of adsorption sites, effective diffusion coefficient, precursor concentration in gas phase and size of the porous monolith. Here we modify the SCM in order to consider undesirable adsorption of byproduct molecules. $TiO_2$ ALD was performed on the cylindrical alumina monolith by using titanium tetrachloride ($TiCl_4$) and water. We observed that the byproduct (i.e., HCl) of $TiO_2$ ALD can chemically adsorb on adsorption sites, unlike the behavior of the byproduct (i.e., ethane) of ZnO ALD. Consequently, the minimum exposure time of $TiCl_4$ (~16 min) was significantly much shorter than that (~71 min) of DEZ. The predicted minimum exposure time by the modified SCM well agrees with the observed time. In addition, the modified SCM gives an effective diffusion coefficient of $TiCl_4$ of ${\sim}1.78{\times}10^{-2}\;cm^2/s$ in the porous alumina monolith.

Estimation of Temporal Acute Exposure Guideline Levels for Emergency Response - A Brief Case using Formaldehyde - (화학사고 대응을 위한 시간별 급성노출기준 참고치 산정 - 폼알데하이드 사례 -)

  • Kim, Eunchae;Cho, Yong-Sung;Lee, Chung-Soo;Yang, Wonho;Hwang, Seung-Ryul;Park, Jihoon
    • Journal of Environmental Health Sciences
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    • v.47 no.2
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    • pp.166-174
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    • 2021
  • Objectives: This study aimed to provide temporal Acute Exposure Guideline Levels (AEGL) for a hazardous substance as a pilot study. Methods: As one of the substances designated by the Korea Ministry of Environment as requiring preparations for potential accidents, formaldehyde was selected to estimate the AEGLs. The calculation was based on Haber's formula (Cn×t=k) using valid toxicity data (for humans/animals). A total of 96 points of AEGL levels were provided using an interval of five minutes over eight hours. Results: The AEGL-1 and 2 values were constant for the entire exposure duration at 0.9 ppm and 14 ppm, respectively. The values were obtained from clinical/animal tests, and the adaptation effect after a given exposure duration was also considered. AEGL-3 was based on animal toxicity data, and it was estimated from 127 ppm for the initial five minutes to 35 ppm for eight hours. Conclusions: More specific AEGL levels for formaldehyde could be obtained in this study using toxicity data with Haber's formula. Based on this methodology, it would be also possible to estimate AEGL levels that can be used at the scene of a chemical accident for other substances requiring preparation for potential accidents.