Safety and Health at Work

Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency (산업안전보건연구원)
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Assessment of Chemical Risks in Moroccan Medical Biology Laboratories in Accordance with the CLP Regulation

  • Mourry, Ghita E. (Microbiology Department, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University) ;
  • Alami, Rachid (Research and Medical Analysis Laboratory of the Fraternelle of the Royal Gendarmerie) ;
  • Elyadini, Adil (Laboratory of Spectroscopy, Molecular Modeling, Materials, Nanomaterials, Water and Environment, Faculty of Sciences Rabat, Mohammed V University) ;
  • Hajjaji, Souad El (Laboratory of Spectroscopy, Molecular Modeling, Materials, Nanomaterials, Water and Environment, Faculty of Sciences Rabat, Mohammed V University) ;
  • kabba, Saad El (Research and Medical Analysis Laboratory of the Fraternelle of the Royal Gendarmerie) ;
  • Zouhdi, Mimoun (Microbiology Department, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University)
  • Received : 2019.08.15
  • Accepted : 2020.03.17
  • Published : 2020.06.30
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Abstract

Background: Medical laboratory workers are frequently exposed to a wide range of chemicals. This exposure can have adverse effects on their health. Furthermore, a knowledge lack of the chemical risk increases the likelihood of exposure. The chemical risk assessment reduces the risk of exposure to hazardous chemicals and therefore, guarantees health and safety of the workers. Method: The chemical risk assessment was conducted using a modified INRS method, according to the new CLP Regulation, of 11 unit laboratories in a Moroccan medical laboratory. Observation of each workstation and analysis of safety data sheets are key tools in this study. Results: A total of 144 substances and reagents that could affect the health of the analytical technicians were identified. Among these products, 17% are concerned by the low priority risk score, with 55% concerned by the average priority risk score and 28% concerned by the high priority risk score. This study also enabled to better identify the chemical agents that have restrictive occupational exposure limit value and controls were conducted to this effect. On the basis of the results obtained, several corrective and preventive measures have been proposed and implemented. Conclusion: Risk assessment is essential to ensure the health and safety of workers and to meet regulatory requirements. It enables to identify all the risky manipulations and to adopt appropriate preventive measures. However, it is not a one-time activity but it must be continuous in order to master the changes and thus ensure the best safety of all.

Keywords

References

  1. Kingdom of Morocco. Ministry of Labor and Occupational Integration. Decree No 2-12-431 of November 25th 2013 laying down the conditions for the use of substances or preparations which could endanger the health of employees or jeopardize their safety. Off Bull 2013-12-19:2722-30. 6214[article 2-54].
  2. Kingdom of Morocco. Ministry of Labor and Occupational Integration. Directorate of Labor. Compendium of laws and regulations relating to health and safety at work; December 2012. p. 97-140.
  3. Kingdom of Morocco. National profile for occupational safety and health. edition; September 2017. 137 p.
  4. Apatsidou M, Konstantopoulou I, Foufa E, Tsarouhas K, Papalexis P, Rezaee R, Spandidos DA, Kouretas D, Tsitsimpikou C. Safe use of chemicals by professional users and health care specialists. Biomed Rep 2018 Feb;8(2):160-5.
  5. Vincent R, Bonthoux F, Mallet G, Iparraguire JF, Rio S. Methodologie d'evaluation simplifiee du risque chimique : un outil d'aide a la decision. INRS - hygiene et securite du travail - cahiers de notes documentaries. ND 2233-200-05; 3seme trimestre. INRS; 2005. p. 39-62.
  6. Kromhout H, Symanski E, Rappaport SM. A comprehensive evaluation of within-and between-worker components of occupational exposure to chemical agents. Ann Occup Hyg 1993;37:253-70. https://doi.org/10.1093/annhyg/37.3.253
  7. Van Leeuwen CJ, Vermeire TG. Risk assessment of chemicals: an introduction. 2nd ed. Springer; 2007. 686 p.
  8. Afnor standardization NF EN ISO 15189. Laboratoires de biologie medicale - exigences concernant la qualite et la competence - laboratoires d'analyses de biologie medicale; Decembre 2012. 56 p.
  9. Afnor standardization NF EN ISO 14001. Systemes de management environnemental - exigences et lignes directrices pour son utilisation; Octobre 2015. 51 p.
  10. Afnor standardization BS OHSAS 18001. Systemes de management de la sante et de la securite des salaries - Exigences; Juillet 2007. 228 p.
  11. Afnor standardization NF EN ISO 45001. Systemes de management de la sante et de la securite au travail - exigences et lignes directrices pour leur utilisation; Mars 2018. 41 p.
  12. Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32008R1272. Accessed December 4, 2018.
  13. Kingdom of Morocco: Ministry of Labor and Occupational Integration. Order No. 4576-14 of December 24, 2014 setting occupational exposure limit values for certain hazardous chemicals.
  14. Fawcett HH. Exposures of personnel to laboratory hazards. Am Ind Hyg Assoc J 1972;33:559-67. https://doi.org/10.1080/0002889728506704
  15. Kauppinen T, Pukkala E, Saalo A, Sasco AJ. Exposure to chemical carcinogens and risk of cancer among Finnish laboratory workers. Am J Ind Med 2003;44:343-50. https://doi.org/10.1002/ajim.10278
  16. Lefebevre V, Gimenez C, , et alBrochard P. Risque chimique dans les laboratoires de biologie moleculaire. Dossier medico-technique 85TC81. Document pour le medecin de travail n85. 1-r trimestre. INRS; 2001.
  17. Sasco AJ. Risques pour la sante dans les laboratories de recherche biologique et medicale : le point sur les connaissances epidemiologiques actuelles. Medicine/Sciences 1989;5:489-98. https://doi.org/10.4267/10608/4006
  18. Orsiere T, Sari-Minodier I, Iarmarcovai G, Botta A. Genotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytes. Mutat Res 2006;605:30-41. https://doi.org/10.1016/j.mrgentox.2006.01.006
  19. Wennborg H, Yuen J, Nise G, Sasco AJ, Vainio H, Gustavsson P. Cancer incidence and work place exposure among Swedish biomedical research personnel. Int Arch Occup Environ Health 2001;74(8):558-64. https://doi.org/10.1007/s004200100267
  20. Molhave L. Volatile organic compounds, indoor air quality and health. Indoor Air 1991;4:357-76. https://doi.org/10.1111/j.1600-0668.1991.00001.x
  21. Mohammed-Brahim B, Garrigou A. Une approche critique du modele dominant de prevention du risque chimique. L'apport de l'ergotoxicologie. @ctivites 2009;6(1):49-67.
  22. Koulaouzidou EA, Roussou K, Sidiropoulos K, Nikolaidis A, Kolokuris I, Tsakalof A, Tsitsimpikou C, Kouretas D. Investigation of the chemical profile and cytotoxicity evaluation of organic components eluted from pit and fissure sealants. Food Chem Toxicol 2018 Oct;120:536-43. https://doi.org/10.1016/j.fct.2018.07.042
  23. Martel B. Guide du risque chimique : identification, evaluation, maîtrise. 3eme edition. Paris: Dunod; 2002. 317 p.
  24. Union of Chemical Industries (UIC). Outil d'evaluation des risques lies aux produits chimiques. Paris La Defense, Chimie promotion; octobre 1999. 44 p.
  25. Persoons R, Dumas L, Stoklov M, Maitre A. Developpement d'une nouvelle methode d'evaluation des risques chimiques : application dans les laboratoires hospitaliers. Arch Mal Prof Environ 2005;66:326-34.
  26. Persoons R, Maitre A, Sawicki B, Dumont D, Denis M-A, Karinthi-Doyon A, Touche S. Outils d'aide a l'evaluation des risques chimiques en etablissement de sante: retour d'experiences d'un reseau inter-CHU. Arch Mal Prof Environ 2009;70:3-12.
  27. Vincent R. Evaluation du risque chimique : hierarchisation des risques potentiels. Cahiers de Notes Documentaires 2000;178:29-34.
  28. Aydin S, Canpinar H, Undeger U, Guc D, Colakoglu M, Kars A, Basaran N. Assessment of immunotoxicity and genotoxicity in workers exposed to low concentrations of formaldehyde. Arch Toxicol 2013;87:145-53. https://doi.org/10.1007/s00204-012-0961-9
  29. Kim KH, Jahan SA, Lee JT. Exposure to formaldehyde and its potential human health hazards. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2011;29:277-99. https://doi.org/10.1080/10590501.2011.629972
  30. Salonen H, Pasanen AL, Lappalainen S, Riuttala H, Tuomi T, Pasanen P. Volatile organic compounds and formaldehyde as explaining factors for sensory irritation in office environments. J Occup Environ Hyg 2009;6:239-47. https://doi.org/10.1080/15459620902735892
  31. Fenga C, Gangemi S, Giambo F, Tsitsimpikou C, Golokhvast K, Tsatsakis A, Costa C. Low-dose occupational exposure to benzene and signal transduction pathways involved in the regulation of cellular response to oxidative stress. Life Sci 2016 Feb 15;147:67-70. https://doi.org/10.1016/j.lfs.2015.12.025
  32. McGregor D, Bolt H, Cogliano V, Richter-Reichelm HB. Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within the context of the 2006 IPCS human framework for the analysis of a cancer mode of action for humans. Crit Rev Toxicol 2006;36:821-35. https://doi.org/10.1080/10408440600977669
  33. Thompson CM, Grafstrom RC. Considerations for the implausibility of leukemia induction by formaldehyde. Toxicol Sci 2011;120:230-2. https://doi.org/10.1093/toxsci/kfq340
  34. Kortenkamp A, Backhaus T, Faust M. State of the art report on mixture toxicity. Final Report. Executive summary. Brussels: European Commission. 2009 [cited 2019 Dec 26]. Available from: http://ec.europa.eu/environment/chemicals/effects/pdf/report_mixture_toxicity.pdf.
  35. Tsatsakis AM, Kouretas D, Tzatzarakis MN, Stivaktakis P, Tsarouhas K, Golokhvast KS, Rakitskii VN, Tutelyan VA, Hernandez AF, Rezaee R, Chung G. Simulating real-life exposures to uncover possible risks to human health: a proposed consensus for a novel methodological approach. Hum Exp Toxicol 2017 Jun;36(6):554-64. https://doi.org/10.1177/0960327116681652
  36. Tsatsakis AM, Docea AO, Tsitsimpikou C. New challenges in risk assessment of chemicals when simulating real exposure scenarios; simultaneous multichemicals' low dose exposure. Food Chem Toxicol 2016 Oct;96:174-6. https://doi.org/10.1016/j.fct.2016.08.011