Development and Application of a Chemical Ranking and Scoring System for the Management of Endocrine Disrupting Chemicals

환경성 내분비계장애물질(EDCs)의 우선관리순위 결정법 개발 및 적용

  • Lim, Miyoung (Department of Environmental Health, Graduate School of Public Health, Seoul National University) ;
  • Park, Ji Young (Institute of Health and Environment, Seoul National University) ;
  • Ji, Kyunghee (Department of Occupational and Environmental Health, Yongin University) ;
  • Lee, Kiyoung (Department of Environmental Health, Graduate School of Public Health, Seoul National University)
  • 임미영 (서울대학교 보건대학원 환경보건학과) ;
  • 박지영 (서울대학교 보건환경연구소) ;
  • 지경희 (용인대학교 산업환경보건학과) ;
  • 이기영 (서울대학교 보건대학원 환경보건학과)
  • Received : 2018.01.22
  • Accepted : 2018.02.09
  • Published : 2018.02.28


Background: Exposure to endocrine disrupting chemicals (EDCs) has been considered one of the main causes of a range of endocrine diseases in modern society. An EDC priority list considering exposure, toxicity, and societal concern should be established for EDC management. Methods: The chemical ranking and scoring (CRS) system for EDCs was based on exposure, toxicity,and societal concern. The exposure score system was based on usage, circulation volume, bioaccumulation, and detection in consumer products. The toxicity score system was based on carcinogenicity and reproductive and developmental toxicity. The societal concern score system was based on domestic or international regulations and mass media reports. Results: A total of 165 EDCs were considered in the CRS system. The top-five priority EDCs were Bis(2-ethylhexyl) phthalate (DEHP), Benzene, Bisphenol A, Dibutyl phthalate (DBP) and Trichloroethylene. Phthalates, bisphenols and parabens were identified as priority chemical groups. Conclusion: We developed a CRS system for EDCs to identify priority EDCs for management. This will be a foundation to provide an EDC management plan based on scientific decision-making.



  1. United States National Institute of Environmental Health Sciences. Endocrine disruptors. Available: [accessed 3 January 2018].
  2. World Health Organization, United Nations Environment Programme. The state of the science of endocrine disrupting chemicals-2012. Available: HSE_PHE_IHE_2013.1_eng.pdf [accessed 15 January 2018].
  3. Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, et al. EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine- Disrupting Chemicals. Endocr Rev. 2015; 36(6): E1-E150.
  4. Sifakis S, Androutsopoulos VP, Tsatsakis AM, Spandidos DA. Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems. Environ Toxicol Pharmacol. 2017; 51: 56-70.
  5. Botton J. Kadawathagedara M. Lauzon-Guillai B. Endocrine disrupting chemicals and growth of children. Annales d'Endocrinologie. 2017; 78: 108-111.
  6. Meeker JD. Exposure to Environmental Endocrine Disruptors and Child Development. Arch Pediatr Adolesc Med. 2012; 166(6): E1-E7.
  7. Keith LH. Environmental endocrine disruptors. Pure & Appl. Chem., 1998; 70(12): 2319-2326.
  8. European Commission. Priority List. Available: [accessed 3 January 2018].
  9. United States Environmental Protection Agency. Final Second List of Chemicals for Tier 1 under the Endocrine Disruptor Screening Program. Available: documents/1.pdf [accessed 15 January 2018].
  10. United States Environmental Protection Agency. Endocrine Disruptor Screening Program Tier 1 Screening Determinations and Associated Data Evaluation Records. Available: endocrine-disruption/endocrine-disruptor-screeningprogram- tier-1-screening-determinations-and [accessed 15 January 2018].
  11. The International Chemical Secretariat. SinList all chemicals. Available listall [accessed 15 January 2018].
  12. Kim YS, Park HS, Lee DS, Shin DC. Comparisons of Chemical Ranking and Scoring Methods. Environmental Health and Toxicology, 2003; 18(3): 183-191.
  13. Rim KT, Lim CH, Kim HY, Cha SW, Heo Y, Yoon JH. Prioritization of Chemicals for Chronic/Carcinogenic Inhalation Testing. Korean Journal of Environmental Health, 2017; 43(1): 23-41.
  14. United States Environmental Protection Agency. comparative evaluation of chemical ranking and scoring methodologies. Available: b11.pdf [accessed 15 January 2018].
  15. United States Agency for Toxic Substances and Disease Registry. ATSDR's Substance Priority List. Available: [accessed 15 January 2018].
  16. Davis GA, Kincaid L, Swanson, M, Schultz T, Bartmess J. Chemical hazard evaluation for management strategies : a method for ranking and scoring chemicals by potential human health and environmental impacts. Washington, DC: United States Environmental Protection Agency; 1994.
  17. Mitchell RR, Summer CL, Blonde SA, Bush DM, Hurlburt GK, Snyder EM, et al. SCRAM: a scoring and ranking system for persistent, bioaccumulative, and toxic substances for the north American Great lakes-resulting chemical scores and rankings. Human and Ecological Risk Assessment. 2002; 8(3), 537-557.
  18. Hanset BG, Haelst AG, Leeuwen K, Zandt P. Priority setting for existing chemicals: European union risk ranking method. Environmental Toxicology and Chemistry. 1999; 18(4): 772-779.
  19. Antweiler W, Harrison K. Canada's Voluntary ARET Program: Limited Success Despite Industry Cosponsorship. Journal of Policy Analysis and Management. 2007; 26(4): 755-774.
  20. Park H, Kim Y, Lee D, Shin Y, Choi S, Park S, et al. Development of Korean Chemical Ranking and Scoring System (CRS-Korea) and its Application to Prioritizing National Toxic Chemicals. Environmental Health and Toxicology. 2005; 20(2): 109-121.
  21. Choi S, Park H, Lee D, Shin Y, Kim Y, Shin D. Development of CRS-Korea II and its Application to Setting the Priority of Toxic Chemicals for Local Provinces. Environmental Health and Toxicology, 2005; 20(4): 311-325.
  22. Yang J, Jang J, Kim S, Kim Y, Lee H, Shin D, et al. Development of Korean Food-Chemical Ranking and Scoring System (Food-CRS-Korea) and Its Application to Prioritizing Food Toxic Chemicals Associated with Environmental Pollutants. Environmental Health and Toxicology. 2010; 25(1):41-55.
  23. Nam S, Kwak J, Yoon S, Jeong S, An Y. Chemical Ranking and Scoring Methodology for the Protection of Human Health and Aquatic Ecosystem in Korean Surfacewater: CRAFT (Chemical RAnking of surFacewater polluTants). Journal of Korean Society on Water Quality. 2011; 27(6): 804-812.
  24. An Y, Jeong S, Kim M, Yang C. Comparative Study of Exposure Potential and Toxicity Factors used in Chemical Ranking and Scoring System. Environmental Health and Toxicology, 2009; 24(2): 95-105.
  25. Jeong J, Jung Y, Hwang M, Jung K, Yoon H. Prioritizing Management Ranking for Hazardous Chemicals Reflecting Aggregate Exposure. Journal of Food Hygiene and Safety. 2012; 27(4): 349-355.
  26. Lim J, Kwon H, Kim S, Choi Y, Gu S, Jeong H, et al. Process and Results of Seoul Metropolitan Government's Environmental Health Policy Road Map. Korean Journal of Environmental Health, 2014; 40(5): 425-434.
  27. Korea Ministry of Environment. Selection and evaluation of priority substances for endocrine disruptors. Available: [accessed 15 January 2018].
  28. The Korea Occupational Safety and Health Agency. Chemical Information. Available: http://msds.kosha. [accessed 15 January 2018].