• Journal of the Institute of Electronics Engineers of Korea CI
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• v.39 no.2
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• pp.1-9
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• 2002

The use of Object-Oriented Distributed Programming(OODP) environment such as DCOM, DSOM, Java RMI, CORBA to implement distributed applications is becoming increasingly popular. However, absence of a fault-tolerance feature in these middleware platforms complicates the design and implementation of reliable distributed object-based applications, although they greatly enhance the quality and reusability of the distributed object-based applications. In this paper, we propose a fault-tolerant programming environment based on RMI, namely Evergreen, for the reliable distributed computing with checkpoints and rollback-recovery mechanism. Based on a series of experiments, we evaluate the performance of Evergreen and find its possibility of extension to fully support our optimal design goal.

• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.4-9
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• 2018

Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells. In cancer cells, depending on the driving oncogenic event, metabolism is re-wired for nutrient import, redox homeostasis, protein quality control, and biosynthesis to support cell growth and division. In general, resting cells rely on oxidative metabolism, while proliferating cells rewire metabolism toward glycolysis, which favors many biosynthetic pathways for proliferation. Oncogenes such as MYC, BRAF, KRAS, and PI3K have been documented to rewire metabolism in favor of proliferation. These cell intrinsic mechanisms, however, are insufficient to drive tumorigenesis because immune surveillance continuously seeks to destroy neo-antigenic tumor cells. In this regard, evasion of cancer cells from immunity involves checkpoints that blunt cytotoxic T cells, which are also attenuated by the metabolic tumor microenvironment, which is rich in immuno-modulating metabolites such as lactate, 2-hydroxyglutarate, kynurenine, and the proton (low pH). As such, a full understanding of tumor metabolism requires an appreciation of the convergence of cancer cell intrinsic metabolism and that of the tumor microenvironment including stromal and immune cells.

• Journal of Radiation Protection and Research
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• v.35 no.4
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• pp.167-171
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• 2010

Fixed radiation portal monitors (RPMs) deployed at border, seaport, airport and key traffic checkpoints have played an important role in preventing the illicit trafficking and transport of nuclear and radioactive materials. However, the RPM is usually large and heavy and can't easily be moved to different locations. These reasons motivate us to develop a mobile radiation detection system. The objective of this paper is to report our experience on developing the mobile radiation detection system for search and detection of nuclear and radioactive materials during road transport. Field tests to characterize the developed detection system were performed at various speeds and distances between the radioactive isotope (RI) transporting car and the measurement car. Results of measurements and detection limits of our system are described in this paper. The mobile radiation detection system developed should contribute to defending public's health and safety and the environment against nuclear and radiological terrorism by detecting nuclear or radioactive material hidden illegally in a vehicle.

• Journal of Genetic Medicine
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• v.13 no.1
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• pp.1-13
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• 2016

Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich environment we live in, the DNA molecule is under constant threat from endogenous or exogenous insults. DNA damage could trigger the DNA damage response (DDR), which involves DNA repair, the regulation of cell cycle checkpoints, and the induction of programmed cell death or senescence. Dysregulation of these physiological responses to DNA damage causes developmental defects, neurological defects, premature aging, infertility, immune system defects, and tumors in humans. Some human syndromes are characterized by unique neurological phenotypes including microcephaly, mental retardation, ataxia, neurodegeneration, and neuropathy, suggesting a direct link between genomic instability resulting from defective DDR and neuropathology. In this review, rare human genetic disorders related to abnormal DDR and damage repair with neural defects will be discussed.

• Journal of Korea Society of Digital Industry and Information Management
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• v.6 no.2
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• pp.233-245
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• 2010

This paper proposes security architecture, security audit framework, and audit check item. These are based on the security requirement that has been researched in the information system audit. The proposed information security architecture is built in a way that it could defend a cyber attack. According to its life cycle, it considers a security service and security control that is required by the information system. It is mapped in a way that it can control the security technology and security environment. As a result, an audit framework of the information system is presented based on the security requirement and security architecture. The standard checkpoints of security audit are of the highest level. It was applied to the system introduction for the next generation of D stock and D life insurance company. Also, it was applied to the human resources information system of K institution and was verified. Before applying to institutions, system developers and administrators were educated about their awareness about security so that they can follow guidelines of a developer security. As a result, the systemic security problems were decreased by more than eighty percent.

• Tuberculosis and Respiratory Diseases
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• v.81 no.1
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• pp.29-41
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• 2018

Lung cancer is one of the most commonly diagnosed cancers and the leading cause of cancer-related deaths worldwide. Although progress in the treatment of advanced non-small cell lung cancer (NSCLC) has been made over the past decade, the 5-year survival rate in patients with lung cancer remains only 10%-20%. Obviously, new therapeutic options are required for patients with advanced NSCLC and unmet medical needs. Cancer immunotherapy is an evolving treatment modality that uses a patient's own immune systems to fight cancer. Theoretically, cancer immunotherapy can result in long-term cancer remission and may not cause the same side effects as chemotherapy and radiation. Immunooncology has become an important focus of basic research as well as clinical trials for the treatment of NSCLC. Immune checkpoint inhibitors are the most promising approach for cancer immunotherapy and they have become the standard of care for patients with advanced NSCLC. This review summarizes basic tumor immunology and the relevant clinical data on immunotherapeutic approaches, especially immune checkpoint inhibitors in NSCLC.

• Research in Community and Public Health Nursing
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• v.14 no.3
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• pp.457-467
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• 2003

Purpose: This study examined the development and performance of the school health promotion policy guideline that is applicable to Korean school health. Methods: 1. The WHO's guideline was translated into Korean and modified by school health experts 2. A questionnaire was conducted to assess the performance of school health policy on 207 nurses in elementary schools in Seoul and Cheonbuk. Result: The Korean version of the school health promotion policy guidelines were developed including 9 components and 36 checkpoints. Compared to that of WHO, the component 'school nursing teacher' was added and three components were eliminated: 'equitable access to school resources', 'control of helminth', and 'sun protection policy'. The performance degree of first-aid, closure of school in a calamity, and control of HIV/AIDS was very low. The performance degree of a healthy diet, and regular physical examination was quite high. This study was the first that developed the school health promotion policy guideline and examined the performance. Further research is needed to validate the guidelines developed by this study.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.27 no.3
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• pp.549-562
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• 2017

In recent years, as the proportion of mobile banking has become bigger with daily usage of mobile banking, security threats are also increasing according to the feeling. Accordingly, the domestic banking system introduces security solution programs in the banking application and sets security check points to ensure the stability of the application in order to check whether it is always executed. This study presents a vulnerability of inactivity bypassing mobile vaccine program operation checkpoints using the intermediate language statically and dynamically analysis when decompiling the android banking applications of major banks in Korea. Also, through the results, it identifies possible attacks that can be exploited and suggest countermeasures.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.1409-1411
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• 2003

The application of simulated KOMPSAT-2 imagery to monitor graveyards is to be developed. Positions calculated from image were compared with those obtained from Geographic Positioning System. With 24 checkpoints, the position of graveyards showed within 5-meter range. Unsupervised classification, supervised classification, and objected-orientation classification algorithms were used to extract the graveyard. Unsupervised classification with masking processes based on National topographic data gives the best result. The graveyards were categorized with four types in field studies while the two types of graveyards were shown in descriptive statistics. Cluster Analysis and discriminant analysis showed the consistency with two types of tombs. It was hard to get a specific spectral signature of graveyards, as they are covered with grasses at different levels and shaded from the surrounding trees. The slopes and aspects of location of graveyards did not make any difference in the spectral signatures. This study gives the basic spectral characteristics for further development of objected-oriented classification algorithms and plausibility of KOMPSAT-2 images for management of mountainous areas in the aspect of position accuracy and classification accuracy.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.10.1-10.11
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• 2018

Cancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. Monoclonal antibodies that target immune checkpoints provided an immense breakthrough in cancer therapeutics. Among the immune checkpoint inhibitors, PD-1/PD-L1 and CTLA-4 inhibitors showed promising therapeutic outcomes, and some have been approved for certain cancer treatments, while others are under clinical trials. Recent reports have shown that patients with various malignancies benefit from immune checkpoint inhibitor treatment. However, mainstream initiation of immune checkpoint therapy to treat cancers is obstructed by the low response rate and immune-related adverse events in some cancer patients. This has given rise to the need for developing sets of biomarkers that predict the response to immune checkpoint blockade and immune-related adverse events. In this review, we discuss different predictive biomarkers for anti-PD-1/PD-L1 and anti-CTLA-4 inhibitors, including immune cells, PD-L1 overexpression, neoantigens, and genetic and epigenetic signatures. Potential approaches for further developing highly reliable predictive biomarkers should facilitate patient selection for and decision-making related to immune checkpoint inhibitor-based therapies.